|
Name |
Accession |
Description |
Interval |
E-value |
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
1-409 |
1.92e-129 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 379.50 E-value: 1.92e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 1 MKLNKQQWSWVFYDWANSSYGIIVTTAVLPVYFKAVAQANGvsAANATAYWGYANSIGTLLVSILAPVLGALADYPRAKK 80
Cdd:COG2270 6 KASRREILAWALYDWANSAFSTVITTFVFPPYFTSVAALGD--PAAATALWGYALAIAGLLVALLAPVLGAIADRSGRKK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 81 RMLNTFALVGMVMTLALSVVPTSAWKWLMVVYILSIIGYSGGNLFYDSFLTDVAPNEQMDRVSTYGYGFGYLGGVLAFIL 160
Cdd:COG2270 84 PFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGRVSGLGWALGYLGGVLLLLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 161 -FLVLQLTNGFGQLSSYGVARWSFVLAAVWWIIFYVPLVKNVHQKYA--LKPSGQPVRSSFKRVWSTLKHIRNYRAAAWF 237
Cdd:COG2270 164 nLALFLKPEAFGLPDAGEAVRISFLLTALWWLLFALPLFLFLPERPRpgPAPPRGAVRAGFRELRRTLRELRRYRDLLRF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 238 LVAYFFYIDGVDTIFTMATSIG-MDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALR 316
Cdd:COG2270 244 LLAYFFYRDGVQTVIAFAGIYAaGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 317 LSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSIL 396
Cdd:COG2270 324 LTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVF 403
|
410
....*....|...
gi 1655159249 397 FVIGLIIFLALPK 409
Cdd:COG2270 404 FVIGLVLLLRVKV 416
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
10-405 |
1.99e-122 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 359.23 E-value: 1.99e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 10 WVFYDWANSSYGIIVTTAVLPVYFKAVAqANGVSAANATAYWGYANSIGTLLVSILAPVLGALADYPRAKKRMLNTFALV 89
Cdd:cd17482 1 WALYDWANSAFATTVTTAVFPVYFKAVA-AQGASPVTSTALWGYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 90 GMVMTLALSVVPTSAWKWLMVVYILSIIGYSGGNLFYDSFLTDVAPNEQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNG 169
Cdd:cd17482 80 GVVSTALLFFVTPGQWLLALLLFILANIGFSGANVFYDAFLPDVASPERMDRVSSLGYALGYIGGGLLFAVNLVLILGPD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 170 FGQLSSYGVARWSFVLAAVWWIIFYVPLvknvhqkyalkpsgqpvrssfkrvwstlkhirnyRAAAWFLVAYFFYIDGVD 249
Cdd:cd17482 160 AFGLDTAEAVRLSFLSVALWWALFSIPL----------------------------------KQLLLFLIAYFFYIDGVQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 250 TIFTMATSIGMDMG-ISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALRLSSAVDFWVLAV 328
Cdd:cd17482 206 TIIRMATIYGAEEGkLGSSALILALLLTQFVAFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAA 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1655159249 329 LVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIFL 405
Cdd:cd17482 286 LIGLVQGGIQALSRSLFGRLIPKGKSAEFFGFYNISGKFAAIIGPLLFGLITQLTGSSRYGILSLIVLFVIGGILLA 362
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
5-408 |
5.37e-47 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 167.83 E-value: 5.37e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 5 KQQWSWVFYDWANSSYGIIVTTAVLPVYFKAVAQANGVSAA----------------------NATAYWGYANSIGTLLV 62
Cdd:pfam11700 4 KELWGWYLYCFAAEPFAVMAMGSFVPLTLQQLARENGVLLSdhsapcsadgdqcvvyfgggeiDTTSFVLYTFSISVLLQ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 63 SILAPVLGALADYPRAKKRMLNTFALVGMVMTLALSVVPTSAWKWLMVVYILSIIGYSGGNLFYDSFLTDVAPN------ 136
Cdd:pfam11700 84 AVVFISLSGIADYGNYRKNLLIAFALIGSASTMLFLGVTPKKYLLGAILYIVGNTCFGASFVFLNSFLPLLARNdpelra 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 137 ----------------------EQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFGQLSSYGVARWSFVLAAVWWIIFY 194
Cdd:pfam11700 164 aaealqdgesaitaeeydslelQLRTRISSRGFGIGYIGGILVQIISIIIVYALGSTASNNTWALRLAITFAGCWWIIFT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 195 VP---LVKNVHQKyALKPSGQPVRSSFKRVWSTLKHIRNYRAAAWFLVAYFFYIDGVDTIFTMA-----TSIGMDMGIST 266
