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Conserved domains on  [gi|1630892107|gb|TJS30380|]
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cell envelope integrity protein TolA [Escherichia coli]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11484310)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-379 6.23e-101

cell envelope integrity inner membrane protein TolA; Provisional


:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 304.04  E-value: 6.23e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510    1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAADAKAKAEADAKAAEEAAKKAAA 160
Cdd:PRK09510   81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 161 D-------AKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKA 233
Cdd:PRK09510  161 KkaaaeakKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 234 AAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 313
Cdd:PRK09510  241 AAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107 314 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:PRK09510  321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-379 6.23e-101

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 304.04  E-value: 6.23e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510    1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAADAKAKAEADAKAAEEAAKKAAA 160
Cdd:PRK09510   81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 161 D-------AKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKA 233
Cdd:PRK09510  161 KkaaaeakKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 234 AAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 313
Cdd:PRK09510  241 AAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107 314 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:PRK09510  321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-379 5.65e-42

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 150.00  E-value: 5.65e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELKQKQaeeaaDAKAKAEADAKAAEEAAKKAAADAKKKAEAEAA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEEKQKQ-----AEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 172 KAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAE 251
Cdd:TIGR02794 154 EEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 252 ADDIFGeLSSGKNAPKTGGGAKgnnaspagsgntknnGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDG 331
Cdd:TIGR02794 234 LGDIFG-LASGSNAEKQGGARG---------------AAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDG 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1630892107 332 MLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:TIGR02794 298 TLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 285-377 7.68e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 136.79  E-value: 7.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 285 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 363
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 1630892107 364 QAVYEVFKNAPLDF 377
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-133 3.42e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 59-131 1.48e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 1.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107  59 AVVEQYkrMQSQESSAK---RSDEQRKMKEQQAAEELREKQAAEQERlkQLEKERLAAQEQKKQAEEAAKQAELKQ 131
Cdd:cd16269   170 EVLQEF--LQSKEAEAEailQADQALTEKEKEIEAERAKAEAAEQER--KLLEEQQRELEQKLEDQERSYEEHLRQ 241
 
Name Accession Description Interval E-value
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 1-379 6.23e-101

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 304.04  E-value: 6.23e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107   1 MSKATEQNDKLKRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSSIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQ 80
Cdd:PRK09510    1 MSKATEQNDKLKRAIIISVVLHIILFALLIWSSFDENIEASGGGGGGSVIDAVMVDPGAVVEQYNRQQQQQKSAKRAEEQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  81 RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAADAKAKAEADAKAAEEAAKKAAA 160
Cdd:PRK09510   81 RKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 161 D-------AKKKAEAEAAKAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKA 233
Cdd:PRK09510  161 KkaaaeakKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 234 AAAKAAAEKAAAAKAAAEADDIFGELSSGKNAPKTGGGAKGNNASPAGSGNTKNNGASGADINNYAGQIKSAIESKFYDA 313
Cdd:PRK09510  241 AAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAPKTGGGAKGNGAQGAGAGNGKKGGASGADIDQYAGQIKSAIQSKFYDA 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107 314 SSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAAAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:PRK09510  321 SSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALCQAALAAAKTAKIPKPPSQEVYEKFKNAPLDFKP 386
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 12-379 5.65e-42

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 150.00  E-value: 5.65e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  12 KRAIIISAVLHVILFAALIWSSFDENIEASAGGGGGSsIDAVMVDSGAVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEE 91
Cdd:TIGR02794   1 RRAFLLSLLLHILLLGLLILGSLYHSVKPEPGGGAEI-IQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  92 LREKQAAEQERLKQLeKERLAAQEQKKQAEEAAKQAELKQKQaeeaaDAKAKAEADAKAAEEAAKKAAADAKKKAEAEAA 171
Cdd:TIGR02794  80 AEKQRAAEQARQKEL-EQRAAAEKAAKQAEQAAKQAEEKQKQ-----AEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 172 KAAAEAQKKAEAAAAALKKKAEAAEAAAAEARKKAATEAAEKAKAEAEKKAAAEKAAADKKAAAAKAAAEKAAAAKAAAE 251
Cdd:TIGR02794 154 EEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAE 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 252 ADDIFGeLSSGKNAPKTGGGAKgnnaspagsgntknnGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDG 331
Cdd:TIGR02794 234 LGDIFG-LASGSNAEKQGGARG---------------AAAGSEVDKYAAIIQQAIQQNLYDDPSFRGKTCRLRIRLAPDG 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1630892107 332 MLLDIKPEGGDPALCQAALA-AAKLAKIPKPPSQAVYEVFKNAPLDFKP 379
Cdd:TIGR02794 298 TLLSVTKSSGDPALCQAALAaVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 285-377 7.68e-40

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 136.79  E-value: 7.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107 285 TKNNGASGADINNYAGQIKSAIESKFYDASSYAGKTCTLRIKLAPDGMLLDIKPEGGDPALCQAALAA-AKLAKIPKPPS 363
Cdd:pfam06519   1 AAGSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAvAKTAKIPKPPS 80

                          90
                  ....*....|....
gi 1630892107 364 QAVYEVFKNAPLDF 377
Cdd:pfam06519  81 QDVYEKFKNINLDF 94
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 68-133 3.42e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.62  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107  68 QSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAE 362
PTZ00121 PTZ00121
MAEBL; Provisional
 67-132 4.14e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 4.14e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1630892107   67 MQSQESSAKRSDE-QRKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQK 132
Cdd:PTZ00121  1410 LKKAAAAKKKADEaKKKAEEKKKADEAKKKaeEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKK 1478
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 80-133 4.57e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 40.41  E-value: 4.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1630892107  80 QRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:pfam05672  20 RRQAREQREREEQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRRE 73
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 61-133 5.95e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 5.95e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1630892107  61 VEQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE 369
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-133 6.85e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 41.48  E-value: 6.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELR-EKQAAEQERLKQLEKER------LAAQE-----------------QK 117
Cdd:pfam15709 359 EQRRLQQEQLERAEKMREELELEQQRRFEEIRlRKQRLEEERQRQEEEERkqrlqlQAAQErarqqqeefrrklqelqRK 438

                          90
                  ....*....|....*.
gi 1630892107 118 KQAEEAAKQAELKQKQ 133
Cdd:pfam15709 439 KQQEEAERAEAEKQRQ 454
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
62-133 7.57e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 7.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1630892107  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG4717   153 ERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEE 224
PTZ00121 PTZ00121
MAEBL; Provisional
 66-132 1.08e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.08e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107   66 RMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQ---ERLKQLEKERLAAQEQKKQAEEAAKQAELKQK 132
Cdd:PTZ00121  1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkkaDELKKAAAAKKKADEAKKKAEEKKKADEAKKK 1439
PTZ00121 PTZ00121
MAEBL; Provisional
 61-133 1.25e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.25e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1630892107   61 VEQYKRMQSQE----SSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:PTZ00121  1635 VEQLKKKEAEEkkkaEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKE 1711
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 59-131 1.48e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 1.48e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107  59 AVVEQYkrMQSQESSAK---RSDEQRKMKEQQAAEELREKQAAEQERlkQLEKERLAAQEQKKQAEEAAKQAELKQ 131
Cdd:cd16269   170 EVLQEF--LQSKEAEAEailQADQALTEKEKEIEAERAKAEAAEQER--KLLEEQQRELEQKLEDQERSYEEHLRQ 241
PTZ00121 PTZ00121
MAEBL; Provisional
 61-133 1.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 1.91e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107   61 VEQYKRMQSQESSAKRSDE-QRKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:PTZ00121  1430 KKKADEAKKKAEEAKKADEaKKKAEEAKKAEEAKKKaeEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKA 1505
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 76-132 1.94e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 39.86  E-value: 1.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  76 RSDEQ---RKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKqAEEaaKQAELKQK 132
Cdd:pfam07946 266 REEEIekiKKAAEEERAEEAQEKKEEAKKKEREEKLAKLSPEEQRK-YEE--KERKKEQR 322
PTZ00121 PTZ00121
MAEBL; Provisional
 62-132 2.47e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 2.47e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107   62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQA-----AEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQK 132
Cdd:PTZ00121  1683 AEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAeelkkAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKK 1758
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 63-133 2.63e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 39.55  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  63 QYKRMQSQESSAKRSDEQRKMKEQQAAEE---------------LREKQAAEQERLKQLEKERLAAQEQKKQA-EEAAKQ 126
Cdd:pfam15709 436 QRKKQQEEAERAEAEKQRQKELEMQLAEEqkrlmemaeeerleyQRQKQEAEEKARLEAEERRQKEEEAARLAlEEAMKQ 515


