NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622157233|ref|XP_028560995|]
View 

zinc finger protein 652 [Podarcis muralis]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
440-489 1.28e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622157233 440 KPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 489
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 382-465 8.19e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622157233 382 GEKPFRCE--NCDERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKR 459
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1622157233 460 HRRTHT 465
Cdd:COG5189   417 HRKHSH 422
PLN03086 super family cl29366
PRLI-interacting factor K; Provisional
 241-305 2.53e-03

PRLI-interacting factor K; Provisional


The actual alignment was detected with superfamily member PLN03086:

Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 40.63  E-value: 2.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622157233 241 EEKETLTCEKCPRVFNTRwYLEKHMNVTHRRMQicdkCGKKFVLESELSL-HQQTDCE-KNIQCVSC 305
Cdd:PLN03086  449 EAKNHVHCEKCGQAFQQG-EMEKHMKVFHEPLQ----CPCGVVLEKEQMVqHQASTCPlRLITCRFC 510
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
440-489 1.28e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622157233 440 KPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 489
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
zf-H2C2_2 pfam13465
Zinc-finger double domain;
456-479 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....
gi 1622157233 456 NMKRHRRTHTGEKPYPCDVCGQRF 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 382-465 8.19e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622157233 382 GEKPFRCE--NCDERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKR 459
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1622157233 460 HRRTHT 465
Cdd:COG5189   417 HRKHSH 422
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 241-305 2.53e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 40.63  E-value: 2.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622157233 241 EEKETLTCEKCPRVFNTRwYLEKHMNVTHRRMQicdkCGKKFVLESELSL-HQQTDCE-KNIQCVSC 305
Cdd:PLN03086  449 EAKNHVHCEKCGQAFQQG-EMEKHMKVFHEPLQ----CPCGVVLEKEQMVqHQASTCPlRLITCRFC 510
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
440-489 1.28e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622157233 440 KPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHK 489
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
zf-H2C2_2 pfam13465
Zinc-finger double domain;
456-479 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|....
gi 1622157233 456 NMKRHRRTHTGEKPYPCDVCGQRF 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 438-489 3.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622157233 438 GEKPFICEI--CGKSFTSRPNMKRHR-------RTH------------TGEKPYPCDVCGQRFRFSNMLKAHK 489
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 382-465 8.19e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622157233 382 GEKPFRCE--NCDERFQYKYQLRSHMsIHiGHkqfmcqwCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFTSRPNMKR 459
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH-GH-------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1622157233 460 HRRTHT 465
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
428-453 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 1622157233 428 YFDEHMKTHTGEKPFICEICGKSFTS 453
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 442-464 1.70e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|...
gi 1622157233 442 FICEICGKSFTSRPNMKRHRRTH 464
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 241-305 2.53e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 40.63  E-value: 2.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622157233 241 EEKETLTCEKCPRVFNTRwYLEKHMNVTHRRMQicdkCGKKFVLESELSL-HQQTDCE-KNIQCVSC 305
Cdd:PLN03086  449 EAKNHVHCEKCGQAFQQG-EMEKHMKVFHEPLQ----CPCGVVLEKEQMVqHQASTCPlRLITCRFC 510
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-460 4.57e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622157233 251 CPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESELSlHQQTD------CEKNIQCVSCNKSF--KKLWSLHEHIKIV 322
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSS-PNESDsssekgFSLPIKSKQCNISFsrSSPLTRHLRSVNH 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622157233 323 HGYAEKKFSC--EICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRS-------------MSLKVHSLQHSGEKPFR 387
Cdd:COG5048   315 SGESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnneppqslqqYKDLKNDKKSETLSNSC 394

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622157233 388 CENCDERFQYKYQLRSHMSIhiGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEICGKSFtSRPNMKRH 460
Cdd:COG5048   395 IRNFKRDSNLSLHIITHLSF--RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR-RDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH