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Conserved domains on  [gi|1645986022|gb|QCP72489|]
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DNA gyrase/topoisomerase IV subunit A [Duncaniella sp. B8]

Protein Classification

DNA gyrase/topoisomerase IV subunit A( domain architecture ID 11486165)

DNA gyrase/topoisomerase IV subunit A is part of the enzyme that regulates the conformational changes in DNA topology by catalyzing the concerted breakage and rejoining of DNA strands

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
38-903 0e+00

DNA gyrase/topoisomerase IV subunit A;


:

Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 1426.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  38 SNDTIRHQLRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGRFNKVANIVGHTMQFHPHGDASIYEA 117
Cdd:PRK12758   15 SEDEALTHVSGMYKNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQYHPHGDASIGDA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 118 LVQLGQKELLVETQGNWGNTLTGASAAAGRYIEARLSQFALDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEG 197
Cdd:PRK12758   95 LVQLGQKDLLIDTQGNWGNILTGDGAAAPRYIEARLSKFALEVVFNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEG 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 198 IAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLYPDFYTGGFIDVSRYNDGERGGVVKIRAKIEKIDNKTLAITEIPYGKT 277
Cdd:PRK12758  175 IAVGLSTKILPHNFNELIDASIAYLKGKEFKLYPDFPTGGIIDVSNYNDGERGGRVRVRAKIEKLDKKTLVITEIPYGTT 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 278 TATLIESIVKAQEAGKIKIRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVL 357
Cdd:PRK12758  255 TSSLIDSILKANDKGKIKIKKVEDNTAADVEILVHLAPGVSPDKTIDALYAFTDCEVSISPNACVIIDNKPHFLGVSDIL 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 358 RHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEERIYKDkgYEESESRAQAIEHIRGRLEKFKDKFIREITDDDII 437
Cdd:PRK12758  335 RRSTDHTVSLLKQELEIRLSELEEQWHFASLEKIFIEERIYKE--IEEAETWEAVIEAIDKGLEPFKKQFIREVTEDDIV 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 438 RLFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKLERLTDYTIEWYENLKRKYGDAYPRMTVLRNFDNIQAASVAEANE 517
Cdd:PRK12758  413 RLTEIKIKRISKFDSDKADELIARLEAEIAEVKHHLAHLTDYAIAYFTNLKKKYGKGRERKTEIRNFDTIEATKVVEANQ 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 518 KLYINREEGFIGTSLKKDEFLCNCSSIDDVIIFYKDGRYKVVRVQEKLFIDKNVLHVDVFKRNDKRTVYNVIYQDGKGGT 597
Cdd:PRK12758  493 KLYVNREEGFIGTGLKKDEYVADCSDIDDVIVFRRDGKYMVTKVADKTFVGKDIIHVAVFKKNDKRTIYNMIYRDGKSGP 572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 598 YYMKRFFVTGITRDKEYNVTGGKPGSRVCWFTVNPNGEAEVVKVTLKPKLRLKTLQFDVDFSKINIKGRASLGNIVTRNE 677
Cdd:PRK12758  573 SYIKRFNVTGVTRDKEYDLTQGTPGSKVLYFSANPNGEAEVVTVTLKPNGRIKKLKFDLDFSEIAIKGRGSKGNILTKYP 652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 678 VHRFSLKEKGRSTLGGRDVWYDPDVMRLNYDGRGEYLGEFNSGDLVLVIQKNGEYYTSTFEASNHYPDNILRIEKFAPHK 757
Cdd:PRK12758  653 VKKIELKEKGVSTLGGRKVWFDDDVGRLNYDERGELLGEFKGDDKILVILQDGDYYTTNFELTNHYEPNIIVLEKFDPEK 732

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 758 VWTAILDDADQKYPYIKRFTFEPTAKPQRYLGDNEKSSLLLLSDEPGLHVEVVFGGADSF-RPAMEIVARDFIAVKSVKA 836
Cdd:PRK12758  733 PWSAIYYDGEKKNYYVKRFLIENTDKKFNFISEHPGSKLELLSTDYYPRIEIVFGKGDGKeRPNLEIDLEEFIAVKGIKA 812

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1645986022 837 KGKRLTTFAIDHITELEPIATEDILDEDDAEPgqssesadqESEDvAEPEKSDDEVRDELTGQHRLF 903
Cdd:PRK12758  813 KGNRLTTYKVKTINELEPLPYEEPEEETAEEP---------EEVD-PEDVKSEDDIDDEDTGQLGLF 869
 
Name Accession Description Interval E-value
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
38-903 0e+00

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 1426.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  38 SNDTIRHQLRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGRFNKVANIVGHTMQFHPHGDASIYEA 117
Cdd:PRK12758   15 SEDEALTHVSGMYKNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQYHPHGDASIGDA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 118 LVQLGQKELLVETQGNWGNTLTGASAAAGRYIEARLSQFALDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEG 197
Cdd:PRK12758   95 LVQLGQKDLLIDTQGNWGNILTGDGAAAPRYIEARLSKFALEVVFNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEG 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 198 IAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLYPDFYTGGFIDVSRYNDGERGGVVKIRAKIEKIDNKTLAITEIPYGKT 277
Cdd:PRK12758  175 IAVGLSTKILPHNFNELIDASIAYLKGKEFKLYPDFPTGGIIDVSNYNDGERGGRVRVRAKIEKLDKKTLVITEIPYGTT 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 278 TATLIESIVKAQEAGKIKIRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVL 357
Cdd:PRK12758  255 TSSLIDSILKANDKGKIKIKKVEDNTAADVEILVHLAPGVSPDKTIDALYAFTDCEVSISPNACVIIDNKPHFLGVSDIL 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 358 RHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEERIYKDkgYEESESRAQAIEHIRGRLEKFKDKFIREITDDDII 437
Cdd:PRK12758  335 RRSTDHTVSLLKQELEIRLSELEEQWHFASLEKIFIEERIYKE--IEEAETWEAVIEAIDKGLEPFKKQFIREVTEDDIV 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 438 RLFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKLERLTDYTIEWYENLKRKYGDAYPRMTVLRNFDNIQAASVAEANE 517
Cdd:PRK12758  413 RLTEIKIKRISKFDSDKADELIARLEAEIAEVKHHLAHLTDYAIAYFTNLKKKYGKGRERKTEIRNFDTIEATKVVEANQ 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 518 KLYINREEGFIGTSLKKDEFLCNCSSIDDVIIFYKDGRYKVVRVQEKLFIDKNVLHVDVFKRNDKRTVYNVIYQDGKGGT 597
Cdd:PRK12758  493 KLYVNREEGFIGTGLKKDEYVADCSDIDDVIVFRRDGKYMVTKVADKTFVGKDIIHVAVFKKNDKRTIYNMIYRDGKSGP 572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 598 YYMKRFFVTGITRDKEYNVTGGKPGSRVCWFTVNPNGEAEVVKVTLKPKLRLKTLQFDVDFSKINIKGRASLGNIVTRNE 677
Cdd:PRK12758  573 SYIKRFNVTGVTRDKEYDLTQGTPGSKVLYFSANPNGEAEVVTVTLKPNGRIKKLKFDLDFSEIAIKGRGSKGNILTKYP 652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 678 VHRFSLKEKGRSTLGGRDVWYDPDVMRLNYDGRGEYLGEFNSGDLVLVIQKNGEYYTSTFEASNHYPDNILRIEKFAPHK 757
Cdd:PRK12758  653 VKKIELKEKGVSTLGGRKVWFDDDVGRLNYDERGELLGEFKGDDKILVILQDGDYYTTNFELTNHYEPNIIVLEKFDPEK 732

