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Conserved domains on  [gi|1653972994|gb|QCQ84441|]
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L1 [human papillomavirus 12]

Protein Classification

major capsid protein L1( domain architecture ID 10010233)

major capsid protein L1 forms an icosahedral capsid with a 50 nm diameter; the capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PHA02778 PHA02778
major capsid L1 protein; Provisional
 1-517 0e+00

major capsid L1 protein; Provisional


:

Pssm-ID: 222928  Cd Length: 503  Bit Score: 1053.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994   1 MALWQAAHGKVYLPPsTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYDNTGKKLEVPKVSGNQHRVFRLKLPD 80
Cdd:PHA02778    1 MALWLPSSGKLYLPP-TPVAKVLSTDEYVTRTNIFYHASSDRLLTVGHPYFPIKDADKNKVTVPKVSGNQYRVFRVKLPD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994  81 PNRFALADMSVYNPDRERLVWACRGLEISRGQPLGVGSTGHPYFNKIKDTENSNNY-GTGSKDDRQNTSFDPKQIQMFIV 159
Cdd:PHA02778   80 PNKFALPDKSVYNPEKERLVWALRGLEVGRGQPLGVGVTGHPLFNKLKDTENPNKYpTAQGTDDRQNVSFDPKQTQLFIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 160 GCTPCVGEHWEKALPCGDAPAENGVCPPIELKNTLIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNETCKYPDFLKMQN 239
Cdd:PHA02778  160 GCTPALGEHWDKAKPCADAPPQAGDCPPIELKNSVIEDGDMVDIGFGAMNFKALQANKSDVPLDIVNSICKYPDYLKMAN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 240 DVYGDACFFYARREQCYARHFFVRGGKTGDDIPDAqiddgnmknqYYIPGAQDQSQKdIGNAMYFPTVSGSLVSSDAQLF 319
Cdd:PHA02778  240 DPYGDSMFFFARREQMYARHFFTRAGTVGEAIPED----------LYLKGASGQAQT-LGSSVYFPTPSGSLVSSDAQLF 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 320 NRPFWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISIYSENQNIHDipnYDSQKFREYLRHVEEYEISIILQLCKVPL 399
Cdd:PHA02778  309 NRPYWLQRAQGHNNGICWNNQLFVTVVDNTRNTNFTISVKTDETPQTT---YKASNFKEYLRHVEEYELSFIFQLCKVPL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 400 KAEVLAQINAMNSSLLEDWQLGFVPTPDNPIHDTYRYIESLATRCPDKNPPKEKPDPYDGLSFWTVDMTERLSLDLDQYS 479
Cdd:PHA02778  386 TPEVLAHLHTMNPSILEDWNLGFVPPPSSSLEDTYRYIQSLATKCPDNVPPKEKEDPYAKYTFWEVDLTERFSLDLDQFP 465

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1653972994 480 LGRKFLFQAGLQQTTVNGTTKSSSyRSSMRGTKRKRKN 517
Cdd:PHA02778  466 LGRKFLFQAGLRRRTRRRKRKSTS-SSSSRSTKRRRRK 502
 
Name Accession Description Interval E-value
PHA02778 PHA02778
major capsid L1 protein; Provisional
 1-517 0e+00

major capsid L1 protein; Provisional


Pssm-ID: 222928  Cd Length: 503  Bit Score: 1053.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994   1 MALWQAAHGKVYLPPsTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYDNTGKKLEVPKVSGNQHRVFRLKLPD 80
Cdd:PHA02778    1 MALWLPSSGKLYLPP-TPVAKVLSTDEYVTRTNIFYHASSDRLLTVGHPYFPIKDADKNKVTVPKVSGNQYRVFRVKLPD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994  81 PNRFALADMSVYNPDRERLVWACRGLEISRGQPLGVGSTGHPYFNKIKDTENSNNY-GTGSKDDRQNTSFDPKQIQMFIV 159
Cdd:PHA02778   80 PNKFALPDKSVYNPEKERLVWALRGLEVGRGQPLGVGVTGHPLFNKLKDTENPNKYpTAQGTDDRQNVSFDPKQTQLFIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 160 GCTPCVGEHWEKALPCGDAPAENGVCPPIELKNTLIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNETCKYPDFLKMQN 239
Cdd:PHA02778  160 GCTPALGEHWDKAKPCADAPPQAGDCPPIELKNSVIEDGDMVDIGFGAMNFKALQANKSDVPLDIVNSICKYPDYLKMAN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 240 DVYGDACFFYARREQCYARHFFVRGGKTGDDIPDAqiddgnmknqYYIPGAQDQSQKdIGNAMYFPTVSGSLVSSDAQLF 319
Cdd:PHA02778  240 DPYGDSMFFFARREQMYARHFFTRAGTVGEAIPED----------LYLKGASGQAQT-LGSSVYFPTPSGSLVSSDAQLF 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 320 NRPFWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISIYSENQNIHDipnYDSQKFREYLRHVEEYEISIILQLCKVPL 399
Cdd:PHA02778  309 NRPYWLQRAQGHNNGICWNNQLFVTVVDNTRNTNFTISVKTDETPQTT---YKASNFKEYLRHVEEYELSFIFQLCKVPL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 400 KAEVLAQINAMNSSLLEDWQLGFVPTPDNPIHDTYRYIESLATRCPDKNPPKEKPDPYDGLSFWTVDMTERLSLDLDQYS 479
Cdd:PHA02778  386 TPEVLAHLHTMNPSILEDWNLGFVPPPSSSLEDTYRYIQSLATKCPDNVPPKEKEDPYAKYTFWEVDLTERFSLDLDQFP 465

