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Conserved domains on  [gi|1655161380|ref|WP_137644701|]
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cysteine hydrolase family protein [Lactiplantibacillus plajomi]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10003554)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

CATH:  3.40.50.850
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 6-184 2.38e-57

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 177.79  E-value: 2.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADnGALTCgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESKLFPPHNVRGSWGRELYG 85
Cdd:COG1335     1 ALLVIDVQNDFVPP-GALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDwfdqHQEDPTVwqfDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:COG1335    79 ELAP----LPGDPVV---DKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                         170
                  ....*....|....*....
gi 1655161380 166 EGHAWALRHFQNsLGATLI 184
Cdd:COG1335   152 EAHEAALARLRA-AGATVV 169
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 6-184 2.38e-57

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 177.79  E-value: 2.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADnGALTCgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESKLFPPHNVRGSWGRELYG 85
Cdd:COG1335     1 ALLVIDVQNDFVPP-GALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDwfdqHQEDPTVwqfDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:COG1335    79 ELAP----LPGDPVV---DKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                         170
                  ....*....|....*....
gi 1655161380 166 EGHAWALRHFQNsLGATLI 184
Cdd:COG1335   152 EAHEAALARLRA-AGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 6-175 2.91e-52

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 164.36  E-value: 2.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADNGALTcgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESkLFPPHNVRGSWGRELYG 85
Cdd:cd00431     1 ALLVVDMQNDFVPGGGLLL--PGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDwfdqhQEDPTVwqFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:cd00431    78 ELAP-----LPDDLV--IEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                         170
                  ....*....|
gi 1655161380 166 EGHAWALRHF 175
Cdd:cd00431   151 EDHEAALERL 160
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 6-184 9.37e-48

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 153.33  E-value: 9.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADNGALTcgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESKLFPPHNVRGSWGRELYG 85
Cdd:pfam00857   2 ALLVIDMQNDFVDSGGPKV--EGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDWFDqhqeDPTVwqfDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:pfam00857  80 ELAPLPG----DLVV---DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSP 152

                         170
                  ....*....|....*....
gi 1655161380 166 EGHAWALRHFQNSlGATLI 184
Cdd:pfam00857 153 EAHDAALERLAQR-GAEVT 170
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-176 1.42e-19

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 82.04  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   1 MPTDQALLIIDYTNDFVADnGALtcGYP-GQQLAPVITALAEkmRANGDWVLLPTDVHTPH-------------DPYHPE 66
Cdd:PTZ00331    9 SSTNDALIIVDVQNDFCKG-GSL--AVPdAEEVIPVINQVRQ--SHHFDLVVATQDWHPPNhisfasnhgkpkiLPDGTT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  67 SKLFPPHNVRGSWGRELYGplkdwfDQHQEDPTVW-----QFDKTRYSSFAG-----TDLDLRLRERHVTTLHLVGVCTD 136
Cdd:PTZ00331   84 QGLWPPHCVQGTKGAQLHK------DLVVERIDIIirkgtNRDVDSYSAFDNdkgskTGLAQILKAHGVRRVFICGLAFD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1655161380 137 ICVLHTAVDAYNLGYQLVIHQDGVASFDAEGHAWALRHFQ 176
Cdd:PTZ00331  158 FCVLFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELL 197
 
Name Accession Description Interval E-value
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 6-184 2.38e-57

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 177.79  E-value: 2.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADnGALTCgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESKLFPPHNVRGSWGRELYG 85
Cdd:COG1335     1 ALLVIDVQNDFVPP-GALAV-PGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAEFDLWPPHCVPGTPGAELVP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDwfdqHQEDPTVwqfDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:COG1335    79 ELAP----LPGDPVV---DKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP 151

                         170
                  ....*....|....*....
gi 1655161380 166 EGHAWALRHFQNsLGATLI 184
Cdd:COG1335   152 EAHEAALARLRA-AGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 6-175 2.91e-52

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 164.36  E-value: 2.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADNGALTcgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESkLFPPHNVRGSWGRELYG 85
Cdd:cd00431     1 ALLVVDMQNDFVPGGGLLL--PGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFAEL-LWPPHCVKGTEGAELVP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDwfdqhQEDPTVwqFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:cd00431    78 ELAP-----LPDDLV--IEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDE 150

                         170
                  ....*....|
gi 1655161380 166 EGHAWALRHF 175
Cdd:cd00431   151 EDHEAALERL 160
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 6-184 9.37e-48

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 153.33  E-value: 9.37e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADNGALTcgYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDPYHPESKLFPPHNVRGSWGRELYG 85
Cdd:pfam00857   2 ALLVIDMQNDFVDSGGPKV--EGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDADFALKDRPSPAFPPGTTGAELVP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  86 PLKDWFDqhqeDPTVwqfDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDA 165
Cdd:pfam00857  80 ELAPLPG----DLVV---DKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSP 152