                  ....*..
gi 1630892107 127 AELKQKQ 133
Cdd:pfam15709 516 AQEQARQ 522
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-139 2.96e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 2.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1630892107  62 EQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQAEEAAD 139
Cdd:COG1196   417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLL 494
PTZ00121 PTZ00121
MAEBL; Provisional
 71-132 3.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 3.91e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1630892107   71 ESSAKRSDE-QRKMKEQQAAEELREK--QAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQK 132
Cdd:PTZ00121  1401 EEDKKKADElKKAAAAKKKADEAKKKaeEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKK 1465
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 59-133 4.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 4.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1630892107  59 AVVEQYKRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   253 AELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 70-133 4.69e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 4.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1630892107  70 QESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   393 RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEE 456
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 50-129 5.10e-03

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 38.39  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1630892107  50 IDAVMVDSGAVVE---------------QYKRMQSQESSAKRSDEQRKmKEQQAAEELREKQAAEQERLKQLEKERLAAQ 114
Cdd:COG0845    34 VEEVLVDEGDRVKkgqvlarldppdlqaALAQAQAQLAAAQAQLELAK-AELERYKALLKKGAVSQQELDQAKAALDQAQ 112

                          90
                  ....*....|....*
gi 1630892107 115 EQKKQAEEAAKQAEL 129
Cdd:COG0845   113 AALAAAQAALEQARA 127
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 62-127 5.77e-03

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 38.78  E-value: 5.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1630892107  62 EQYKRMQSQESSAKRSDEQRKMKE---QQAAEELREKQAAEQERLKQL-------EKERLAAQEQKKQAEEAAKQA 127
Cdd:pfam15709 433 QELQRKKQQEEAERAEAEKQRQKElemQLAEEQKRLMEMAEEERLEYQrqkqeaeEKARLEAEERRQKEEEAARLA 508
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 62-133 7.10e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 7.10e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1630892107  62 EQYKRMQSQESSAkrsdEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   281 LELEEAQAEEYEL----LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEE 348
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 65-133 7.67e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.38  E-value: 7.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1630892107  65 KRMQSQESSAKRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAELKQKQ 133
Cdd:COG1196   308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 75-133 7.79e-03

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 37.38  E-value: 7.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1630892107  75 KRSDEQRKMKEQQAAEELREKQAAEQERLKQLEKERLAAQEQKKqAEEAAKQAELKQKQ 133
Cdd:pfam13904  61 LAAKQRQRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRK-ARQQTKKREESHKQ 118
Radial_spoke_3 pfam06098
Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) ...
 78-126 9.35e-03

Radial spoke protein 3; This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organizms from protists to humans. They are centred by precisely organized, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation.


Pssm-ID: 461827  Cd Length: 286  Bit Score: 37.62  E-value: 9.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1630892107  78 DEQRKMKEQQAA-EELREKQAAEQERL------KQLEKERLAAQ--EQKKQAEEAAKQ 126
Cdd:pfam06098 153 EELANLREQQRAfEELRNAELAEVQRLeeqerrLREEKERRIAQqrEALKKEKETAEK 210
YidC COG1422
Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope ...
 94-133 9.37e-03

Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441032  Cd Length: 198  Bit Score: 36.80  E-value: 9.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1630892107  94 EKQAAEQERLKQLEKERLAAQE----------QKKQAEEAAKQAELKQKQ 133
Cdd:COG1422    67 EKMGKYQERMKAFQKERREAQErgddealkklQEEQMEMMGDQMGMSKEQ 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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