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Conserved domains on  [gi|1626712289|gb|TII19841|]
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E3 ubiquitin-protein ligase SlrP [Salmonella enterica subsp. arizonae serovar 18:z4,z23:- str. CVM 32450]

Protein Classification

SPI-1 type III secretion system effector E3 ubiquitin transferase SlrP( domain architecture ID 11487756)

SPI-1 type III secretion system effector E3 ubiquitin transferase SlrP is a leucine-rich repeat-containing E3 ubiquitin ligase that interferes with the host's ubiquitination pathway; it can ubiquitinate both ubiquitin and host thioredoxin, which leads to the increase of host cell death

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-766 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 1615.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289   1 MFNITNTQSTVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYSAY 80
Cdd:PRK15370    1 MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  81 ADNIQCGREGTNQYCILNENSQEILSIIFNSDSYTVECGGEAVTYTRETAGEQASSASGhgSKDAVNYDVIWSEWVKSAP 160
Cdd:PRK15370   81 ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASG--SKDAVNYELIWSEWVKEAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 161 TEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPENLHANIKELSVRENNLTRLPET 240
Cdd:PRK15370  159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 241 LPDTIEIMDLDRNNIIELPEHLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTF 320
Cdd:PRK15370  239 LPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 321 LPATLPMNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLEASYN 400
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 401 QLARLPESLPSFLSEGPQPARILIEHNPISERTIQNMQMLMSSEGYRGPRVFFAMGEFSNVRVTRPLHEAVQGWLTCLKE 480
Cdd:PRK15370  399 NLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEE 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 481 EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISCEDRVTLAYHQMQ 560
Cdd:PRK15370  479 EDVNQWRAFETEVNAAAFSMFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQ 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 561 EATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 640
Cdd:PRK15370  559 EATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 641 ITESDLDEAEVRIKVAENSQFNQWFSCWEPWHKVLERIAPDDWQEMMNKRVEYIESNEYQSRVNAKLSALKIAGDSDPer 720
Cdd:PRK15370  639 ITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAECIETDEYQSRVNAELEALGIAGDPDA-- 716

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 1626712289 721 aieiradaERAIGRQVMEEINQSLFTELTEKVLTKQRINSLMTPYW 766
Cdd:PRK15370  717 --------ERMAGMRIMEEINQTLFTEIMENILLKKEVSSLMSAYW 754
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-766 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 1615.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289   1 MFNITNTQSTVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYSAY 80
Cdd:PRK15370    1 MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  81 ADNIQCGREGTNQYCILNENSQEILSIIFNSDSYTVECGGEAVTYTRETAGEQASSASGhgSKDAVNYDVIWSEWVKSAP 160
Cdd:PRK15370   81 ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASG--SKDAVNYELIWSEWVKEAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 161 TEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPENLHANIKELSVRENNLTRLPET 240
Cdd:PRK15370  159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 241 LPDTIEIMDLDRNNIIELPEHLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTF 320
Cdd:PRK15370  239 LPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 321 LPATLPMNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLEASYN 400
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 401 QLARLPESLPSFLSEGPQPARILIEHNPISERTIQNMQMLMSSEGYRGPRVFFAMGEFSNVRVTRPLHEAVQGWLTCLKE 480
Cdd:PRK15370  399 NLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEE 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 481 EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISCEDRVTLAYHQMQ 560
Cdd:PRK15370  479 EDVNQWRAFETEVNAAAFSMFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQ 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 561 EATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 640
Cdd:PRK15370  559 EATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 641 ITESDLDEAEVRIKVAENSQFNQWFSCWEPWHKVLERIAPDDWQEMMNKRVEYIESNEYQSRVNAKLSALKIAGDSDPer 720
Cdd:PRK15370  639 ITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAECIETDEYQSRVNAELEALGIAGDPDA-- 716

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 1626712289 721 aieiradaERAIGRQVMEEINQSLFTELTEKVLTKQRINSLMTPYW 766
Cdd:PRK15370  717 --------ERMAGMRIMEEINQTLFTEIMENILLKKEVSSLMSAYW 754
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 474-682 3.16e-77

