NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1624387452|ref|XP_028818108|]
View 

LOW QUALITY PROTEIN: platelet glycoprotein V-like [Denticeps clupeoides]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-526 1.24e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 1.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 100 IKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFRSLGSLRFLNLGRNll 179
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 180 arlppALFHPLARLQHLMIYSNRLQTLEAgAFDGLAELRELKLHSNRI*EPPPRLFFFTpELSTLTLSSNALQNVPErTF 259
Cdd:COG4886   107 -----EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPE-EL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 260 YHLPDITKLTLFKNPLLFLPDQLvGHMPKLKELYLYGTKLTTVPWNLfANMTGLESLNLHLNsELRDLPRdlFCCQPNLQ 339
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN-QLTDLPE--LGNLTNLE 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 340 KLSLRYNNLENLHPQLf*hltnlqvlllnnnrlralpehifyNLSNLQSIQLHENRLRSLpaNIFTLKMNNRSALQNVTL 419
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLL 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 420 GGNPWDCTCSTAGMLDWIRDHENHILDDPTCQEPFELQNISVASVRHVPCPTSPAVRVTTSQGSVATPVHNPTSVTSSPH 499
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                         410       420
                  ....*....|....*....|....*..
gi 1624387452 500 WTTSTLAAISNHSPDTPTAHTSSSAFS 526
Cdd:COG4886   386 LLTLLLLLLTTTAGVLLLTLALLDAVN 412
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-526 1.24e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 1.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 100 IKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFRSLGSLRFLNLGRNll 179
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 180 arlppALFHPLARLQHLMIYSNRLQTLEAgAFDGLAELRELKLHSNRI*EPPPRLFFFTpELSTLTLSSNALQNVPErTF 259
Cdd:COG4886   107 -----EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPE-EL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 260 YHLPDITKLTLFKNPLLFLPDQLvGHMPKLKELYLYGTKLTTVPWNLfANMTGLESLNLHLNsELRDLPRdlFCCQPNLQ 339
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN-QLTDLPE--LGNLTNLE 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 340 KLSLRYNNLENLHPQLf*hltnlqvlllnnnrlralpehifyNLSNLQSIQLHENRLRSLpaNIFTLKMNNRSALQNVTL 419
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLL 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 420 GGNPWDCTCSTAGMLDWIRDHENHILDDPTCQEPFELQNISVASVRHVPCPTSPAVRVTTSQGSVATPVHNPTSVTSSPH 499
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                         410       420
                  ....*....|....*....|....*..
gi 1624387452 500 WTTSTLAAISNHSPDTPTAHTSSSAFS 526
Cdd:COG4886   386 LLTLLLLLLTTTAGVLLLTLALLDAVN 412
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
95-315 2.00e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.13  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  95 QQLRSIKLSENNLSSLPSPVFMGLsllEELHLDGNQITSIDRMLFEglvNLTELDVSRNSVTYLDAdvfRSLGSLRFLNL 174
Cdd:PRK15370  199 EQITTLILDNNELKSLPENLQGNI---KTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE---RLPSALQSLDL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 175 GRNLLARLPPALfhPlARLQHLMIYSNRLQTLEAGAFDGLAELrelKLHSNRI*EPPPRLfffTPELSTLTLSSNALQNV 254
Cdd:PRK15370  270 FHNKISCLPENL--P-EELRYLSVYDNSIRTLPAHLPSGITHL---NVQSNSLTALPETL---PPGLKTLEAGENALTSL 340

