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Conserved domains on  [gi|164663902|ref|NP_705795|]
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SLAIN motif-containing protein 2 isoform a [Mus musculus]

Protein Classification

SLAIN motif-containing protein( domain architecture ID 12172998)

SLAIN motif-containing protein is a microtubule plus-end tracking protein, similar to human SLAIN2 that binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 130-607 1.69e-153

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


:

Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 448.01  E-value: 1.69e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  130 WLYSSPKKKLtPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSVSYSNSYSPNasSPYS 209
Cdd:pfam15301   1 WLYVSPKKKV-PSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSSAYSGNAEA--SSYS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  210 SGFNSPSSTPVRPpivKQLILPGNSGNFKSSSdrnpPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEES 289
Cdd:pfam15301  75 SGLNSPGYLKSTN---KQLLTCGSSGYLRRHS----ALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEES 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  290 LRQEYAASTSRRSSGSSCN---STRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNsprpspkqSPRNSPRSR 366
Cdd:pfam15301 148 LRQDYASTSASASRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  367 SPARGIEYSRASPQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSSTQ-VDSVKSSRS-DSNFQVPNGG 444
Cdd:pfam15301 220 SPSTSQEYSRLSAQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  445 IPRMQPQASAtsqrlkslprtslkakqllptsstkrVPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSGsqettqftqt 523
Cdd:pfam15301 295 LSRLQQSSSS--------------------------IPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVA---------- 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  524 TSSPGPPVVQNSAPANPSSninSATLTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSW 602
Cdd:pfam15301 339 GPSKGLPSSQSLPSGGSSG---SPLPSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESW 415


                  ....*
gi 164663902  603 KDGCY 607
Cdd:pfam15301 416 KDGCY 420
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 130-607 1.69e-153

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 448.01  E-value: 1.69e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  130 WLYSSPKKKLtPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSVSYSNSYSPNasSPYS 209
Cdd:pfam15301   1 WLYVSPKKKV-PSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSSAYSGNAEA--SSYS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  210 SGFNSPSSTPVRPpivKQLILPGNSGNFKSSSdrnpPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEES 289
Cdd:pfam15301  75 SGLNSPGYLKSTN---KQLLTCGSSGYLRRHS----ALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEES 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  290 LRQEYAASTSRRSSGSSCN---STRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNsprpspkqSPRNSPRSR 366
Cdd:pfam15301 148 LRQDYASTSASASRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  367 SPARGIEYSRASPQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSSTQ-VDSVKSSRS-DSNFQVPNGG 444
Cdd:pfam15301 220 SPSTSQEYSRLSAQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  445 IPRMQPQASAtsqrlkslprtslkakqllptsstkrVPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSGsqettqftqt 523
Cdd:pfam15301 295 LSRLQQSSSS--------------------------IPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVA---------- 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  524 TSSPGPPVVQNSAPANPSSninSATLTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSW 602
Cdd:pfam15301 339 GPSKGLPSSQSLPSGGSSG---SPLPSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESW 415


                  ....*
gi 164663902  603 KDGCY 607
Cdd:pfam15301 416 KDGCY 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 345-601 1.61e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  345 PSPRNSPRPSPKQS---PRNSPRSRSPARGIEYSRASPQPMISRLQQPRLSLQGHPTDLQtsnvkneeklrrslPNLSRT 421
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP--------------PSPLPP 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  422 SSTQVDSVKSSRSDSNFQVPNGGI----PRMQPQASATSQRLKSLPRTSLKAKQLLPTSSTKRvpspgkFRSPAAPSPLA 497
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR------PRRRAARPTVG 2693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  498 lrqPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAGTT-----------AMRSGLPRPS 566
Cdd:PHA03247 2694 ---SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggparparpPTTAGPPAPA 2770

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 164663902  567 APSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDS 601
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 130-607 1.69e-153