                         170
                  ....*....|....*....
gi 1655161380 166 EGHAWALRHFQNSlGATLI 184
Cdd:pfam00857 153 EAHDAALERLAQR-GAEVT 170
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
6-176 3.62e-20

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 83.36  E-value: 3.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADNGAltCGYPGQQLAPVITALAEKMRANGDWVllptdVHT--PHDPyHPESklfpphnvRGSWgREL 83
Cdd:COG1535    21 ALLIHDMQNYFLRPYDP--DEPPIRELVANIARLRDACRAAGIPV-----VYTaqPGDQ-TPED--------RGLL-NDF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  84 YGPLKDWFDQHQE-------DPTVWQFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIH 156
Cdd:COG1535    84 WGPGLTAGPEGQEivdelapAPGDTVLTKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVV 163

                         170       180
                  ....*....|....*....|
gi 1655161380 157 QDGVASFDAEGHAWALRHFQ 176
Cdd:COG1535   164 ADAVADFSREEHRMALEYVA 183
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-176 1.42e-19

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 82.04  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   1 MPTDQALLIIDYTNDFVADnGALtcGYP-GQQLAPVITALAEkmRANGDWVLLPTDVHTPH-------------DPYHPE 66
Cdd:PTZ00331    9 SSTNDALIIVDVQNDFCKG-GSL--AVPdAEEVIPVINQVRQ--SHHFDLVVATQDWHPPNhisfasnhgkpkiLPDGTT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  67 SKLFPPHNVRGSWGRELYGplkdwfDQHQEDPTVW-----QFDKTRYSSFAG-----TDLDLRLRERHVTTLHLVGVCTD 136
Cdd:PTZ00331   84 QGLWPPHCVQGTKGAQLHK------DLVVERIDIIirkgtNRDVDSYSAFDNdkgskTGLAQILKAHGVRRVFICGLAFD 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1655161380 137 ICVLHTAVDAYNLGYQLVIHQDGVASFDAEGHAWALRHFQ 176
Cdd:PTZ00331  158 FCVLFTALDAVKLGFKVVVLEDATRAVDPDAISKQRAELL 197
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 6-172 4.74e-19

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 79.17  E-value: 4.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADngaltcGYPGQQLAPVITALAEKM---RANGDWVllptdVHTPHDpyHPESKLFPPhnvrGSWGRE 82
Cdd:cd01014     1 ALLVIDVQNGYFDG------GLPPLNNEAALENIAALIaaaRAAGIPV-----IHVRHI--DDEGGSFAP----GSEGWE 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  83 LYGPLkdwfdQHQEDPTVwqFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVAS 162
Cdd:cd01014    64 IHPEL-----APLEGETV--IEKTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACAT 136

                         170
                  ....*....|
gi 1655161380 163 FDAEGHAWAL 172
Cdd:cd01014   137 FDLPDHGGVL 146
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 6-184 7.67e-19

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 79.62  E-value: 7.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFVADnGALTCGyPGQQLAPVITALAEKmrANGDWVLLPTDVHTPH---------------DPYHPESKLF 70
Cdd:cd01011     3 ALLVVDVQNDFCPG-GALAVP-GGDAIVPLINALLSL--FQYDLVVATQDWHPANhasfasnhpgqmpfiTLPPGPQVLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  71 PPHNVRGSWGRELYG--PLKDwFDQHQEDPTVWQFDKtrYSSF------AGTDLDLRLRERHVTTLHLVGVCTDICVLHT 142
Cdd:cd01011    79 PDHCVQGTPGAELHPglPVPD-IDLIVRKGTNPDIDS--YSAFfdndrrSSTGLAEYLRERGIDRVDVVGLATDYCVKAT 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1655161380 143 AVDAYNLGYQLVIHQDGVASFDAEGHAWALRHFQnSLGATLI 184
Cdd:cd01011   156 ALDALKAGFEVRVLEDACRAVDPETIERAIEEMK-EAGVVLV 196
PRK11440 PRK11440
putative hydrolase; Provisional
 105-174 2.45e-14

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 67.45  E-value: 2.45e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380 105 KTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDAEGHAWALRH 174
Cdd:PRK11440  101 KRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAEQHQNSMNH 170
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
3-159 3.49e-11

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 59.62  E-value: 3.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   3 TDQALLIIDYTNDFVAdNGALTCGyPGQQLAPVITALAEKMRANGDWVLLPTDVH-TPHDPYHPESK------------- 68
Cdd:PRK11609    1 MKRALLLVDLQNDFCA-GGALAVP-EGDSTIDVANRLIDWCQSRGIPVIASQDWHpANHGSFASNHGaepgtqgeldglp 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  69 --LFPPHNVRGSWGRELYGPLK----DWFDQHQEDPtvwQFDKtrYSSF------AGTDLDLRLRERHVTTLHLVGVCTD 136
Cdd:PRK11609   79 qtWWPDHCVQNSEGAALHPLLNqkaiDAVFHKGENP---LIDS--YSAFfdnghrQKTALDDWLREHGITELIVMGLATD 153