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 248.02  E-value: 3.16e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 474 WLTCLKE---EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTR--HPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISC 548
Cdd:pfam14496   1 WLQACAElrpERLAAWRALEAEEGAAAFFRFLARLRETASFRndAEALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 549 EDRVTLAYHQMQEATLVYDAERGAFDSKFT-ELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLT 627
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNRLaALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1626712289 628 TMTQDMRFYNVSGITESDLDEAEVRIKVAE-NSQFNQWFSCWEPWHKVLERIAPDD 682
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-436 5.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.24  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 180 KNETRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPENLH--ANIKELSVRENNLTRLPETLPD--TIEIMDLDRN 253
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 254 NIIELPEHL--PSALQTLIVSCNALTALPDTLPD--GLQTLDVYRNNLTALPE--HLPSsIVELFVFNNSLTFLPATLPM 327
Cdd:COG4886   193 QITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 328 -NLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLEASYNQLARLP 406
Cdd:COG4886   272 tNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260       270
                  ....*....|....*....|....*....|
gi 1626712289 407 ESLPSFLSEGPQPARILIEHNPISERTIQN 436
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 296-405 5.08e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 5.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 296 NLTALPE-HLPSSIVELFVFNNSLTFLPA--TLPmNLEILVADDNALTCLP--ESLPpALKNLSVKNNRITVLpETL--P 368
Cdd:cd21340    13 NITKIDNlSLCKNLKVLYLYDNKITKIENleFLT-NLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISVV-EGLenL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1626712289 369 PTLQELYINHNlliNLPENLP------------AALQYLEASYNQLARL 405
Cdd:cd21340    90 TNLEELHIENQ---RLPPGEKltfdprslaalsNSLRVLNISGNNIDSL 135
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1-766 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 1615.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289   1 MFNITNTQSTVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYSAY 80
Cdd:PRK15370    1 MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  81 ADNIQCGREGTNQYCILNENSQEILSIIFNSDSYTVECGGEAVTYTRETAGEQASSASGhgSKDAVNYDVIWSEWVKSAP 160
Cdd:PRK15370   81 ADNIQYSRGGADQYCILSENSQEILSIVFNTEGYTVEGGGKSVTYTRVTESEQASSASG--SKDAVNYELIWSEWVKEAP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 161 TEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPENLHANIKELSVRENNLTRLPET 240
Cdd:PRK15370  159 AKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 241 LPDTIEIMDLDRNNIIELPEHLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTF 320
Cdd:PRK15370  239 LPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 321 LPATLPMNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLEASYN 400
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRN 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 401 QLARLPESLPSFLSEGPQPARILIEHNPISERTIQNMQMLMSSEGYRGPRVFFAMGEFSNVRVTRPLHEAVQGWLTCLKE 480
Cdd:PRK15370  399 NLVRLPESLPHFRGEGPQPTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTNLEE 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 481 EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISCEDRVTLAYHQMQ 560
Cdd:PRK15370  479 EDVNQWRAFETEVNAAAFSMFLDRLSDTQNTRHPDFKEQVSAWLMRLAEDSALRETAFIIAMDATISCEDRVTLAYHQMQ 558

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 561 EATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 640
Cdd:PRK15370  559 EATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSG 638

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 641 ITESDLDEAEVRIKVAENSQFNQWFSCWEPWHKVLERIAPDDWQEMMNKRVEYIESNEYQSRVNAKLSALKIAGDSDPer 720
Cdd:PRK15370  639 ITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAECIETDEYQSRVNAELEALGIAGDPDA-- 716