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1624387452 255 PERTfyhLPDITKLTLFKNPLLFLPDQLVghmPKLKELYLYGTKLTTVPWNLFANMTGLES 315
Cdd:PRK15370  341 PASL---PPELQVLDVSKNQITVLPETLP---PTITTLDVSRNALTNLPENLPAALQIMQA 395
LRR_8 pfam13855
Leucine rich repeat;
121-179 1.80e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.80e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1624387452 121 LEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFRSLGSLRFLNLGRNLL 179
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-292 6.39e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 6.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  78 VTH-----SGLDALHpqAFGQSQQLRSIKLSENNLSSLPSpvFMGLSLLEELHLDGNQITSIDRmlFEGLVNLTELDVSR 152
Cdd:cd21340     4 ITHlylndKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 153 NSVTYLDAdvFRSLGSLRFLNLGRNllaRLP--------PALFHPLAR-LQHLMIYSNRLQTLEagafdGLAELRELKlh 223
Cdd:cd21340    78 NRISVVEG--LENLTNLEELHIENQ---RLPpgekltfdPRSLAALSNsLRVLNISGNNIDSLE-----PLAPLRNLE-- 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 224 snri*eppprlffftpelsTLTLSSNALQNVPE--RTFYHLPDITKLTLFKNPLLFLP---DQLVGHMPKLKEL 292
Cdd:cd21340   146 -------------------QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPkyrDKIILASKSLEVL 200
LRRCT smart00082
Leucine rich repeat C-terminal domain;
422-453 2.73e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 2.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1624387452  422 NPWDCTCSTAGMLDWIRDHEnHILD--DPTCQEP 453
Cdd:smart00082   1 NPFICDCELRWLLRWLQANE-HLQDpvDLRCASP 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-526 1.24e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 1.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 100 IKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFRSLGSLRFLNLGRNll 179
Cdd:COG4886    29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 180 arlppALFHPLARLQHLMIYSNRLQTLEAgAFDGLAELRELKLHSNRI*EPPPRLFFFTpELSTLTLSSNALQNVPErTF 259
Cdd:COG4886   107 -----EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPE-EL 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 260 YHLPDITKLTLFKNPLLFLPDQLvGHMPKLKELYLYGTKLTTVPWNLfANMTGLESLNLHLNsELRDLPRdlFCCQPNLQ 339
Cdd:COG4886   179 GNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN-QLTDLPE--LGNLTNLE 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 340 KLSLRYNNLENLHPQLf*hltnlqvlllnnnrlralpehifyNLSNLQSIQLHENRLRSLpaNIFTLKMNNRSALQNVTL 419
Cdd:COG4886   254 ELDLSNNQLTDLPPLA--------------------------NLTNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLL 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 420 GGNPWDCTCSTAGMLDWIRDHENHILDDPTCQEPFELQNISVASVRHVPCPTSPAVRVTTSQGSVATPVHNPTSVTSSPH 499
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                         410       420
                  ....*....|....*....|....*..
gi 1624387452 500 WTTSTLAAISNHSPDTPTAHTSSSAFS 526
Cdd:COG4886   386 LLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-419 1.09e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.86  E-value: 1.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  49 TYHLILHATHVRALGKDELARLPLITRFAVTHSGLDALHPQAFGQSQQLRSIKLSENNLsslpspvFMGLSLLEELHLDG 128
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 129 NQITSIDRMLfEGLVNLTELDVSRNSVTYLDADvFRSLGSLRFLNLGRNLLARLPPALFhPLARLQHLMIYSNRLQTLEA 208
Cdd:COG4886   123 NQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 209 gAFDGLAELRELKLHSNRI*EPPPRLFFFTpELSTLTLSSNALQNVPErtFYHLPDITKLTLFKNPLLFLPDQlvGHMPK 288
Cdd:COG4886   200 -PLGNLTNLEELDLSGNQLTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTN 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 289 LKELYLYGTKLTTVPWNLFANMTGLESL--NLHLNSELRDLPRDLFCCQPNLQKLSLRYN-NLENLHPQLF*HLTNLQVL 365
Cdd:COG4886   274 LKTLDLSNNQLTDLKLKELELLLGLNSLllLLLLLNLLELLILLLLLTTLLLLLLLLKGLlVTLTTLALSLSLLALLTLL 353