                         170       180
                  ....*....|....*....|...
gi 1655161380 137 ICVLHTAVDAYNLGYQLVIHQDG 159
Cdd:PRK11609  154 YCVKFTVLDALALGYQVNVITDG 176
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 97-174 6.14e-11

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 58.50  E-value: 6.14e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1655161380  97 DPTVWQFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQDGVASFDAEGHAWALRH 174
Cdd:cd01013   114 QPDDTVLTKWRYSAFKRSPLLERLKESGRDQLIITGVYAHIGCLSTAVDAFMRDIQPFVVADAIADFSLEEHRMALKY 191
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 6-181 1.94e-10

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 57.03  E-value: 1.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTNDFvADNGALTCGYPGQQLAPV--ITALAekmRANGDWVLLPTDVHTPHDPYHPESKLFPPHNVRGSWGREL 83
Cdd:cd01015     1 ALLVIDLVEGY-TQPGSYLAPGIAAALENVqrLLAAA---RAAGVPVIHTTVVYDPDGADGGLWARKVPAMSDLVEGSPL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  84 ------YGPlkdwfdqhQEDPTVwqFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQ 157
Cdd:cd01015    77 aaicdeLAP--------QEDEMV--LVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVR 146

                         170       180
                  ....*....|....*....|....
gi 1655161380 158 DGVASFDAEGHAWALRHFQNSLGA 181
Cdd:cd01015   147 ECVGDRAPAPHEANLFDIDNKYGD 170
PLN02621 PLN02621
nicotinamidase
 84-168 2.92e-08

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 51.32  E-value: 2.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  84 YGPLKDWFDQH------------QEDPTVWQFD----KTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAY 147
Cdd:PLN02621   70 YGMLGEWWDGDlildgtteaelmPEIGRVTGPDevveKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAF 149

                          90       100
                  ....*....|....*....|.
gi 1655161380 148 NLGYQLVIHQDGVASFDAEGH 168
Cdd:PLN02621  150 VRGFRVFFSTDATATANEELH 170
PLN02743 PLN02743
nicotinamidase
 7-164 3.98e-08

nicotinamidase


Pssm-ID: 215396  Cd Length: 239  Bit Score: 51.28  E-value: 3.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   7 LLIIDYTNDF-VADNGALTCGYPGQQLAPVI---TALAEKMRANGDWVLLPTDVHTPHDPYHPesklFPPHNVRGSWGRE 82
Cdd:PLN02743   30 LVLVDEVNGFcTVGAGNLAPREPDKQISKMVdesARLAREFCERKWPVLAFLDSHHPDKPEHP----YPPHCIVGTGEEN 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  83 LYGPLKdWFdqhQEDPTVWQFDKTRYSSFAG--------TDLDLrLRERHVTTLHLVGVCTDICVLH---TAVDAYNLGY 151
Cdd:PLN02743  106 LVPALQ-WL---ENDPNVTLRRKDCIDGFVGaiekdgsnVFVDW-VNNNKIKVILVVGICTDICVLDfvaSALSARNHGI 180

                         170
                  ....*....|....*...
gi 1655161380 152 -----QLVIHQDGVASFD 164
Cdd:PLN02743  181 lppleDVVVYSRGCATYD 198
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 6-173 3.33e-07

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 47.59  E-value: 3.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380   6 ALLIIDYTndfvadngaltcgypgQQLAPVItALAEKMRANGDWVL-------LPTdVHTPHDPyhpeSKLFPphnvrgs 78
Cdd:cd01012     1 ALLLVDVQ----------------EKLAPAI-KSFDELINNTVKLAkaaklldVPV-ILTEQYP----KGLGP------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  79 wgreLYGPLKDWFDQHQEdptvwqFDKTRYSSFAGTDLDLRLRERHVTTLHLVGVCTDICVLHTAVDAYNLGYQLVIHQD 158
Cdd:cd01012    52 ----TVPELREVFPDAPV------IEKTSFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVAD 121

                         170
                  ....*....|....*
gi 1655161380 159 GVASFDAEGHAWALR 173
Cdd:cd01012   122 ACGSRSKEDHELALA 136
PHA02676 PHA02676
A-type inclusion protein; Provisional
 22-102 9.57e-03

A-type inclusion protein; Provisional


Pssm-ID: 177458 [Multi-domain]  Cd Length: 520  Bit Score: 36.05  E-value: 9.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655161380  22 ALTCGYPGQQLAPVITALAEKMRANGDWVLLPTDVHTPHDP-----YHPESKLFPPHNVRGSWGRELYGPLKDW--FDQH 94
Cdd:PHA02676  427 AKTCCESNRGAGKHLEHHIETMRQYAVLVSNKTDVHTCNRPgaevtRHAIDGSLPPPHVLGNWGARSYCGRRRHypRVSH 506


                  ....*...
gi 1655161380  95 QEDPTVWQ 102
Cdd:PHA02676  507 GEKPWWWG 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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