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Conserved domains on  [gi|1625498531|gb|TIB55079|]
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hypothetical protein E3P79_04008 [Wallemia ichthyophaga]

Protein Classification

bromodomain-containing protein( domain architecture ID 10914864)

bromodomain-containing protein, similar to Oryza sativa transcription factor GTE4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromodomain super family cl02556
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 542-643 1.08e-46

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


The actual alignment was detected with superfamily member cd05498:

Pssm-ID: 445827  Cd Length: 102  Bit Score: 161.68  E-value: 1.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 542 QMRHCAFILKELHKKVHSSYAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKY 621
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 1625498531 622 NPPGTPVHEAGKQTEKVFDDKW 643
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
Bromodomain super family cl02556
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 373-477 9.34e-29

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


The actual alignment was detected with superfamily member cd05500:

Pssm-ID: 445827  Cd Length: 103  Bit Score: 110.87  E-value: 9.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 373 QLKYVSTLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRRVQktikaeEGGYHNFNDWEADVRRIFRNT 452
Cdd:cd05500     5 QHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLK------SNVYTSVEEFTADFNLMVDNC 78

                          90       100
                  ....*....|....*....|....*
gi 1625498531 453 EWFNGVEHPVSKMGKQVEESFDKQL 477
Cdd:cd05500    79 LTFNGPEHPVSQMGKRLQAAFEKHL 103
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 734-796 9.83e-20

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


:

Pssm-ID: 435704  Cd Length: 64  Bit Score: 83.70  E-value: 9.83e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 734 EITFDMKKELAGKIQQLEGDQLDKAIKIIYET-LDLDNNSDEIELDIDVLPTKTLQKLYMFVVK 796
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERnPELQSDDDEIELDIDALDDDTLRKLYNFVKK 64
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 95-297 6.35e-14

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 76.52  E-value: 6.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   95 PTPiPQDPPTPQPAAMATPTDIPADT-----PQHFQPSQVPQTVKADSPAL-----PAPVTQSETSAAPVEPS-TEAPSA 163
Cdd:PHA03247  2769 PAP-PAAPAAGPPRRLTRPAVASLSEsreslPSPWDPADPPAAVLAPAAALppaasPAGPLPPPTSAQPTAPPpPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  164 ESLDVKPAIAAEG-------QPQPLNQPLAPPQPEVQQSSEPQPnlthsslPPSTDAVAQPPLEQTHQPVAASSTEPQPQ 236
Cdd:PHA03247  2848 PSLPLGGSVAPGGdvrrrppSRSPAAKPAAPARPPVRRLARPAV-------SRSTESFALPPDQPERPPQPQAPPPPQPQ 2920

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531  237 -----------AMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQP 297
Cdd:PHA03247  2921 pqpppppqpqpPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
 
Name Accession Description Interval E-value
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 542-643 1.08e-46

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 161.68  E-value: 1.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 542 QMRHCAFILKELHKKVHSSYAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKY 621
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 1625498531 622 NPPGTPVHEAGKQTEKVFDDKW 643
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
BROMO smart00297
bromo domain;
541-646 2.66e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 112.37  E-value: 2.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  541 DQMRHCAFILKELHKKVHSS-YAAPFYDPVDYLALglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCY 619
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDSHpLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 1625498531  620 KYNPPGTPVHEAGKQTEKVFDDKWTQL 646
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 373-477 9.34e-29

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 110.87  E-value: 9.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 373 QLKYVSTLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRRVQktikaeEGGYHNFNDWEADVRRIFRNT 452
Cdd:cd05500     5 QHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLK------SNVYTSVEEFTADFNLMVDNC 78

                          90       100
                  ....*....|....*....|....*
gi 1625498531 453 EWFNGVEHPVSKMGKQVEESFDKQL 477
Cdd:cd05500    79 LTFNGPEHPVSQMGKRLQAAFEKHL 103
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 734-796 9.83e-20

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 83.70  E-value: 9.83e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 734 EITFDMKKELAGKIQQLEGDQLDKAIKIIYET-LDLDNNSDEIELDIDVLPTKTLQKLYMFVVK 796
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERnPELQSDDDEIELDIDALDDDTLRKLYNFVKK 64
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 549-634 3.14e-18

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 80.05  E-value: 3.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 549 ILKELHKKVHSSYAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPV 628
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVD--PDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVI 78


                  ....*.
gi 1625498531 629 HEAGKQ 634
Cdd:pfam00439  79 YKAAEK 84
BROMO smart00297
bromo domain;
379-480 1.09e-15

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 73.47  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  379 TLMKQLKKMKAAVPFLTPVDYMSlgVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFRNTEWFNGV 458
Cdd:smart00297  14 AVLDKLDSHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKL------ENGKYSSVEEFVADFNLMFSNARTYNGP 85

                           90       100
                   ....*....|....*....|..
gi 1625498531  459 EHPVSKMGKQVEESFDKQLKKM 480
Cdd:smart00297  86 DSEVYKDAKKLEKFFEKKLREL 107
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 428-675 2.28e-14

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 75.61  E-value: 2.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 428 IKAEEGGYHNFNDWEADVRRIFRNT---EWFNGVEHPVSKMGKQVEESFDKQLKKMPPSTNDAVPST------------- 491
Cdd:COG5076     1 LEFDEVSYSQLGRPSVLKEEFGNELlrlVDNDSSPFPNAPEEEGSKNLFQKQLKRMPKEYITSIVDDrepgsmanvnddl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 492 SRGRGAPRRSQETGRPRRdTQQPVTAQQANDANRGRR---------RKTTAY--GRNGTADQM--RHCAFILKELHKKV- 557
Cdd:COG5076    81 ENVGGITYSPFEKNRPES-LRFDEIVFLAIESVTPESglgsllmahLKTSVKkrKTPKIEDELlyADNKAIAKFKKQLFl 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 558 --HSSYAAPF-YDPVDYLAlglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQ 634
Cdd:COG5076   160 rdGRFLSSIFlGLPSKREY---PDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKE 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1625498531 635 TEKVFdDKWTQLPPLSTPLEISDDENSDTVKALQRQIEDMQ 675
Cdd:COG5076   237 LEKYF-LKLIEEIPEEMLELSIKPGREEREERESVLITNSQ 276
PHA03247 PHA03247
large tegument protein UL36; Provisional
 95-297 6.35e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 76.52  E-value: 6.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   95 PTPiPQDPPTPQPAAMATPTDIPADT-----PQHFQPSQVPQTVKADSPAL-----PAPVTQSETSAAPVEPS-TEAPSA 163
Cdd:PHA03247  2769 PAP-PAAPAAGPPRRLTRPAVASLSEsreslPSPWDPADPPAAVLAPAAALppaasPAGPLPPPTSAQPTAPPpPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  164 ESLDVKPAIAAEG-------QPQPLNQPLAPPQPEVQQSSEPQPnlthsslPPSTDAVAQPPLEQTHQPVAASSTEPQPQ 236
Cdd:PHA03247  2848 PSLPLGGSVAPGGdvrrrppSRSPAAKPAAPARPPVRRLARPAV-------SRSTESFALPPDQPERPPQPQAPPPPQPQ 2920

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531  237 -----------AMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQP 297
Cdd:PHA03247  2921 pqpppppqpqpPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 378-468 9.31e-12

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 61.56  E-value: 9.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 378 STLMKQLKKMKAAVPFLTPVDYMSLgvPHYPEVISEPSDLGSVDRrvqktiKAEEGGYHNFNDWEADVRRIFRNTEWFNG 457
Cdd:pfam00439   2 LEILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKK------KLENGEYKSLAEFLADVKLIFSNARTYNG 73

                          90
                  ....*....|.
gi 1625498531 458 VEHPVSKMGKQ 468
Cdd:pfam00439  74 PGSVIYKAAEK 84
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 91-258 2.31e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.77  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  91 QSTQPTPIPQDPPTPQPAAMATPTDIPADT-------------PQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPS 157
Cdd:pfam03154 175 QAQSGAASPPSPPPPGTTQAATAGPTPSAPsvppqgspatsqpPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQ 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 158 TEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPnlthSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPqa 237
Cdd:pfam03154 255 PPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQP----FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP-- 328

                         170       180
                  ....*....|....*....|.
gi 1625498531 238 mevTAQSQAQPADAQGEEVAP 258
Cdd:pfam03154 329 ---PSQSQLQSQQPPREQPLP 346
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 92-279 5.07e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 43.35  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  92 STQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQP--SQVPQTVKADSPALPAPvtqSETSAAPVEPSTEAPSA------ 163
Cdd:TIGR00601  84 VAPPAATPTSAPTPTPSPPASPASGMSAAPASAVEekSPSEESATATAPESPST---SVPSSGSDAASTLVVGSeretti 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 164 --------ESLDVKPAI-AAEGQPQP------LNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPV-- 226
Cdd:TIGR00601 161 eeimemgyEREEVERALrAAFNNPDRaveyllTGIPEDPEQPEPVQQTAASTAAATTETPQHGSVFEQAAQGGTEQPAte 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1625498531 227 AASSTEP------QPQAMEVTAQSQAQPADAQgeevAPYQQAGKSNPQEHHAVKAEPEQ 279
Cdd:TIGR00601 241 AAQGGNPleflrnQPQFQQLRQVVQQNPQLLP----PLLQQIGQENPQLLQQISQHPEQ 295
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 125-345 8.38e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 125 QPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLnqPLAPPQPEVQQSSE------- 197
Cdd:NF033839  256 EIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKP--EPETPKPEVKPQLEkpkpevk 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 198 PQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEP 277
Cdd:NF033839  334 PQPEKPKPEVKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQP 413

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1625498531 278 EQTDEGVNGESVKVETPQQPY-EAYQVEHQPQP-FDAPGVVAHDAHDYPDGEDTSSAP-PIVPPTPAGTEP 345
Cdd:NF033839  414 EKPKPEVKPQPEKPKPEVKPQpEKPKPEVKPQPeKPKPEVKPQPETPKPEVKPQPEKPkPEVKPQPEKPKP 484
 
Name Accession Description Interval E-value
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 542-643 1.08e-46

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 161.68  E-value: 1.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 542 QMRHCAFILKELHKKVHSSYAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKY 621
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|..
gi 1625498531 622 NPPGTPVHEAGKQTEKVFDDKW 643
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDRW 102
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 543-643 3.42e-36

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 132.02  E-value: 3.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 543 MRHCAFILKELHKKVHSSYAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYN 622
Cdd:cd05499     2 LKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                          90       100
                  ....*....|....*....|.
gi 1625498531 623 PPGTPVHEAGKQTEKVFDDKW 643
Cdd:cd05499    82 PEGTDVYMMGHQLEEVFNDKW 102
BROMO smart00297
bromo domain;
541-646 2.66e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 112.37  E-value: 2.66e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  541 DQMRHCAFILKELHKKVHSS-YAAPFYDPVDYLALglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCY 619
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDSHpLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 1625498531  620 KYNPPGTPVHEAGKQTEKVFDDKWTQL 646
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 373-477 9.34e-29

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 110.87  E-value: 9.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 373 QLKYVSTLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRRVQktikaeEGGYHNFNDWEADVRRIFRNT 452
Cdd:cd05500     5 QHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLK------SNVYTSVEEFTADFNLMVDNC 78

                          90       100
                  ....*....|....*....|....*
gi 1625498531 453 EWFNGVEHPVSKMGKQVEESFDKQL 477
Cdd:cd05500    79 LTFNGPEHPVSQMGKRLQAAFEKHL 103
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 543-643 1.55e-28

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 109.77  E-value: 1.55e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 543 MRHCAFILKELHKKVHSsYAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYN 622
Cdd:cd04369     2 KKKLRSLLDALKKLKRD-LSEPFLEPVD--PKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYN 78

                          90       100
                  ....*....|....*....|.
gi 1625498531 623 PPGTPVHEAGKQTEKVFDDKW 643
Cdd:cd04369    79 GPGSPIYKDAKKLEKLFEKLL 99
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 539-640 2.11e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 103.93  E-value: 2.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 539 TADQMRHCAFILKELhKKVHSsyAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNC 618
Cdd:cd05500     2 TKHQHKFLLSSIRSL-KRLKD--ARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNC 78

                          90       100
                  ....*....|....*....|..
gi 1625498531 619 YKYNPPGTPVHEAGKQTEKVFD 640
Cdd:cd05500    79 LTFNGPEHPVSQMGKRLQAAFE 100
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 543-643 8.27e-26