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 366 LLNNNRLRALPEHIFYNLSNLQSIQLHENRLRSLPANIFTLKMNNRSALQNVTL 419
Cdd:COG4886   354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLAL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-423 1.59e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  97 LRSIKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFR-SLGSLRFLNLG 175
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLlSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 176 RNLLARLPPALFHPLARLQHLMIYSNRlqtleagAFDGLAELRELKLHSNRI*EPPPRLFFFTpELSTLTLSSNALQNVP 255
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTDLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 256 ErTFYHLPDITKLTLFKNPLLFLPDQLvGHMPKLKELYLYGTKLTTVPWNLfANMTGLESLNLHlNSELRDLPRDLFCCq 335
Cdd:COG4886   153 E-PLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLS-GNQLTDLPEPLANL- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 336 PNLQKLSLRYNNLenlhpqlf*hltnlqvlllnnnrlRALPEhiFYNLSNLQSIQLHENRLRSLPaniFTLKMNNrsaLQ 415
Cdd:COG4886   228 TNLETLDLSNNQL------------------------TDLPE--LGNLTNLEELDLSNNQLTDLP---PLANLTN---LK 275


                  ....*...
gi 1624387452 416 NVTLGGNP 423
Cdd:COG4886   276 TLDLSNNQ 283
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
95-315 2.00e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.13  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  95 QQLRSIKLSENNLSSLPSPVFMGLsllEELHLDGNQITSIDRMLFEglvNLTELDVSRNSVTYLDAdvfRSLGSLRFLNL 174
Cdd:PRK15370  199 EQITTLILDNNELKSLPENLQGNI---KTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE---RLPSALQSLDL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 175 GRNLLARLPPALfhPlARLQHLMIYSNRLQTLEAGAFDGLAELrelKLHSNRI*EPPPRLfffTPELSTLTLSSNALQNV 254
Cdd:PRK15370  270 FHNKISCLPENL--P-EELRYLSVYDNSIRTLPAHLPSGITHL---NVQSNSLTALPETL---PPGLKTLEAGENALTSL 340

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1624387452 255 PERTfyhLPDITKLTLFKNPLLFLPDQLVghmPKLKELYLYGTKLTTVPWNLFANMTGLES 315
Cdd:PRK15370  341 PASL---PPELQVLDVSKNQITVLPETLP---PTITTLDVSRNALTNLPENLPAALQIMQA 395
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-354 4.66e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 4.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  69 RLPLITRFAVTHSGLDALHPQA-FGQSQQLRSIKLSENNLS-SLPSPvfmGLSLLEELHLDGNQIT----------SIDR 136
Cdd:PLN00113   91 RLPYIQTINLSNNQLSGPIPDDiFTTSSSLRYLNLSNNNFTgSIPRG---SIPNLETLDLSNNMLSgeipndigsfSSLK 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 137 MLFEG-----------LVNLTELDVSRNSVTYLDADVFRSLG---SLRFLNLGRNLLARLPPALFHPLARLQHLMIYSNR 202
Cdd:PLN00113  168 VLDLGgnvlvgkipnsLTNLTSLEFLTLASNQLVGQIPRELGqmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNN 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 203 LQTLEAGAFDGLAELRELKLHSNRI*EPPPRLFFFTPELSTLTLSSNALQ-NVPErTFYHLPDITKLTLFKNPLLFLPDQ 281
Cdd:PLN00113  248 LTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE-LVIQLQNLEILHLFSNNFTGKIPV 326

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 282 LVGHMPKLKELYLYGTKLT-TVPWNLfANMTGLESLNLHLNSELRDLPRDLfCCQPNLQKLSLRYNNLENLHPQ 354
Cdd:PLN00113  327 ALTSLPRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGEIPEGL-CSSGNLFKLILFSNSLEGEIPK 398
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-332 5.00e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 68.96  E-value: 5.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  41 IPSPMPVHTYHLILHathvralgKDELARLPlitrfavthsglDALHpqafgqsQQLRSIKLSENNLSSLPSPVfmgLSL 120
Cdd:PRK15370  193 IPACIPEQITTLILD--------NNELKSLP------------ENLQ-------GNIKTLYANSNQLTSIPATL---PDT 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 121 LEELHLDGNQITSIDRMLFEGLvnlTELDVSRNSVTYLDADVFRSLgslRFLNLGRNLLARLPPalfHPLARLQHLMIYS 200
Cdd:PRK15370  243 IQEMELSINRITELPERLPSAL---QSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTLPA---HLPSGITHLNVQS 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 201 NRL-----------QTLEAG--AFDGLAE-----LRELKLHSNRI*EPPPRLfffTPELSTLTLSSNALQNVPErtfyHL 262
Cdd:PRK15370  314 NSLtalpetlppglKTLEAGenALTSLPAslppeLQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPE----NL 386

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 263 PDITK-LTLFKNPLLFLPDQL---VGHMPKLKELylygtkltTVPWNLFANMTgLESLNLHLNSELRDLPRDLF 332
Cdd:PRK15370  387 PAALQiMQASRNNLVRLPESLphfRGEGPQPTRI--------IVEYNPFSERT-IQNMQRLMSSVGYQGPRVLF 451
LRR_8 pfam13855
Leucine rich repeat;
121-179 1.80e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 1.80e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1624387452 121 LEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFRSLGSLRFLNLGRNLL 179
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-356 2.50e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.71  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  95 QQLRSIKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSidrMLFEGLVNLTELDVSRNSVTYLDADVFRSLG---SLRF 171
Cdd:PLN00113  284 QKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG---KIPVALTSLPRLQVLQLWSNKFSGEIPKNLGkhnNLTV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 172 LNLGRN-LLARLPPALFHPlARLQHLMIYSNRLQTLEAGAFDGLAELRELKLHSNRI*EPPPRLFFFTPELSTLTLSSNA 250
Cdd:PLN00113  361 LDLSTNnLTGEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNN 439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 251 LQNVPERTFYHLPDITKLTLFKNPLLF-LPDQLvgHMPKLKELYLYGTKLTTVPWNLFANMTGLESLNLHLNSELRDLPR 329
Cdd:PLN00113  440 LQGRINSRKWDMPSLQMLSLARNKFFGgLPDSF--GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPD 517

                         250       260
                  ....*....|....*....|....*..
gi 1624387452 330 DLFCCQpNLQKLSLRYNNLENLHPQLF 356
Cdd:PLN00113  518 ELSSCK-KLVSLDLSHNQLSGQIPASF 543
LRR_8 pfam13855
Leucine rich repeat;
168-227 2.54e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.54e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 168 SLRFLNLGRNLLARLPPALFHPLARLQHLMIYSNRLQTLEAGAFDGLAELRELKLHSNRI 227
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
144-403 5.62e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 62.41  E-value: 5.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 144 NLTELDVSRNSVTYLDADVFRSLGSLRflnLGRNLLARLPPALFhplARLQHLMIYSNRLQTLEAGAFDglaELRELKLH 223
Cdd:PRK15370  179 NKTELRLKILGLTTIPACIPEQITTLI---LDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATLPD---TIQEMELS 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 224 SNRI*EPPPRLfffTPELSTLTLSSNALQNVPErtfyHLPD-ITKLTLFKNPLLFLPDqlvgHMPK-LKELYLYGTKLTT 301
Cdd:PRK15370  250 INRITELPERL---PSALQSLDLFHNKISCLPE----NLPEeLRYLSVYDNSIRTLPA----HLPSgITHLNVQSNSLTA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 302 VPWNLFANMTGLESLNLHLNSELRDLPrdlfccqPNLQKLSLRYNNLenlhpqlf*hltnlqvlllnnnrlRALPEHIfy 381
Cdd:PRK15370  319 LPETLPPGLKTLEAGENALTSLPASLP-------PELQVLDVSKNQI------------------------TVLPETL-- 365

