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Conserved domains on  [gi|1624818622|gb|QCF59131|]
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deoxyribonuclease [human gammaherpesvirus 4]

Protein Classification

YqaJ viral recombinase family protein( domain architecture ID 10484778)

YqaJ viral recombinase family protein similar to Escherichia virus Lambda exonuclease that facilitates phage DNA recombination through the double-strand break repair (DSBR) and single-strand annealing pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Viral_alk_exo pfam01771
Viral alkaline exonuclease; This family includes various alkaline exonucleases from members of ...
 9-462 0e+00

Viral alkaline exonuclease; This family includes various alkaline exonucleases from members of the Herpesviridae and Baculoviridae. Alkaline exonuclease appears to have an important role in the replication of herpes simplex virus.


:

Pssm-ID: 396366  Cd Length: 460  Bit Score: 682.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622   9 DPMEEMTSYTFARFLRSPETEAFVRNLDRPPQMPAMRYVYLYCLCKQIQEFSGETGFCDFVSSLVQENDS-QDGPSLKSI 87
Cdd:pfam01771   1 EQKTVLNSEPFSHFLKHPEVQQFESAAHRPVPMPALRHVYVYYLFKKIGDFIGETTVAALFSKEMQQNIAgKRLPELASV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622  88 YWGLQEATDEQRTVLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTIK--NGPTKVFEPAPISTNHYFGGPVAFGLRC 165
Cdd:pfam01771  81 YEACEKAPAVQQRRICLLIERETRGQSENPLWDLLRDGTISASKLYWAVKqqNPSKKIFEPWPITNNHYVASPVAFGLRC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 166 EDTVKDIVCKLICGDASANR-QFGFMISPTDGIFGVSLDLCVNV-ESQGDFILFTDRSCIYEIKCRFKYLFSKSEFDPIY 243
Cdd:pfam01771 161 EPVVKTLVAELVVTPDGEVVhDCGFLIDPTDGIFGASLDLCVNVsTGTDNPLPFKPDAEIYEIKCRFKYLFDKEECDPLY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 244 PSYTALYKRPCKRSFIRFINSIARPTVEYVPDGRLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDL--VADSLAANRGVES 321
Cdd:pfam01771 241 QAYTELYNRPTKAALIDFIYSIPKPAVEYVGPGRLPSEREYLLTYDQAWDLAPKRKRKLTPGHKLaaIADLLELNSTVES 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 322 MLYVMTDPSENAGRIGIKDRVPVNIFINPRHNYFYQVLLQYKIV-GDYVRHSGGgkPGRDCSPRVNIVTAFFRKRSPLDP 400
Cdd:pfam01771 321 EVIVFTDPSETKGTITIKARFKVPVFVNPRHAYFYQILLQYYVVsQYYIQLHPG--PEFLGTPKVFIVTAFFRKRNEEDP 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624818622 401 ATCTLGSDLLLDASVEIPVAVLVTPVVLPDSVIRKTLSTAAGSWKAYADNTFDTAPWVPSGL 462
Cdd:pfam01771 399 AACYLGGDGTLDPHVEIPVLLIVTPVYIPPEVTRETLSTAANFWSASAKETFDLPPWVPSAL 460
 
Name Accession Description Interval E-value
Viral_alk_exo pfam01771
Viral alkaline exonuclease; This family includes various alkaline exonucleases from members of ...
 9-462 0e+00

Viral alkaline exonuclease; This family includes various alkaline exonucleases from members of the Herpesviridae and Baculoviridae. Alkaline exonuclease appears to have an important role in the replication of herpes simplex virus.