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 102.02  E-value: 8.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 543 MRHCAFILKEL--HKkvhssYAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYK 620
Cdd:cd05506     2 MKQCGTLLRKLmkHK-----WGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMR 76

                          90       100
                  ....*....|....*....|...
gi 1625498531 621 YNPPGTPVHEAGKQTEKVFDDKW 643
Cdd:cd05506    77 YNPPGNDVHTMAKELLKIFETRW 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 540-642 2.05e-24

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 98.40  E-value: 2.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 540 ADQMRHcafILKELhkKVHSSyAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCY 619
Cdd:cd05509     3 YTQLKK---VLDSL--KNHKS-AWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCR 74

                          90       100
                  ....*....|....*....|...
gi 1625498531 620 KYNPPGTPVHEAGKQTEKVFDDK 642
Cdd:cd05509    75 LYNGPDTEYYKCANKLEKFFWKK 97
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 373-475 2.13e-20

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 86.95  E-value: 2.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 373 QLKYVSTLMKQL--KKMKA-AVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRrvqktiKAEEGGYHNFNDWEADVRRIF 449
Cdd:cd05498     1 QLKFCSGILKELfsKKHKAyAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKK------KLDNREYADAQEFAADVRLMF 74

                          90       100
                  ....*....|....*....|....*.
gi 1625498531 450 RNTEWFNGVEHPVSKMGKQVEESFDK 475
Cdd:cd05498    75 SNCYKYNPPDHPVHAMARKLQDVFED 100
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 549-646 4.34e-20

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 86.32  E-value: 4.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 549 ILKELHKKVHssyAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPV 628
Cdd:cd05497    13 VLKALWKHKF---AWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDV 89

                          90
                  ....*....|....*...
gi 1625498531 629 HEAGKQTEKVFDDKWTQL 646
Cdd:cd05497    90 VLMAQTLEKLFLQKLAQM 107
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 734-796 9.83e-20

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 83.70  E-value: 9.83e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 734 EITFDMKKELAGKIQQLEGDQLDKAIKIIYET-LDLDNNSDEIELDIDVLPTKTLQKLYMFVVK 796
Cdd:pfam17035   1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERnPELQSDDDEIELDIDALDDDTLRKLYNFVKK 64
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 379-475 1.91e-18

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 81.22  E-value: 1.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 379 TLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFRNTEWFNGV 458
Cdd:cd05506     7 TLLRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKL------EKGEYSSPEEFAADVRLTFANAMRYNPP 80

                          90
                  ....*....|....*..
gi 1625498531 459 EHPVSKMGKQVEESFDK 475
Cdd:cd05506    81 GNDVHTMAKELLKIFET 97
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 524-646 2.18e-18

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 81.67  E-value: 2.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 524 NRGRRRKTTAYGRNGTADQMrhcafiLKELHKkvHSSyAAPFYDPVdyLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEG 603
Cdd:cd05504     1 RRRSEGRHHGPLNLSALEQL------LVEIVK--HKD-SWPFLRPV--SKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKL 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1625498531 604 PNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVFDDKWTQL 646
Cdd:cd05504    70 AEEFLSDIQLVFSNCFLYNPEHTSVYKAGTRLQRFFIKRCRKL 112
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 549-634 3.14e-18

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 80.05  E-value: 3.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 549 ILKELHKKVHSSYAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPV 628
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVD--PDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVI 78


                  ....*.
gi 1625498531 629 HEAGKQ 634
Cdd:pfam00439  79 YKAAEK 84
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 371-480 5.26e-18

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 79.91  E-value: 5.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 371 FNQLKyvsTLMKQLKKMKAAVPFLTPVDymSLGVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFR 450
Cdd:cd05509     3 YTQLK---KVLDSLKNHKSAWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKL------ENGYYVTLEEFVADLKLIFD 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 1625498531 451 NTEWFNGVEHPVSKMGKQVEESFDKQLKKM 480
Cdd:cd05509    72 NCRLYNGPDTEYYKCANKLEKFFWKKLKEL 101
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 550-639 1.91e-17

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 78.64  E-value: 1.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 550 LKELHKKVHSS--YAAPFYDPVDYLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTP 627
Cdd:cd05495     8 LMPTLEKLYKQdpESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSR 87

                          90
                  ....*....|..
gi 1625498531 628 VHEAGKQTEKVF 639
Cdd:cd05495    88 VYKYCTKLAEVF 99
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 375-477 3.60e-17

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 77.41  E-value: 3.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 375 KYVSTLMKQLKK--MKAAVPFLTPVDYmsLGVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFRNT 452
Cdd:cd04369     3 KKLRSLLDALKKlkRDLSEPFLEPVDP--KEAPDYYEVIKNPMDLSTIKKKL------KNGEYKSLEEFEADVRLIFSNA 74

                          90       100
                  ....*....|....*....|....*
gi 1625498531 453 EWFNGVEHPVSKMGKQVEESFDKQL 477
Cdd:cd04369    75 KTYNGPGSPIYKDAKKLEKLFEKLL 99
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 374-475 4.00e-17

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 77.33  E-value: 4.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 374 LKYVSTLMKQLKKMKA---AVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRrvqktiKAEEGGYHNFNDWEADVRRIFR 450
Cdd:cd05499     2 LKFCEEVLKELMKPKHsayNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISK------KLQNGQYQSAKEFERDVRLIFK 75

                          90       100
                  ....*....|....*....|....*
gi 1625498531 451 NTEWFNGVEHPVSKMGKQVEESFDK 475
Cdd:cd05499    76 NCYTFNPEGTDVYMMGHQLEEVFND 100
BROMO smart00297
bromo domain;
379-480 1.09e-15

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 73.47  E-value: 1.09e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  379 TLMKQLKKMKAAVPFLTPVDYMSlgVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFRNTEWFNGV 458
Cdd:smart00297  14 AVLDKLDSHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKL------ENGKYSSVEEFVADFNLMFSNARTYNGP 85

                           90       100
                   ....*....|....*....|..
gi 1625498531  459 EHPVSKMGKQVEESFDKQLKKM 480
Cdd:smart00297  86 DSEVYKDAKKLEKFFEKKLREL 107
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 563-648 1.57e-15

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 73.09  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 563 APFYDPVDYLAlglPDYPQVIQQPMDLSTIGQKF---NYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVF 639
Cdd:cd05502    23 LPFHEPVSPSV---PNYYKIIKTPMDLSLIRKKLqpkSPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFF 99


                  ....*....
gi 1625498531 640 DDKWTQLPP 648
Cdd:cd05502   100 EEQLKEILP 108
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 546-643 1.85e-15

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 72.79  E-value: 1.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 546 CAFILKELHKkvHSSyAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPG 625
Cdd:cd05503     5 CETILDEMEA--HED-AWPFLEPVN--TKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDD 79

                          90
                  ....*....|....*...
gi 1625498531 626 TPVHEAGKQTEKVFDDKW 643
Cdd:cd05503    80 SEVGRAGHNMRKFFEKRW 97
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 372-480 2.19e-15

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 72.84  E-value: 2.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 372 NQLKYV-STLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRRVQKTIkaeeggYHNFNDWEADVRRIFR 450
Cdd:cd05497     4 NQLQYLlKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNY------YWSASECIQDFNTMFT 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1625498531 451 NTEWFNGVEHPVSKMGKQVEESFDKQLKKM 480
Cdd:cd05497    78 NCYIYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 548-646 2.24e-14

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 69.99  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 548 FILKELHKKVHS-SYAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGT 626
Cdd:cd05511     3 FILDEIVNELKNlPDSWPFHTPVN--KKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80

                          90       100
                  ....*....|....*....|....*..
gi 1625498531 627 P-------VHEAGKQTEKVFDDKWTQL 646
Cdd:cd05511    81 VytkkakeMLELAEELLAEREEKLTQL 107
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 428-675 2.28e-14

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 75.61  E-value: 2.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 428 IKAEEGGYHNFNDWEADVRRIFRNT---EWFNGVEHPVSKMGKQVEESFDKQLKKMPPSTNDAVPST------------- 491
Cdd:COG5076     1 LEFDEVSYSQLGRPSVLKEEFGNELlrlVDNDSSPFPNAPEEEGSKNLFQKQLKRMPKEYITSIVDDrepgsmanvnddl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 492 SRGRGAPRRSQETGRPRRdTQQPVTAQQANDANRGRR---------RKTTAY--GRNGTADQM--RHCAFILKELHKKV- 557
Cdd:COG5076    81 ENVGGITYSPFEKNRPES-LRFDEIVFLAIESVTPESglgsllmahLKTSVKkrKTPKIEDELlyADNKAIAKFKKQLFl 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 558 --HSSYAAPF-YDPVDYLAlglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQ 634
Cdd:COG5076   160 rdGRFLSSIFlGLPSKREY---PDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKE 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1625498531 635 TEKVFdDKWTQLPPLSTPLEISDDENSDTVKALQRQIEDMQ 675
Cdd:COG5076   237 LEKYF-LKLIEEIPEEMLELSIKPGREEREERESVLITNSQ 276
PHA03247 PHA03247
large tegument protein UL36; Provisional
 95-297 6.35e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 76.52  E-value: 6.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   95 PTPiPQDPPTPQPAAMATPTDIPADT-----PQHFQPSQVPQTVKADSPAL-----PAPVTQSETSAAPVEPS-TEAPSA 163
Cdd:PHA03247  2769 PAP-PAAPAAGPPRRLTRPAVASLSEsreslPSPWDPADPPAAVLAPAAALppaasPAGPLPPPTSAQPTAPPpPPGPPP 2847

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  164 ESLDVKPAIAAEG-------QPQPLNQPLAPPQPEVQQSSEPQPnlthsslPPSTDAVAQPPLEQTHQPVAASSTEPQPQ 236
Cdd:PHA03247  2848 PSLPLGGSVAPGGdvrrrppSRSPAAKPAAPARPPVRRLARPAV-------SRSTESFALPPDQPERPPQPQAPPPPQPQ 2920

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531  237 -----------AMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQP 297
Cdd:PHA03247  2921 pqpppppqpqpPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASS 2992
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 577-642 1.15e-13

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 67.86  E-value: 1.15e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVFDDK 642
Cdd:cd05518    37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKEK 102
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 562-623 1.62e-13

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 67.87  E-value: 1.62e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531 562 AAPFYDPVDYLALglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNP 623
Cdd:cd05496    23 SEPFRQPVDLLKY--PDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTP 82
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 553-641 1.93e-12

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 64.09  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 553 LHKKVHSSYAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAG 632
Cdd:cd05505     9 LSKILKYRFSWPFREPVT--ADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYVLSCM 86


                  ....*....
gi 1625498531 633 KQTEKVFDD 641
Cdd:cd05505    87 RKTEQCCVN 95
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 383-481 4.93e-12

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 63.44  E-value: 4.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 383 QLKKMKAAVPFLTPVDymSLGVPHYPEVISEPSDLGSVdrrvQKTIKaeEGGYHNFNDWEADVRRIFRNTEWFNGVEHPV 462
Cdd:cd05511    11 ELKNLPDSWPFHTPVN--KKKVPDYYKIIKRPMDLQTI----RKKIS--KHKYQSREEFLEDIELIVDNSVLYNGPDSVY 82

                          90
                  ....*....|....*....
gi 1625498531 463 SKMGKQVEESFDKQLKKMP 481
Cdd:cd05511    83 TKKAKEMLELAEELLAERE 101
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 392-482 8.92e-12

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 62.69  E-value: 8.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 392 PFLTPVdymSLGVPHYPEVISEPSDLGSVDRRVQKTikaEEGGYHNFNDWEADVRRIFRNTEWFNGVEHPVSKMGKQVEE 471
Cdd:cd05502    24 PFHEPV---SPSVPNYYKIIKTPMDLSLIRKKLQPK---SPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELEL 97

                          90
                  ....*....|.
gi 1625498531 472 SFDKQLKKMPP 482
Cdd:cd05502    98 FFEEQLKEILP 108
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 378-468 9.31e-12

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 61.56  E-value: 9.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 378 STLMKQLKKMKAAVPFLTPVDYMSLgvPHYPEVISEPSDLGSVDRrvqktiKAEEGGYHNFNDWEADVRRIFRNTEWFNG 457
Cdd:pfam00439   2 LEILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKK------KLENGEYKSLAEFLADVKLIFSNARTYNG 73

                          90
                  ....*....|.
gi 1625498531 458 VEHPVSKMGKQ 468
Cdd:pfam00439  74 PGSVIYKAAEK 84
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 549-634 2.80e-11