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 1626712289 721 aieiradaERAIGRQVMEEINQSLFTELTEKVLTKQRINSLMTPYW 766
Cdd:PRK15370  717 --------ERMAGMRIMEEINQTLFTEIMENILLKKEVSSLMSAYW 754
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
9-766 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 540.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289   9 STVRNQSISHGASKEAPPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYSAYADNIQCGR 88
Cdd:PRK15387   12 ATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAYAGWEESIHSGQ 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  89 EGTNQYCILNENSQEILSIIFN-SDSYTVECGGEAVTYTRETAGEQASSASGHGS-----------------KDAVNYDV 150
Cdd:PRK15387   92 HGENYFCILDEDSQEILSVTLDdAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEgasgtfrtsflpattapQTPAEYDA 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 151 IWSEWVKSAPTEEAPNREKAVQRMRDCLKKNETRLCLDRLKLTTIPHSIPEQIITLILDKNNLLSLPEnLHANIKELSVR 230
Cdd:PRK15387  172 VWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA-LPPELRTLEVS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 231 ENNLTRLPETLPDTIEiMDLDRNNIIELPEhLPSALQTLIVSCNALTALPdTLPDGLQTLDVYRNNLTALPEhLPSSIVE 310
Cdd:PRK15387  251 GNQLTSLPVLPPGLLE-LSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPA-LPSELCK 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 311 LFVFNNSLTFLPaTLPMNLEILVADDNALTCLPE-------------------SLPPALKNLSVKNNRITVLPeTLPPTL 371
Cdd:PRK15387  327 LWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTlpselyklwaynnrltslpALPSGLKELIVSGNRLTSLP-VLPSEL 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 372 QELYINHNLLINLPEnLPAALQYLEASYNQLARLPESLPSFLSEgpqpARILIEHNPISERTIQNMQMLMSSEGYRGPRV 451
Cdd:PRK15387  405 KELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIHLSSE----TTVNLEGNPLSERTLQALREITSAPGYSGPII 479

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 452 FFAMGEFSNVRVTRPLHEAVQGWLTCLKEED---VNQWRAFETEVNAAAFSIFLDRLSDTQN-TRHPDFKEQVSAWLMRL 527
Cdd:PRK15387  480 RFDMAGASAPRETRALHLAAADWLVPAREGEpapADRWHMFGQEDNADAFSLFLDRLSETENfIKDAGFKAQISSWLAQL 559

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 528 AEDSTLRERAFTIAMDATISCEDRVTLAYHQMQEATLVYDAERGAFDSKFTELIMAGREIFRLEKIESLAREKVKRLFFI 607
Cdd:PRK15387  560 AEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALV 639

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 608 DEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAEVRIKVAENSQFNQWFSCWEPWHKVLERIAPDDWQEMM 687
Cdd:PRK15387  640 DEIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALR 719

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1626712289 688 NKRVEYIESNeYQSRVNAKLSALKIAGDSdperaieiraDAERAIGRQVMEEINQSLFTELteKVLTKQRINSLMTPYW 766
Cdd:PRK15387  720 EKQISDYEET-YRMLSDTELRPSGLVGNT----------DAERTIGARAMESAKKTFLDGL--RPLVEEMLGSYLNVQW 785
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 474-682 3.16e-77

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 248.02  E-value: 3.16e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 474 WLTCLKE---EDVNQWRAFETEVNAAAFSIFLDRLSDTQNTR--HPDFKEQVSAWLMRLAEDSTLRERAFTIAMDATISC 548
Cdd:pfam14496   1 WLQACAElrpERLAAWRALEAEEGAAAFFRFLARLRETASFRndAEALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 549 EDRVTLAYHQMQEATLVYDAERGAFDSKFT-ELIMAGREIFRLEKIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLT 627
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNRLaALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1626712289 628 TMTQDMRFYNVSGITESDLDEAEVRIKVAE-NSQFNQWFSCWEPWHKVLERIAPDD 682
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-436 5.66e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.24  E-value: 5.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 180 KNETRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPENLH--ANIKELSVRENNLTRLPETLPD--TIEIMDLDRN 253
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 254 NIIELPEHL--PSALQTLIVSCNALTALPDTLPD--GLQTLDVYRNNLTALPE--HLPSsIVELFVFNNSLTFLPATLPM 327
Cdd:COG4886   193 QITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDLPPLANL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 328 -NLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLEASYNQLARLP 406
Cdd:COG4886   272 tNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                         250       260       270
                  ....*....|....*....|....*....|
gi 1626712289 407 ESLPSFLSEGPQPARILIEHNPISERTIQN 436
Cdd:COG4886   352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
PRK15372 PRK15372
type III secretion system effector SseI;
31-132 1.67e-21

type III secretion system effector SseI;


Pssm-ID: 185270  Cd Length: 292  Bit Score: 95.57  E-value: 1.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  31 WNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYSAYADNIQCGREGTNQYCILNENSQEILSIIFN 110
Cdd:PRK15372    4 WEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAYDGWEENIHSGLHGENYFCILDEDSQEILSVTLD 83