Cdd:pfam11700 244 IPwalWLRPRPGP-PLPSGLNYLIYGWKQLGRTLKQARKLKDALLFLVAWFLLSDGIATVSSTAvlfakTELGMSTSQLT 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 267 TTLMLVLLVVQLVAFPFSLLYGWLANKTSTRtgILLGIVIYLGICLYAL--------RLSSAVDFWVLAVLVGTSQGGIQ 338
Cdd:pfam11700 323 LLNIVAMIAAVLGAFLWPFVSRRFNLKTKQT--LIACIVLFELIPLYGLlgiilgkiGLKNPWEFWVLQAFYGLVLGGLR 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 339 ALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIFLALP 408
Cdd:pfam11700 401 SYSRSLYSELIPRGKEAQFFSLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAILLVVPLPLLLLVD 470
|
|
| MFS_Atg22_like |
cd17483 |
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ... |
10-405 |
1.56e-40 |
|
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341036 Cd Length: 467 Bit Score: 150.11 E-value: 1.56e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 10 WVFYDWANSSYGIIVTTAVLPVYFKAVAQANGVSAA---------------------------NATAYWGYANSIGTLLV 62
Cdd:cd17483 1 WYSYGFAAEGFAVVAVGSYLPLLLQQLARDNGVLLSdhstpcdtsvgssandkcvlpigggyiDTSSFALYVFSISVLLQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 63 SILAPVLGALADYPRAKKRMLNTFALVGMVMT-LALSVVPTSAWKWLMVVYILSIIGYSGGNLFYDSFL----------- 130
Cdd:cd17483 81 AVLFISLGSLADYGNYRKRLLLTFTIIGSISSiLFLFVPSPSLWWLAALLYIVSNICYGASLVFYNSFLpilarnhpdvr 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 131 ------------TDVAPNEQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFGQLSSYGVARWSFVLAAVWWIIFYVP-- 196
Cdd:cd17483 161 aardkgsslsaeATEEEISLEEKVSSRISSLGFASGYVGGIIVQIISIIILFVLGNSIVSLRIAIAVVGVWWLIFSVPtf 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 197 -LVKNVHQKYaLKPSGQPVRSSFKRVWSTLKHIRNYRAAAWFLVAYFFYIDGVDTIFTMATSIG-MDMGISTTTLMLVLL 274
Cdd:cd17483 241 lWLKPRPGPP-LPGGSHPIFYSWKSLFRTLKHARKLPETFIFLLAWFFLSDGINTISSTAVLFAkSQLHMSTLQLILIGL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 275 VVQLVAFPFSLLYGWLAN--KTSTRTGILLGIVIYLGICLYAL--------RLSSAVDFWVLAVLVGTSQGGIQALSRSY 344
Cdd:cd17483 320 LTPITAILGAFFFPRIQRrfNLSTKTMLMLIVVLTALIPLYGLlgfftgkfGLKHPWEMYVLAVWFGFFLGGLQSYSRSL 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1655159249 345 FGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIFL 405
Cdd:cd17483 400 FSELIPPGHEAEFFSLFSITDKGSSWIGPLVVGAIIDATGNIRYGFIFLFALFVLPLPLLW 460
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-405 |
7.06e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 82.26 E-value: 7.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 24 VTTAVLPVYFKAVAqanGVSAANAtaywGYANSIGTLLVSILAPVLGALADYPRAK----KRMLNTFALVGMVMTLALSV 99
Cdd:COG2211 28 LLSAYLLYFYTDVL---GLSAALV----GLILLVARLWDAITDPLIGALSDRTRTRwgrrRPWILIGAIPLALSFVLLFT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 100 VP----TSAWKWLMVVYILSIIGYSGGNLFYDSFLTDVAPN-EQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFGQLS 174
Cdd:COG2211 101 APdlspTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 175 SYgvaRWSFVLAAVWWIIFYVPLVKNVHQKYALKPSGQPVRSSFKRVWSTlkhirnyRAAAWFLVAYFFYIDGVDTIFTM 254
Cdd:COG2211 181 GY---RLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKN-------RPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 255 ATSIGMD-MGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLG--ICLYALRLSSAVDFWVLAVLVG 331
Cdd:COG2211 251 LLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALglLLLFFLGPGNLWLLLVLAALAG 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 332 TSQGGIQALSRSYFGRLIPKESGSE-------FFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIF 404
Cdd:COG2211 331 IGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFF 410
|
.