Pssm-ID: 396366  Cd Length: 460  Bit Score: 682.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622   9 DPMEEMTSYTFARFLRSPETEAFVRNLDRPPQMPAMRYVYLYCLCKQIQEFSGETGFCDFVSSLVQENDS-QDGPSLKSI 87
Cdd:pfam01771   1 EQKTVLNSEPFSHFLKHPEVQQFESAAHRPVPMPALRHVYVYYLFKKIGDFIGETTVAALFSKEMQQNIAgKRLPELASV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622  88 YWGLQEATDEQRTVLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTIK--NGPTKVFEPAPISTNHYFGGPVAFGLRC 165
Cdd:pfam01771  81 YEACEKAPAVQQRRICLLIERETRGQSENPLWDLLRDGTISASKLYWAVKqqNPSKKIFEPWPITNNHYVASPVAFGLRC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 166 EDTVKDIVCKLICGDASANR-QFGFMISPTDGIFGVSLDLCVNV-ESQGDFILFTDRSCIYEIKCRFKYLFSKSEFDPIY 243
Cdd:pfam01771 161 EPVVKTLVAELVVTPDGEVVhDCGFLIDPTDGIFGASLDLCVNVsTGTDNPLPFKPDAEIYEIKCRFKYLFDKEECDPLY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 244 PSYTALYKRPCKRSFIRFINSIARPTVEYVPDGRLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDL--VADSLAANRGVES 321
Cdd:pfam01771 241 QAYTELYNRPTKAALIDFIYSIPKPAVEYVGPGRLPSEREYLLTYDQAWDLAPKRKRKLTPGHKLaaIADLLELNSTVES 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 322 MLYVMTDPSENAGRIGIKDRVPVNIFINPRHNYFYQVLLQYKIV-GDYVRHSGGgkPGRDCSPRVNIVTAFFRKRSPLDP 400
Cdd:pfam01771 321 EVIVFTDPSETKGTITIKARFKVPVFVNPRHAYFYQILLQYYVVsQYYIQLHPG--PEFLGTPKVFIVTAFFRKRNEEDP 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624818622 401 ATCTLGSDLLLDASVEIPVAVLVTPVVLPDSVIRKTLSTAAGSWKAYADNTFDTAPWVPSGL 462
Cdd:pfam01771 399 AACYLGGDGTLDPHVEIPVLLIVTPVYIPPEVTRETLSTAANFWSASAKETFDLPPWVPSAL 460
PHA03293 PHA03293
deoxyribonuclease; Provisional
 8-427 2.31e-43

deoxyribonuclease; Provisional


Pssm-ID: 223034  Cd Length: 523  Bit Score: 160.24  E-value: 2.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622   8 EDPMEEMTSYTFARFLRSpeteafvrnLDRPPQMPAM------RYVYLYCLCKQIQE--FSGETGFCDFVSSLVQENDSQ 79
Cdd:PHA03293   32 SALPPGVAAETFEDYLLG---------LLRGVDSPLDveplyhRLAYIRDLVKRLESegLVDGGLASHLLGLERPALFTS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622  80 DGPSLKSIYWGLQEATDEQRtvLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTiKNGPtkVFEPAPISTNHYFGG-- 157
Cdd:PHA03293  103 GTNTPAEELSSNLPAADARD--ILLFVEAATRNQAECDLWALLRRGLLTASTLKWG-ANGP--CFPPQWCKVNTGARGip 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 158 ---PVAFGLRCEDTVKDIVCKLiC--------GDASANRQF-----------------GFMISPTDGIFGVSLDlcvnve 209
Cdd:PHA03293  178 qsaAVAFGRTNEPLARALIEAY-CvgpstddgGTDPDDGEFfvfdepvgsppeeayacGLLIDARTGMVGASLD------ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 210 sqgdfILFTDRSC--------------IYEIKCRFKYLFSKSEFDPIYPSYTALYKRPCKRSFIRFINSIARPTVEYVPD 275
Cdd:PHA03293  251 -----MLVCDRDPhgvlaphptqttleFFEIKCRAKYAFPPDDGSPLSQAYERLLARRTAAALRAFLRSIRNPGVEYFAP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 276 GRLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDLVADSLAANRGVESMLYVMTDPSENAGRIGIKD--------RVPvnIF 347
Cdd:PHA03293  326 DRVPGAAEALITCDDAWKPGRAAGEARIRCSAFDRRHLALNRNVSSRVWLFGEPDLETNTITPAAwdtgelalEVP--IF 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 348 INPRHNYFYQVLLQYKIVGDYVrhsgggkPgrDCSPRVNIVTAFFRKRSPL----------DPATCTLGSDLLLDASVEI 417
Cdd:PHA03293  404 ANPRHPNFKQILVQAYVLSGYF-------P--DRPLRPHLVTFIGRHRRPCeegrtfrledGPGALYAALKCSIPPEQAI 474

                         490
                  ....*....|
gi 1624818622 418 PVAVLVTPVV 427
Cdd:PHA03293  475 PVLLIITPVI 484
 
Name Accession Description Interval E-value
Viral_alk_exo pfam01771
Viral alkaline exonuclease; This family includes various alkaline exonucleases from members of ...
 9-462 0e+00

Viral alkaline exonuclease; This family includes various alkaline exonucleases from members of the Herpesviridae and Baculoviridae. Alkaline exonuclease appears to have an important role in the replication of herpes simplex virus.