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 60.89  E-value: 2.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 549 ILKELHKKVHSSYaapFYDPV-DYLAlglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTP 627
Cdd:cd05513     9 LIRQLQRKDPHGF---FAFPVtDFIA---PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTI 82


                  ....*..
gi 1625498531 628 VHEAGKQ 634
Cdd:cd05513    83 YYKAAKK 89
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 564-627 6.31e-11

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 60.06  E-value: 6.31e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 564 PFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTP 627
Cdd:cd05528    23 AFTKPVD--EEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDP 84
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 549-622 9.68e-11

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 59.76  E-value: 9.68e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 549 ILKELhkKVHSSYAAPFYDPVDylALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYN 622
Cdd:cd05510    15 VLNEL--KTYTEHSTPFLTKVS--KREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYN 84
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 576-639 1.02e-10

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 59.24  E-value: 1.02e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 576 LPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVF 639
Cdd:cd05515    36 YPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVL 99
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 565-632 1.79e-10

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 58.56  E-value: 1.79e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625498531 565 FYDPVDYLALglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAG 632
Cdd:cd05512    22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAA 87
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 374-475 2.50e-10

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 58.15  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 374 LKYVSTLMKQLKKMKAAVPFLTPVDYMSlgVPHYPEVISEPSDLgsvdrrvqKTI--KAEEGGYHNFNDWEADVRRIFRN 451
Cdd:cd05503     2 LALCETILDEMEAHEDAWPFLEPVNTKL--VPGYRKIIKKPMDF--------STIreKLESGQYKTLEEFAEDVRLVFDN 71

                          90       100
                  ....*....|....*....|....
gi 1625498531 452 TEWFNGVEHPVSKMGKQVEESFDK 475
Cdd:cd05503    72 CETFNEDDSEVGRAGHNMRKFFEK 95
PHA03247 PHA03247
large tegument protein UL36; Provisional
 91-361 2.79e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 2.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   91 QSTQPTPI-PQDPPTPQ-PAAMATPTDIPADTPQHFQPSQVPQTVKADSP--ALPAPVTQSETSAAPVEPSTEAPSAESL 166
Cdd:PHA03247  2730 QASPALPAaPAPPAVPAgPATPGGPARPARPPTTAGPPAPAPPAAPAAGPprRLTRPAVASLSESRESLPSPWDPADPPA 2809

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  167 DVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQ---THQPVAASSTEPQPQAMEVtaq 243
Cdd:PHA03247  2810 AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRrppSRSPAAKPAAPARPPVRRL--- 2886

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  244 sqAQPADAQGEEVAPYQQAGKSN-PQEHHAVKAEPEQTDEGVNGESVKVETPQQPYEAYQVEHQPQPFDAPGVVAHDAHD 322
Cdd:PHA03247  2887 --ARPAVSRSTESFALPPDQPERpPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1625498531  323 YPDGEDTSSAPPIVPPTPAGTEPIilPNGSKLPPRSAAI 361
Cdd:PHA03247  2965 GALVPGRVAVPRFRVPQPAPSREA--PASSTPPLTGHSL 3001
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 379-477 3.33e-10

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 57.84  E-value: 3.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 379 TLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGSVDRrvqktiKAEEGGYHNFNDWEADVRRIFRNTEWFNGV 458
Cdd:cd05495    11 TLEKLYKQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRR------KLDTGQYQDPWQYVDDVWLMFDNAWLYNRK 84

                          90
                  ....*....|....*....
gi 1625498531 459 EHPVSKMGKQVEESFDKQL 477
Cdd:cd05495    85 TSRVYKYCTKLAEVFEQEI 103
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 540-641 9.96e-10

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 57.35  E-value: 9.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 540 ADQMrhCAFILKELHK---KVHSSYAAPFYDPVDyLALGLPDYPQVIQQPMDLSTIGQKF--NYgdYEGPNDFFSDMKLM 614
Cdd:cd05529    22 RDEE--RERLISGLDKlllSLQLEIAEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLenRY--YRSLEALRHDVRLI 96

                          90       100
                  ....*....|....*....|....*..
gi 1625498531 615 LGNCYKYNPPGTPVHEAGKQTEKVFDD 641
Cdd:cd05529    97 LSNAETFNEPNSEIAKKAKRLSDWLLR 123
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 576-640 6.02e-09

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 54.36  E-value: 6.02e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1625498531 576 LPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVFD 640
Cdd:cd05516    37 LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFK 101
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 577-642 7.67e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 53.88  E-value: 7.67e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVFDDK 642
Cdd:cd05520    37 PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLMQAK 102
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 379-480 2.41e-08

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 52.78  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 379 TLMKQLKKMKAAVPFLTPVdyMSLGVPHYPEVISEPSDLGSVDRRVQKtikaeeGGYHNFNDWEADVRRIFRNTEWFNGV 458
Cdd:cd05504    19 QLLVEIVKHKDSWPFLRPV--SKIEVPDYYDIIKKPMDLGTIKEKLNM------GEYKLAEEFLSDIQLVFSNCFLYNPE 90

                          90       100
                  ....*....|....*....|..
gi 1625498531 459 EHPVSKMGKQVEESFDKQLKKM 480
Cdd:cd05504    91 HTSVYKAGTRLQRFFIKRCRKL 112
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
95-258 3.10e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.58  E-value: 3.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  95 PTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVP-QTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESldVKPAIA 173
Cdd:PRK12323  397 PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAlAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAG--PRPVAA 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 174 AEGQPQPLNQPLAPPQPEVQQS---SEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPAD 250
Cdd:PRK12323  475 AAAAAPARAAPAAAPAPADDDPppwEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAA 554


                  ....*...
gi 1625498531 251 AQGEEVAP 258
Cdd:PRK12323  555 AATEPVVA 562
PHA03247 PHA03247
large tegument protein UL36; Provisional
 89-365 4.61e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 4.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   89 LNQSTQPTPIPQ------------------DPPTPQPAAMATPTDIPADTPQhfqpSQVPQTVKADSPALPAPVTQSETS 150
Cdd:PHA03247  2670 LGRAAQASSPPQrprrraarptvgsltslaDPPPPPPTPEPAPHALVSATPL----PPGPAAARQASPALPAAPAPPAVP 2745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  151 AAPVEPSTEAPSAEsldvKPAIAAEGQPQPLNQPLAPPQ-----PEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQP 225
Cdd:PHA03247  2746 AGPATPGGPARPAR----PPTTAGPPAPAPPAAPAAGPPrrltrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPA 2821

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  226 VAASSTEPQPQAMEVTAQSQA----QPADAQGEEVAPYQQAGKSNPQEHHAVK--AEPEQTDEGVNGESVKVETPQQPYE 299
Cdd:PHA03247  2822 ASPAGPLPPPTSAQPTAPPPPpgppPPSLPLGGSVAPGGDVRRRPPSRSPAAKpaAPARPPVRRLARPAVSRSTESFALP 2901

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  300 AYQVEHQPQPFDAPGVVAHDAHDYPDGEDTSSAPPIVPPTP----AGTEPIILPNGSKLPPRSAAIgIPG 365
Cdd:PHA03247  2902 PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPlaptTDPAGAGEPSGAVPQPWLGAL-VPG 2970
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 577-640 6.76e-08

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 51.57  E-value: 6.76e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVFD 640
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFL 102
PHA03247 PHA03247
large tegument protein UL36; Provisional
 87-368 7.10e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 7.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   87 DQLNQSTQPTPIPQDPPT----------PQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPalPAPVTQSETSAAPVEP 156
Cdd:PHA03247  2565 DRSVPPPRPAPRPSEPAVtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP--PPPSPSPAANEPDPHP 2642

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  157 STEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEvQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQ 236
Cdd:PHA03247  2643 PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPL 2721

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  237 AMEVTAQSQAQPAdAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPyeayqveHQPQPFDAPGVV 316
Cdd:PHA03247  2722 PPGPAAARQASPA-LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-------RLTRPAVASLSE 2793

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1625498531  317 AHDAhdYPDGEDTSSAPPIVPPTPAGTEPIILPNGSKLPPRSAAIGIPGGPS 368
Cdd:PHA03247  2794 SRES--LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP 2843
rne PRK10811
ribonuclease E; Reviewed
 127-341 8.20e-08

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 56.20  E-value: 8.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  127 SQVPQTVKADSPALPA-------PVTQseTSAAPVEPSTEAPSAESLDV-----KPAIAAEGQPQPLNQPLAPPQPEVQQ 194
Cdd:PRK10811   823 SPMPLTVACASPEMASgkvwiryPVVR--PQDVQVEEQREAEEVQVQPVvaevpVAAAVEPVVSAPVVEAVAEVVEEPVV 900

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  195 SSEPQPnlthsslppstdaVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAPyqqagksnPQEHHAVK 274
Cdd:PRK10811   901 VAEPQP-------------EEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVE--------PQDETADI 959

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625498531  275 AEPEQTDE-GVNGESVKVETPQQPYEAYQVEHQPQPFDAPGVVAHDAHDYPDGEDTSSAPPIVPPTPA 341
Cdd:PRK10811   960 EEAAETAEvVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPAPE 1027
PHA03247 PHA03247
large tegument protein UL36; Provisional
 85-367 9.30e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 9.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   85 ESDQLNQSTQPTPIPQD---PPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAP 161
Cdd:PHA03247  2604 DRGDPRGPAPPSPLPPDthaPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRP 2683

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  162 SAESLdvKPAIAaegqpqPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAasstePQPQAMEVT 241
Cdd:PHA03247  2684 RRRAA--RPTVG------SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAP-----PAVPAGPAT 2750

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  242 AQSQAQPAdaqgeevAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPyeayqveHQPQPFDAPGVVAHDAH 321
Cdd:PHA03247  2751 PGGPARPA-------RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP-------SPWDPADPPAAVLAPAA 2816

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1625498531  322 DYPdgEDTSSAPPIVPPTPAGTEPIILPNGSKLPPRSAAIGI-PGGP 367
Cdd:PHA03247  2817 ALP--PAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVaPGGD 2861
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 555-634 1.61e-07

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 50.06  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 555 KKVHSS-YAAPFYDPV-DYLAlglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAG 632
Cdd:cd05507    13 RTLASHrYASVFLKPVtEDIA---PGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMA 89


                  ..
gi 1625498531 633 KQ 634
Cdd:cd05507    90 VE 91
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 95-361 2.08e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 2.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   95 PTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPV----EPSTEAPSAESLDVKP 170
Cdd:PHA03307    63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPpaspPPSPAPDLSEMLRPVG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  171 AIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQ--THQPVAASSTEPQPQAMEVTAQSQAQP 248
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPppSTPPAAASPRPPRRSSPISASASSPAP 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  249 ADAQGEEVAPYQQAGKSnpqehhavkAEPEQTDEGVNGESvkvETPQQPyeayqvehqPQPFDAPGVVAHDAHDYPDGED 328
Cdd:PHA03307   223 APGRSAADDAGASSSDS---------SSSESSGCGWGPEN---ECPLPR---------PAPITLPTRIWEASGWNGPSSR 281

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1625498531  329 TSSAPPIVPPTPAGTEPiiLPNGSKLPPRSAAI 361
Cdd:PHA03307   282 PGPASSSSSPRERSPSP--SPSSPGSGPAPSSP 312
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 91-258 2.31e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.77  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  91 QSTQPTPIPQDPPTPQPAAMATPTDIPADT-------------PQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPS 157
Cdd:pfam03154 175 QAQSGAASPPSPPPPGTTQAATAGPTPSAPsvppqgspatsqpPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQ 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 158 TEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPnlthSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPqa 237
Cdd:pfam03154 255 PPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQP----FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP-- 328

                         170       180
                  ....*....|....*....|.
gi 1625498531 238 mevTAQSQAQPADAQGEEVAP 258
Cdd:pfam03154 329 ---PSQSQLQSQQPPREQPLP 346
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 87-284 2.63e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.61  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  87 DQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESL 166
Cdd:PRK07764  610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAA 689

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 167 DVKPAIAAEGQPQPlNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLeqthqpvaASSTEPQPQAMEVTAQSQA 246
Cdd:PRK07764  690 PAAPAGAAPAQPAP-APAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL--------PPEPDDPPDPAGAPAQPPP 760

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1625498531 247 QPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGV 284
Cdd:PRK07764  761 PPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDR 798
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 92-370 2.72e-07