                         250       260
                  ....*....|....*....|..
gi 1624387452 382 nLSNLQSIQLHENRLRSLPANI 403
Cdd:PRK15370  366 -PPTITTLDVSRNALTNLPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-292 6.39e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 6.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  78 VTH-----SGLDALHpqAFGQSQQLRSIKLSENNLSSLPSpvFMGLSLLEELHLDGNQITSIDRmlFEGLVNLTELDVSR 152
Cdd:cd21340     4 ITHlylndKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 153 NSVTYLDAdvFRSLGSLRFLNLGRNllaRLP--------PALFHPLAR-LQHLMIYSNRLQTLEagafdGLAELRELKlh 223
Cdd:cd21340    78 NRISVVEG--LENLTNLEELHIENQ---RLPpgekltfdPRSLAALSNsLRVLNISGNNIDSLE-----PLAPLRNLE-- 145

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 224 snri*eppprlffftpelsTLTLSSNALQNVPE--RTFYHLPDITKLTLFKNPLLFLP---DQLVGHMPKLKEL 292
Cdd:cd21340   146 -------------------QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPkyrDKIILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
95-153 5.08e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1624387452  95 QQLRSIKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRN 153
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-317 1.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.95  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 100 IKLSENNLSSLPspvfmGLSL---LEELHLDGNQITSIDRmlFEGLVNLTELDVSRNSVTYLDadvfrslgslrflnlgr 176
Cdd:cd21340     7 LYLNDKNITKID-----NLSLcknLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE----------------- 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 177 NLlarlppalfHPLARLQHLMIYSNRLQTLEAgaFDGLAELRELKLHSNRI*ePPPRLFFFTPE--------LSTLTLSS 248
Cdd:cd21340    63 NL---------ENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL--PPGEKLTFDPRslaalsnsLRVLNISG 129

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 249 NALQNVpeRTFYHLPDITKLTLFKNPLLFLPD--QLVGHMPKLKELYLYGTKLTTVPW---NLFANMTGLESLN 317
Cdd:cd21340   130 NNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKyrdKIILASKSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
144-203 1.69e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 1.69e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 144 NLTELDVSRNSVTYLDADVFRSLGSLRFLNLGRNLLARLPPALFHPLARLQHLMIYSNRL 203
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
71-131 2.29e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.99  E-value: 2.29e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1624387452  71 PLITRFAVTHSGLDALHPQAFGQSQQLRSIKLSENNLSSLPSPVFMGLSLLEELHLDGNQI 131
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-356 3.71e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 3.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  88 PQAFGQSQQLRSIKLSENNLSSLPSPVFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYLDADVFRSLG 167
Cdd:PLN00113  205 PRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQ 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 168 SLRFLNLGRNLLARLPPALFHPLARLQHLMIYSNRLQTLEAGAFDGLAELRELKLHSNRI*EPPPRLFFFTPELSTLTLS 247
Cdd:PLN00113  285 KLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLS 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 248 SNALQNVPERTFYHLPDITKLTLFKNpllflpdQLVGHMPK------------LKELYLYG------TKLTTVPW----- 304
Cdd:PLN00113  365 TNNLTGEIPEGLCSSGNLFKLILFSN-------SLEGEIPKslgacrslrrvrLQDNSFSGelpsefTKLPLVYFldisn 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 305 -NLFAN-------MTGLESLNLHLNSELRDLPrDLFCCQpNLQKLSLRYNNLENLHPQLF 356
Cdd:PLN00113  438 nNLQGRinsrkwdMPSLQMLSLARNKFFGGLP-DSFGSK-RLENLDLSRNQFSGAVPRKL 495
LRR_8 pfam13855
Leucine rich repeat;
287-348 5.65e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1624387452 287 PKLKELYLYGTKLTTVPWNLFANMTGLESLNLHLNSeLRDLPRDLFCCQPNLQKLSLRYNNL 348
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-LTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
192-251 5.82e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 5.82e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 192 RLQHLMIYSNRLQTLEAGAFDGLAELRELKLHSNRI*EPPPRLFFFTPELSTLTLSSNAL 251
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-188 1.47e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  37 SIADIPSPMPVHTYHLILHATHVRALGkdelARLPL-ITRFAVTHSGLDALhPQAFgqSQQLRSIKLSENNLSSLPSpvf 115
Cdd:PRK15370  273 KISCLPENLPEELRYLSVYDNSIRTLP----AHLPSgITHLNVQSNSLTAL-PETL--PPGLKTLEAGENALTSLPA--- 342

