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Conserved domains on  [gi|1655079180|ref|WP_137578649|]
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autotransporter outer membrane beta-barrel domain-containing protein, partial [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
autotrans_barl super family cl36898
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 1-151 3.66e-27

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


The actual alignment was detected with superfamily member TIGR01414:

Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 104.77  E-value: 3.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   1 YAGAEAGYRYHV-TEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKdkdYNPLIGRTGVDVGKSF---SGKDWKVTARA 76
Cdd:TIGR01414 285 TASLEAGYRYNLgGNGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGG---GDSLQGRLGLRVGYQFdlgTGRAVKPYLKA 361

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1655079180  77 GLGYQFDllaNGETVLRDasGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF 151
Cdd:TIGR01414 362 NVLHEFK---GGTGVRVN--GVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
 
Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 1-151 3.66e-27

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 104.77  E-value: 3.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   1 YAGAEAGYRYHV-TEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKdkdYNPLIGRTGVDVGKSF---SGKDWKVTARA 76
Cdd:TIGR01414 285 TASLEAGYRYNLgGNGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGG---GDSLQGRLGLRVGYQFdlgTGRAVKPYLKA 361

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1655079180  77 GLGYQFDllaNGETVLRDasGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF 151
Cdd:TIGR01414 362 NVLHEFK---GGTGVRVN--GVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 2-130 5.54e-17

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 74.73  E-value: 5.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   2 AGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQ 81
Cdd:pfam03797 120 ASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTESGGAAALSVDSQSYDSLTGRLGLRLSYTFDLGGGTLTPYARLGWR 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1655079180  82 FDLLANGETV-----LRDASGEKRIKGEKDSR--MLMSVGLNAEIRDNVRFGLEFE 130
Cdd:pfam03797 200 HEFGDDDPVTtaafaGLSGAGSFTVAGADLARdsLELGAGLSAQLSDNLSLYANYD 255
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-138 1.61e-14

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 68.36  E-value: 1.61e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180    1 YAGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGM-HLSMKDKDYNPLIGRTGVDVGKSFS-GKDWKVTARAGL 78
Cdd:smart00869 122 GASLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTESGGGAfGLSVDSQSLDSLSLPLGLRLEYRLAlGDGATLTPYLRL 201

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1655079180   79 GYQFDLLANGETVLR-----DASGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYN 138
Cdd:smart00869 202 AYVHDFYDDNPVVTAsllgsGASFTTSGTDLDRNAAELGLGLSAKLSNGLSLSLNYDGEFGGSSR 266
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 2-151 1.28e-11

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 61.33  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   2 AGAEAGYRYHVtEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFS-GKDWKVTARAGLGY 80
Cdd:COG4625   746 AFLEAGYRFDL-GGLTLTPFAGLAYVRLRTDGFTETGGAAALSVDSQSTDSLRSTLGLRASRTFSlGGGVTLTPSGRLGW 824

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1655079180  81 QFDLLANGETV---LRDASGEK-RIKGEKDSR--MLMSVGLNAEIRDNVRFGLEFEkSAFGKYNVDNAVNANFRYSF 151
Cdd:COG4625   825 RHEFGDDDPSTtasFAGAPGAAfTVAGAPLARdaLVLGAGLSARLSDGLSLGLGYD-GEFGSGYTDHGGSAGLRYRF 900
 
Name Accession Description Interval E-value
autotrans_barl TIGR01414
outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, ...
 1-151 3.66e-27

outer membrane autotransporter barrel domain; A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 273608 [Multi-domain]  Cd Length: 431  Bit Score: 104.77  E-value: 3.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   1 YAGAEAGYRYHV-TEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKdkdYNPLIGRTGVDVGKSF---SGKDWKVTARA 76
Cdd:TIGR01414 285 TASLEAGYRYNLgGNGWYVEPQAQLSYFGVSGDDYKESNGTRVLGGG---GDSLQGRLGLRVGYQFdlgTGRAVKPYLKA 361

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1655079180  77 GLGYQFDllaNGETVLRDasGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF 151
Cdd:TIGR01414 362 NVLHEFK---GGTGVRVN--GVTIRNDFSGTRAEYGVGVNAKIKDNLSLYADVDYQKGGKKYTDNQGNLGVRYSF 431
Autotransporter pfam03797
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 2-130 5.54e-17

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.