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 54.71  E-value: 2.72e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   92 STQPTPIPQDPPTPQPAaMATPTDIPADTPQHFQPSQVPQTvkadspalPAPVTQSETSAAPVEPSTEAPsaesldvkpa 171
Cdd:PRK10263   329 ATQSWAAPVEPVTQTPP-VASVDVPPAQPTVAWQPVPGPQT--------GEPVIAPAPEGYPQQSQYAQP---------- 389

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  172 iaAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADA 251
Cdd:PRK10263   390 --AVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQT 467

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  252 QGEEVAPyqqagksnPQEHHAVKAEPEQTdeGVNGESVKVET-PQQP--YEAYQVEHQ---------------PQPFDAP 313
Cdd:PRK10263   468 YQQPAAQ--------EPLYQQPQPVEQQP--VVEPEPVVEETkPARPplYYFEEVEEKrarereqlaawyqpiPEPVKEP 537

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531  314 GVVahdahdypdgedTSSAPPIVPPT--PAGTEPIILPNGSKLPPRSAAIGIPGG---PSFS 370
Cdd:PRK10263   538 EPI------------KSSLKAPSVAAvpPVEAAAAVSPLASGVKKATLATGAAATvaaPVFS 587
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 142-258 3.46e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 54.22  E-value: 3.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 142 APVTQSETSAAPVEPSTEAPSAEsldvkPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQ 221
Cdd:PRK07764  392 GAPAAAAPSAAAAAPAAAPAPAA-----AAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQP 466

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1625498531 222 THQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAP 258
Cdd:PRK07764  467 APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
PHA03247 PHA03247
large tegument protein UL36; Provisional
 99-367 4.83e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 4.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   99 PQDPPTPQPAAMATPTDIPADTpqhfqpsqVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAEsldvKPAIAAEGQP 178
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPLPP--------GPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR----PPTTAGPPAP 2769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  179 QPLNQPLAPPQPEVqqssepqPNLTHSSLPPSTDAVAQPPleqthQPVAASSTEPQPQAMEVTAQSQAQPadaqgeeVAP 258
Cdd:PHA03247  2770 APPAAPAAGPPRRL-------TRPAVASLSESRESLPSPW-----DPADPPAAVLAPAAALPPAASPAGP-------LPP 2830

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  259 YQQAGKSNPQEHHAVKAEPEQTDEGVngesvkveTPQQPyeayqVEHQPQPFDAPGVVAhdahdypdgedTSSAPPI--- 335
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPPPSLPLGGSV--------APGGD-----VRRRPPSRSPAAKPA-----------APARPPVrrl 2886

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1625498531  336 -VPPTPAGTEPIILPNGSKLPPRSAAIGIPGGP 367
Cdd:PHA03247  2887 aRPAVSRSTESFALPPDQPERPPQPQAPPPPQP 2919
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 375-620 5.90e-07

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 52.50  E-value: 5.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 375 KYVSTLMKQLKKMKAA---VPFLT-PVDYMslgVPHYPEVISEPSDLGSvdrrVQKTIKAEEggYHNFNDWEADVRRIFR 450
Cdd:COG5076   148 KAIAKFKKQLFLRDGRflsSIFLGlPSKRE---YPDYYEIIKSPMDLLT----IQKKLKNGR--YKSFEEFVSDLNLMFD 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 451 NTEWFNGVEHPVSKMGKQVEESFDKQLKKMPPSTNDAVPSTSRGRGAPRRSQETGrprrdtqqpvtaqqANDANRGRRRK 530
Cdd:COG5076   219 NCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEEMLELSIKPGREEREERESVLIT--------------NSQAHVGAWPF 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 531 TTAYGRNGTADqMRHCAFILKELHKKVHsSYAAPFYDPVDyLALGLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSD 610
Cdd:COG5076   285 LRPVSDEEVPD-YYKDIRDPMDLSTKEL-KLRNNYYRPEE-TFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTR 361

                         250
                  ....*....|
gi 1625498531 611 MKLMLGNCYK 620
Cdd:COG5076   362 LIREYPKLID 371
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
124-370 6.03e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.34  E-value: 6.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 124 FQPSQV-----PQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESldvkPAIAAEGQPQPLNQPLAPPQPEVQQSSEP 198
Cdd:PRK12323  363 FRPGQSgggagPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAA----PAAAAAARAVAAAPARRSPAPEALAAARQ 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 199 QPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQehhavkAEPE 278
Cdd:PRK12323  439 ASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFAS------PAPA 512

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 279 QTDEGvngesvkvetpqqpYEAYQVEHQPQPFDAPgvvahdahdypdgEDTSSAPPIVPPTPAGTEPIILPNGSKLPPRS 358
Cdd:PRK12323  513 QPDAA--------------PAGWVAESIPDPATAD-------------PDDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565

                         250
                  ....*....|..
gi 1625498531 359 AAIGIPGGPSFS 370
Cdd:PRK12323  566 PRASASGLPDMF 577
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 138-317 8.56e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 52.56  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 138 PALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQP 217
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 218 PleqthQPVAASSTEPQPQAME-VTAQSQAQPADAQGEEVAPYQQAGKSNPQEHhavkaepeqtdegvngESVKVETPQQ 296
Cdd:PRK07994  441 S-----EPAAASRARPVNSALErLASVRPAPSALEKAPAKKEAYRWKATNPVEV----------------KKEPVATPKA 499

                         170       180
                  ....*....|....*....|.
gi 1625498531 297 PYEAyqVEHQPQPFDAPGVVA 317
Cdd:PRK07994  500 LKKA--LEHEKTPELAAKLAA 518
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 131-356 1.31e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 52.39  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  131 QTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAiaaegqpqplnqplappQPEVQQSSEPQPNLTHSSLPPS 210
Cdd:PRK10263   314 APITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPA-----------------QPTVAWQPVPGPQTGEPVIAPA 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  211 TDAVaqPPLEQTHQPVAASStepQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTdegVNGESVK 290
Cdd:PRK10263   377 PEGY--PQQSQYAQPAVQYN---EPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQP---VAGNAWQ 448

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531  291 VETPQQPYEAYQVEHQPQPFDAPgVVAHDAHDYPdgedtssaPPIVPPTPAGTEPIILPNGSKLPP 356
Cdd:PRK10263   449 AEEQQSTFAPQSTYQTEQTYQQP-AAQEPLYQQP--------QPVEQQPVVEPEPVVEETKPARPP 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 103-242 2.22e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 51.25  E-value: 2.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 103 PTPQPAAMATPTDIPADTPqhfQPSQVPQTVKADSPALPAPVTQSetsaAPVEPSTEAPSAesldvkPAIAAegqpqpln 182
Cdd:PRK14951  371 EAAAPAEKKTPARPEAAAP---AAAPVAQAAAAPAPAAAPAAAAS----APAAPPAAAPPA------PVAAP-------- 429

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531 183 qPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQ--THQPVAASSTEPQPQAMEVTA 242
Cdd:PRK14951  430 -AAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVApePAVASAAPAPAAAPAAARLTP 490
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 87-320 2.72e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  87 DQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALP-APVTQSETSAAPVEPSTEAPSAES 165
Cdd:PRK07764  576 EELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAgAAAAPAEASAAPAPGVAAPEHHPK 655

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 166 LDVKPAIAAEGQPQPLN-QPLAPPQPEVQQSSEPQPnlthsslPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTA-Q 243
Cdd:PRK07764  656 HVAVPDASDGGDGWPAKaGGAAPAAPPPAPAPAAPA-------APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQgA 728

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 244 SQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPYEAYQ---VEHQPQPFDAPGVVAHDA 320
Cdd:PRK07764  729 SAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEddaPSMDDEDRRDAEEVAMEL 808
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 134-345 2.79e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 2.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 134 KADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPA-IAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTD 212
Cdd:PRK07764  593 GAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAgAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 213 AVAQPPLEQTHQPVAASSTEPQPQamevtAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVngesvkve 292
Cdd:PRK07764  673 AGGAAPAAPPPAPAPAAPAAPAGA-----APAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPV-------- 739

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1625498531 293 tPQQPYEAYqvehQPQPFDAPGVVAHDAHdyPDGEDTSSAPPIVPPTPAGTEP 345
Cdd:PRK07764  740 -PLPPEPDD----PPDPAGAPAQPPPPPA--PAPAAAPAAAPPPSPPSEEEEM 785
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 577-639 3.20e-06

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 46.66  E-value: 3.20e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVF 639
Cdd:cd05517    37 PDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 51-360 3.47e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.94  E-value: 3.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   51 PTTKPLDGPEKLENFHQSNQLPTPAPSEPPQPPLESDqlNQSTQPTPIPQDPP--TPQPAAMA--TPTDIPADTPQHFQP 126
Cdd:PHA03307    67 PPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPARE--GSPTPPGPSSPDPPppTPPPASPPpsPAPDLSEMLRPVGSP 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  127 SQVPQTVKADSPALPAPVTQSETS---AAPVEPSTEA-------PSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSS 196
Cdd:PHA03307   145 GPPPAASPPAAGASPAAVASDAASsrqAALPLSSPEEtarapssPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAP 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  197 E-----PQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTA---------QSQAQPADAQGEEVAPYQQA 262
Cdd:PHA03307   225 GrsaadDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWngpssrpgpASSSSSPRERSPSPSPSSPG 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  263 GKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPYEAYQVEHQPQPFDAPGvvahdaHDYPDGEDTSSAPPIVPPTPAG 342
Cdd:PHA03307   305 SGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRP------PPPADPSSPRKRPRPSRAPSSP 378

                          330
                   ....*....|....*...
gi 1625498531  343 TEpiilPNGSKLPPRSAA 360
Cdd:PHA03307   379 AA----SAGRPTRRRARA 392
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
105-334 3.92e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.62  E-value: 3.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 105 PQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQP 184
Cdd:PRK07003  381 PAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASAD 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 185 LAPPQPEVQQSSEPQPNLT-HSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAG 263
Cdd:PRK07003  461 SRCDERDAQPPADSGSASApASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAA 540

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 264 KSNPQEHHAVKAEPEQTDEGVNGESVK----------------VETPQQPYEAYQVEHQPQPFDAPGVVAHDAHDYPDGE 327
Cdd:PRK07003  541 APAARAGGAAAALDVLRNAGMRVSSDRgaraaaaakpaaapaaAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAA 620


                  ....*..
gi 1625498531 328 DTSSAPP 334
Cdd:PRK07003  621 ESRGAPP 627
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 67-345 4.90e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  67 QSNQLPTPAPSEPPQPPLESDQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQhfQPSQVPQTVKADSPALPAPVTQ 146
Cdd:PRK07764  436 APAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPA--AAPAAPAAPAAPAGADDAATLR 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 147 ----------------------SETSAAPVEPST------------------------------------------EAPS 162
Cdd:PRK07764  514 erwpeilaavpkrsrktwaillPEATVLGVRGDTlvlgfstgglarrfaspgnaevlvtalaeelggdwqveavvgPAPG 593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 163 AESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDA--VAQPPLEQTHQPVAASSTEPQPQAMEV 240
Cdd:PRK07764  594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPApgVAAPEHHPKHVAVPDASDGGDGWPAKA 673

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 241 TAQSQAQPADAQGeEVAPYQQAGKSNPQEHHAVKAEP--EQTDEGVNGESVKVET--PQQPYEAYQVEHQPQPFDAPGVV 316
Cdd:PRK07764  674 GGAAPAAPPPAPA-PAAPAAPAGAAPAQPAPAPAATPpaGQADDPAAQPPQAAQGasAPSPAADDPVPLPPEPDDPPDPA 752

                         330       340
                  ....*....|....*....|....*....
gi 1625498531 317 AHDAHDYPDGEDTSSAPPIVPPTPAGTEP 345
Cdd:PRK07764  753 GAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781
PHA03247 PHA03247
large tegument protein UL36; Provisional
 95-368 5.47e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   95 PTPIPQDPPTPQPAAMATPTDIPADTPQHfqPSQ------VPQTVKADSPALPAPVTQSETSAAP---VEPSTEAPSAes 165
Cdd:PHA03247  2502 GPPDPDAPPAPSRLAPAILPDEPVGEPVH--PRMltwirgLEELASDDAGDPPPPLPPAAPPAAPdrsVPPPRPAPRP-- 2577

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  166 ldVKPAIAAEGQpqplnQPLAPPQPE-----VQQSSEPQPNLTHSSLPPSTDAVAQPPLEQThqPVAASSTEPQPQAMEV 240
Cdd:PHA03247  2578 --SEPAVTSRAR-----RPDAPPQSArprapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS--PAANEPDPHPPPTVPP 2648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  241 TAQSQAQPADAQGEE----VAPYQQAGKSNPQEHHAVKAEPEQTdegvnGESVKVETPQQPyeayqvEHQPQPFDAPGVV 316
Cdd:PHA03247  2649 PERPRDDPAPGRVSRprraRRLGRAAQASSPPQRPRRRAARPTV-----GSLTSLADPPPP------PPTPEPAPHALVS 2717