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 448.01  E-value: 1.69e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  130 WLYSSPKKKLtPMQKSVSPLVWCRQVLDYPSPDVECAKKSLIHKLDQtmsALKRQNLYNNPFNSVSYSNSYSPNasSPYS 209
Cdd:pfam15301   1 WLYVSPKKKV-PSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQ---ASRWRSLYSSPSSSSSAYSGNAEA--SSYS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  210 SGFNSPSSTPVRPpivKQLILPGNSGNFKSSSdrnpPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILARMQEES 289
Cdd:pfam15301  75 SGLNSPGYLKSTN---KQLLTCGSSGYLRRHS----ALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEES 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  290 LRQEYAASTSRRSSGSSCN---STRRGTFSDQELDAQSLDDEDDSLQHAVHPALNRFSPSPRNsprpspkqSPRNSPRSR 366
Cdd:pfam15301 148 LRQDYASTSASASRRSSSFslhSLRRGTYSDQELDAYSLEDEEEEYCSLPQPRLHRFSPLPHS--------SPRDSPRSR 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  367 SPARGIEYSRASPQpmisRLQQPRLSLQGHPTDLQtSNVKNEEKLRRSLPNLSRTSSTQ-VDSVKSSRS-DSNFQVPNGG 444
Cdd:pfam15301 220 SPSTSQEYSRLSAQ----RLRQPRRSLQGPGAELQ-KYAKSEEKLRRSMPNLARRTSLRsLESVRNSRSfESNLQVPNSG 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  445 IPRMQPQASAtsqrlkslprtslkakqllptsstkrVPSPGKFR-SPAAPSPLALRQPVKAFSNHGSGSGsqettqftqt 523
Cdd:pfam15301 295 LSRLQQSSSS--------------------------IPSPSKLRvQSAGQSPLALRQPVKATSYVSSTVA---------- 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  524 TSSPGPPVVQNSAPANPSSninSATLTRPAGT-TAMRSGLPRPSAPSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDSW 602
Cdd:pfam15301 339 GPSKGLPSSQSLPSGGSSG---SPLPSRPSGGySGGRSSLPRPASFVGGTSPVPRSKLAQPVRRSLTPPKTYSALRDESW 415


                  ....*
gi 164663902  603 KDGCY 607
Cdd:pfam15301 416 KDGCY 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 345-601 1.61e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  345 PSPRNSPRPSPKQS---PRNSPRSRSPARGIEYSRASPQPMISRLQQPRLSLQGHPTDLQtsnvkneeklrrslPNLSRT 421
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAP--------------PSPLPP 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  422 SSTQVDSVKSSRSDSNFQVPNGGI----PRMQPQASATSQRLKSLPRTSLKAKQLLPTSSTKRvpspgkFRSPAAPSPLA 497
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR------PRRRAARPTVG 2693

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  498 lrqPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAGTT-----------AMRSGLPRPS 566
Cdd:PHA03247 2694 ---SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAtpggparparpPTTAGPPAPA 2770

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 164663902  567 APSAGGIPVPRSKLVQPVRRSLPAPKSYGSMKDDS 601
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
PHA03247 PHA03247
large tegument protein UL36; Provisional
 338-591 5.33e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  338 PALNRFSPSPRNSPRPSpkqSPRNSPRSRSPArgieysrASPQPmisrlQQPRLSlqGHPTDlqtsnvkneEKLRRSLPN 417
Cdd:PHA03247 2562 AAPDRSVPPPRPAPRPS---EPAVTSRARRPD-------APPQS-----ARPRAP--VDDRG---------DPRGPAPPS 2615

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  418 LSRTSSTQVDSVKSSRSDSNFQVPNGGI----PRMQPQASATSQRLKSLPRTSLKAKQLLPTSSTKRvpspgkFRSPAAP 493
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPptvpPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR------PRRRAAR 2689

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  494 SPLAlrqPVKAFSNHGSGSGSQETTQFTQTTSSPGPPVVQNSAPANPSSNINSATLTRPAG--TTAMRSGLPRPSAPSAG 571
Cdd:PHA03247 2690 PTVG---SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpaTPGGPARPARPPTTAGP 2766

                         250       260
                  ....*....|....*....|
gi 164663902  572 GIPVPRSKLVQPVRRSLPAP 591
Cdd:PHA03247 2767 PAPAPPAAPAAGPPRRLTRP 2786
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 205-436 2.03e-03

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 40.97  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  205 SSPYSSGFNSPSSTPVRPPIVKqlilPGNSGNFKSSSDRNPPLSPQSSIDSeLSASELDEDS----IGSNYKLNDVTD-- 278
Cdd:pfam08580 420 SPATLVANKTPGSSPPSSVIMT----PVNKGSKTPSSRRGSSFDFGSSSER-VINSKLRRESklpqIASTLKQTKRPSki 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  279 -VQILARMQEESLRQEYAASTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDSLQHaVHPALNRFSPSP-----RNSPR 352
Cdd:pfam08580 495 pRASPNHSGFLSTPSNTATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGH-NFKPLTLTTPSPtpsrsSRSSS 573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663902  353 PSPKQSPRNSPRSRSPARG------IEYSRASPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSSTQV 426
Cdd:pfam08580 574 TLPPVSPLSRDKSRSPAPTcrsvsrASRRRASRKPTRIGSPNSRTSLLDEPPYPKLTLSKGLPRTPRNRQSYAGTSPSRS 653

                         250
                  ....*....|
gi 164663902  427 DSVKSSRSDS 436
Cdd:pfam08580 654 VSVSSGLGPQ 663
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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