gi 1655159249 405 L 405
Cdd:COG2211 411 L 411
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
48-405 |
2.29e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.08 E-value: 2.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 48 TAYWGYANSIGTLLVSILAPVLGALADYPRAKkRMLNTFALVGMVMTLALSVVPtsAWKWLMVVYILSIIGYSGGNLFYD 127
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRR-PVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLIDPAVL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 128 SFLTDVAPNEQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFGQlssygvaRWSFVLAAVWWIIFYVPLVKNVHQKYAl 207
Cdd:cd06174 107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW-------RAVFLIAAALALLAAILLLLVVPDPPE- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 208 KPSGQPVRSSFKRVWSTLKHIRNYRAAAWFLVAYFFYIDGVDTIFTMATSIGMD-MGISTTTLMLVLLVVQLVAFPFSLL 286
Cdd:cd06174 179 SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 287 YGWLANKTSTRTGILL-GIVIYLGICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILG 365
Cdd:cd06174 259 LGLLSDRLIGRKPLLLiGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1655159249 366 KFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIFL 405
Cdd:cd06174 339 FLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
52-365 |
1.95e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 52 GYANSIGTLLVSILAPVLGALADYpRAKKRMLNTFALVGMVMTLALSVVPTSAWkwLMVVYILSIIGYSGGNLFYDSFLT 131
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAALALIA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 132 DVAPNEQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFgqlssygvaRWSFVLAAVWWIIFYVPLVKNVHQkyalkpsg 211
Cdd:COG2814 125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW---------RWVFLVNAVLALLALLLLLRLLPE-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 212 qPVRSSFKRVWSTLKHIRNYRAAAWFLVAYFFYIDGVDTIFTMATSIGMD-MGISTTTLMLVLLVVQLVAFPFSLLYGWL 290
Cdd:COG2814 188 -SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1655159249 291 ANKTSTRTGILLGIVIYLGICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILG 365
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-373 |
2.34e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.42 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 23 IVTTAVLPVYFKAVAQANGVSAANAtaywGYANSIGTLLVSILAPVLGALADYPRAKKRMLNTFALVGMVMTLALsvvPT 102
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDLGISPTEI----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL---FA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 103 SAWKWLMVVYILSIIGYSGGNLFYDSFLTDVAPNEQMDRVSTYGYGFGYLGGVLAFILFlvlqltngfGQLSSYGVARWS 182
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLG---------GLLASLFGWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 183 FVLAAVWWIIFYVPLVKNVHQKYALKPSgqPVRSSFKRVWSTLKHIRNyRAAAWFLVAYFFYIDGVDTIFTMATSIGMDM 262
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPK--PAEEARLSLIVAWKALLR-DPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 263 GISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALRLSSAVD---FWVLAVLVGTSQGGIQA 339
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSslwLLLALLLLGFGFGLVFP 310
|
330 340 350
....*....|....*....|....*....|....