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1624387452 116 mglSL---LEELHLDGNQITSIDRMLFEglvNLTELDVSRNSVTYLDADVfrsLGSLRFLNLGRNLLARLPPALFH 188
Cdd:PRK15370  343 ---SLppeLQVLDVSKNQITVLPETLPP---TITTLDVSRNALTNLPENL---PAALQIMQASRNNLVRLPESLPH 409
LRR_8 pfam13855
Leucine rich repeat;
216-275 1.51e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.51e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 216 ELRELKLHSNRI*EPPPRLFFFTPELSTLTLSSNALQNVPERTFYHLPDITKLTLFKNPL 275
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
26-300 1.65e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.32  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  26 CNKNG-AVMCTGS--IADIPSPMPVHTYHLILhathvralGKDELARLPlitrfavthsgldALHPQafgqsqqLRSIKL 102
Cdd:PRK15387  198 CLNNGnAVLNVGEsgLTTLPDCLPAHITTLVI--------PDNNLTSLP-------------ALPPE-------LRTLEV 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 103 SENNLSSLP--SPVFMGLSLLE--------------ELHLDGNQITSIDrMLFEGlvnLTELDVSRNSVTYLDA------ 160
Cdd:PRK15387  250 SGNQLTSLPvlPPGLLELSIFSnplthlpalpsglcKLWIFGNQLTSLP-VLPPG---LQELSVSDNQLASLPAlpselc 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 161 ------DVFRSL----GSLRFLNLGRNLLARLPPAlfhpLARLQHLMIYSNRLQTLEAGAfdglAELRELKLHSNRI*EP 230
Cdd:PRK15387  326 klwaynNQLTSLptlpSGLQELSVSDNQLASLPTL----PSELYKLWAYNNRLTSLPALP----SGLKELIVSGNRLTSL 397

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1624387452 231 PprlfFFTPELSTLTLSSNALQNVPertfyHLPD-ITKLTLFKNPLLFLPDQLVgHMPKLKELYLYGTKLT 300
Cdd:PRK15387  398 P----VLPSELKELMVSGNRLTSLP-----MLPSgLLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLS 458
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-288 3.80e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  83 LDALHPQAFGQSQQLRSIKLSENNLSSLPSPVFMGLSLLEELHLDGNQIT-SIDRMLFEgLVNLTELDVSRNSVTYLDAD 161
Cdd:PLN00113  392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARNKFFGGLPD 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 162 VFRSlGSLRFLNLGRNLLARLPPAlfhplarlqhlmiysnrlqtleagAFDGLAELRELKLHSNRI*EPPPRLFFFTPEL 241
Cdd:PLN00113  471 SFGS-KRLENLDLSRNQFSGAVPR------------------------KLGSLSELMQLKLSENKLSGEIPDELSSCKKL 525

