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Conserved domains on  [gi|1622943|gb|AAB68948|]
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MIP [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
24-759 4.87e-26

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 115.04  E-value: 4.87e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   24 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 89
Cdd:COG5215  16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   90 FIKSECSNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSD 166
Cdd:COG5215  94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APE 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  167 VLDRPLNIMIPKFLQFFKHSSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPE 230
Cdd:COG5215 169 DLIQMSNVILFAIVMGALKNETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  231 VRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 309
Cdd:COG5215 237 LQHAAFGCLNKIMMLYYKFMQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFAR 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  310 YSDIDII--LLKGDVEEDetiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLA 387
Cdd:COG5215 317 AAVADVLpeLLSLLEKQG---EDYYGD-------------------------------------DWNPSMAASSCLQLFA 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  388 NVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA 466
Cdd:COG5215 357 QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIA 436

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  467 -HWVVSQPPDTYLKPLMTELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKN 537
Cdd:COG5215 437 dHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNES 514

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  538 LL--ILYDAIGTL----ADSVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPV 608
Cdd:COG5215 515 NLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDV 594

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  609 YQRCVNLVQKTLAQAMLNNAQPDQYEApdkdfmivaldlLSGLAEGLGGNIELLVarSNILTLMYQCMQDKMPEVRQSSF 688
Cdd:COG5215 595 EDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAV 660

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  689 ALLGDLTKACFQHVKPCIADFM---------PILGTNLNPEFISVcnnatwaIGEISIQMGIEMQPYIPMVLHQLVEIIN 759
Cdd:COG5215 661 GLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
24-759 4.87e-26

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 115.04  E-value: 4.87e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   24 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 89
Cdd:COG5215  16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   90 FIKSECSNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSD 166
Cdd:COG5215  94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APE 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  167 VLDRPLNIMIPKFLQFFKHSSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPE 230
Cdd:COG5215 169 DLIQMSNVILFAIVMGALKNETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  231 VRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 309
Cdd:COG5215 237 LQHAAFGCLNKIMMLYYKFMQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFAR 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  310 YSDIDII--LLKGDVEEDetiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLA 387
Cdd:COG5215 317 AAVADVLpeLLSLLEKQG---EDYYGD-------------------------------------DWNPSMAASSCLQLFA 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  388 NVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA 466
Cdd:COG5215 357 QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIA 436

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  467 -HWVVSQPPDTYLKPLMTELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKN 537
Cdd:COG5215 437 dHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNES 514

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  538 LL--ILYDAIGTL----ADSVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPV 608
Cdd:COG5215 515 NLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDV 594

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  609 YQRCVNLVQKTLAQAMLNNAQPDQYEApdkdfmivaldlLSGLAEGLGGNIELLVarSNILTLMYQCMQDKMPEVRQSSF 688
Cdd:COG5215 595 EDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAV 660

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  689 ALLGDLTKACFQHVKPCIADFM---------PILGTNLNPEFISVcnnatwaIGEISIQMGIEMQPYIPMVLHQLVEIIN 759
Cdd:COG5215 661 GLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 411-465 3.25e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.78  E-value: 3.25e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622943    411 WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 465
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 34-101 3.67e-06

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 45.31  E-value: 3.67e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622943      34 QQKLEQLNQYPDFNNYLIFVLTKlkSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECSNNIGD 101
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
24-759 4.87e-26

