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Conserved domains on  [gi|162462297|ref|NP_001104815|]
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doublesex isoform M [Bombyx mori]

Protein Classification

DM and DSX_dimer domain-containing protein( domain architecture ID 10465243)

DM and DSX_dimer domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DSX_dimer super family cl07436
Doublesex dimerization domain; Doublesex (DSX) is a transcription factor that regulates ...
 169-216 4.32e-22

Doublesex dimerization domain; Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila. The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor.


The actual alignment was detected with superfamily member pfam08828:

Pssm-ID: 462612  Cd Length: 49  Bit Score: 86.31  E-value: 4.32e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 162462297  169 VPSETLVENCHRLLEKFHYSWEMMPLVLVIMNYARSDLDEASRKIYEG 216
Cdd:pfam08828   1 LGVDVLLEYCQKLLEKFQYPWEMMPLMYVILKDADADLEEASRRIDEG 48
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 32-77 5.87e-21

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


:

Pssm-ID: 459924  Cd Length: 47  Bit Score: 83.10  E-value: 5.87e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 162462297   32 PPNCARCRNHRLKIELKGHKRYCKYQHCTCEKCRLTADRQRVMAKQ 77
Cdd:pfam00751   2 SPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
 
Name Accession Description Interval E-value
DSX_dimer pfam08828
Doublesex dimerization domain; Doublesex (DSX) is a transcription factor that regulates ...
 169-216 4.32e-22

Doublesex dimerization domain; Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila. The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor.


Pssm-ID: 462612  Cd Length: 49  Bit Score: 86.31  E-value: 4.32e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 162462297  169 VPSETLVENCHRLLEKFHYSWEMMPLVLVIMNYARSDLDEASRKIYEG 216
Cdd:pfam08828   1 LGVDVLLEYCQKLLEKFQYPWEMMPLMYVILKDADADLEEASRRIDEG 48
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 32-77 5.87e-21

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 83.10  E-value: 5.87e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 162462297   32 PPNCARCRNHRLKIELKGHKRYCKYQHCTCEKCRLTADRQRVMAKQ 77
Cdd:pfam00751   2 SPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
32-84 5.02e-17

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 72.78  E-value: 5.02e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 162462297    32 PPNCARCRNHRLKIELKGHKRYCKYQHCTCEKCRLTADRQRVMAKQTAIRRAQ 84
Cdd:smart00301   2 IPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQIKLKREQ 54
 
Name Accession Description Interval E-value
DSX_dimer pfam08828
Doublesex dimerization domain; Doublesex (DSX) is a transcription factor that regulates ...
 169-216 4.32e-22

Doublesex dimerization domain; Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila. The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor.


Pssm-ID: 462612  Cd Length: 49  Bit Score: 86.31  E-value: 4.32e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 162462297  169 VPSETLVENCHRLLEKFHYSWEMMPLVLVIMNYARSDLDEASRKIYEG 216
Cdd:pfam08828   1 LGVDVLLEYCQKLLEKFQYPWEMMPLMYVILKDADADLEEASRRIDEG 48
DM pfam00751
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ...
 32-77 5.87e-21

DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA.


Pssm-ID: 459924  Cd Length: 47  Bit Score: 83.10  E-value: 5.87e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 162462297   32 PPNCARCRNHRLKIELKGHKRYCKYQHCTCEKCRLTADRQRVMAKQ 77
Cdd:pfam00751   2 SPKCARCRNHGVRVPLKGHKRYCPYRDCSCPKCLLVAERQRVMAAQ 47
DM smart00301
Doublesex DNA-binding motif;
32-84 5.02e-17

Doublesex DNA-binding motif;


Pssm-ID: 214606  Cd Length: 54  Bit Score: 72.78  E-value: 5.02e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 162462297    32 PPNCARCRNHRLKIELKGHKRYCKYQHCTCEKCRLTADRQRVMAKQTAIRRAQ 84
Cdd:smart00301   2 IPYCQKCENHGVKVPLKGHKPECPFRDCECEKCTLVEKRRALMALQIKLKREQ 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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