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 758 VWTAILDDADQKYPYIKRFTFEPTAKPQRYLGDNEKSSLLLLSDEPGLHVEVVFGGADSF-RPAMEIVARDFIAVKSVKA 836
Cdd:PRK12758  733 PWSAIYYDGEKKNYYVKRFLIENTDKKFNFISEHPGSKLELLSTDYYPRIEIVFGKGDGKeRPNLEIDLEEFIAVKGIKA 812

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1645986022 837 KGKRLTTFAIDHITELEPIATEDILDEDDAEPgqssesadqESEDvAEPEKSDDEVRDELTGQHRLF 903
Cdd:PRK12758  813 KGNRLTTYKVKTINELEPLPYEEPEEETAEEP---------EEVD-PEDVKSEDDIDDEDTGQLGLF 869
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
65-485 8.12e-138

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 417.72  E-value: 8.12e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  65 RAVPNIEDGLKPVQRRILHAMK--LLDDGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KELLVETQGNWGNT 137
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFelLNLDKPYKKVARLVGDVMgKYHPHGDASLYDAIVRMAQdfvgNIPLLDGQGNFGSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 138 LTGASAAAGRYIEARLSQFALDVV--YNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLSSKILPHNFNEII 215
Cdd:pfam00521  81 IDGDKDAAMRYTETRLSKIARELFpdIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 216 DAAVAYLRGEEFTL------YPDFYTGGFIDVS-----RYNDGErgGVVKIRAKIEKIDNKTLAITEIPYGKTTATLIES 284
Cdd:pfam00521 161 DALIALLDGPEATLlmkyimGPDFPTGGGIIGKggikeAYKTGR--GKITVRAKVEIEDRKTIVITELPYGVWTSDLIEK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 285 IVKAQEAGKIK-IRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVLRHNVDS 363
Cdd:pfam00521 239 IEELVKNGKIKgISDIRDESDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEILKEFLDH 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 364 TRTILGKELQIQLGEVREQLHfaslerifIEERIYKdkgyeESESRAQAIEHIRGRL--EKFKDKFIREITDDDIIRLFE 441
Cdd:pfam00521 319 RLEVYERRKEYLLEKLEERLH--------ILEGLLI-----ALNNIDFVIEIIRGSIdrKKAKKNLIEELSEIQADYLLD 385

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1645986022 442 IKMGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIEWYE 485
Cdd:pfam00521 386 MRLRRLTKEEVDKLLEEIDELEKEIAELEKLLaseKKLNDLWIEELD 432
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 54-473 9.75e-100

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 318.74  E-value: 9.75e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022   54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGR---FNKVANIVGHTMQ-FHPHGDASIYEALVQLGQK----E 125
Cdd:smart00434  11 YLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdepKVKSARGVGDVMGkYHPHGDSSLYDTIVRMAQDfsnnY 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  126 LLVETQGNWGNTLTGASAAAGRYIEARLSQFA--LDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLS 203
Cdd:smart00434  91 PLLDGQGNFGSRLDGDDAAAMRYTETRLSPLArlLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  204 SKILPHNFNEIIDAAVAYLRGEEFTL--------YPDFYTGGFIDVSRYndgerggvVKIRAKIEKIDNKTLAITEIPYG 275
Cdd:smart00434 171 TNIPPHNLREVIDAVRRLIDNPDASIdelmmipwGPDFPTGGEIVGPGK--------YVVRGKIEIEDDNTIVITELPYQ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  276 KTTATLIESIVKAQEAGKIK-IRSVDD--NTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISEN-KPHFI 351
Cdd:smart00434 243 VNTADLIEKIAELVKDKKIEgIIDVRDesHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFDNgRPKKY 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  352 GVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEERIykDKGYEESESRAQAIEHIRGRL-EKFkdkfirE 430
Cdd:smart00434 323 NLKEILKEFLDHRLEVYTRRKEYLLGKLEAERLHILEGLFIALSII--DEIIVLIRSSKDLAKEAKEKLmERF------E 394

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1645986022  431 ITDDDIIRLFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL 473
Cdd:smart00434 395 LSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKIL 437
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 64-473 1.08e-80

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 267.90  E-value: 1.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  64 ERAVPNIEDGLKPVQRRILHAM---KLLDDGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KELLVETQGNWG 135
Cdd:cd00187     2 GRALPDVRDGLKPVQRRILYAMfkrGLTPDKPEKKVARLVGDVAgKYHPHGDSSLYDTIVRMAQdfsnNIPLLDPQGNFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 136 nTLTGASAAAGRYIEARLSQFALDVV--YNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLSSKILPHNFNE 213
Cdd:cd00187    82 -SRDGDDAAAMRYTETRLSPIARLLLpdIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 214 IIDAAVAYLRGEEFTLY--------PDFYTGGFIdvsRYNDGER------GGVVKIRAKIEKIDNK---TLAITEIPYGK 276
Cdd:cd00187   161 VIDALRALIDNPEASIDelmeiikgPDFPTGGII---EGRAGIReayetgRGRYIIRGKYEIEDDEgrnTIEITELPYQV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 277 TTATLIESIVKAQEAGKIK-IRSV-DDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISEN-KPHFIGV 353
Cdd:cd00187   238 NKAKLKEKIAELVKDKKIEgISDVrDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPNgRPKKLNL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 354 SDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEEriyKDKGYEESESRAQAIEHIRGRLEKFKdkfIREITD 433
Cdd:cd00187   318 KEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILN---IDEVINLIRSSDEAKKALIEELEKLG---FSEIQA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1645986022 434 DDIirlFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL 473
Cdd:cd00187   392 DAI---LDMRLRRLTKLEREKLLKELKELEAEIEDLEKIL 428
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 54-555 7.58e-74