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1653972994 480 LGRKFLFQAGLQQTTVNGTTKSSSyRSSMRGTKRKRKN 517
Cdd:PHA02778  466 LGRKFLFQAGLRRRTRRRKRKSTS-SSSSRSTKRRRRK 502
Late_protein_L1 pfam00500
L1 (late) protein;
4-515 0e+00

L1 (late) protein;


Pssm-ID: 459833  Cd Length: 497  Bit Score: 904.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994   4 WQAAHGKVYLPPsTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYDNTGKKLeVPKVSGNQHRVFRLKLPDPNR 83
Cdd:pfam00500   1 WLPSQQKLYLPP-QPVTKVLSTDEYVTRTNIFYHAGTDRLLTVGHPYFEIKGRNDKVL-VPKVSGNQYRVFRLKLPDPNR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994  84 FALADMSVYNPDRERLVWACRGLEISRGQPLGVGSTGHPYFNKIKDTENSNNY-GTGSKDDRQNTSFDPKQIQMFIVGCT 162
Cdd:pfam00500  79 FALPDKSLYDPDKERLVWALRGLEIGRGQPLGIGVTGHPLFNKFDDAENPNKYiNAQGGDNRQNMAFDPKQTQMFIVGCT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 163 PCVGEHWEKALPCGDAPAENGVCPPIELKNTLIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNETCKYPDFLKMQNDVY 242
Cdd:pfam00500 159 PAIGEHWDKASPCPNQVPKTGDCPPIELKNTVIEDGDMCDIGFGAMDFKALQANKSDVPLDIVNSICKYPDYLKMAEDPY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 243 GDACFFYARREQCYARHFFVRGGKTGDDIPDAqiddgnmknqYYIPGAQdQSQKDIGNAMYFPTVSGSLVSSDAQLFNRP 322
Cdd:pfam00500 239 GDSMFFYARREQMYARHFFSRAGTVGEAVPED----------LYIKGAG-EEQNTLATSNYFGTPSGSLVSSDGQLFNRP 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 323 FWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISIYSENQnihDIPNYDSQKFREYLRHVEEYEISIILQLCKVPLKAE 402
Cdd:pfam00500 308 YWLQRAQGHNNGICWNNQLFVTVVDNTRGTNFTISVKADEN---DETTYDASNFKEYLRHVEEYELSFIFQLCKVKLTPE 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 403 VLAQINAMNSSLLEDWQLGFVPTPDNPIHDTYRYIESLATRCPDKNPPKEKPDPYDGLSFWTVDMTERLSLDLDQYSLGR 482
Cdd:pfam00500 385 NLAYLHTMNPSILEDWNLGVTPPPSSSLEDTYRYIESLATKCPDNPPPAEKEDPYKGLKFWEVDLSERLSADLDQFPLGR 464

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1653972994 483 KFLFQAGLQQTTVNGTTKSSSYRSSMRGTKRKR 515
Cdd:pfam00500 465 KFLYQSGLTQSSSSTKRKAPASVAVSRSSKRKR 497
 
Name Accession Description Interval E-value
PHA02778 PHA02778
major capsid L1 protein; Provisional
 1-517 0e+00