gi 1655159249 340 LSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGP 373
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
41-405 |
6.39e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.01 E-value: 6.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 41 GVSAANATAYWGyansIGTLLVSILAPVLGALADYPRAK--KRMlnTFALVGMVM-TLALSVVPTSAW----------KW 107
Cdd:cd17313 30 GLSHALIGFVWT----LGPILGLFVQPLVGSLSDRCNSRigRRR--PFILVGAPLaALGLILIPNAADiglalgdgprTW 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 108 LMVVYILSIIGYSGGNLFYD----SFLTDVAPNEQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFGQLSSYGVaRWSF 183
Cdd:cd17313 104 ALVLFVLGIVLLDFAMNVCQgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNL-KVPF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 184 VLAAVWWIIFYVPLVKNVHQK-----YALKPSGQPVRSSFKRVWSTLKHI-RNYRA---------AAWFLVAYFF--YID 246
Cdd:cd17313 183 YIGAIILLVCVLVTLFFVKEPplspeAGEHSENPSLGEVLKSLLKLLKIMpRSLLRlllviffwwIAFFPFELFFtdYMG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 247 GVDTIFTMATSIGMDMGISTTTLMLVLLVVQLVAfpFSLLYGWLANKTSTRTGILLGIVIYlGICLYALRLSSAVD-FWV 325
Cdd:cd17313 263 EEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLI--FSLPIGKLGKKIGRKKVYLIGLVLF-AVGMALMALVHNVTvALV 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 326 LAVLVGTSQGGIQALSRSYFGRLIPKESGS--EFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLII 403
Cdd:cd17313 340 LFALGGIGWATININPYPLVSDYHSESGRGqgTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGA 419
|
..
gi 1655159249 404 FL 405
Cdd:cd17313 420 LF 421
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-409 |
1.05e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.18 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 27 AVLPVYFKAVAQANGVSAANAtaywGYANSIGTLLVSILAPVLGALADypRAKKRMLNTFALVGMVMTLALSVVPTSAWk 106
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQA----GLLTTLPLLAFGLFAPLAPRLAR--RFGLERTLLLALLLLAAGLLLRSLAPSVA- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 107 WLMVVYILSIIGYSGGNLFYDSFLTDVAPneqmDRVSTYGYGFGYLGGVLAFI-LFLVLQLTNGFGQLSSYGVarWSF-- 183
Cdd:COG2807 108 LLLAGTALIGAGIAVGNVLLPGLIKRWFP----DRVGLMTGLYTAAMGLGAALaAGLTVPLAAALGWRGALAV--WALla 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 184 VLAAVWWIIFYVPLVKNVHQKYALKPSGQPVRSsfKRVWSTlkhirnyrAAAWFLVAYFFYidgvdTIFTMATSIGMDMG 263
Cdd:COG2807 182 LLALLLWLPLLRRRPAAAAAAPAAASLRSLWRS--PLAWLL--------TLFFGLQSLLYY-----AVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 264 ISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRS 343
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALT 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1655159249 344 YFGRLIPKESG-SEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIFLALPK 409
Cdd:COG2807 327 LIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
64-406 |
1.10e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.21 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 64 ILAPVLGALADYPRAK----KRMLNTFALVGMVMTLALSVVPTSAWK----WLMVVYILSIIGYSGGNLFYDSFLTDVAP 135
Cdd:cd17332 50 INDPLMGYLIDRTRSRwgrfRPWLLWGAIPLALLFVLLFTTPDGSGTgkliYALITYILLDLLYTLVNIPYTALIPELTD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 136 N-EQMDRVSTY--GYGFGYLGGVLAFILFLVLQLTNGFGQLSSYGVARWSFVLAAVWWIIFYvplvKNVHQKYALKPSgQ 212
Cdd:cd17332 130 DpEERTSLTSWrmFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICF----FGTRERVVPPEE-E 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 213 PVRSSFKRVWSTLKHIRNYRaaaWFLVAYFFYIDGVDTIFTM----ATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYG 288
Cdd:cd17332 205 KSKLPLLKSLKALLKNRPFL---ILLLAYLLYFLAFNIVNTVlvyyFKYVLGGRAELVLLLLLILSGALLALLPWPPLKK 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 289 WLANKTSTRTGILLGIVIYLGicLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLI-------PKESGSEFFGFY 361
Cdd:cd17332 282 RFGKKKAFFIGLLLAILGLLL--LFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIdygelktGKRREGIFYSVM 359
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1655159249 362 NILGKFSAVMGPVLVGIVTQLTG-QSTIGAASLSILFVIGLIIFLA 406
Cdd:cd17332 360 TFFRKLGLALAGALVGLILSLAGyVANAAAQSASALNGIRLLIAVL 405
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
229-408 |
1.41e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.89 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 229 RNYRAAAWFLVAYFFYIDGVDTIFTMATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYL 308
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 309 GICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTI 388
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180
....*....|....*....|
gi 1655159249 389 GAASLSILFVIGLIIFLALP 408
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLP 186
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
237-409 |
4.09e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 4.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 237 FLVAYFFYIDGVDTIFTMATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALR 316
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 317 LSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSIL 396
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170
....*....|...