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 115.04  E-value: 4.87e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   24 SPDTTIQRTVQQKLEQLnQYPDFNNY---LIFVLTKLKSEDEpTRSLSGLILKNNVKAH-----------FQNFPNGVTD 89
Cdd:COG5215  16 SPDPNARLRAEAQLLEL-QSGDFEQFislLVQVLCDLNSNDQ-LRMVAGLILKNSLHANdpelqkgcsqrWLGMRHESKE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   90 FIKSECSNNIGDSSPLIRATVGILITTIASKgELQN--WPDLLPKLCSLL-DSEDYNTCEGAFGALQKICEDSaeilDSD 166
Cdd:COG5215  94 QVKGMALRALKSPEPRFCTMAAQLLAAIARM-ELPNslWPGLMEEMVRNVgDEQPVSGKCESLGICGYHCESE----APE 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  167 VLDRPLNIMIPKFLQFFKHSSPKIRShavacvnqfiisRTQALMLHIDS--FIENLFALAGD--------------EEPE 230
Cdd:COG5215 169 DLIQMSNVILFAIVMGALKNETTSAV------------RLAALKALMDSlmFVQGNFCYEEErnyfmqvvceatqgNDEE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  231 VRKNVCRALVMLLEVRMDRLLPHMHN-IVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMK 309
Cdd:COG5215 237 LQHAAFGCLNKIMMLYYKFMQSYMENaLAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEVPAQNHGFAR 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  310 YSDIDII--LLKGDVEEDetiPDSEQDirprfhrsrtvaqqhdedgieeedddddeiddddtisDWNLRKCSAAALDVLA 387
Cdd:COG5215 317 AAVADVLpeLLSLLEKQG---EDYYGD-------------------------------------DWNPSMAASSCLQLFA 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  388 NVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEG-CMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYA 466
Cdd:COG5215 357 QLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIA 436

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  467 -HWVVSQPPDTYLKPLMTELLKRILDSNKRVqeAACS--------AFATLEEEACTELVPYLAYILDTLVFAFSKYQHKN 537
Cdd:COG5215 437 dHVAMIISPCGHLVLEVSASLIGLMDCPFRS--INCSwrkenlvdHIAKAVREVESFLAKFYLAILNALVKGTELALNES 514

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  538 LL--ILYDAIGTL----ADSVGHHL-NKPEYIQMLMPPLIQ-KWNMLKDEDKDLF-PLLECLSSVATALQSGFLPYCEPV 608
Cdd:COG5215 515 NLrvSLFSALGTLilicPDAVSDILaGFYDYTSKKLDECISvLGQILATEDQLLVeELQSNYIGVLEAIIRTRRRDIEDV 594

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  609 YQRCVNLVQKTLAQAMLNNAQPDQYEApdkdfmivaldlLSGLAEGLGGNIELLVarSNILTLMYQCMQDKMPEVRQSSF 688
Cdd:COG5215 595 EDQLMELFIRILESTKPTTAFGDVYTA------------ISALSTSLEERFEQYA--SKFIPYLTRALNCTDRFVLNSAV 660

                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  689 ALLGDLTKACFQHVKPCIADFM---------PILGTNLNPEFISVcnnatwaIGEISIQMGIEMQPYIPMVLHQLVEIIN 759
Cdd:COG5215 661 GLVGDLANTLGTDFNIYADVLMsslvqclssEATHRDLKPAILSV-------FGDIALAIGANFESYLDMIMMLFQQASE 733
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 411-465 3.25e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 67.78  E-value: 3.25e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622943    411 WVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRY 465
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
IBN_N pfam03810
Importin-beta N-terminal domain;
34-101 9.63e-10

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 55.32  E-value: 9.63e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622943     34 QQKLEQLNQYPDFNNYLIFVLTKLKSeDEPTRSLSGLILKNNVKAHFQ----NFPNGVTDFIKSECSNNIGD 101
Cdd:pfam03810   2 EKQLEQFEKSPGFWSKLLQILSNSEN-PLEVRQLAALYLKNLITRHWEeeknSLPPEEKEQIKNNLLNLLGS 72
CSE1 COG5657
CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; ...
 23-188 8.49e-08

CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning];


Pssm-ID: 227944 [Multi-domain]  Cd Length: 947  Bit Score: 56.36  E-value: 8.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   23 QSPDTTIQRTVQQKLEQLNQYPDFNnYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHF-QNFPNGV----TDFIKSECSN 97
Cdd:COG5657  14 QSPDPPSVKCAEERLRQWEKQHGFA-LKLLSINLSAFNSMSLRWAALIQFKNYIDKHWrEENGNSIlpdeNVLIRDELFS 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943   98 NIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIP 177
Cdd:COG5657  93 LIISSSNQLQIQNALAVSRIARLDFPDEWPTLVPDLLSLLSEKDMVTNENSLRVLHHIFKRLRRLFRSDALFLEIAPVLL 172