                          90       100
                  ....*....|....*....|...
gi 1626712289 111 S-DSYTVECGGEAVTYTRETAGE 132
Cdd:PRK15372   84 DvGNYTVNCQGYSETHHLTMATE 106
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
186-412 5.14e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 5.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 186 CLDRLKLTTIPHSIPEQIITLILDKNNLLSLPENLHANIKELSVRENNLTRLPETLPDTIEIMDLDRNNIIELPEHLPSA 265
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 266 LQTLIVSCNALTALPDtlpdGLQTLDVYRNNLTALPEHLpssiVELFVFNNSLTFLPATLPM--NLEILVADDNALTCLP 343
Cdd:COG4886    81 LLSLLLLGLTDLGDLT----NLTELDLSGNEELSNLTNL----ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1626712289 344 ESLP--PALKNLSVKNNRITVLPETLP--PTLQELYINHNLLINLPENL--PAALQYLEASYNQLARLPESLPSF 412
Cdd:COG4886   153 EPLGnlTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANL 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-396 3.85e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 3.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 180 KNETRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPENLHA--NIKELSVRENNLTRLPETLPD--TIEIMDLDRN 253
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNltNLEELDLSGNQLTDLPEPLANltNLETLDLSNN 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 254 NIIELPE--HLPSaLQTLIVSCNALTALPDTLP-DGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTFLPATLPMNLE 330
Cdd:COG4886   239 QLTDLPElgNLTN-LEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1626712289 331 ILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLE 396
Cdd:COG4886   318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
180-406 1.39e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 180 KNETRLCLDRLKLTTIPHSI--PEQIITLILDKNNLLSLPENLHA--NIKELSVRENNLTRLPE--TLPDtIEIMDLDRN 253
Cdd:COG4886   182 TNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLTN-LEELDLSNN 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 254 NIIELPEHLP-SALQTLIVSCNALTALpdtlpdGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTFLPATLPMNLEIL 332
Cdd:COG4886   261 QLTDLPPLANlTNLKTLDLSNNQLTDL------KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1626712289 333 VADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINLPENLPAALQYLEASYNQLARLP 406
Cdd:COG4886   335 VTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
PRK15386 PRK15386
type III secretion effector GogB;
247-392 3.35e-09

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 59.88  E-value: 3.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 247 IMDLDRNNIIELPeHLPSALQTL-IVSCNALTALPDTLPDGLQTLDV-YRNNLTALPEHLpSSIVELFVFNNSLTFLPAT 324
Cdd:PRK15386   56 RLYIKDCDIESLP-VLPNELTEItIENCNNLTTLPGSIPEGLEKLTVcHCPEISGLPESV-RSLEIKGSATDSIKNVPNG 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1626712289 325 LPmNLEILVADDNALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQ--ELYINHNLLINLP-ENLPAAL 392
Cdd:PRK15386  134 LT-SLSINSYNPENQARIDNLISPSLKTLSLTGCSNIILPEKLPESLQsiTLHIEQKTTWNISfEGFPDGL 203
PRK15381 PRK15381
type III secretion system effector;
5-128 1.17e-06

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 51.59  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289   5 TNTQSTVRNQSISHGASKeapPEEDIWNKTSVFFSSEHQVEAKNCISYLCHPPE-TVSPEEIKSKFEWLKGLAYSAYADN 83
Cdd:PRK15381   11 TSSISSEKFNAIKESARL---PELSLWEKIKAYFFTTHHAEALECIFNLYHHQElNLTPVQVRGAYIKLRALASQGCKEQ 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1626712289  84 -IQCGREGTNQYCILNENSQEILSIifnsdsyTVECGGEAVTYTRE 128
Cdd:PRK15381   88 fIIESQEHADKLIIKDDNGENILSI-------EVECHPEAFGLAKE 126
LRR_8 pfam13855
Leucine rich repeat;
348-402 1.06e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1626712289 348 PALKNLSVKNNRITVLPETL---PPTLQELYINHNLLINLPEN----LPAaLQYLEASYNQL 402
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGafsgLPS-LRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
183-384 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 183 TRLCLDRLKLTTIPHSIPE--QIITLILDKNNLLSLPE--NLHaNIKELSVRENNLTRLPETLP-DTIEIMDLDRNNIIE 257
Cdd:COG4886   208 EELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTD 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 258 LPEHLPSALQTLIVSCNALTALPDTLPDGLQTLDVYRNNLTALPEHLPSSIVELFVFNNSLTFLPATLPMNLEILVADDN 337
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1626712289 338 ALTCLPESLPPALKNLSVKNNRITVLPETLPPTLQELYINHNLLINL 384
Cdd:COG4886   367 LTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 199-411 1.59e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 45.25  E-value: 1.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  199 IPEQIITLILDKNNLLSLPENLHA-NIKELSVRENNLTRLPETLPDT--IEIMDLDRN-NIIELPE-HLPSALQTLIVS- 272
Cdd:PLN03210   587 LPPKLRLLRWDKYPLRCMPSNFRPeNLVKLQMQGSKLEKLWDGVHSLtgLRNIDLRGSkNLKEIPDlSMATNLETLKLSd 666