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1624387452 242 STLTLSSNALQNVPERTFYHLPDITKLTLFKNpllflpdQLVGHMPK 288
Cdd:PLN00113  526 VSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN-------QLSGEIPK 565
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
78-331 4.03e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.16  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  78 VTHSGLDALhPQAFgqSQQLRSIKLSENNLSSLPS-PvfmglSLLEELHLDGNQITSIDrMLFEGLVnltELDVSRNSVT 156
Cdd:PRK15387  208 VGESGLTTL-PDCL--PAHITTLVIPDNNLTSLPAlP-----PELRTLEVSGNQLTSLP-VLPPGLL---ELSIFSNPLT 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 157 YLDAdvfRSLGSLRFLNLGRNL--LARLPPALfhplarlQHLMIYSNRLQTLEAGAfdglAELRELKLHSNRI*EPPPrl 234
Cdd:PRK15387  276 HLPA---LPSGLCKLWIFGNQLtsLPVLPPGL-------QELSVSDNQLASLPALP----SELCKLWAYNNQLTSLPT-- 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 235 ffFTPELSTLTLSSNALQNVPErtfyhLP-DITKLTLFKNPLLFLPDQLVG------------HMP----KLKELYLYGT 297
Cdd:PRK15387  340 --LPSGLQELSVSDNQLASLPT-----LPsELYKLWAYNNRLTSLPALPSGlkelivsgnrltSLPvlpsELKELMVSGN 412

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1624387452 298 KLTTVPwnlfANMTGLESLNLHLNsELRDLPRDL 331
Cdd:PRK15387  413 RLTSLP----MLPSGLLSLSVYRN-QLTRLPESL 441
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 97-229 2.19e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.96  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  97 LRSIKLSENNLSSLP----SPVFMGLSLLEELHLDGNQIT-SIDRMLFEGL---VNLTELDVSRNSVTYLD----ADVFR 164
Cdd:cd00116   139 LEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGdAGIRALAEGLkanCNLEVLDLNNNGLTDEGasalAETLA 218

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1624387452 165 SLGSLRFLNLGRNLL-----ARLPPALFHPLARLQHLMIYSNRLQTLEAGAF-DGLAE---LRELKLHSNRI*E 229
Cdd:cd00116   219 SLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLaEVLAEkesLLELDLRGNKFGE 292
LRR_8 pfam13855
Leucine rich repeat;
239-299 6.10e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 6.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1624387452 239 PELSTLTLSSNALQNVPERTFYHLPDITKLTLFKNPLLFLPDQLVGHMPKLKELYLYGTKL 299
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
172-400 1.45e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 172 LNLGRNLLARLPPALfhpLARLQHLMIYSNRLQTLEAgafdglaelrelklhsnri*eppprlffFTPELSTLTLSSNAL 251
Cdd:PRK15387  206 LNVGESGLTTLPDCL---PAHITTLVIPDNNLTSLPA----------------------------LPPELRTLEVSGNQL 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 252 QNVPERTfyhlPDITKLTLFKNPLLFLPDQLVGhmpkLKELYLYGTKLTTVPW------------NLFANMTGLESLNLH 319
Cdd:PRK15387  255 TSLPVLP----PGLLELSIFSNPLTHLPALPSG----LCKLWIFGNQLTSLPVlppglqelsvsdNQLASLPALPSELCK 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 320 L---NSELRDLPrdlfCCQPNLQKLSLRYNNLENLhPQLF*HLTNLQVLLLNNNRLRALPehifynlSNLQSIQLHENRL 396
Cdd:PRK15387  327 LwayNNQLTSLP----TLPSGLQELSVSDNQLASL-PTLPSELYKLWAYNNRLTSLPALP-------SGLKELIVSGNRL 394


                  ....
gi 1624387452 397 RSLP 400
Cdd:PRK15387  395 TSLP 398
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 90-178 2.93e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 40.99  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  90 AFGQSQQLRSIKLSeNNLSSLPSPVFMGlSLLEELHLdGNQITSIDRMLFEGLVNLTELDVSrNSVTYLDADVFRSLgSL 169
Cdd:pfam13306  29 AFSNCTSLKSITLP-SSLTSIGSYAFYN-CSLTSITI-PSSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAFSNC-SL 103