Pssm-ID: 461054 [Multi-domain]  Cd Length: 255  Bit Score: 74.73  E-value: 5.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   2 AGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQ 81
Cdd:pfam03797 120 ASLEAGYRFALGGGWTLEPFAGLAYVRLRLDGFTESGGAAALSVDSQSYDSLTGRLGLRLSYTFDLGGGTLTPYARLGWR 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1655079180  82 FDLLANGETV-----LRDASGEKRIKGEKDSR--MLMSVGLNAEIRDNVRFGLEFE 130
Cdd:pfam03797 200 HEFGDDDPVTtaafaGLSGAGSFTVAGADLARdsLELGAGLSAQLSDNLSLYANYD 255
Autotransporter smart00869
Autotransporter beta-domain; Secretion of protein products occurs by a number of different ...
 1-138 1.61e-14

Autotransporter beta-domain; Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type IV pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C-terminus of the proteins it occurs in. The N-terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different peptidase is used and in some cases no cleavage occurs.


Pssm-ID: 214872 [Multi-domain]  Cd Length: 268  Bit Score: 68.36  E-value: 1.61e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180    1 YAGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGM-HLSMKDKDYNPLIGRTGVDVGKSFS-GKDWKVTARAGL 78
Cdd:smart00869 122 GASLEAGYRFYLGGGLTLTPFAGLAYSRVRQDGFTESGGGAfGLSVDSQSLDSLSLPLGLRLEYRLAlGDGATLTPYLRL 201

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1655079180   79 GYQFDLLANGETVLR-----DASGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYN 138
Cdd:smart00869 202 AYVHDFYDDNPVVTAsllgsGASFTTSGTDLDRNAAELGLGLSAKLSNGLSLSLNYDGEFGGSSR 266
COG4625 COG4625
Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function ...
 2-151 1.28e-11

Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain [Function unknown];


Pssm-ID: 443664 [Multi-domain]  Cd Length: 900  Bit Score: 61.33  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   2 AGAEAGYRYHVtEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFS-GKDWKVTARAGLGY 80
Cdd:COG4625   746 AFLEAGYRFDL-GGLTLTPFAGLAYVRLRTDGFTETGGAAALSVDSQSTDSLRSTLGLRASRTFSlGGGVTLTPSGRLGW 824

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1655079180  81 QFDLLANGETV---LRDASGEK-RIKGEKDSR--MLMSVGLNAEIRDNVRFGLEFEkSAFGKYNVDNAVNANFRYSF 151
Cdd:COG4625   825 RHEFGDDDPSTtasFAGAPGAAfTVAGAPLARdaLVLGAGLSARLSDGLSLGLGYD-GEFGSGYTDHGGSAGLRYRF 900
AidA COG3468
Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular ...
 2-151 5.90e-10

Autotransporter adhesin AidA [Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442691 [Multi-domain]  Cd Length: 846  Bit Score: 56.49  E-value: 5.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1655079180   2 AGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAwKDQGMHLSMKDKDYnpLIGRTGVDVGKSFSGKD---WKVTARAGL 78
Cdd:COG3468   700 ASLEAGYPFKLGEGWSLEPQAQLIYQGVDFDDFT-DSNGTRVSGDDGDS--LQGRLGLRLGYEFHWDDgraLQPYLEANW 776

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1655079180  79 GYQF----DLLANGETVLRDASGekrikgekdSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNAN--FRYSF 151
Cdd:COG3468   777 LHEFlgdnSVTVNGVSFSQDGSG---------TWGELGLGVTGQLNKNLSLYGDVGYQTGLDGYDSSDTSGNlgVRYSF 846
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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