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Conserved domains on  [gi|1635591406|ref|WP_137200672|]
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SH3 domain-containing protein [Bacillus subtilis]

Protein Classification

SH3 domain-containing protein( domain architecture ID 10645187)

Src Homology 3 (SH3) domain-containing protein similar to Streptococcus suis PlySs2 family phage lysin that displays potent lytic activity

CATH:  2.30.30.40
Gene Ontology:  GO:0005515|GO:0070064
PubMed:  28510178|1639195|11256992
SCOP:  4000369

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SH3b smart00287
Bacterial SH3 domain homologues;
42-104 9.51e-15

Bacterial SH3 domain homologues;


:

Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 65.05  E-value: 9.51e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1635591406   42 SDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQIHFK-GKKAYIsTHFLMKT 104
Cdd:smart00287   1 SETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLGVDGQDWAKITYGsGQRGYV-PGYVVNT 63
 
Name Accession Description Interval E-value
SH3b smart00287
Bacterial SH3 domain homologues;
42-104 9.51e-15

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 65.05  E-value: 9.51e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1635591406   42 SDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQIHFK-GKKAYIsTHFLMKT 104
Cdd:smart00287   1 SETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLGVDGQDWAKITYGsGQRGYV-PGYVVNT 63
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 41-164 1.08e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 66.69  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635591406  41 SSDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGfVNADWAQIHF-KGKKAYISTHFLMKTASQAKTTKQTA--FY 117
Cdd:COG3103     3 AETRYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVLG-RSGGWYKVRYsNGKTGWVSSRYLTVTPSARERLPDELnlRA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1635591406 118 TPTPENGKAKQLSSGTDLTILGwgfSENGgfdftWAFVDYGGViGYI 164
Cdd:COG3103    82 GPSTSSEVLGLLPKGETVTVLK---KSGG-----WFKVGYRGT-GWV 119
SH3_3 pfam08239
Bacterial SH3 domain;
52-101 1.03e-11

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 56.87  E-value: 1.03e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1635591406  52 LNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQI-HFKGKKAYISTHFL 101
Cdd:pfam08239   3 LNVRSGPSTSSEVVGTLPKGEKVEVLEEQGGGWYKVrTYDGYEGWVSSSYL 53
wall_bind_EntB NF040676
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 41-115 2.08e-11

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 61.34  E-value: 2.08e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1635591406  41 SSDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQIHFKGKKAYISTHFLMKTA-SQAKT---TKQTA 115
Cdd:NF040676   81 TKDVYHVTANLLNVRTEANTESEILGRLKKDDVIESTHQVKDGWLQFEYKGKTAYANVSFLSSTApTEKKAdekTKQVA 159
 
Name Accession Description Interval E-value
SH3b smart00287
Bacterial SH3 domain homologues;
42-104 9.51e-15

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 65.05  E-value: 9.51e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1635591406   42 SDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQIHFK-GKKAYIsTHFLMKT 104
Cdd:smart00287   1 SETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLGVDGQDWAKITYGsGQRGYV-PGYVVNT 63
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 41-164 1.08e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 66.69  E-value: 1.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635591406  41 SSDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGfVNADWAQIHF-KGKKAYISTHFLMKTASQAKTTKQTA--FY 117
Cdd:COG3103     3 AETRYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVLG-RSGGWYKVRYsNGKTGWVSSRYLTVTPSARERLPDELnlRA 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1635591406 118 TPTPENGKAKQLSSGTDLTILGwgfSENGgfdftWAFVDYGGViGYI 164
Cdd:COG3103    82 GPSTSSEVLGLLPKGETVTVLK---KSGG-----WFKVGYRGT-GWV 119
SH3_3 pfam08239
Bacterial SH3 domain;
52-101 1.03e-11

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 56.87  E-value: 1.03e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1635591406  52 LNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQI-HFKGKKAYISTHFL 101
Cdd:pfam08239   3 LNVRSGPSTSSEVVGTLPKGEKVEVLEEQGGGWYKVrTYDGYEGWVSSSYL 53
wall_bind_EntB NF040676
cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as ...
 41-115 2.08e-11

cell wall-binding protein EntB; This HMM describes the cell wall-binding protein EntB, as found in Bacillus cereus. EntB is related to EntA, EntC, and EndD. All Ent family proteins have a signal peptide, an N-terminal SH3 domain and a C-terminal 3D (Asp-Asp-Asp) domain. EntB and EndC have a central region with a highly variable number of repeats resembling KAXEXX. The gene symbol derives from the notion that at least some members of the family function as enterotoxins, but more recent descriptions focus on roles in stress response and cell wall integrity.


Pssm-ID: 468642 [Multi-domain]  Cd Length: 476  Bit Score: 61.34  E-value: 2.08e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1635591406  41 SSDTYIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDGFVNADWAQIHFKGKKAYISTHFLMKTA-SQAKT---TKQTA 115
Cdd:NF040676   81 TKDVYHVTANLLNVRTEANTESEILGRLKKDDVIESTHQVKDGWLQFEYKGKTAYANVSFLSSTApTEKKAdekTKQVA 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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