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1625498531  317 AHDAHDYPD-GEDTSSAPPIVPPTPAGTEPIILPNGSKLPPRSAAIGIPGGPS 368
Cdd:PHA03247  2718 ATPLPPGPAaARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA 2770
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 92-364 5.71e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 50.37  E-value: 5.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  92 STQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPA 171
Cdd:PRK07764  428 APQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 172 IAAEGQ---PQPLNQ---------PLAPPQPEVQQSSEPQPNLTHSS--------LPPSTDAVAQPPLEQTHQ------- 224
Cdd:PRK07764  508 DAATLRerwPEILAAvpkrsrktwAILLPEATVLGVRGDTLVLGFSTgglarrfaSPGNAEVLVTALAEELGGdwqveav 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 225 ----PVAASSTEPQPQAMEVTAQSQAQPA--DAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPY 298
Cdd:PRK07764  588 vgpaPGAAGGEGPPAPASSGPPEEAARPAapAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1625498531 299 EAYQVEHQPQPFDAPGVVAHDAHDYPDGE---DTSSAPPIVPPTPAGTEPIILP----NGSKLPPRSAAIGIP 364
Cdd:PRK07764  668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAapaQPAPAPAATPPAGQADDPAAQPpqaaQGASAPSPAADDPVP 740
PHA03378 PHA03378
EBNA-3B; Provisional
 98-396 6.88e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.07  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  98 IPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPA-----LPAPVTQ-SETSAAPVE----PSTEAPSAESLD 167
Cdd:PHA03378  548 IESDEPASTEPVHDQLLPAPGLGPLQIQPLTSPTTSQLASSApsyaqTPWPVPHpSQTPEPPTTqshiPETSAPRQWPMP 627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 168 VKPAIAAEGQPQPLN-QPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQA 246
Cdd:PHA03378  628 LRPIPMRPLRMQPITfNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPP 707

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 247 Q--------PADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPYEAYQVEHQPQPfdaPGVVAH 318
Cdd:PHA03378  708 AappgraqrPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQP---PPQAPP 784

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1625498531 319 DAHDYPDGEDTSSAPPIVPPTPAGTEPIILPNGSKLPPRSAAIGIPGGPSFSFNQLKYVSTLMKQlkkmKAAVPFLTP 396
Cdd:PHA03378  785 APQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQ----AAAGPTPSP 858
rne PRK10811
ribonuclease E; Reviewed
 85-246 1.01e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 49.65  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   85 ESDQLNQSTQPTPIPQDPPTPQPAAmaTPTDIPADTPQHFQPSQVPQTVKAD---SPALPAPVTQSETSAAPVEPSTEAP 161
Cdd:PRK10811   854 QVEEQREAEEVQVQPVVAEVPVAAA--VEPVVSAPVVEAVAEVVEEPVVVAEpqpEEVVVVETTHPEVIAAPVTEQPQVI 931

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  162 SAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVT 241
Cdd:PRK10811   932 TESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEVAPAQVPEATV 1011


                   ....*
gi 1625498531  242 AQSQA 246
Cdd:PRK10811  1012 EHNHA 1016
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
88-237 1.38e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 49.00  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  88 QLNQSTQPTPIPQDPPTP---QPAAMATPTDIPADTPQHFQPSQVPQtvkadsPALPAPVTQSETSAAPVepsTEAPSAe 164
Cdd:PRK14971  364 QKGDDASGGRGPKQHIKPvftQPAAAPQPSAAAAASPSPSQSSAAAQ------PSAPQSATQPAGTPPTV---SVDPPA- 433

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531 165 sldvkpaiaaegqPQPLNQPLAPPQ---PEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQA 237
Cdd:PRK14971  434 -------------AVPVNPPSTAPQavrPAQFKEEKKIPVSKVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQKEI 496
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 577-642 2.22e-05

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 44.25  E-value: 2.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVFDDK 642
Cdd:cd05519    37 PDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKK 102
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 553-641 2.30e-05

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 43.96  E-value: 2.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 553 LHKKVHSSYAAPFYDPVDYLalgLPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNC---YKYNPPGTPVH 629
Cdd:cd05501    10 LLLKVYCMSKSGFFISKPYY---IRDYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHklfYKDDDFGQVGI 86

                          90
                  ....*....|..
gi 1625498531 630 EAGKQTEKVFDD 641
Cdd:cd05501    87 TLEKKFEKNFKE 98
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 545-638 2.53e-05

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 43.91  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 545 HCAFILKELHKKVHSSYAAPFYDPVDYLALglPDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPP 624
Cdd:cd05508     3 QLSKLLKFALERMKQPGAEPFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGG 80

                          90
                  ....*....|....
gi 1625498531 625 GTPVHEAGKQTEKV 638
Cdd:cd05508    81 DHKLTQAAKAIVKI 94
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 102-240 2.67e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 102 PPTPQPAAMATPTDIPADTPQHFQPsqvpqtvkadsPALPAPVTQSETSAAPVEPSTEAPSAESLDvkPAIAAEGQPQPL 181
Cdd:PRK07764  393 APAAAAPSAAAAAPAAAPAPAAAAP-----------AAAAAPAPAAAPQPAPAPAPAPAPPSPAGN--APAGGAPSPPPA 459

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1625498531 182 NQPLAPPQPEVQQSSEPQPnlthsSLPPSTDAVAQPPLEQthQPVAASSTEPQPQAMEV 240
Cdd:PRK07764  460 AAPSAQPAPAPAAAPEPTA-----APAPAPPAAPAPAAAP--AAPAAPAAPAGADDAAT 511
rne PRK10811
ribonuclease E; Reviewed
 103-272 3.39e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 47.73  E-value: 3.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  103 PTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETsAAPVEPSTEAPSAESLDVK-----PAIAAEG- 176
Cdd:PRK10811   846 PVVRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVA-EVVEEPVVVAEPQPEEVVVvetthPEVIAAPv 924

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  177 --QPQPLNQPLAPPQPEVQQSSEPqpnlthSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQA---QPADA 251
Cdd:PRK10811   925 teQPQVITESDVAVAQEVAEHAEP------VVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEvetVTAVE 998

                          170       180
                   ....*....|....*....|.
gi 1625498531  252 QGEEVAPYQQAGKSNpqeHHA 272
Cdd:PRK10811   999 PEVAPAQVPEATVEH---NHA 1016
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 85-228 4.73e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.17  E-value: 4.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  85 ESDQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQHfQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAE 164
Cdd:PRK07994  367 EPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPAS-APQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSEPAA 445

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1625498531 165 SLDVKPAIA-----AEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAA 228
Cdd:PRK07994  446 ASRARPVNSalerlASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTPELAA 514
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
103-364 5.68e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.79  E-value: 5.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 103 PTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESldvkPAIAAEgqpqpln 182
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS----PAPEAL------- 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 183 qPLAPPQPEVQQSSEPQPnlthSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAmEVTAQSQAQPADAQGEEVAPYQQA 262
Cdd:PRK12323  434 -AAARQASARGPGGAPAP----APAPAAAPAAAARPAAAGPRPVAAAAAAAPARA-APAAAPAPADDDPPPWEELPPEFA 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 263 gksnpqehhavKAEPEQTDEGVNGesvkVETPQQPYEAYQVEHQPQPFDAPgvvahdahdypdgedtSSAPPIVPPTPAG 342
Cdd:PRK12323  508 -----------SPAPAQPDAAPAG----WVAESIPDPATADPDDAFETLAP----------------APAAAPAPRAAAA 556

                         250       260
                  ....*....|....*....|..
gi 1625498531 343 TEPIILPNgsklPPRSAAIGIP 364
Cdd:PRK12323  557 TEPVVAPR----PPRASASGLP 574
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 379-457 5.81e-05

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 42.77  E-value: 5.81e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1625498531 379 TLMKQLKKMKAAVPFLTPVDYMSlgVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFRNTEWFNG 457
Cdd:cd05512     8 KTLDQLQEKDTAEIFSEPVDLSE--VPDYLDHIKQPMDFSTMRKKL------ESQRYRTLEDFEADFNLIINNCLAYNA 78
PHA03247 PHA03247
large tegument protein UL36; Provisional
 101-367 6.28e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 6.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  101 DPPTPQPAAMATPT-DIPADTPQHF-QPSQVPQTVKADSPALPApvtQSETSAAPVEPSteapsaeslDVKPAIAAEGQP 178
Cdd:PHA03247  2550 DPPPPLPPAAPPAApDRSVPPPRPApRPSEPAVTSRARRPDAPP---QSARPRAPVDDR---------GDPRGPAPPSPL 2617

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  179 QPLNQPLAPPQPevqqssEPQPnltHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAmevTAQSQAQPADAQGEEVAP 258
Cdd:PHA03247  2618 PPDTHAPDPPPP------SPSP---AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA---RRLGRAAQASSPPQRPRR 2685

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  259 YQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVeTPQQPYEAYQVEHQPQPFDAPgvvahdahdypdgedTSSAPPIVPP 338
Cdd:PHA03247  2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSA-TPLPPGPAAARQASPALPAAP---------------APPAVPAGPA 2749

                          250       260
                   ....*....|....*....|....*....
gi 1625498531  339 TPAGTEPIILPNGSKLPPRSAAIGIPGGP 367
Cdd:PHA03247  2750 TPGGPARPARPPTTAGPPAPAPPAAPAAG 2778
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 390-456 8.73e-05

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 42.83  E-value: 8.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1625498531 390 AVPFLTPVDymSLGVPHYPEVISEPSDLGSVDRrvqktiKAEEGGYHNFNDWEADVRRIFRNTEWFN 456
Cdd:cd05496    23 SEPFRQPVD--LLKYPDYRDIIDTPMDLGTVKE------TLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 122-297 8.75e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 8.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  122 QHFQPSQVPQTVKADSPALPAPVTQSETSA-APVEPSTEAP-SAESLDVKP--AIAAEGQPQPLNQPLAPPQPEVQQSSE 197
Cdd:PRK10263   681 QHDVPVNAEDADAAAEAELARQFAQTQQQRySGEQPAGANPfSLDDFEFSPmkALLDDGPHEPLFTPIVEPVQQPQQPVA 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  198 PQPNLTHSSLPpstdAVAQPPLEQTHQPVAASSTEPQPQ---AMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVK 274
Cdd:PRK10263   761 PQQQYQQPQQP----VAPQPQYQQPQQPVAPQPQYQQPQqpvAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQP 836

                          170       180
                   ....*....|....*....|....*....
gi 1625498531  275 AEPEQTDEGV------NGESVKVETPQQP 297
Cdd:PRK10263   837 VAPQPQDTLLhpllmrNGDSRPLHKPTTP 865
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 577-639 9.33e-05

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 42.23  E-value: 9.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYNPPGTPVHEAGKQTEKVF 639
Cdd:cd05522    38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEKEA 100
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 90-247 1.05e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.18  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  90 NQSTQPTPIPQDPPTPQPAAMATPtdiPADTPQHFQPSQVPQtvkadspALPAPVTQSETSAAPVEPSTEAPSAESLDVK 169
Cdd:pfam09770 209 KPAQQPAPAPAQPPAAPPAQQAQQ---QQQFPPQIQQQQQPQ-------QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQ 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 170 PAIAAEGQPQPLNQPLAPPQPE--VQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAAS-----STEPQpQAMEVTA 242
Cdd:pfam09770 279 PSIQPQAQQFHQQPPPVPVQPTqiLQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGrqapiITHPQ-QLAQLSE 357


                  ....*
gi 1625498531 243 QSQAQ 247
Cdd:pfam09770 358 EEKAA 362
PHA03378 PHA03378
EBNA-3B; Provisional
 95-221 1.09e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  95 PTPIPQDPPTP--QPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESldvkPAI 172
Cdd:PHA03378  703 PMRPPAAPPGRaqRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT----PQP 778

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1625498531 173 AAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQ 221
Cdd:PHA03378  779 PPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQ 827
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 139-256 1.11e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 45.96  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 139 ALPAPVTqsetSAAPVEPSTEAPSAesldVKPAIAAEGQPQP---LNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVA 215
Cdd:PRK14950  358 ALLVPVP----APQPAKPTAAAPSP----VRPTPAPSTRPKAaaaANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAP 429