major capsid L1 protein; Provisional


Pssm-ID: 222928  Cd Length: 503  Bit Score: 1053.26  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994   1 MALWQAAHGKVYLPPsTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYDNTGKKLEVPKVSGNQHRVFRLKLPD 80
Cdd:PHA02778    1 MALWLPSSGKLYLPP-TPVAKVLSTDEYVTRTNIFYHASSDRLLTVGHPYFPIKDADKNKVTVPKVSGNQYRVFRVKLPD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994  81 PNRFALADMSVYNPDRERLVWACRGLEISRGQPLGVGSTGHPYFNKIKDTENSNNY-GTGSKDDRQNTSFDPKQIQMFIV 159
Cdd:PHA02778   80 PNKFALPDKSVYNPEKERLVWALRGLEVGRGQPLGVGVTGHPLFNKLKDTENPNKYpTAQGTDDRQNVSFDPKQTQLFIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 160 GCTPCVGEHWEKALPCGDAPAENGVCPPIELKNTLIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNETCKYPDFLKMQN 239
Cdd:PHA02778  160 GCTPALGEHWDKAKPCADAPPQAGDCPPIELKNSVIEDGDMVDIGFGAMNFKALQANKSDVPLDIVNSICKYPDYLKMAN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 240 DVYGDACFFYARREQCYARHFFVRGGKTGDDIPDAqiddgnmknqYYIPGAQDQSQKdIGNAMYFPTVSGSLVSSDAQLF 319
Cdd:PHA02778  240 DPYGDSMFFFARREQMYARHFFTRAGTVGEAIPED----------LYLKGASGQAQT-LGSSVYFPTPSGSLVSSDAQLF 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 320 NRPFWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISIYSENQNIHDipnYDSQKFREYLRHVEEYEISIILQLCKVPL 399
Cdd:PHA02778  309 NRPYWLQRAQGHNNGICWNNQLFVTVVDNTRNTNFTISVKTDETPQTT---YKASNFKEYLRHVEEYELSFIFQLCKVPL 385

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 400 KAEVLAQINAMNSSLLEDWQLGFVPTPDNPIHDTYRYIESLATRCPDKNPPKEKPDPYDGLSFWTVDMTERLSLDLDQYS 479
Cdd:PHA02778  386 TPEVLAHLHTMNPSILEDWNLGFVPPPSSSLEDTYRYIQSLATKCPDNVPPKEKEDPYAKYTFWEVDLTERFSLDLDQFP 465

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1653972994 480 LGRKFLFQAGLQQTTVNGTTKSSSyRSSMRGTKRKRKN 517
Cdd:PHA02778  466 LGRKFLFQAGLRRRTRRRKRKSTS-SSSSRSTKRRRRK 502
Late_protein_L1 pfam00500
L1 (late) protein;
4-515 0e+00

L1 (late) protein;


Pssm-ID: 459833  Cd Length: 497  Bit Score: 904.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994   4 WQAAHGKVYLPPsTPVARVQSTDEYIQRTNIYYHANTDRLLTVGHPYFNVYDNTGKKLeVPKVSGNQHRVFRLKLPDPNR 83
Cdd:pfam00500   1 WLPSQQKLYLPP-QPVTKVLSTDEYVTRTNIFYHAGTDRLLTVGHPYFEIKGRNDKVL-VPKVSGNQYRVFRLKLPDPNR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994  84 FALADMSVYNPDRERLVWACRGLEISRGQPLGVGSTGHPYFNKIKDTENSNNY-GTGSKDDRQNTSFDPKQIQMFIVGCT 162
Cdd:pfam00500  79 FALPDKSLYDPDKERLVWALRGLEIGRGQPLGIGVTGHPLFNKFDDAENPNKYiNAQGGDNRQNMAFDPKQTQMFIVGCT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 163 PCVGEHWEKALPCGDAPAENGVCPPIELKNTLIEDGDMADIGFGNMNFKTLQQNRSDVSLDIVNETCKYPDFLKMQNDVY 242
Cdd:pfam00500 159 PAIGEHWDKASPCPNQVPKTGDCPPIELKNTVIEDGDMCDIGFGAMDFKALQANKSDVPLDIVNSICKYPDYLKMAEDPY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 243 GDACFFYARREQCYARHFFVRGGKTGDDIPDAqiddgnmknqYYIPGAQdQSQKDIGNAMYFPTVSGSLVSSDAQLFNRP 322
Cdd:pfam00500 239 GDSMFFYARREQMYARHFFSRAGTVGEAVPED----------LYIKGAG-EEQNTLATSNYFGTPSGSLVSSDGQLFNRP 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 323 FWLQRAQGHNNGILWANQMFVTVVDNTRNTNFSISIYSENQnihDIPNYDSQKFREYLRHVEEYEISIILQLCKVPLKAE 402
Cdd:pfam00500 308 YWLQRAQGHNNGICWNNQLFVTVVDNTRGTNFTISVKADEN---DETTYDASNFKEYLRHVEEYELSFIFQLCKVKLTPE 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1653972994 403 VLAQINAMNSSLLEDWQLGFVPTPDNPIHDTYRYIESLATRCPDKNPPKEKPDPYDGLSFWTVDMTERLSLDLDQYSLGR 482
Cdd:pfam00500 385 NLAYLHTMNPSILEDWNLGVTPPPSSSLEDTYRYIESLATKCPDNPPPAEKEDPYKGLKFWEVDLSERLSADLDQFPLGR 464

                         490       500       510
                  ....*....|....*....|....*....|...
gi 1653972994 483 KFLFQAGLQQTTVNGTTKSSSYRSSMRGTKRKR 515
Cdd:pfam00500 465 KFLYQSGLTQSSSSTKRKAPASVAVSRSSKRKR 497
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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