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Conserved domains on  [gi|1631936471|ref|YP_009614204|]
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hypothetical protein FDI61_gp086 [Mycobacterium phage Marvin]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
10-79 3.04e-09

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 48.83  E-value: 3.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631936471  10 KGARRMPEKLRREVIKRDrkmGRGCWFlytdiCLG-IDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVR 79
Cdd:COG1403     1 RRPGREWPALRRAVLKRD---NGRCQY-----CGRpFSGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRR 63
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
10-79 3.04e-09

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 48.83  E-value: 3.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631936471  10 KGARRMPEKLRREVIKRDrkmGRGCWFlytdiCLG-IDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVR 79
Cdd:COG1403     1 RRPGREWPALRRAVLKRD---NGRCQY-----CGRpFSGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRR 63
HNHc smart00507
HNH nucleases;
18-77 1.06e-07

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 44.76  E-value: 1.06e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631936471   18 KLRREVIKRDRKmgrgCWFlytdiCLGIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCH 77
Cdd:smart00507   1 KLRRLLLHRDGV----CAY-----CGKPASEGLEVDHIIPLSDGGNDDLDNLVLLCPKCH 51
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 44-83 6.59e-07

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 42.72  E-value: 6.59e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1631936471  44 GIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVRYSAR 83
Cdd:pfam01844   8 FHISDALTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
guided_IscB NF040563
RNA-guided endonuclease IscB;
38-83 1.34e-06

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 44.85  E-value: 1.34e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1631936471  38 YTDICLGIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVRYSAR 83
Cdd:NF040563  194 RTCQYCGAKDVPLEVHHIVPRSKGGSDRVSNLILACEPCNQKKGNQ 239
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 17-77 6.04e-06

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 40.53  E-value: 6.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631936471  17 EKLRREVIKRDRKmgrgCWflytdICL-GIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCH 77
Cdd:cd00085     1 RSHRLVLLARDGL----CP-----YCGkPGGTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCH 53
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
10-79 3.04e-09

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 48.83  E-value: 3.04e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1631936471  10 KGARRMPEKLRREVIKRDrkmGRGCWFlytdiCLG-IDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVR 79
Cdd:COG1403     1 RRPGREWPALRRAVLKRD---NGRCQY-----CGRpFSGDALEVDHIIPRSRGGTDTWENLVLLCRRCNRR 63
HNHc smart00507
HNH nucleases;
18-77 1.06e-07

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 44.76  E-value: 1.06e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1631936471   18 KLRREVIKRDRKmgrgCWFlytdiCLGIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCH 77
Cdd:smart00507   1 KLRRLLLHRDGV----CAY-----CGKPASEGLEVDHIIPLSDGGNDDLDNLVLLCPKCH 51
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 44-83 6.59e-07

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 42.72  E-value: 6.59e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1631936471  44 GIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVRYSAR 83
Cdd:pfam01844   8 FHISDALTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
guided_IscB NF040563
RNA-guided endonuclease IscB;
38-83 1.34e-06

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 44.85  E-value: 1.34e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1631936471  38 YTDICLGIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCHVRYSAR 83
Cdd:NF040563  194 RTCQYCGAKDVPLEVHHIVPRSKGGSDRVSNLILACEPCNQKKGNQ 239
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 17-77 6.04e-06

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 40.53  E-value: 6.04e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1631936471  17 EKLRREVIKRDRKmgrgCWflytdICL-GIDQPRVQVHHIIDAEDDGPDDPDNLVTACTPCH 77
Cdd:cd00085     1 RSHRLVLLARDGL----CP-----YCGkPGGTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCH 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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