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  273 CNALTALP--------------------DTLPDGLQTLDVYRNNLT------ALPEhLPSSIVELFVFNNSLTFLPATLP 326
Cdd:PLN03210   667 CSSLVELPssiqylnkledldmsrcenlEILPTGINLKSLYRLNLSgcsrlkSFPD-ISTNISWLDLDETAIEEFPSNLR 745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  327 M-NLEILVADDNALTCLPESLPPalknlsvknnrITVLPETLPPTLQELYinhnlLINLPE--NLPAALQYLeasyNQLA 403
Cdd:PLN03210   746 LeNLDELILCEMKSEKLWERVQP-----------LTPLMTMLSPSLTRLF-----LSDIPSlvELPSSIQNL----HKLE 805

                          250
                   ....*....|....*
gi 1626712289  404 RLP-------ESLPS 411
Cdd:PLN03210   806 HLEiencinlETLPT 820
TTSSLRR pfam12468
Type III secretion system leucine rich repeat protein; This domain family is found in bacteria, ...
 107-172 3.08e-04

Type III secretion system leucine rich repeat protein; This domain family is found in bacteria, and is approximately 50 amino acids in length. There are two completely conserved residues (Y and W) that may be functionally important. This family consists of leucine-rich repeat proteins involved in type III secretion.


Pssm-ID: 432576 [Multi-domain]  Cd Length: 54  Bit Score: 39.07  E-value: 3.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1626712289 107 IIFNSDSYTVECGGEAVTYTRETAGEqassasghgsKDAVNYDVIWSEWVKSAPTEEapNREKAVQ 172
Cdd:pfam12468   1 INNNFSGSSVSFSNISSDRSVESERE----------KTPADYLRIWDEWEKNAPPGE--QRGEAVR 54
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 296-405 5.08e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 5.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 296 NLTALPE-HLPSSIVELFVFNNSLTFLPA--TLPmNLEILVADDNALTCLP--ESLPpALKNLSVKNNRITVLpETL--P 368
Cdd:cd21340    13 NITKIDNlSLCKNLKVLYLYDNKITKIENleFLT-NLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISVV-EGLenL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1626712289 369 PTLQELYINHNlliNLPENLP------------AALQYLEASYNQLARL 405
Cdd:cd21340    90 TNLEELHIENQ---RLPPGEKltfdprslaalsNSLRVLNISGNNIDSL 135
sifA PRK09498
type III secretion system effector SifA;
30-128 1.09e-03

type III secretion system effector SifA;


Pssm-ID: 181911  Cd Length: 336  Bit Score: 41.93  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289  30 IWNKTSVFFSSEHQVEAKNCISYLCHPPETVSPEEIKSKFEWLKGLAYSAYADNIQCGREGTNQ----YCILNENSQ-EI 104
Cdd:PRK09498   30 LWEKIKDFFFSTGKAKADRCLHEMLFADRAPTRERLTEIFFELKELACASQRDRFQVHNPHENDatiiLRIMDQNEEnEL 109

                          90       100
                  ....*....|....*....|....
gi 1626712289 105 LSIIFNSDSYTVECGGEAVTYTRE 128
Cdd:PRK09498  110 LRITQNTDTFSCEVMGNLYFLMKD 133
LRR_8 pfam13855
Leucine rich repeat;
266-318 2.74e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.74e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1626712289 266 LQTLIVSCNALTALPDTLPDG---LQTLDVYRNNLTALPE----HLPsSIVELFVFNNSL 318
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGlsnLKVLDLSNNLLTTLSPgafsGLP-SLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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