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1625498531 216 QPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEV 256
Cdd:PRK14950  430 KLTRAAIPVDEKPKYTPPAPPKEEEKALIADGDVLEQLEAI 470
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 124-255 1.18e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.86  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 124 FQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSaesldVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLT 203
Cdd:PRK14951  364 FKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPA-----PAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAP 438

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1625498531 204 H---SSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEE 255
Cdd:PRK14951  439 AaapAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 374-437 1.19e-04

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 42.43  E-value: 1.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1625498531 374 LKYVSTLMKQLKKMKAAVPFLTPVDYMSLGVPHYPEVISEPSDLGS-VDRRVQKTIKAEEGGYHN 437
Cdd:cd05494     5 LERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTkVNNIVETGARDLEDLQIV 69
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 129-279 1.26e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 129 VPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAEsldvkpaiAAEGQPQPlnqPLAPPQPEVQQSSEPqpnlthsslP 208
Cdd:PRK07764  367 ASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAA--------AAAPAAAP---APAAAAPAAAAAPAP---------A 426

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1625498531 209 PSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSnPQEHHAVKAEPEQ 279
Cdd:PRK07764  427 AAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPA-PPAAPAPAAAPAA 496
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 99-258 1.51e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 45.63  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  99 PQDP-PTPQPAAMATPtdiPADTPQhfqpsQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESldvkPAIAAEGQ 177
Cdd:PRK07994  361 PAAPlPEPEVPPQSAA---PAASAQ-----ATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTS----QLLAARQQ 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 178 PQPLNQPLAPPQPEVQQSSEPQP----NLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVT--AQSQAQPADA 251
Cdd:PRK07994  429 LQRAQGATKAKKSEPAAASRARPvnsaLERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATpkALKKALEHEK 508


                  ....*..
gi 1625498531 252 QGEEVAP 258
Cdd:PRK07994  509 TPELAAK 515
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 125-243 1.56e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.49  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 125 QPSQVPQTVKADSPAL----PAPVTQSETSAAPvEPSTEAPSAESLDVKPAIAAegQPQPLNQPLAPPQPEVQQSSEPQP 200
Cdd:PHA03269   22 LNTNIPIPELHTSAATqkpdPAPAPHQAASRAP-DPAVAPTSAASRKPDLAQAP--TPAASEKFDPAPAPHQAASRAPDP 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1625498531 201 NLTHSSLPPSTDAVAQPPLE--QTHQ-----PVAASSTEPQPQAMEVTAQ 243
Cdd:PHA03269   99 AVAPQLAAAPKPDAAEAFTSaaQAHEapadaGTSAASKKPDPAAHTQHSP 148
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 577-622 1.59e-04

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 41.61  E-value: 1.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1625498531 577 PDYPQVIQQPMDLSTIGQKFNYGDYEGPNDFFSDMKLMLGNCYKYN 622
Cdd:cd05525    39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYY 84
PHA03247 PHA03247
large tegument protein UL36; Provisional
 92-231 2.17e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   92 STQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPvEPSTEAPSAESLDVKPA 171
Cdd:PHA03247  2868 SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP-QPPPPPPPRPQPPLAPT 2946

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  172 IAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASST 231
Cdd:PHA03247  2947 TDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 18-228 2.68e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 2.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   18 SNKRQKY--DQPQESDLRSTSSNHVSlPLSQVIDNPTTKPLDGPEKL-ENFHQSNQLPTPAPSEPPQPPLESDQLNQSTQ 94
Cdd:PRK10263   705 QTQQQRYsgEQPAGANPFSLDDFEFS-PMKALLDDGPHEPLFTPIVEpVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQ 783

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   95 PTPIPQDPPTPQPAAMATPTDIPADTPQHFQpsqvPQTVKADSPALPAPVTQSetsaaPVEPSTEAPSaESLdVKPAIAA 174
Cdd:PRK10263   784 PVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ----PQYQQPQQPVAPQPQYQQ-----PQQPVAPQPQ-DTL-LHPLLMR 852

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1625498531  175 EGQPQPLNQPlappqpevqqsSEPQPNLTHSSLPPS-TDAVAQPPLEQTHQPVAA 228
Cdd:PRK10263   853 NGDSRPLHKP-----------TTPLPSLDLLTPPPSeVEPVDTFALEQMARLVEA 896
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 86-321 3.12e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 44.64  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  86 SDQLNQSTQPTPIPQDPPTPQPAAMATPtdiPADT--PQHFQPSQVPQ-TVKAD----SPALPAPVTQS-ETSAAPVEPS 157
Cdd:pfam09770 111 AAQSSAQPPASSLPQYQYASQQSQQPSK---PVRTgyEKYKEPEPIPDlQVDASlwgvAPKKAAAPAPApQPAAQPASLP 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 158 TEAPSAESLD-VKPAIAAEGQPQPLNQPLAPPQ-----PEVQQSSEPQpnlthsslPPSTDAVAQPPLEQTHQPVAASST 231
Cdd:pfam09770 188 APSRKMMSLEeVEAAMRAQAKKPAQQPAPAPAQppaapPAQQAQQQQQ--------FPPQIQQQQQPQQQPQQPQQHPGQ 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 232 EPQPQAMEVTAQSQAQPADAQGeevapyQQAGKSNPQEHHAVKAEPEQTdegvngesvkVETPQQPYEAYQVEHQPQPFD 311
Cdd:pfam09770 260 GHPVTILQRPQSPQPDPAQPSI------QPQAQQFHQQPPPVPVQPTQI----------LQNPNRLSAARVGYPQNPQPG 323

                         250
                  ....*....|
gi 1625498531 312 APGVVAHDAH 321
Cdd:pfam09770 324 VQPAPAHQAH 333
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
189-360 3.27e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 44.21  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 189 QPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVA----------ASSTEPQPQAMEVTAQSQAQPADAQgeevAP 258
Cdd:PRK12727   69 PAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDmiaamalrqpVSVPRQAPAAAPVRAASIPSPAAQA----LA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 259 YQQAGKSNPQEHHAVKAEPEQ------TDEGVNgESVKVETPQQPYEAYQVEHQPQPFDAPGVVAHDAHDYPDGEDTSSA 332
Cdd:PRK12727  145 HAAAVRTAPRQEHALSAVPEQlfadflTTAPVP-RAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDEQLDDDGFDLDDA 223

                         170       180
                  ....*....|....*....|....*...
gi 1625498531 333 PPIVPPTPAgtepiiLPNGSKLPPRSAA 360
Cdd:PRK12727  224 LPQILPPAA------LPPIVVAPAAPAA 245
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 128-334 3.29e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 44.31  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 128 QVPQTVKADSPAL---PAPVTQSETSAAPVEPSTEA--PSA----------ESLDVKPAIAAEGQPQPLNQPLAPPQPEV 192
Cdd:PRK08691  378 QSPSAQTAEKETAakkPQPRPEAETAQTPVQTASAAamPSEgktagpvsnqENNDVPPWEDAPDEAQTAAGTAQTSAKSI 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 193 QQSSEPqpnlthSSLPPSTDAVAQPPLEQTHQPVaasSTEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHA 272
Cdd:PRK08691  458 QTASEA------ETPPENQVSKNKAADNETDAPL---SEVPSENPIQATPNDEAVETETFAHEAPAEPFYGYGFPDNDCP 528

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 273 VKAEpeqtdegvngesvkVETPQQPYEayqvehQPQPFDAPGVVAHDAHD--YPDGEDTSSAPP 334
Cdd:PRK08691  529 PEDG--------------AEIPPPDWE------HAAPADTAGGGADEEAEagGIGGNNTPSAPP 572
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 92-279 5.07e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 43.35  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  92 STQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQP--SQVPQTVKADSPALPAPvtqSETSAAPVEPSTEAPSA------ 163
Cdd:TIGR00601  84 VAPPAATPTSAPTPTPSPPASPASGMSAAPASAVEekSPSEESATATAPESPST---SVPSSGSDAASTLVVGSeretti 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 164 --------ESLDVKPAI-AAEGQPQP------LNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPV-- 226
Cdd:TIGR00601 161 eeimemgyEREEVERALrAAFNNPDRaveyllTGIPEDPEQPEPVQQTAASTAAATTETPQHGSVFEQAAQGGTEQPAte 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1625498531 227 AASSTEP------QPQAMEVTAQSQAQPADAQgeevAPYQQAGKSNPQEHHAVKAEPEQ 279
Cdd:TIGR00601 241 AAQGGNPleflrnQPQFQQLRQVVQQNPQLLP----PLLQQIGQENPQLLQQISQHPEQ 295
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
164-313 5.36e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.61  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 164 ESLDVKPAIAAEGQPQP-LNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDavaqppleqthQPVAASSTEPQPQAMEVTA 242
Cdd:PRK14971  365 KGDDASGGRGPKQHIKPvFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAP-----------QSATQPAGTPPTVSVDPPA 433

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1625498531 243 QSQAQPADAQGEEVAPYQQAGKSNPqehhAVKAEPEQTDEGVNGESVKVETPQQPYEAYQVEHQPQPFDAP 313
Cdd:PRK14971  434 AVPVNPPSTAPQAVRPAQFKEEKKI----PVSKVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQKEIFTEE 500
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
97-266 5.62e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  97 PIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPST-------EAPSAESLDVK 169
Cdd:PRK07003  442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATpaavpdaRAPAAASREDA 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 170 PAIAAEgqPQPLNQPLAP----PQPEVQQSSEPQPNLTHSSLPPSTD---AVAQPPLEQTHQPVAASSTEPQPQAMEVTA 242
Cdd:PRK07003  522 PAAAAP--PAPEARPPTPaaaaPAARAGGAAAALDVLRNAGMRVSSDrgaRAAAAAKPAAAPAAAPKPAAPRVAVQVPTP 599

                         170       180
                  ....*....|....*....|....
gi 1625498531 243 QSQAQPADAQGEEVAPYQQAGKSN 266
Cdd:PRK07003  600 RARAATGDAPPNGAARAEQAAESR 623
flhF PRK06995
flagellar biosynthesis protein FlhF;
150-257 5.67e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 235904 [Multi-domain]  Cd Length: 484  Bit Score: 43.42  E-value: 5.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 150 SAAPVEPSTEAPSAESLDVKPAIAAEGQPQPL----NQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPleqthqP 225
Cdd:PRK06995   56 AAAPAAAQPPPAAAPAAVSRPAAPAAEPAPWLvehaKRLTAQREQLVARAAAPAAPEAQAPAAPAERAAAENA------A 129

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1625498531 226 VAASSTEPQPQAMEVTAQSQAQPADAQGEEVA 257
Cdd:PRK06995  130 RRLARAAAAAPRPRVPADAAAAVADAVKARIE 161
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 88-218 5.74e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.56  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  88 QLNQSTQPTPIP----------QDP-PTPQPAAMATPTDIPADTPQHfQPSQVPQTVKADSPAL-----PAPVTQSETSA 151
Cdd:PHA03269   16 NLIIANLNTNIPipelhtsaatQKPdPAPAPHQAASRAPDPAVAPTS-AASRKPDLAQAPTPAAsekfdPAPAPHQAASR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1625498531 152 APvEPSteapsaesldVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPP 218
Cdd:PHA03269   95 AP-DPA----------VAPQLAAAPKPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSPPP 150
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 92-279 5.92e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  92 STQPTPIPQD---PPTPQPAAMATPTDIPAdTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDV 168
Cdd:pfam17823  87 TAEHTPHGTDlsePATREGAADGAASRALA-AAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAA 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 169 KPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNL--THSSLPP----STDAVA--QPPLEQTHQPVAASSTEPQPQAMEV 240
Cdd:pfam17823 166 SAPHAASPAPRTAASSTTAASSTTAASSAPTTAAssAPATLTPargiSTAATAtgHPAAGTALAAVGNSSPAAGTVTAAV 245

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1625498531 241 TAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQ 279
Cdd:pfam17823 246 GTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAK 284
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
95-258 6.36e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  95 PTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPAlPAPVTQSETSAAPVEP----STEAPSAESLDVKP 170
Cdd:PRK12323  411 AAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPA-AAPAAAARPAAAGPRPvaaaAAAAPARAAPAAAP 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 171 AIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPpsTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPAD 250
Cdd:PRK12323  490 APADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIP--DPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567