gi 1655159249 397 FVIGLIIFLALPK 409
Cdd:pfam07690 162 LLAAVLLLLPRPP 174
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
236-409 |
1.21e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 236 WFLVAYFFYIDGVDTIFT--MATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLY 313
Cdd:COG2271 183 WLLALAYFLVYFALYGFLtwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALAL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 314 AL--RLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTiGAA 391
Cdd:COG2271 263 LLlaLLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA-AFL 341
|
170
....*....|....*...
gi 1655159249 392 SLSILFVIGLIIFLALPK 409
Cdd:COG2271 342 LLAALALLAALLALLLLR 359
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-407 |
8.93e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 8.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 16 ANSSYGIIVTtaVLPVYfkavAQANGVSAAnataYWGYANSIGTLLVSILAPVLGALADYpRAKKRMLNTFALVGMVMTL 95
Cdd:cd17325 8 DMLGYGIIIP--ILPLY----AESLGASVA----QIGLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 96 ALSVVPTsaWKWLMVVYILSIIGYSGGNLFYDSFLTDVAPNEQMDRVSTYGYGFGYLGGVLAFILFlvlqltngfGQLSS 175
Cdd:cd17325 77 LFAFATS--YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG---------GLLAD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 176 YGVARWSFVLAAVWWIIFYVPLVKNVHQKYALKPSGQPVRSSFKRVWSTLKHIRNYRAAAWFLVAYFFYIDGVDTIF-TM 254
Cdd:cd17325 146 ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLpLY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 255 ATSIgmdMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIyLGICLYALRLSSAVD-FWVLAVLVGTS 333
Cdd:cd17325 226 AAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL-SAVALLLLPLATSFWlLLLLLALLGLG 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1655159249 334 QGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTiGAASLSILFVIGLIIFLAL 407
Cdd:cd17325 302 LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT-PFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
283-405 |
1.29e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 283 FSLLYGWLANKTSTRTGILLGIVIYLGICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYN 362
Cdd:cd17370 250 AAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFN 329
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1655159249 363 ILGKFSAVMGPVLVGIVTQLTGQSTIGAASlSILFVIGLIIFL 405
Cdd:cd17370 330 TVVGIGWLLASLIAGYLWDLISPSAAFLFS-AVLALIALLLLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-406 |
2.33e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.91 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 57 IGTLLVSILAPVLGALADYpRAKKRMLNTFALVGMVMTLALSVVPTSAWKWLMVVYILSIIGYSGGNLF---YDSFLTDV 133
Cdd:cd06173 42 AFFLPFLLFSPFAGVLADR-FDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFgpaRQALLPEL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 134 APNEQMDRVSTYGYGFGYLGGVLAFILFLVLQLTNGFGqlSSYGVARWSFVLAAvwWIIFYVPLVKNVHQKyalkPSGQP 213
Cdd:cd06173 121 VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG--GAFAINALSFLLSA--LLLLFIRRPPPAAPG----ESSSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 214 VRSSFKRVWSTLKHIRNYRAAAWFLVAYFFYIDGVDTIFtmATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANK 293
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL--PLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 294 TSTRTGILLGIVIyLGICLYALRLSSAVDFWVLA-VLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMG 372
Cdd:cd06173 271 RRRGRLLLIGALL-LGLALLVLGLSPSLWLLLAAlFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330 340 350
....*....|....*....|....*....|....