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 258.78  E-value: 7.58e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLD---DGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KE 125
Cdd:TIGR01063  14 YLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGltpDKPYKKSARIVGDVMgKYHPHGDSAIYDTLVRMAQdfslRY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGnTLTGASAAAGRYIEARLSQFALDVVYN-PKVT-DWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLS 203
Cdd:TIGR01063  94 PLVDGQGNFG-SIDGDPPAAMRYTEARLTKIAEELLRDiDKETvDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 204 SKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIDvsrYNDGERG------GVVKIRAK--IEKIDNK-- 265
Cdd:TIGR01063 173 TNIPPHNLGEIIDALLAYIDNPDISIQellevikgPDFPTGGIIL---GRSGIRSayetgrGSIVIRARaeIEEDSKGre 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 266 TLAITEIPYGKTTATLIESIVKAQEAGKIK----IRSVDDNTGehANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCC 341
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAELVREKKIEgisdIRDESDREG--IRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINML 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 342 VISENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIF---IEERIYKDKgyeESESRAQAIEHIRg 418
Cdd:TIGR01063 328 ALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIAldnIDEVIALIR---ASQNTEEAKTRLV- 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 419 rlEKFKdkfIREITDDDIIrlfEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIEWYENLKRKYGDay 495
Cdd:TIGR01063 404 --ERFS---LSEIQAQAIL---DMRLQRLTGLEREKLQEEYKELLELIADLEDILaseERVLEIIREELEEIKEQFGD-- 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 496 PRMTVlrnfdnIQAASVAEANEKLYINREE--------GFI-------------------GTSLKKDEFLCN---CSSID 545
Cdd:TIGR01063 474 PRRTE------IVYDESEDIDIEDLIARENvvvtlshnGYVkrvpvsayrlqkrggkgvsGADMKDDDFIEQllvASTHD 547

                         570
                  ....*....|
gi 1645986022 546 DVIIFYKDGR 555
Cdd:TIGR01063 548 YLLFFTNRGK 557
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
54-563 8.54e-72

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 253.04  E-value: 8.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLD---DGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KE 125
Cdd:COG0188    23 YLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGltpDKPYKKSARVVGDVMgKYHPHGDSAVYDALVRMAQdfsmRY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGNtLTGASAAAGRYIEARLSQFAL--------DVVynpkvtDWTLSYDGRKKEPVTLPVKFPLLLSKGAEG 197
Cdd:COG0188   103 PLVDGQGNFGS-IDGDPAAAMRYTEARLAKIAEelladidkDTV------DFVPNYDGSEQEPTVLPARFPNLLVNGSSG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 198 IAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIdVSR------YNDGeRGGvVKIRAK--IEK 261
Cdd:COG0188   176 IAVGMATNIPPHNLGEVIDACIALIDNPDATIEelmeyipgPDFPTGGII-VGRegireaYETG-RGS-IRVRAKaeIEE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 262 IDN--KTLAITEIPYGKTTATLIESIVKAQEAGKIK-IRSVDDNTGEHA-NVIVYLQPGTSSDKTIDALYAFTDCEVSIS 337
Cdd:COG0188   253 LKRgrEQIVVTEIPYQVNKARLIEKIAELVKEKKIEgISDVRDESDRDGmRIVIELKRDANPEVVLNQLYKHTQLQTSFG 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 338 PNCCVISENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLH--------FASLERIfIeeRIYKdkgyeESESR 409
Cdd:COG0188   333 INMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHileglliaLDNIDEV-I--AIIR-----ASKDP 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 410 AQAiehiRGRL-EKFkdkfirEITD---DDIIrlfEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIE 482
Cdd:COG0188   405 DEA----KEALmERF------GLSEiqaEAIL---DMRLRRLTGLEREKIEDEYAELLKEIAELEDILaseERLLKIIKE 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 483 WYENLKRKYGDayPRMTVlrnfdnIQAASVAEANEKLyINREE--------GFI-------------------GTSLKKD 535
Cdd:COG0188   472 ELLEIKKKYGD--ERRTE------IEEAEGEIDIEDL-IPDEDvvvtlshkGYIkrtpldtyraqrrggkgvsGMGTKEE 542

                         570       580       590
                  ....*....|....*....|....*....|....
gi 1645986022 536 ---EFLCNCSSIDDVIIFYKDGRY---KVVRVQE 563
Cdd:COG0188   543 dfvEHLFVASTHDTLLFFTNKGRVyrlKVYELPE 576
 
Name Accession Description Interval E-value
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
38-903 0e+00

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 1426.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  38 SNDTIRHQLRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGRFNKVANIVGHTMQFHPHGDASIYEA 117
Cdd:PRK12758   15 SEDEALTHVSGMYKNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQYHPHGDASIGDA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 118 LVQLGQKELLVETQGNWGNTLTGASAAAGRYIEARLSQFALDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEG 197
Cdd:PRK12758   95 LVQLGQKDLLIDTQGNWGNILTGDGAAAPRYIEARLSKFALEVVFNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEG 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 198 IAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLYPDFYTGGFIDVSRYNDGERGGVVKIRAKIEKIDNKTLAITEIPYGKT 277
Cdd:PRK12758  175 IAVGLSTKILPHNFNELIDASIAYLKGKEFKLYPDFPTGGIIDVSNYNDGERGGRVRVRAKIEKLDKKTLVITEIPYGTT 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 278 TATLIESIVKAQEAGKIKIRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVL 357
Cdd:PRK12758  255 TSSLIDSILKANDKGKIKIKKVEDNTAADVEILVHLAPGVSPDKTIDALYAFTDCEVSISPNACVIIDNKPHFLGVSDIL 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 358 RHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEERIYKDkgYEESESRAQAIEHIRGRLEKFKDKFIREITDDDII 437
Cdd:PRK12758  335 RRSTDHTVSLLKQELEIRLSELEEQWHFASLEKIFIEERIYKE--IEEAETWEAVIEAIDKGLEPFKKQFIREVTEDDIV 412