                  ....*...
gi 1625498531 251 AQGEEVAP 258
Cdd:PRK12323  568 ASASGLPD 575
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 86-225 6.54e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 42.54  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  86 SDQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTqsetSAAPVEPSTEAPSAeS 165
Cdd:PHA02682   70 SACMQRPSGQSPLAPSPACAAPAPACPACAPAAPAPAVTCPAPAPACPPATAPTCPPPAV----CPAPARPAPACPPS-T 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 166 LDVKPAiaaegQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQP 225
Cdd:PHA02682  145 RQCPPA-----PPLPTPKPAPAAKPIFLHNQLPPPDYPAASCPTIETAPAASPVLEPRIP 199
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 91-362 6.56e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 6.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  91 QSTQPTPIPQDP-PTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVK 169
Cdd:PRK07764  395 AAAAPSAAAAAPaAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAP 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 170 PAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAME--------VT 241
Cdd:PRK07764  475 EPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEILAAVPKRSRKTWAILLPEATVLGVRgdtlvlgfST 554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 242 AQSQAQPADAQGEEV---APYQQAGKsnpqeHHAVKAEPEQTDEGVNGESVKVETPQQPYEAYQvehQPQPFDAPGVvah 318
Cdd:PRK07764  555 GGLARRFASPGNAEVlvtALAEELGG-----DWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAA---RPAAPAAPAA--- 623

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1625498531 319 DAHDYPDGEDTSSAPPIVPPTPAGTEPIILPNGSKLPPRSAAIG 362
Cdd:PRK07764  624 PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 138-262 7.00e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 7.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 138 PALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQP 217
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1625498531 218 PLEQTHQPVAASSTEPQPQAMEV-TAQSQAQPADAQGEEVAPYQQA 262
Cdd:PRK14951  446 ALAPAPPAQAAPETVAIPVRVAPePAVASAAPAPAAAPAAARLTPT 491
PHA03247 PHA03247
large tegument protein UL36; Provisional
 94-248 7.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 7.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   94 QPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIA 173
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  174 AEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHS-------SLPPSTDAVAQPPL-EQTHQPVAassTEPQPQAMEvtAQSQ 245
Cdd:PHA03247  3006 SWASSLALHEETDPPPVSLKQTLWPPDDTEDSdadslfdSDSERSDLEALDPLpPEPHDPFA---HEPDPATPE--AGAR 3080


                   ...
gi 1625498531  246 AQP 248
Cdd:PHA03247  3081 ESP 3083
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 166-317 7.69e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 7.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 166 LDVKPAIAAEGQPQPLNQPLAPPQ---PEVQQSSEPQPNLTHSSLPPSTDAVAQPPleqthqPVAASSTEPQPQAMEVTA 242
Cdd:PRK14951  362 LAFKPAAAAEAAAPAEKKTPARPEaaaPAAAPVAQAAAAPAPAAAPAAAASAPAAP------PAAAPPAPVAAPAAAAPA 435

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1625498531 243 QSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEPEQTDEGVNGESVKVETPQQPYEAYQVEHQ--PQPFDAPGVVA 317
Cdd:PRK14951  436 AAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHAtvQQLAAAEAITA 512
PRK10118 PRK10118
flagellar hook length control protein FliK;
102-235 9.59e-04

flagellar hook length control protein FliK;


Pssm-ID: 236652 [Multi-domain]  Cd Length: 408  Bit Score: 42.55  E-value: 9.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 102 PPTPQPAAmatptdiPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAeslDVKPAIAAEGQPQPL 181
Cdd:PRK10118  151 PGQDNTTP-------VADAPSTVLPAEKPTLLTKDMPSAPQDETHTLSSDEHEKGLTSAQLT---TAQPDDAPGTPAQPL 220

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 182 NQPLAPPQPEVQQSSEPQPnLTHSSLPPSTDAVAQPpleqthQPVAASSTEPQP 235
Cdd:PRK10118  221 TPLAAEAQAKAEVISTPSP-VTAAASPTITPHQTQP------LPTAAAPVLSAP 267
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 390-481 1.02e-03

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 39.73  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 390 AVPFLTPVDYMSlgVPHYPEVISEPSDLGSVDRRVQKtikaeeGGYHNFNDWEADVRRIFRNTEWFNGVE-HPVSKMGKQ 468
Cdd:cd05510    26 STPFLTKVSKRE--APDYYDIIKKPMDLGTMLKKLKN------LQYKSKAEFVDDLNLIWKNCLLYNSDPsHPLRRHANF 97

                          90
                  ....*....|...
gi 1625498531 469 VEESFDKQLKKMP 481
Cdd:cd05510    98 MKKKAEHLLKLIP 110
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 95-200 1.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  95 PTPIPQDPPTPQPAAMATPTDIPADTPqhfqPSQVPQTVKADSPALPAPVtQSETSAAPVEPSTEAPSAEsldvkpAIAA 174
Cdd:PRK14951  396 QAAAAPAPAAAPAAAASAPAAPPAAAP----PAPVAAPAAAAPAAAPAAA-PAAVALAPAPPAQAAPETV------AIPV 464

                          90       100
                  ....*....|....*....|....*.
gi 1625498531 175 EGQPQPLNQPLAPPQPEVQQSSEPQP 200
Cdd:PRK14951  465 RVAPEPAVASAAPAPAAAPAAARLTP 490
PHA03378 PHA03378
EBNA-3B; Provisional
 22-270 1.10e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  22 QKYDQPQESDLRSTSSNHVSLPL-----SQVIDNPTTKPLdGPEKLENFHQSNQLPTPAPSEPPQPPLESDQLNQSTQPT 96
Cdd:PHA03378  575 QPLTSPTTSQLASSAPSYAQTPWpvphpSQTPEPPTTQSH-IPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQ 653

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  97 PiPQDPPTPQPAAMATPTDIPAD----TPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPsteaPSAESLDVKPAI 172
Cdd:PHA03378  654 P-PQVEITPYKPTWTQIGHIPYQpsptGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQR----PAAATGRARPPA 728

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 173 AAEGQ---PQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQP------PLEQTHQPVAASSTEPQPQAMEVTAQ 243
Cdd:PHA03378  729 AAPGRarpPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPqpppqaPPAPQQRPRGAPTPQPPPQAGPTSMQ 808

                         250       260
                  ....*....|....*....|....*..
gi 1625498531 244 sqaqpadaqgeeVAPYQQAGKSNPQEH 270
Cdd:PHA03378  809 ------------LMPRAAPGQQGPTKQ 823
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 380-480 1.14e-03

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 40.01  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 380 LMKQLKKM------KAAVPFLTPVDYMSLgVPHYPEVISEPSDLGSVDRRVqktikaEEGGYHNFNDWEADVRRIFRNTE 453
Cdd:cd05529    29 LISGLDKLllslqlEIAEYFEYPVDLRAW-YPDYWNRVPVPMDLETIRSRL------ENRYYRSLEALRHDVRLILSNAE 101

                          90       100
                  ....*....|....*....|....*..
gi 1625498531 454 WFNGVEHPVSKMGKQVEESFDKQLKKM 480
Cdd:cd05529   102 TFNEPNSEIAKKAKRLSDWLLRILSSL 128
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
125-345 1.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 125 QPSQVPQTVKAdspalPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPevqqssepqpnlth 204
Cdd:PRK07003  372 VPARVAGAVPA-----PGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAP-------------- 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 205 sslPPSTDAVAQPpleqthqpVAASSTEPQPQAMEVTAQSQAQPADAQgEEVAPYQQAGKSNPQEhHAVKAEPEQTDEGV 284
Cdd:PRK07003  433 ---PATADRGDDA--------ADGDAPVPAKANARASADSRCDERDAQ-PPADSGSASAPASDAP-PDAAFEPAPRAAAP 499

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1625498531 285 NGESVKVETPQQPYEAYQVEHQPQPFDAPgvvahdahdypdgedtssAPPIVPPTPAGTEP 345
Cdd:PRK07003  500 SAATPAAVPDARAPAAASREDAPAAAAPP------------------APEARPPTPAAAAP 542
PHA03369 PHA03369
capsid maturational protease; Provisional
 134-266 1.30e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 42.29  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 134 KADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQP--QPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPST 211
Cdd:PHA03369  347 ILKTASLTAPSRVLAAAAKVAVIAAPQTHTGPADRQRPQRPDGIPysVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGT 426

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531 212 DAVAQPpleqthqpvaASSTEPQPQAMEVTAQSQAQ-PADAQGEEVAPYQQAGKSN 266
Cdd:PHA03369  427 SYGPEP----------VGPVPPQPTNPYVMPISMANmVYPGHPQEHGHERKRKRGG 472
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 405-471 1.41e-03

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 38.96  E-value: 1.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1625498531 405 PHYPEVISEPSDLGSVDRRVQktikaeEGGYHNFNDWEADVRRIFRNTEWFNgveHPVSKMGKQVEE 471
Cdd:cd05517    37 PDYYAVIKEPIDLKTIAQRIQ------SGYYKSIEDMEKDLDLMVKNAKTFN---EPGSQVYKDANA 94
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 67-257 1.47e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  67 QSNQLPTPAPSEPPQPPLESDQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQ 146
Cdd:PRK07764  620 APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA 699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 147 SETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPevqqssEPQPNLTHSSLPPSTDAVAQPPLEQTHQPV 226
Cdd:PRK07764  700 QPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP------EPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1625498531 227 AASSTEPQPQAMEVTAQSQAQPADAQ-GEEVA 257
Cdd:PRK07764  774 PPPSPPSEEEEMAEDDAPSMDDEDRRdAEEVA 805
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
151-299 1.57e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.07  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 151 AAPVEPSTeapsaesldvkpaiaaegqpqplNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPlEQTHQPVAASS 230
Cdd:PRK14971  376 KQHIKPVF-----------------------TQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQP-AGTPPTVSVDP 431

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1625498531 231 TEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKaepeQTDEGVNGESVKVETPQQPYE 299
Cdd:PRK14971  432 PAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQ----EKAEQATGNIKEAPTGTQKEI 496
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 90-267 1.72e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 41.87  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  90 NQSTQPTPIPQDPPTPQPAAMATPT---DIPADTPQHFQPSQVPQTVKADSPALPAPvTQSETSAAPVEPSTEAPSAESL 166
Cdd:pfam17823 233 NSSPAAGTVTAAVGTVTPAALATLAaaaGTVASAAGTINMGDPHARRLSPAKHMPSD-TMARNPAAPMGAQAQGPIIQVS 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 167 DVKPAIAAEGQPQPlnqplAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQThQPVAASSTEPQPQAMEVTAQSQ- 245
Cdd:pfam17823 312 TDQPVHNTAGEPTP-----SPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASP-VPVLHTSMIPEVEATSPTTQPSp 385

                         170       180
                  ....*....|....*....|....*
gi 1625498531 246 ---AQPADAQGEEVAPYQQAGKSNP 267
Cdd:pfam17823 386 llpTQGAAGPGILLAPEQVATEATA 410
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 65-299 2.09e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.00  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  65 FHQSNQLPTPAPSEPPQPPLESDQLNQSTQPTPIPQDPPTPQPAAMATPTDIPADtpqhfqpSQVPQTVKAdspalPAPV 144
Cdd:PRK08691  358 FAPLAAASCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASA-------AAMPSEGKT-----AGPV 425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 145 TQSETSAAPvePSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEV--QQSSEPQPNLTHSSLPPSTDAVAQPPLEQT 222
Cdd:PRK08691  426 SNQENNDVP--PWEDAPDEAQTAAGTAQTSAKSIQTASEAETPPENQVskNKAADNETDAPLSEVPSENPIQATPNDEAV 503

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1625498531 223 HQPVAASSTEPQPQAMEVTAQSQAQPADaqGEEVAPyqqagksnPQEHHAVKAEPEQTDEGVNGESVKVETPQQPYE 299
Cdd:PRK08691  504 ETETFAHEAPAEPFYGYGFPDNDCPPED--GAEIPP--------PDWEHAAPADTAGGGADEEAEAGGIGGNNTPSA 570
PRK10927 PRK10927
cell division protein FtsN;
177-282 2.22e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.20  E-value: 2.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 177 QPQPLNQPLAPPQPEVQQSSEPQPNLThsslPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQgeeV 256
Cdd:PRK10927  154 QRQRQAQQLAEQQRLAQQSRTTEQSWQ----QQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQ---A 226