gi 1655159249 373 PVLVGIVTQLTGQSTIGAASLSILFVIGLIIFLA 406
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
157-409 |
2.39e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 157 AFILFLVLQLTNGFGQLSSYGVARWSFVLAAVWWIIFYvplvknvhqKYALKPSGQPVRSSFKRVWSTLKHIRNYRAAAW 236
Cdd:COG2223 143 AVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFL---------RDPPAGAAAAAKASLRDQLEALRDPRFWLLSLL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 237 FLVAYFFYIdgvdTIFTMATSIGMDM-GISTTTLMLVLLVVQLVAFPFSLLYGWLANKT-STRTGILLGIVIYLGICLYA 314
Cdd:COG2223 214 YFGTFGSFI----GFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLA 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 315 LRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLS 394
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFA 369
|
250
....*....|....*
gi 1655159249 395 ILFVIGLIIFLALPK 409
Cdd:COG2223 370 VLALVALVLTLLLYR 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
237-415 |
2.72e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 237 FLVAYFFYIDGVDTIFTMATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALR 316
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 317 LSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLTGQSTIGAASLSIL 396
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170
....*....|....*....
gi 1655159249 397 FVIGLIIFLALPKLDQTKS 415
Cdd:cd06174 161 LALLAAILLLLVVPDPPES 179
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
261-408 |
3.53e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 261 DMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLGIVIYLGICLYALRLSSAVDFWVLAVLVGTSQGGIQAL 340
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1655159249 341 SRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLtGQSTIGAASLSILFVIGLIIFLALP 408
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLP 175
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
56-407 |
4.56e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 56 SIGTLLVSILAPVLGALADypRAKKRMLNTFALVGMVMTLALSVVPTSAWkWLMVVYILSIIGYSGGnlFYDSFLTDVAP 135
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLD--RFGPRRVMLLGLLLLAAGLVLLALATSLW-QLYLLWGLLGGGGAGT--LAAVAFATVAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 136 NEQMDRVSTYGYGFGYLGGVLAFILF-LVLQLTNGFGQLSSYGVArwSFVLAAVWWIIFYVPLVKN--VHQKYALKPSGQ 212
Cdd:cd17355 120 WWFERRRGLALGILTAGGGLGSLVFLpLGAALIEAFGWRTALLVL--ALLALLVLVPVLLLLRRRPadLALRAYDDASPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 213 PVRSSFKRVWstlkhirnyRAAAWFLVAYFFYIDGVDTIFTMATSIGM--DMGISTTTLMLVLLVVQLVAFPFSLLYGWL 290
Cdd:cd17355 198 SPGSTLKEAL---------RSASFWLLALAFFLCGFAVVGLIVHLVPYlaDRGISPAAAAVALALIGLFNIVGRLLSGWL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 291 ANKTSTR--TGILLGIVIyLGICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFS 368
Cdd:cd17355 269 GDRYSPRrlLAASYALRA-LGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLG 347
|
330 340 350
....*....|....*....|....*....|....*....
gi 1655159249 369 AVMGPVLVGIVTQLTGQSTIGAASLSILFVIGLIIFLAL 407
Cdd:cd17355 348 SALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
226-407 |
5.26e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.70 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 226 KHIRNYRAAAWFLVAYFFYIDGVD--TIFTMATSIGMDMGISTTTLMLVLLVVQLVAFPFSLLYGWLANKTSTRTGILLG 303
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDrsNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655159249 304 IVIYLGICLYALRLSSAVDFWVLAVLVGTSQGGIQALSRSYFGRLIPKESGSEFFGFYNILGKFSAVMGPVLVGIVTQLT 383
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180
....*....|....*....|....
gi 1655159249 384 GQSTIGAASLSILFVIGLIIFLAL 407
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLRFWLL 185
|
|
| |