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 438 RLFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKLERLTDYTIEWYENLKRKYGDAYPRMTVLRNFDNIQAASVAEANE 517
Cdd:PRK12758  413 RLTEIKIKRISKFDSDKADELIARLEAEIAEVKHHLAHLTDYAIAYFTNLKKKYGKGRERKTEIRNFDTIEATKVVEANQ 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 518 KLYINREEGFIGTSLKKDEFLCNCSSIDDVIIFYKDGRYKVVRVQEKLFIDKNVLHVDVFKRNDKRTVYNVIYQDGKGGT 597
Cdd:PRK12758  493 KLYVNREEGFIGTGLKKDEYVADCSDIDDVIVFRRDGKYMVTKVADKTFVGKDIIHVAVFKKNDKRTIYNMIYRDGKSGP 572

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 598 YYMKRFFVTGITRDKEYNVTGGKPGSRVCWFTVNPNGEAEVVKVTLKPKLRLKTLQFDVDFSKINIKGRASLGNIVTRNE 677
Cdd:PRK12758  573 SYIKRFNVTGVTRDKEYDLTQGTPGSKVLYFSANPNGEAEVVTVTLKPNGRIKKLKFDLDFSEIAIKGRGSKGNILTKYP 652

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 678 VHRFSLKEKGRSTLGGRDVWYDPDVMRLNYDGRGEYLGEFNSGDLVLVIQKNGEYYTSTFEASNHYPDNILRIEKFAPHK 757
Cdd:PRK12758  653 VKKIELKEKGVSTLGGRKVWFDDDVGRLNYDERGELLGEFKGDDKILVILQDGDYYTTNFELTNHYEPNIIVLEKFDPEK 732

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 758 VWTAILDDADQKYPYIKRFTFEPTAKPQRYLGDNEKSSLLLLSDEPGLHVEVVFGGADSF-RPAMEIVARDFIAVKSVKA 836
Cdd:PRK12758  733 PWSAIYYDGEKKNYYVKRFLIENTDKKFNFISEHPGSKLELLSTDYYPRIEIVFGKGDGKeRPNLEIDLEEFIAVKGIKA 812

                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1645986022 837 KGKRLTTFAIDHITELEPIATEDILDEDDAEPgqssesadqESEDvAEPEKSDDEVRDELTGQHRLF 903
Cdd:PRK12758  813 KGNRLTTYKVKTINELEPLPYEEPEEETAEEP---------EEVD-PEDVKSEDDIDDEDTGQLGLF 869
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 46-684 0e+00

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 674.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  46 LRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGRFNKVANIVGHTMQFHPHGDASIYEALVQLGQKE 125
Cdd:PRK09631    4 IKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVGNTMKYHPHGDASIYEALVNLANKD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGNTLTGASAAAGRYIEARLSQFALDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLSSK 205
Cdd:PRK09631   84 LFIDKQGNFGNLFTGDPASAARYIECRLTPLAKEVLYNKEITEYEPSYDGRNNEPLCLPAKIPVILIQGAEGIAVGMATK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 206 ILPHNFNEIIDAAVAYLRGEEFTLYPDFYTGGFIDVSRYNDGErgGVVKIRAKIEKIDNKTLAITEIPYGKTTATLIESI 285
Cdd:PRK09631  164 ILPHNFNEILQAVKSELLGESFALYPDFPTGGIVDVSEYADGN--GKVLVRAKIETKDEKTIVIREIPFGTTTESLIASI 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 286 VKAQEAGKIKIRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVLRHNVDSTR 365
Cdd:PRK09631  242 EKAARKGKIKISSINDYTAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDRYPVIYTVTDIIKFHAEHLQ 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 366 TILGKELQIQLGEVREQLHFASLERIFIEERIYKDkgYEESESRAQAIEHIRGRLEKFKDKFIREITDDDIIRLFEIKMG 445
Cdd:PRK09631  322 KVLKMELELERAKLLEKIFAKTLEQIFIEERIYKR--IETISSEEDVISIVLSELKPFKEELSRDVTEEDIENLLKIPIR 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 446 RILKFNVDKCEEQIAAFNDRISDLNSKLERLTDYTIEWYENLKRKYGDAYPRMTVLRNFDNIQAASVAEANEKLYINREE 525
Cdd:PRK09631  400 RISLFDIDKNQKEIRILNKELKSVEKNLKSIKGYAINFIDKLLAKYSKEYPRKTEISLIKSVDVREIATKNLKVYYDLKT 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 526 GFIGTSLKKDEFLCNCSSIDDVIIFYKDGRYKVVRVQEKLFIDKNVLHVDVFKRND-KRTVYNVIYQDGKGGTYYMKRFF 604
Cdd:PRK09631  480 GFVGTSVKDGEFIGNASYYDKILVIRKDGTYVVKNIPDKTFIDKKNVYVGVVDINNsKEQVFSIIYRDKKDNFYYVKRFK 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 605 VTGITRDKEYNVTGgkPGSRVCWFTvnpNGEAEVVKVTLKPKLRLKTLQFDVDFSKINIKGRASLGNIVTRNEVHRFSLK 684
Cdd:PRK09631  560 IDKFILDKVYRFLP--EGTEILFLS---TFEDFSLNLQFVPKPRQKDIVKMFRIDDFLVKGRSAIGKRISSREVKKVKFK 634
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
65-485 8.12e-138

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 417.72  E-value: 8.12e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  65 RAVPNIEDGLKPVQRRILHAMK--LLDDGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KELLVETQGNWGNT 137
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFelLNLDKPYKKVARLVGDVMgKYHPHGDASLYDAIVRMAQdfvgNIPLLDGQGNFGSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 138 LTGASAAAGRYIEARLSQFALDVV--YNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLSSKILPHNFNEII 215
Cdd:pfam00521  81 IDGDKDAAMRYTETRLSKIARELFpdIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 216 DAAVAYLRGEEFTL------YPDFYTGGFIDVS-----RYNDGErgGVVKIRAKIEKIDNKTLAITEIPYGKTTATLIES 284
Cdd:pfam00521 161 DALIALLDGPEATLlmkyimGPDFPTGGGIIGKggikeAYKTGR--GKITVRAKVEIEDRKTIVITELPYGVWTSDLIEK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 285 IVKAQEAGKIK-IRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVLRHNVDS 363
Cdd:pfam00521 239 IEELVKNGKIKgISDIRDESDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEILKEFLDH 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 364 TRTILGKELQIQLGEVREQLHfaslerifIEERIYKdkgyeESESRAQAIEHIRGRL--EKFKDKFIREITDDDIIRLFE 441
Cdd:pfam00521 319 RLEVYERRKEYLLEKLEERLH--------ILEGLLI-----ALNNIDFVIEIIRGSIdrKKAKKNLIEELSEIQADYLLD 385