                          90       100
                  ....*....|....*....|....*.
gi 1625498531 257 APYQQAGKsnpqehhAVKAEPEQTDE 282
Cdd:PRK10927  227 APVTRAAD-------APKPTAEKKDE 245
PRK13700 PRK13700
conjugal transfer protein TraD; Provisional
 169-307 2.31e-03

conjugal transfer protein TraD; Provisional


Pssm-ID: 184256 [Multi-domain]  Cd Length: 732  Bit Score: 41.87  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 169 KPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQP 248
Cdd:PRK13700  565 RPKVAPEFIPRDINPEMENRLSAVLAAREAEGRQMASLFEPDVPEVASGEDVTQAEQPQQPQQPQQPQQPQQPQQPVSPV 644

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 249 ADAQGEEVAPYQQAGKSNPQehhaVKAEPEQTDE-----GVNGESVKVEtpQQPYEAYQVEHQP 307
Cdd:PRK13700  645 INDKKSDAGVNVPAGGIEQE----LKMKPEEEMEqqlppGISESGEVVD--MAAYEAWQQENHP 702
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 126-228 2.42e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.33  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 126 PSQVPQTVKADSPAlPAPVTQSetsAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPqpnLTHS 205
Cdd:PRK14950  362 PVPAPQPAKPTAAA-PSPVRPT---PAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPK---LTRA 434

                          90       100
                  ....*....|....*....|...
gi 1625498531 206 SLPPSTDAVAQPPLEQTHQPVAA 228
Cdd:PRK14950  435 AIPVDEKPKYTPPAPPKEEEKAL 457
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 91-246 2.43e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   91 QSTQPTpIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKP 170
Cdd:PRK10263   385 QYAQPA-VQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQ 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  171 AIAAEGQPQPLNQPLAPPQPEVQQSS-EPQPNL--THSSLPP--------STDAVAQPPLEQTHQPVAASSTEPQPQAME 239
Cdd:PRK10263   464 TEQTYQQPAAQEPLYQQPQPVEQQPVvEPEPVVeeTKPARPPlyyfeeveEKRAREREQLAAWYQPIPEPVKEPEPIKSS 543


                   ....*..
gi 1625498531  240 VTAQSQA 246
Cdd:PRK10263   544 LKAPSVA 550
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 94-181 2.73e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.41  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   94 QPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQsetsAAPVEPSTEAPSAESLDVKPAIA 173
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAA----AAAAAAPAAPPAAAAAAAPAAAA 112


                   ....*...
gi 1625498531  174 AEGQPQPL 181
Cdd:PRK12270   113 VEDEVTPL 120
dnaA PRK14086
chromosomal replication initiator protein DnaA;
122-372 2.79e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 41.35  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 122 QHFQPSQVPQTVKADSPALPAPVTQS----ETSAAPvePSTEAPSAE-SLDVKPAIAAEgqpqPLNQPLAPPQPEVQQSS 196
Cdd:PRK14086   33 EAWLKRCQPLALVADTALLAVPNEFAkevlEGRLAP--IISETLSRElGRPIRIAITVD----PSAGEPAPPPPHARRTS 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 197 EPQpnlTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGE-EVAPYQQAGKSNPQEHHAVKA 275
Cdd:PRK14086  107 EPE---LPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAaDDYGWQQQRLGFPPRAPYASP 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 276 EPEQTDEGVNGESVKVETPQQPYEAYQVEHQPQPFDAPGvvaHDAHDYPD-----GEDTSSAPPIVPPTPAGTEPIILPN 350
Cdd:PRK14086  184 ASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPR---RDRTDRPEpppgaGHVHRGGPGPPERDDAPVVPIRPSA 260

                         250       260
                  ....*....|....*....|..
gi 1625498531 351 GSKLPPRSAAIGIPGGPSFSFN 372
Cdd:PRK14086  261 PGPLAAQPAPAPGPGEPTARLN 282
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
90-237 2.99e-03

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 41.07  E-value: 2.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  90 NQSTQPTPIPQDPPTPQPAAmATPTDIPADTPQHfQPSQVPQTVKADSPALPA-PVTQSETSAAPVEP-STEAPSAesld 167
Cdd:pfam16014  43 GQNSEQQTASASPPSQHPAQ-AIPTILAPAAPPS-QPSVVLSTLPAAMAVTPPiPASMANVVAPPTQPaASSTAAC---- 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 168 vkpaiaaegqpqplnqPLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQA 237
Cdd:pfam16014 117 ----------------AVSSVLPEIKIKQEAEPMDTSQSVPPLTPTSISPALTSLANNLSVPAGDLLPGA 170
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 95-345 3.41e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  95 PTPIPQDPPTPQPAA-MATPTD-IPADTPQHFQPSQ--VPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKP 170
Cdd:pfam05109 490 PSPSPRDNGTESKAPdMTSPTSaVTTPTPNATSPTPavTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNA 569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 171 AIAAEGQPQPLNQPLAP----PQPEVQQSSePQPNLTHSSL--PPSTDAVAQPPLEQThqpvaASSTEPQPQAMEVTAQS 244
Cdd:pfam05109 570 TIPTLGKTSPTSAVTTPtpnaTSPTVGETS-PQANTTNHTLggTSSTPVVTSPPKNAT-----SAVTTGQHNITSSSTSS 643

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 245 QAQPADAQGEEVAPyqqAGKSNPQEHHAVKAEPEQTdegvNGESVKVETPQQPYEAYQVEHQPQPfdAPGVVAHDAHdyP 324
Cdd:pfam05109 644 MSLRPSSISETLSP---STSDNSTSHMPLLTSAHPT----GGENITQVTPASTSTHHVSTSSPAP--RPGTTSQASG--P 712

                         250       260
                  ....*....|....*....|.
gi 1625498531 325 DGEDTSSAPPIVPPTpAGTEP 345
Cdd:pfam05109 713 GNSSTSTKPGEVNVT-KGTPP 732
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 55-198 4.00e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  55 PLDGPEKLENFHQSNQLPTPAPSEPPQPPLESDQLNQSTQPTPIPQDPPTPQPAaMATPTDIPADTPQHFQPSQVPQTVK 134
Cdd:pfam03154 408 PSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSP-FPQHPFVPGGPPPITPPSGPPTSTS 486

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1625498531 135 ADSPALPAPVTQSETSAAPVepsteaPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEP 198
Cdd:pfam03154 487 SAMPGIQPPSSASVSSSGPV------PAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEP 544
PRK10856 PRK10856
cytoskeleton protein RodZ;
90-174 4.15e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 40.39  E-value: 4.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  90 NQSTQPTPIPQDPPTPQPAAMATPTDIPADTPQHFQPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVK 169
Cdd:PRK10856  167 STTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAPATPDGAAPLPTDQAGVST 246


                  ....*
gi 1625498531 170 PAIAA 174
Cdd:PRK10856  247 PAADP 251
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 549-592 4.16e-03

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 37.81  E-value: 4.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1625498531 549 ILKELHKKVHSSYAAPFYDPVDYLALGLPDYPQVIQQPMDLSTI 592
Cdd:cd05494     8 VLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTK 51
PHA03418 PHA03418
hypothetical E4 protein; Provisional
 95-241 5.20e-03

hypothetical E4 protein; Provisional


Pssm-ID: 177646 [Multi-domain]  Cd Length: 230  Bit Score: 39.34  E-value: 5.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  95 PTPIPQDPPTPQPAAMATPTDIPADTPQ-----HFQPSQVPQTVKADSPalPAPVTQSETSAAPVEPSTEAPSAESLDVK 169
Cdd:PHA03418   52 PSPPPDPPLTPRPPAQPNGHNKPPVTKQpggegTEEDHQAPLAADADDD--PRPGKRSKADEHGPAPGRAALAPFKLDLD 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1625498531 170 paiaaegQPQPLNQPLAPPQPEVQQSSEPqPNLTHSSLPPSTDAVAQPpleQTHQPVAASSTEPQPQAMEVT 241
Cdd:PHA03418  130 -------QDPLHGDPDPPPGATGGQGEEP-PEGGEESQPPLGEGEGAV---EGHPPPLPPAPEPKPHNGDAT 190
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 141-310 5.84e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 40.10  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 141 PAPVTQSETSAAP--VEPSTEAPSAESLDVKPAIAAEGQPQPLNQPLAPPQPEVQQSSEPQPnlthsslppstdavaqpp 218
Cdd:PHA03269   25 NIPIPELHTSAATqkPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAP------------------ 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 219 leqthQPVAASSTEPQPQAMEVTAQSQA-QPAdaqgeeVAPyqqagKSNPQEHhavkaePEQTDEGVNGESvkvetpQQP 297
Cdd:PHA03269   87 -----APHQAASRAPDPAVAPQLAAAPKpDAA------EAF-----TSAAQAH------EAPADAGTSAAS------KKP 138

                         170
                  ....*....|...
gi 1625498531 298 YEAYQVEHQPQPF 310
Cdd:PHA03269  139 DPAAHTQHSPPPF 151
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 405-480 7.86e-03

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 36.93  E-value: 7.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1625498531 405 PHYPEVISEPSDLgsvdRRVQKTIKAEEggYHNFNDWEADVRRIFRNTEWFNGVEHPVSKMGKQVEESFDKQLKKM 480
Cdd:cd05524    39 PEYYEVVSNPIDL----LKIQQKLKTEE--YDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSARNEV 108
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 125-345 8.38e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 8.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 125 QPSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLnqPLAPPQPEVQQSSE------- 197
Cdd:NF033839  256 EIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKP--EPETPKPEVKPQLEkpkpevk 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 198 PQPNLTHSSLPPSTDAVAQPPLEQTHQPVAASSTEPQPQAMEVTAQSQAQPADAQGEEVAPYQQAGKSNPQEHHAVKAEP 277
Cdd:NF033839  334 PQPEKPKPEVKPQLETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQP 413

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1625498531 278 EQTDEGVNGESVKVETPQQPY-EAYQVEHQPQP-FDAPGVVAHDAHDYPDGEDTSSAP-PIVPPTPAGTEP 345
Cdd:NF033839  414 EKPKPEVKPQPEKPKPEVKPQpEKPKPEVKPQPeKPKPEVKPQPETPKPEVKPQPEKPkPEVKPQPEKPKP 484
PHA03247 PHA03247
large tegument protein UL36; Provisional
 90-180 8.49e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 8.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531   90 NQSTQPTPIPQDPPTPQPAAMATPTDIPADTPqhfqpSQVPQTVKADSPALPAPVTQSETSAAPVEPSTEAPSAESLDvk 169
Cdd:PHA03247   403 DQTRPAAPVPASVPTPAPTPVPASAPPPPATP-----LPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKALD-- 475

                           90
                   ....*....|.
gi 1625498531  170 pAIAAEGQPQP 180
Cdd:PHA03247   476 -ALRERRPPEP 485
PRK11633 PRK11633
cell division protein DedD; Provisional
 127-237 9.27e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 38.83  E-value: 9.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531 127 SQVPQTVKADSPALP--------APVTQSETSAAPVEPSTEAPSAESLDVKPAIAAEGQPQPLNQPlaPPQPEVQQSSEP 198
Cdd:PRK11633   50 RDEPDMMPAATQALPtqppegaaEAVRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKP--KPKPKPQQKVEA 127

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1625498531 199 QPnlthsslppstdavaQPPLEQthQPVAASSTEPQPQA 237
Cdd:PRK11633  128 PP---------------APKPEP--KPVVEEKAAPTGKA 149
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 107-369 9.44e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 9.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  107 PAAMATPTDIPAD-----TPQHFQPSQVPQTVKADSPALPAPVTQSETsAAPVEPSTEAPSAESLDVKP---------AI 172
Cdd:PHA03307    22 PRPPATPGDAADDllsgsQGQLVSDSAELAAVTVVAGAAACDRFEPPT-GPPPGPGTEAPANESRSTPTwslstlapaSP 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  173 AAEGQPQPLNQ--PLAPPQPEVQQSSEPQPNLTHSSLPPSTDAVAQPPleqTHQPVAASSTEPQPQAMEVTAQSQAQPAD 250
Cdd:PHA03307   101 AREGSPTPPGPssPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPP---AASPPAAGASPAAVASDAASSRQAALPLS 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1625498531  251 AQGEEVAPyqqagKSNPQEHHAVKAEPEQTDEGVNGESVkvetpqqPYEAYQVEHQPQPFDAPGVVAHDAHDypdgEDTS 330
Cdd:PHA03307   178 SPEETARA-----PSSPPAEPPPSTPPAAASPRPPRRSS-------PISASASSPAPAPGRSAADDAGASSS----DSSS 241

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1625498531  331 SAPPIVPPTPAGTEPIILPNGSKLPPRSAAIGIPGGPSF 369
Cdd:PHA03307   242 SESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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