                       170
                ....*....|.
gi 1622943  178 KFLQFFKHSSP 188
Cdd:COG5657 173 SILCPFLFSSA 183
HEAT COG1413
HEAT repeat [General function prediction only];
380-524 1.31e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.47  E-value: 1.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  380 AAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITC 459
Cdd:COG1413   3 RAAARALGRLGDPA----AVPALIAALADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAA 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622943  460 WTLSRYAHWVVSqppdtylkPLMTELLKrilDSNKRVQEAACSAFATLEEEactELVPYLAYILD 524
Cdd:COG1413  69 EALGRIGDPEAV--------PALIAALK---DEDPEVRRAAAEALGRLGDP---AAVPALLEALK 119
HEAT COG1413
HEAT repeat [General function prediction only];
121-278 2.20e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  121 GELQNwPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAeildsdvldrplnimIPKFLQFFKHSSPKIRSHAVACVNQ 200
Cdd:COG1413  10 GRLGD-PAAVPALIAALADEDPDVRAAAARALGRLGDPRA---------------VPALLEALKDPDPEVRAAAAEALGR 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622943  201 fiISRTQAlmlhidsfIENLFALAGDEEPEVRKNVCRALVMLLEVRmdrllphmhnIVEYMLQRTQDQDENVALEACE 278
Cdd:COG1413  74 --IGDPEA--------VPALIAALKDEDPEVRRAAAEALGRLGDPA----------AVPALLEALKDPDWEVRRAAAR 131
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 34-101 3.67e-06

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 45.31  E-value: 3.67e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622943      34 QQKLEQLNQYPDFNNYLIFVLTKlkSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECSNNIGD 101
Cdd:smart00913   2 EKQLEQFQKSPGFWLLLLEILAN--SEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLLS 67
HEAT COG1413
HEAT repeat [General function prediction only];
371-507 1.15e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.78  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  371 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDK 450
Cdd:COG1413  28 EDPDVR---AAAARALGRLGDPR----AVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDE 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622943  451 KALVRSITCWTLSRYAhwvvsqppDTYLKPLMTELLKrilDSNKRVQEAACSAFATL 507
Cdd:COG1413  91 DPEVRRAAAEALGRLG--------DPAAVPALLEALK---DPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
371-466 1.74e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.31  E-value: 1.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  371 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDK 450
Cdd:COG1413  59 PDPEVR---AAAAEALGRIGDPE----AVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDP 121

                        90
                ....*....|....*.
gi 1622943  451 KALVRSITCWTLSRYA 466
Cdd:COG1413 122 DWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
413-583 1.09e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  413 VKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITCWTLSRYAHwvvsqppDTYLKPLMtELLKrilDS 492
Cdd:COG1413   1 VRRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLGD-------PRAVPALL-EALK---DP 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943  493 NKRVQEAACSAFATL-EEEACTELVPYLayildtlvfafskyQHKNLLILYDAIGTLAdsvghHLNKPEYIqmlmPPLIQ 571
Cdd:COG1413  60 DPEVRAAAAEALGRIgDPEAVPALIAAL--------------KDEDPEVRRAAAEALG-----RLGDPAAV----PALLE 116

                       170
                ....*....|..
gi 1622943  572 kwnMLKDEDKDL 583
Cdd:COG1413 117 ---ALKDPDWEV 125
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 371-463 2.04e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.09  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943    371 SDWNLRkcsAAALDVLANVYRDEllphILPLLKELLFHHEWVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCL-SD 449
Cdd:pfam13646  12 PDPEVR---AAAIRALGRIGDPE----AVPALLELLKDEDPAVRRAAAEALGKIGD----------PEALPALLELLrDD 74

                          90
                  ....*....|....
gi 1622943    450 KKALVRSITCWTLS 463
Cdd:pfam13646  75 DDDVVRAAAAEALA 88
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 399-505 2.36e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.09  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622943    399 LPLLKELLFHHE-WVVKESGILVLGAIAEgcmqgmipylPELIPHLIQCLSDKKALVRSITCWTLSRYahwvvsQPPDTY 477
Cdd:pfam13646   1 LPALLQALLRDPdPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKI------GDPEAL 64

                          90       100
                  ....*....|....*....|....*...
gi 1622943    478 lkPLMTELLKRilDSNKRVQEAACSAFA 505
Cdd:pfam13646  65 --PALLELLRD--DDDDVVRAAAAEALA 88
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 188-239 3.72e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 3.72e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622943    188 PKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRAL 239
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 229-277 5.20e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 5.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622943    229 PEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEAC 277
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAA 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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