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1645986022 442 IKMGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIEWYE 485
Cdd:pfam00521 386 MRLRRLTKEEVDKLLEEIDELEKEIAELEKLLaseKKLNDLWIEELD 432
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 44-514 2.86e-123

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 381.55  E-value: 2.86e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  44 HQLRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGRFNKVANIVGHTMQFHPHGDASIYEALVQLGQ 123
Cdd:PRK09630    2 SDVSDLFKTHFMHYASYVILERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRTMALHPHGDAPIVEALVVLAN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 124 KELLVETQGNWGNTLTGASAAAGRYIEARLSQFALDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLS 203
Cdd:PRK09630   82 KGYLIDTQGNFGNPLTGDPHAAARYIEARLSPLAKEVLFNTDLMTFHDSYDGREKEPDILPAKLPLLLLHGVDGIAVGMT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 204 SKILPHNFNEIIDAAVAYLRGEEFTLYPDFYTGGFIDVSRYNDGErgGVVKIRAKIEKIDNKTLAITEIPYGKTTATLIE 283
Cdd:PRK09630  162 TKIFPHNFCELLEAQIAILNDQPFTLLPDFPSGGTMDASEYQDGL--GSITLRASIDIINDKTLLIKEICPSTTTETLIR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 284 SIVKAQEAGKIKIRSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVLRHNVDS 363
Cdd:PRK09630  240 SIENAAKRGIIKIDSIQDFSTDLPHIEIKLPKGIYAKDLLRPLFTHTECQVILTSRPTAIYQNKPVETSISEILRLHTET 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 364 TRTILGKELQIQLGEVREQLHFASLERIFIEERIY--------KDKGYEESESRAQAIEHirgRLEKFKDKFIREITDDD 435
Cdd:PRK09630  320 LQGYLKKELLILEDSLSREHYHKTLEYIFIKHKLYdtvremlsKRKTSPSSSDLHNAVLE---ALTPFLDTLPTPVDKQA 396

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1645986022 436 IIRLFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKLERLTDYTIEWYENLKRKYGDAYPRMTVLRNFDNIQAASVAE 514
Cdd:PRK09630  397 TAQLASLTIKKILCFNENSYTKELACIEKKQAAVQKDLSQLKKYTVKYLKGLLETYGQLGHRKTQIAKFKAKKLSALKQ 475
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 54-473 9.75e-100

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 318.74  E-value: 9.75e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022   54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLDDGR---FNKVANIVGHTMQ-FHPHGDASIYEALVQLGQK----E 125
Cdd:smart00434  11 YLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdepKVKSARGVGDVMGkYHPHGDSSLYDTIVRMAQDfsnnY 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  126 LLVETQGNWGNTLTGASAAAGRYIEARLSQFA--LDVVYNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLS 203
Cdd:smart00434  91 PLLDGQGNFGSRLDGDDAAAMRYTETRLSPLArlLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVNGSSGIAVGMA 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  204 SKILPHNFNEIIDAAVAYLRGEEFTL--------YPDFYTGGFIDVSRYndgerggvVKIRAKIEKIDNKTLAITEIPYG 275
Cdd:smart00434 171 TNIPPHNLREVIDAVRRLIDNPDASIdelmmipwGPDFPTGGEIVGPGK--------YVVRGKIEIEDDNTIVITELPYQ 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  276 KTTATLIESIVKAQEAGKIK-IRSVDD--NTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISEN-KPHFI 351
Cdd:smart00434 243 VNTADLIEKIAELVKDKKIEgIIDVRDesHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFDNgRPKKY 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  352 GVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEERIykDKGYEESESRAQAIEHIRGRL-EKFkdkfirE 430
Cdd:smart00434 323 NLKEILKEFLDHRLEVYTRRKEYLLGKLEAERLHILEGLFIALSII--DEIIVLIRSSKDLAKEAKEKLmERF------E 394

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 1645986022  431 ITDDDIIRLFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL 473
Cdd:smart00434 395 LSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKIL 437
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 64-473 1.08e-80

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 267.90  E-value: 1.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  64 ERAVPNIEDGLKPVQRRILHAM---KLLDDGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KELLVETQGNWG 135
Cdd:cd00187     2 GRALPDVRDGLKPVQRRILYAMfkrGLTPDKPEKKVARLVGDVAgKYHPHGDSSLYDTIVRMAQdfsnNIPLLDPQGNFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 136 nTLTGASAAAGRYIEARLSQFALDVV--YNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLSSKILPHNFNE 213
Cdd:cd00187    82 -SRDGDDAAAMRYTETRLSPIARLLLpdIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 214 IIDAAVAYLRGEEFTLY--------PDFYTGGFIdvsRYNDGER------GGVVKIRAKIEKIDNK---TLAITEIPYGK 276
Cdd:cd00187   161 VIDALRALIDNPEASIDelmeiikgPDFPTGGII---EGRAGIReayetgRGRYIIRGKYEIEDDEgrnTIEITELPYQV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 277 TTATLIESIVKAQEAGKIK-IRSV-DDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISEN-KPHFIGV 353
Cdd:cd00187   238 NKAKLKEKIAELVKDKKIEgISDVrDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPNgRPKKLNL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 354 SDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEEriyKDKGYEESESRAQAIEHIRGRLEKFKdkfIREITD 433
Cdd:cd00187   318 KEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILN---IDEVINLIRSSDEAKKALIEELEKLG---FSEIQA 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1645986022 434 DDIirlFEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL 473
Cdd:cd00187   392 DAI---LDMRLRRLTKLEREKLLKELKELEAEIEDLEKIL 428
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
54-384 3.27e-74

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 258.50  E-value: 3.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLL---DDGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KE 125
Cdd:PRK05561   23 YLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELgltPDAKFKKSARVVGDVLgKYHPHGDSSIYDAMVRMAQdfsyRY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGNtLTGASAAAGRYIEARLSQFAL--------DVVynpkvtDWTLSYDGRKKEPVTLPVKFPLLLSKGAEG 197
Cdd:PRK05561  103 PLVDGQGNFGS-IDGDPAAAMRYTEARLSPIAEllleeideGTV------DFVPNFDGTLKEPTVLPARFPNLLLNGATG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 198 IAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIDVSRynDG-----ERG-GVVKIRAKIEKID 263
Cdd:PRK05561  176 IAVGMATDIPPHNLREVIDAAIHLIDNPDATLEelmefvpgPDFPTGGEIITGR--DGirkayETGrGSIRVRARWEIED 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 264 ----NKTLAITEIPYGKTTATLIESIVKAQEAGKIK-IRSVDDNTGEHANV-IVyLQPGTS---SDKTIDALYAFTDCEV 334
Cdd:PRK05561  254 laggRWQIVITELPYQVSKAKLIEQIAELMNAKKLPgIADVRDESDRENPVrIV-IEPKSNrvdPEALMNHLFATTDLES 332

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1645986022 335 SISPNCCVIS-ENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLH 384
Cdd:PRK05561  333 SYRVNMNAIGlDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLH 383
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 54-555 7.58e-74

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 258.78  E-value: 7.58e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLD---DGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KE 125
Cdd:TIGR01063  14 YLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGltpDKPYKKSARIVGDVMgKYHPHGDSAIYDTLVRMAQdfslRY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGnTLTGASAAAGRYIEARLSQFALDVVYN-PKVT-DWTLSYDGRKKEPVTLPVKFPLLLSKGAEGIAVGLS 203
Cdd:TIGR01063  94 PLVDGQGNFG-SIDGDPPAAMRYTEARLTKIAEELLRDiDKETvDFVPNYDGSEQEPTVLPSRFPNLLVNGSSGIAVGMA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 204 SKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIDvsrYNDGERG------GVVKIRAK--IEKIDNK-- 265
Cdd:TIGR01063 173 TNIPPHNLGEIIDALLAYIDNPDISIQellevikgPDFPTGGIIL---GRSGIRSayetgrGSIVIRARaeIEEDSKGre 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 266 TLAITEIPYGKTTATLIESIVKAQEAGKIK----IRSVDDNTGehANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCC 341
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAELVREKKIEgisdIRDESDREG--IRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINML 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 342 VISENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIF---IEERIYKDKgyeESESRAQAIEHIRg 418
Cdd:TIGR01063 328 ALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIAldnIDEVIALIR---ASQNTEEAKTRLV- 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 419 rlEKFKdkfIREITDDDIIrlfEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIEWYENLKRKYGDay 495
Cdd:TIGR01063 404 --ERFS---LSEIQAQAIL---DMRLQRLTGLEREKLQEEYKELLELIADLEDILaseERVLEIIREELEEIKEQFGD-- 473

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 496 PRMTVlrnfdnIQAASVAEANEKLYINREE--------GFI-------------------GTSLKKDEFLCN---CSSID 545
Cdd:TIGR01063 474 PRRTE------IVYDESEDIDIEDLIARENvvvtlshnGYVkrvpvsayrlqkrggkgvsGADMKDDDFIEQllvASTHD 547

                         570
                  ....*....|
gi 1645986022 546 DVIIFYKDGR 555
Cdd:TIGR01063 548 YLLFFTNRGK 557
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
54-563 8.54e-72

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 253.04  E-value: 8.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMKLLD---DGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KE 125
Cdd:COG0188    23 YLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGltpDKPYKKSARVVGDVMgKYHPHGDSAVYDALVRMAQdfsmRY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGNtLTGASAAAGRYIEARLSQFAL--------DVVynpkvtDWTLSYDGRKKEPVTLPVKFPLLLSKGAEG 197
Cdd:COG0188   103 PLVDGQGNFGS-IDGDPAAAMRYTEARLAKIAEelladidkDTV------DFVPNYDGSEQEPTVLPARFPNLLVNGSSG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 198 IAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIdVSR------YNDGeRGGvVKIRAK--IEK 261
Cdd:COG0188   176 IAVGMATNIPPHNLGEVIDACIALIDNPDATIEelmeyipgPDFPTGGII-VGRegireaYETG-RGS-IRVRAKaeIEE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 262 IDN--KTLAITEIPYGKTTATLIESIVKAQEAGKIK-IRSVDDNTGEHA-NVIVYLQPGTSSDKTIDALYAFTDCEVSIS 337
Cdd:COG0188   253 LKRgrEQIVVTEIPYQVNKARLIEKIAELVKEKKIEgISDVRDESDRDGmRIVIELKRDANPEVVLNQLYKHTQLQTSFG 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 338 PNCCVISENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLH--------FASLERIfIeeRIYKdkgyeESESR 409
Cdd:COG0188   333 INMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHileglliaLDNIDEV-I--AIIR-----ASKDP 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 410 AQAiehiRGRL-EKFkdkfirEITD---DDIIrlfEIKMGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIE 482
Cdd:COG0188   405 DEA----KEALmERF------GLSEiqaEAIL---DMRLRRLTGLEREKIEDEYAELLKEIAELEDILaseERLLKIIKE 471

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 483 WYENLKRKYGDayPRMTVlrnfdnIQAASVAEANEKLyINREE--------GFI-------------------GTSLKKD 535
Cdd:COG0188   472 ELLEIKKKYGD--ERRTE------IEEAEGEIDIEDL-IPDEDvvvtlshkGYIkrtpldtyraqrrggkgvsGMGTKEE 542

                         570       580       590
                  ....*....|....*....|....*....|....
gi 1645986022 536 ---EFLCNCSSIDDVIIFYKDGRY---KVVRVQE 563
Cdd:COG0188   543 dfvEHLFVASTHDTLLFFTNKGRVyrlKVYELPE 576
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 54-563 2.26e-63

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 229.15  E-value: 2.26e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  54 FLDYASYVILERAVPNIEDGLKPVQRRILHAMK---LLDDGRFNKVANIVGHTM-QFHPHGDASIYEALVQLGQ----KE 125
Cdd:PRK05560   18 YLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNelgNTPDKPYKKSARIVGDVMgKYHPHGDSAVYDALVRMAQdfsmRY 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 126 LLVETQGNWGnTLTGASAAAGRYIEARLSQFA------LDvvynpKVT-DWTLSYDGRKKEPVTLPVKFPLLLSKGAEGI 198
Cdd:PRK05560   98 PLVDGQGNFG-SIDGDPAAAMRYTEARMSKIAhelladID-----KETvDFVPNYDGSEQEPTVLPARFPNLLVNGSSGI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 199 AVGLSSKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIdVSR------YNDGeRGGVVkIRAK--IEKI 262
Cdd:PRK05560  172 AVGMATNIPPHNLGEVIDACLALIDNPDITIEelmeiipgPDFPTGGII-LGRsgireaYRTG-RGSIV-MRAKaeIEEI 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 263 DNKT-LAITEIPYGKTTATLIESIVKAQEAGKIK----IRSVDDNTGehANVIVYLQPGTSSDKTIDALYAFTDCEVSIS 337
Cdd:PRK05560  249 KGREaIIVTEIPYQVNKARLIEKIAELVKEKKIEgisdLRDESDRDG--MRIVIELKRDAVPEVVLNNLYKHTQLQTSFG 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 338 PNCCVISENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFasLE--RI---FIEE--RIYKdkgyeESESRA 410
Cdd:PRK05560  327 INMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHI--LEglLIaldNIDEviALIR-----ASPTPA 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 411 QAIEHIRGRLEkFKDKFIREITDddiIRLfeikmGRILKFNVDKCEEQIAAFNDRISDLNSKL---ERLTDYTIEWYENL 487
Cdd:PRK05560  400 EAKEGLMERFG-LSEIQAQAILD---MRL-----QRLTGLERDKIEDEYKELLALIADLKDILaspERLLEIIKEELLEI 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 488 KRKYGDayPRMTVlrnfdnIQAASVAEANEKLyINREE--------GFI-------------------GTSLKKDEF--- 537
Cdd:PRK05560  471 KEKFGD--PRRTE------IIEGEGDIDDEDL-IPEEDvvvtlthgGYIkrtpldeyraqrrggkgvsGAKTKEDDFveh 541

                         570       580
                  ....*....|....*....|....*....
gi 1645986022 538 LCNCSSIDDVIIFYKDGR-Y--KVVRVQE 563
Cdd:PRK05560  542 LFVASTHDTLLFFTNRGRvYrlKVYEIPE 570
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 46-511 5.47e-61

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 221.32  E-value: 5.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  46 LRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAM---KLLDDGRFNKVANIVGHTM-QFHPHGDASIYEALVQL 121
Cdd:TIGR01062   6 LGNFTEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMselGLNANAKYKKSARTVGDVLgKYHPHGDSACYEAMVLM 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 122 GQ----KELLVETQGNWGNTLTGASAAAGRYIEARLSQFALDVV--YNPKVTDWTLSYDGRKKEPVTLPVKFPLLLSKGA 195
Cdd:TIGR01062  86 AQpfsyRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISELLLeeLGQGTVDFRPNFDGTLLEPVILPARLPNILLNGT 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 196 EGIAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFIDVSR------YNDGErgGVVKIRAKIEK 261
Cdd:TIGR01062 166 TGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDdilnivqgPDFPTEAEIIDKAeeirkiYETGR--GSFRMRARWKK 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 262 IDNKtLAITEIPYGKTTATLIESIVKAQEAGKIKIRSVDDNTGEHANVI-VYLQPGTSS---DKTIDALYAFTDCEVSIS 337
Cdd:TIGR01062 244 EDGQ-IVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENPIrVVIVPRSNRvdpDIVMEHLFATTDLEKSYR 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 338 PNCCVI-SENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFASLERIF---IEERIYKDKgyEESESRAQAi 413
Cdd:TIGR01062 323 LNMNMIgLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAflnIDEVIEIIR--EEDEPKTIL- 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 414 ehirgrLEKFKdkfireITDDDIIRLFEIKMGRILKFNvdkcEEQIAAFNDRISDLNSKLERLTDYTIEWYENLKR---- 489
Cdd:TIGR01062 400 ------MERFK------LSAIQAEAILNLRLRHLAKLE----EHAIIDEQSELEKERAILEKILKSERELNQLVKKeiqa 463

                         490       500
                  ....*....|....*....|....*
gi 1645986022 490 ---KYGDayPRMTVLRNFDNIQAAS 511
Cdd:TIGR01062 464 datKYGL--ARRSSLEEREEAKQVS 486
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 33-569 3.96e-59

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 218.82  E-value: 3.96e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  33 IIVDTSNDTIRHQLRGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRIL---HAMKLLDDGRFNKVANIVGHTM-QFHP 108
Cdd:PRK13979    5 IVIPKDNNIIKIPLEEAMPENYLPYAVEVAKDRALPDVRDGLKPVHRRILygaYMLKAFPDKPYYKSARIVGDILgKYHP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 109 HGDASIYEALVQLGQ----KELLVETQGNWGnTLTGASAAAGRYIEARLSQFALDVVYN--PKVTDWTLSYDGRKKEPVT 182
Cdd:PRK13979   85 HGDSSVYDAMVILAQdfttRMPLIDGHGNWG-SIDGDSAAAMRYTEARLTPIAMEMLRDidKDVVNMVDNYSDSEKEPEV 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 183 LPVKFPLLLSKGAEGIAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLY--------PDFYTGGFID-----VSRYNDGEr 249
Cdd:PRK13979  164 LPARYPNLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKelmnyikgPDLPTGGILIgkkslLSAYETGE- 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 250 gGVVKIRAK--IEKIDNKTLA--ITEIPYGKTTATLIESI---------VKAQEaGKIKIRSVDDNTGEHAnVIVYLQPG 316
Cdd:PRK13979  243 -GKVTLRAKtkIEKLENGRLGivITEFPYRRNKAKLLQTIsemtadkkhSKALE-NISDIRDESDRNGIRA-VIEFKKSA 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 317 T--SSDKTIDALYAFTDCEVSISPNCCVISENKPHFIGVSDVLRHNVDSTRTILGKELQIQLGEVREQLHFAS--LERIF 392
Cdd:PRK13979  320 DedVAEKVLKYLYKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEgfIKAIG 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 393 IEERIYKDkgYEESESRAQAIEHIrgrLEKFkdkfirEITDDDIIRLFEIKMGRILKFNVDKCEEQIAAFNDRISD---- 468
Cdd:PRK13979  400 IMDEIIKT--IRSSKSKKDASENL---IEKF------GFTDEQAEAILELMLYRLTGLEIVAFEKEYKELEKLIKKltki 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 469 LNSKLERLTDYTIEWYEnLKRKYGDAypRMTVLRNFDNIQAASVAE--ANEKLYIN-REEGFIG-TSLK----------- 533
Cdd:PRK13979  469 LSSEKELLKVIKKELKE-VKEKYGDE--RRTSIIEDDEKAKIDVEEliVVEDVVITlSNEGFIKrIPLKsynrsnsnved 545

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*.
gi 1645986022 534 -------KDEFLCNCSSIDDVIIFYKDG---RYKVVRVQEKLFIDK 569
Cdd:PRK13979  546 ieyregdFNKFLIQSNTKDTLLIFTDKGnmyQIKGINIPEFKWKEK 591
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 55-439 3.78e-38

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 148.28  E-value: 3.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  55 LDYASYVILERAVPNIEDGLKPVQRRILH-AMKLLDDGR--FNKVANIVGH-TMQFHPHGDASIYEALVQLGQKEL---- 126
Cdd:PHA02592   17 LEYAMYTVEERAIPNLIDGLKPVQRFVIHrALEYAKGNKekFDKVAAIAGGvADLGYHHGETSAQDAGALMANTWNnnip 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 127 LVETQGNWGnTLTGASAAAGRYIEARLSQfALDVVYnpKVTDWTLSY-DGRKKEPV-TLPVkFPLLLSKGAEGIAVGLSS 204
Cdd:PHA02592   97 LLDGQGNFG-SRLVQKAAAARYIFARVHD-NFRKIY--KDEDLAPVHeDPEHIPPAfYLPI-IPMVLLNGVSGIATGYAT 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 205 KILPHNFNEIIDAAVAYLRGEEFTL----YPDFYtggfidvSRYNDGERGGvVKIRAKIEKIDNKTLAITEIPYGKTTAT 280
Cdd:PHA02592  172 NILPHSPKSVIKAVLAALNGKDITEpkvqFPEFK-------GEVVEIEPGS-YEIRGTYELNGKTKLHITEIPVKYDRET 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 281 LIESIVKAQEAGKIKirSVDDNTGEHANVIVYLQPGTSSDKTIDALYAFTDCEVSISPNCCVISENK--PHFIGVSDVLR 358
Cdd:PHA02592  244 YVAVLDPLEEKGKIV--SYDDCTEDGFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVINENGklKVYENAEDLIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022 359 HNVDSTRTILGKELQIQLGEVREQLHFASLERIFIEERIyKDKGYEESESRAQAIEHIRG--RLEKFKDKF----IREIT 432
Cdd:PHA02592  322 DFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVI-AGEIVLQGKTRSELTEELSDnkDFGEYADKLvamnIYSMT 400


                  ....*..
gi 1645986022 433 DDDIIRL 439
Cdd:PHA02592  401 SDEREKL 407
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 64-316 1.35e-25

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 114.37  E-value: 1.35e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022   64 ERAVPNIEDGLKPVQRRILHAMKLLDDGRFNKVANIVGHTMQ---FHpHGDASIYEALVQLGQKEL------LVETQGNW 134
Cdd:PTZ00108   679 ERSIPSLVDGLKPGQRKILFACFKRNLKNEIKVAQLSGYVSEhsaYH-HGEQSLQQTIVGMAQNFVgsnninLLYPCGQF 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  135 GNTLTGAS-AAAGRYIEARLSQFALDVVynPKVTDWTLSY---DGRKKEPV-TLPVkFPLLLSKGAEGIAVGLSSKILPH 209
Cdd:PTZ00108   758 GSRLQGGKdHAAARYIFTKLSKITRYIF--PEEDDPILDYledDGQSVEPFyYVPI-IPMVLVNGAEGIGTGFSTSIPNY 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  210 NFNEIIDAAVAYLRGEEFT-LYPdFYTG--GFIdvsryndgERGGVVKIRAK--IEKIDNKTLAITEIPYGKTTAT---L 281
Cdd:PTZ00108   835 NPLDIIDNLRRRLNGEEVRpLVP-WYRGfkGTI--------ERNPKGKFISKgiYEKVPDGTVEITELPIGKWTEDykeF 905

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1645986022  282 IESIVKAQEAGKIKIRsvDDNTGEHANVIVYLQPG 316
Cdd:PTZ00108   906 LESETLKEKDVIVDYR--DYSTANTVHFTVKLNDG 938
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 27-311 3.16e-25

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 112.88  E-value: 3.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022   27 DGFDPRIIVDTSNDTIRHqlrGMFQSWFLDYASYVILERAVPNIEDGLKPVQRRILHAM---KLLDDGrfnKVANIVGHT 103
Cdd:PLN03128   638 NNYEPGTFLDQTGNGISY---SDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACfkrNLKSEI---KVAQLSGYV 711

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  104 MQ---FHpHGDASIYEALVQLGQK-------ELLVETqGNWGNTLTG-ASAAAGRYIEARLSQFALDVVynPKVTDWTLS 172
Cdd:PLN03128   712 AEhsaYH-HGEASLASTIIGMAQDfvgsnniNLLTPS-GQFGTRLQGgKDAASARYIFTRLSPITRALF--PKDDDVLLN 787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  173 Y---DGRKKEP-VTLPVkFPLLLSKGAEGIAVGLSSKILPHNFNEIIDAAVAYLRGEEFTLYPDFYTG--GFIDVSrynD 246
Cdd:PLN03128   788 YlneDGQSIEPeWYCPI-IPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGfkGTITEV---S 863

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1645986022  247 GERGGVVKIRAKIEKIDNKTLAITEIPYGKTTATLIESIVKAQEAGKIKIRSVDDNTGEHANVIV 311
Cdd:PLN03128   864 TSRSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKEFLEALLTGTKKKEPEIKDFKENHTDTTV 928
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 63-273 1.14e-15

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 82.22  E-value: 1.14e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022   63 LERAVPNIEDGLKPVQRRILHAM---KLLDDGrfnKVANIVGHTMQ---FHpHGDASIYEALVQLGQKEL------LVET 130
Cdd:PLN03237   696 LQRSIPSMVDGLKPGQRKILFCSfkrNFVKEA---KVAQLSGYVSEhsaYH-HGEQSLASTIIGMAQDFVgsnninLLLP 771

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  131 QGNWGNTLTGAS-AAAGRYIEARLSQFALDVVynPKVTDWTLSY---DGRKKEPV-TLPVkFPLLLSKGAEGIAVGLSSK 205
Cdd:PLN03237   772 NGQFGTRLQGGKdHASARYIFTRLSPITRFLF--PKDDDILLDYlneDGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTF 848

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1645986022  206 ILPHNFNEIIDAAVAYLRGEEFTLYPDFYTG--GFIDVSRYNDGERGgvVKIRAKIEKIDNKTLAITEIP 273
Cdd:PLN03237   849 IPNYNPRDIVANIRRLLNGESMEPMHPWYRGfkGTIEKTASKEGGCT--YTITGLYEEVDETTLRITELP 916
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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