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Conserved domains on  [gi|16418357|ref|NP_443087|]
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ankyrin repeat domain-containing protein 40 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-93 2.10e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.98  E-value: 2.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418357  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIM 93
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-93 2.10e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.98  E-value: 2.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418357  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIM 93
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
Ank_4 pfam13637
Ankyrin repeats (many copies);
14-64 2.74e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 2.74e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16418357    14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLL 64
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-92 1.22e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 1.22e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16418357   14 LREAAALGDIREVQKLVESGVDVNSQnEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKI 92
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 43-72 7.40e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 7.40e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 16418357     43 NGWTCLHWACKRNHGQVVSYLLKSGADKEI 72
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-93 2.10e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.98  E-value: 2.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418357  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIM 93
Cdd:COG0666 157 LHLAAANGNLEIVKLLLEAGADVNARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-80 1.59e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.29  E-value: 1.59e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16418357   2 NALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMP 80
Cdd:COG0666  79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDK-DGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-80 7.38e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 7.38e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16418357  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMP 80
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189
Ank_4 pfam13637
Ankyrin repeats (many copies);
14-64 2.74e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 2.74e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 16418357    14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLL 64
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDG-NGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
14-65 5.22e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 5.22e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16418357    14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLK 65
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLE 51
Ank_2 pfam12796
Ankyrin repeats (3 copies);
17-72 6.10e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.73  E-value: 6.10e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16418357    17 AAALGDIREVQKLVESgVDVNSQNevNGWTCLHWACKRNHGQVVSYLLKSGADKEI 72
Cdd:pfam12796  37 AAKNGHLEIVKLLLEH-ADVNLKD--NGRTALHYAARSGHLEIVKLLLEKGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
14-92 2.32e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.88  E-value: 2.32e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16418357  14 LREAAALGDIREVQKLVESGVDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKI 92
Cdd:COG0666 190 LHLAAENGHLEIVKLLLEAGADVNAKDN-DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-92 1.22e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 1.22e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16418357   14 LREAAALGDIREVQKLVESGVDVNSQnEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKI 92
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163
PHA03095 PHA03095
ankyrin-like protein; Provisional
 26-93 1.76e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.64  E-value: 1.76e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16418357   26 VQKLVESGVDVNSQNeVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIM 93
Cdd:PHA03095 240 VLPLLIAGISINARN-RYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAV 306
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 43-72 7.40e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 7.40e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 16418357     43 NGWTCLHWACKRNHGQVVSYLLKSGADKEI 72
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 43-74 7.66e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 42.28  E-value: 7.66e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 16418357    43 NGWTCLHWACKR-NHGQVVSYLLKSGADKEILT 74
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 26-92 8.35e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 8.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418357   26 VQKLVESGVDVNSQNEVN---------------GWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIR 90
Cdd:PHA03100 159 LKLLIDKGVDINAKNRVNyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238


                 ..
gi 16418357   91 KI 92
Cdd:PHA03100 239 EI 240
Ank_5 pfam13857
Ankyrin repeats (many copies);
29-83 8.37e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 8.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16418357    29 LVESG-VDVNSQNEvNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQL 83
Cdd:pfam13857   1 LLEHGpIDLNRLDG-EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PHA02741 PHA02741
hypothetical protein; Provisional
 23-95 2.68e-05

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 44.26  E-value: 2.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16418357   23 IREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLL-KSGADKEILTTKGEMPVQLTSRREIRKIMGV 95
Cdd:PHA02741  77 AEIIDHLIELGADINAQEMLEGDTALHLAAHRRDHDLAEWLCcQPGIDLHFCNADNKSPFELAIDNEDVAMMQI 150
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-93 4.88e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.56  E-value: 4.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418357   2 NALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPV 81
Cdd:COG0666  45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124

                        90
                ....*....|..
gi 16418357  82 QLTSRREIRKIM 93
Cdd:COG0666 125 HLAAYNGNLEIV 136
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 43-69 1.09e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.78  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*..
gi 16418357    43 NGWTCLHWACKRNHGQVVSYLLKSGAD 69
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 23-95 1.33e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.79  E-value: 1.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16418357   23 IREVQKLVESGVDVNSQNEVNGWTCLHWACKRNHGQVVSYLLKS-GADKEILTTKGEMPVQLTSRREIRKIMGV 95
Cdd:PHA02736  71 QEKLKLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNI 144
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 26-95 1.36e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 1.36e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16418357   26 VQKLVESGVDVNSQNEVNGwTCLHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIMGV 95
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELK-TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 2-77 8.99e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.20  E-value: 8.99e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16418357    2 NALLEQKEQQERLREAAALGDIREVQKLVESGVDVNSQnEVNGWTCLHWACKRNHGQVVSYLLKSGADKEILTTKG 77
Cdd:PHA02876 137 DKINESIEYMKLIKERIQQDELLIAEMLLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDD 211
Ank_2 pfam12796
Ankyrin repeats (3 copies);
48-93 1.62e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 1.62e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 16418357    48 LHWACKRNHGQVVSYLLKSGADKEILTTKGEMPVQLTSRREIRKIM 93
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV 46
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 26-81 2.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 2.86e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 16418357   26 VQKLVESGVDVNSQNEVNGwTCLHWACKRN-HGQVVSYLLKSGADKEILTTKGEMPV 81
Cdd:PHA02876 425 VKTLIDRGANVNSKNKDLS-TPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL 480
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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