Pssm-ID: 396366  Cd Length: 460  Bit Score: 682.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622   9 DPMEEMTSYTFARFLRSPETEAFVRNLDRPPQMPAMRYVYLYCLCKQIQEFSGETGFCDFVSSLVQENDS-QDGPSLKSI 87
Cdd:pfam01771   1 EQKTVLNSEPFSHFLKHPEVQQFESAAHRPVPMPALRHVYVYYLFKKIGDFIGETTVAALFSKEMQQNIAgKRLPELASV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622  88 YWGLQEATDEQRTVLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTIK--NGPTKVFEPAPISTNHYFGGPVAFGLRC 165
Cdd:pfam01771  81 YEACEKAPAVQQRRICLLIERETRGQSENPLWDLLRDGTISASKLYWAVKqqNPSKKIFEPWPITNNHYVASPVAFGLRC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 166 EDTVKDIVCKLICGDASANR-QFGFMISPTDGIFGVSLDLCVNV-ESQGDFILFTDRSCIYEIKCRFKYLFSKSEFDPIY 243
Cdd:pfam01771 161 EPVVKTLVAELVVTPDGEVVhDCGFLIDPTDGIFGASLDLCVNVsTGTDNPLPFKPDAEIYEIKCRFKYLFDKEECDPLY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 244 PSYTALYKRPCKRSFIRFINSIARPTVEYVPDGRLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDL--VADSLAANRGVES 321
Cdd:pfam01771 241 QAYTELYNRPTKAALIDFIYSIPKPAVEYVGPGRLPSEREYLLTYDQAWDLAPKRKRKLTPGHKLaaIADLLELNSTVES 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 322 MLYVMTDPSENAGRIGIKDRVPVNIFINPRHNYFYQVLLQYKIV-GDYVRHSGGgkPGRDCSPRVNIVTAFFRKRSPLDP 400
Cdd:pfam01771 321 EVIVFTDPSETKGTITIKARFKVPVFVNPRHAYFYQILLQYYVVsQYYIQLHPG--PEFLGTPKVFIVTAFFRKRNEEDP 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624818622 401 ATCTLGSDLLLDASVEIPVAVLVTPVVLPDSVIRKTLSTAAGSWKAYADNTFDTAPWVPSGL 462
Cdd:pfam01771 399 AACYLGGDGTLDPHVEIPVLLIVTPVYIPPEVTRETLSTAANFWSASAKETFDLPPWVPSAL 460
PHA03293 PHA03293
deoxyribonuclease; Provisional
 8-427 2.31e-43

deoxyribonuclease; Provisional


Pssm-ID: 223034  Cd Length: 523  Bit Score: 160.24  E-value: 2.31e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622   8 EDPMEEMTSYTFARFLRSpeteafvrnLDRPPQMPAM------RYVYLYCLCKQIQE--FSGETGFCDFVSSLVQENDSQ 79
Cdd:PHA03293   32 SALPPGVAAETFEDYLLG---------LLRGVDSPLDveplyhRLAYIRDLVKRLESegLVDGGLASHLLGLERPALFTS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622  80 DGPSLKSIYWGLQEATDEQRtvLCSYVESMTRGQSENLMWDILRNGIISSSKLLSTiKNGPtkVFEPAPISTNHYFGG-- 157
Cdd:PHA03293  103 GTNTPAEELSSNLPAADARD--ILLFVEAATRNQAECDLWALLRRGLLTASTLKWG-ANGP--CFPPQWCKVNTGARGip 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 158 ---PVAFGLRCEDTVKDIVCKLiC--------GDASANRQF-----------------GFMISPTDGIFGVSLDlcvnve 209
Cdd:PHA03293  178 qsaAVAFGRTNEPLARALIEAY-CvgpstddgGTDPDDGEFfvfdepvgsppeeayacGLLIDARTGMVGASLD------ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 210 sqgdfILFTDRSC--------------IYEIKCRFKYLFSKSEFDPIYPSYTALYKRPCKRSFIRFINSIARPTVEYVPD 275
Cdd:PHA03293  251 -----MLVCDRDPhgvlaphptqttleFFEIKCRAKYAFPPDDGSPLSQAYERLLARRTAAALRAFLRSIRNPGVEYFAP 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 276 GRLPSEGDYLLTQDEAWNLKDVRKRKLGPGHDLVADSLAANRGVESMLYVMTDPSENAGRIGIKD--------RVPvnIF 347
Cdd:PHA03293  326 DRVPGAAEALITCDDAWKPGRAAGEARIRCSAFDRRHLALNRNVSSRVWLFGEPDLETNTITPAAwdtgelalEVP--IF 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624818622 348 INPRHNYFYQVLLQYKIVGDYVrhsgggkPgrDCSPRVNIVTAFFRKRSPL----------DPATCTLGSDLLLDASVEI 417
Cdd:PHA03293  404 ANPRHPNFKQILVQAYVLSGYF-------P--DRPLRPHLVTFIGRHRRPCeegrtfrledGPGALYAALKCSIPPEQAI 474

                         490
                  ....*....|
gi 1624818622 418 PVAVLVTPVV 427
Cdd:PHA03293  475 PVLLIITPVI 484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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