                  ....*....
gi 1624387452 170 RFLNLGRNL 178
Cdd:pfam13306 104 KSITIPSSV 112
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 95-300 3.28e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  95 QQLRSIKLSENNLS----SLPSPVFMGLSLLEELHLDGNQITSIDRML------FEGLVNLTELDVSRNSVTYLDADVFR 164
Cdd:cd00116    23 LCLQVLRLEGNTLGeeaaKALASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDGCGVLE 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 165 SL---GSLRFLNLGRNLLARLP-----PALFHPLARLQHLMIYSNRL--QTLE--AGAFDGLAELRELKLHSNRI*EPPP 232
Cdd:cd00116   103 SLlrsSSLQELKLNNNGLGDRGlrllaKGLKDLPPALEKLVLGRNRLegASCEalAKALRANRDLKELNLANNGIGDAGI 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 233 RLFF----FTPELSTLTLSSNAL--QNVP--ERTFYHLPDITKLTLFKNPL-----LFLPDQLVGHMPKLKELYLYGTKL 299
Cdd:cd00116   183 RALAeglkANCNLEVLDLNNNGLtdEGASalAETLASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDI 262


                  .
gi 1624387452 300 T 300
Cdd:cd00116   263 T 263
LRR_9 pfam14580
Leucine-rich repeat;
96-196 7.07e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.90  E-value: 7.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452  96 QLRSIKLSENNLSSLPSpvFMGLSLLEELHLDGNQITSIDRMLFEGLVNLTELDVSRNSVTYL-DADVFRSLGSLRFLNL 174
Cdd:pfam14580  43 QFDTIDFSDNEIRKLDG--FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKKLTFLSL 120

                          90       100
                  ....*....|....*....|..
gi 1624387452 175 GRNLLARLPPALFHPLARLQHL 196
Cdd:pfam14580 121 LRNPVTNKPHYRLYVIYKVPQL 142
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
242-426 8.23e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 8.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 242 STLTLSSNALQNVPertfYHLPD-ITKLTLFKNPLLFLPDQLVGHmpkLKELYLYGTKLTTVPWNLFANMTGLE------ 314
Cdd:PRK15370  181 TELRLKILGLTTIP----ACIPEqITTLILDNNELKSLPENLQGN---IKTLYANSNQLTSIPATLPDTIQEMElsinri 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1624387452 315 -SLNLHLNSELRDLprDLFC----CQPN-----LQKLSLRYNNLenlhpqlf*hltnlqvlllnnnrlRALPEHIfynLS 384
Cdd:PRK15370  254 tELPERLPSALQSL--DLFHnkisCLPEnlpeeLRYLSVYDNSI------------------------RTLPAHL---PS 304

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1624387452 385 NLQSIQLHENRLRSLPAnifTLKMNnrsaLQNVTLGGNPWDC 426
Cdd:PRK15370  305 GITHLNVQSNSLTALPE---TLPPG----LKTLEAGENALTS 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-153 1.06e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1624387452 121 LEELHLDGNQITSIDrmLFEGLVNLTELDVSRN 153
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
422-453 2.73e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.25  E-value: 2.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1624387452  422 NPWDCTCSTAGMLDWIRDHEnHILD--DPTCQEP 453
Cdd:smart00082   1 NPFICDCELRWLLRWLQANE-HLQDpvDLRCASP 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 287-328 7.92e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1624387452 287 PKLKELYLYGTKLTTVPwnLFANMTGLESLNLHLNSELRDLP 328
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLS 40
LRR_8 pfam13855
Leucine rich repeat;
336-404 8.70e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 8.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1624387452 336 PNLQKLSLRYNNLENLHPqlf*hltnlqvlllnnnrlralpeHIFYNLSNLQSIQLHENRLRSLPANIF 404
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD------------------------GAFKGLSNLKVLDLSNNLLTTLSPGAF 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH