![](files/infoQ.gif)
MAG: methylated-DNA--[protein]-cysteine S-methyltransferase [Phenylobacterium sp.]
methylated-DNA--[protein]-cysteine S-methyltransferase( domain architecture ID 11417447)
methylated-DNA--[protein]-cysteine S-methyltransferase is involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA; it repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||||
AdaB | COG0350 | DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ... |
18-180 | 1.34e-64 | ||||
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair]; : Pssm-ID: 440119 [Multi-domain] Cd Length: 163 Bit Score: 195.86 E-value: 1.34e-64
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
AdaB | COG0350 | DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ... |
18-180 | 1.34e-64 | ||||
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair]; Pssm-ID: 440119 [Multi-domain] Cd Length: 163 Bit Score: 195.86 E-value: 1.34e-64
|
||||||||
PRK10286 | PRK10286 | methylated-DNA--[protein]-cysteine S-methyltransferase; |
17-175 | 1.95e-54 | ||||
methylated-DNA--[protein]-cysteine S-methyltransferase; Pssm-ID: 182355 [Multi-domain] Cd Length: 171 Bit Score: 170.43 E-value: 1.95e-54
|
||||||||
DNA_binding_1 | pfam01035 | 6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal ... |
96-176 | 8.03e-46 | ||||
6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases. Pssm-ID: 460036 Cd Length: 81 Bit Score: 145.20 E-value: 8.03e-46
|
||||||||
ogt | TIGR00589 | O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are ... |
95-174 | 1.31e-44 | ||||
O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273157 Cd Length: 80 Bit Score: 142.45 E-value: 1.31e-44
|
||||||||
ATase | cd06445 | The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT ... |
97-175 | 1.07e-39 | ||||
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases are specific for repair of guanines with O6-alkyl adducts, however human ATase is not limited to O6-methylguanine, repairing many other adducts at the O6-position of guanine as well. ATase is widely distributed among species. Most ATases have N- and C-terminal domains. The C-terminal domain contains the conserved active-site cysteine motif (PCHR), the O6-alkylguanine binding channel, and the helix-turn-helix (HTH) DNA-binding motif. The active site is located near the recognition helix of the HTH motif. While the C-terminal domain of ATase contains residues that are necessary for DNA binding and alkyl transfer, the function of the N-terminal domain is still unknown. Removal of the N-terminal domain abolishes the activity of the C-terminal domain, suggesting an important structural role for the N-terminal domain in orienting the C-terminal domain for proper catalysis. Some ATase C-terminal domain homologs are either single-domain proteins that lack an N-terminal domain, or have a tryptophan substituted in place of the acceptor cysteine (i.e. the motif PCHR is replaced by PWHR). ATase null mutant mice are viable, fertile, and have a normal lifespan. Pssm-ID: 119438 [Multi-domain] Cd Length: 79 Bit Score: 129.91 E-value: 1.07e-39
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
AdaB | COG0350 | DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, ... |
18-180 | 1.34e-64 | ||||
DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair]; Pssm-ID: 440119 [Multi-domain] Cd Length: 163 Bit Score: 195.86 E-value: 1.34e-64
|
||||||||
PRK10286 | PRK10286 | methylated-DNA--[protein]-cysteine S-methyltransferase; |
17-175 | 1.95e-54 | ||||
methylated-DNA--[protein]-cysteine S-methyltransferase; Pssm-ID: 182355 [Multi-domain] Cd Length: 171 Bit Score: 170.43 E-value: 1.95e-54
|
||||||||
DNA_binding_1 | pfam01035 | 6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal ... |
96-176 | 8.03e-46 | ||||
6-O-methylguanine DNA methyltransferase, DNA binding domain; This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases. Pssm-ID: 460036 Cd Length: 81 Bit Score: 145.20 E-value: 8.03e-46
|
||||||||
ogt | TIGR00589 | O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are ... |
95-174 | 1.31e-44 | ||||
O-6-methylguanine DNA methyltransferase; All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273157 Cd Length: 80 Bit Score: 142.45 E-value: 1.31e-44
|
||||||||
PRK00901 | PRK00901 | methylated-DNA--protein-cysteine methyltransferase; Provisional |
75-175 | 8.39e-41 | ||||
methylated-DNA--protein-cysteine methyltransferase; Provisional Pssm-ID: 234860 [Multi-domain] Cd Length: 155 Bit Score: 135.18 E-value: 8.39e-41
|
||||||||
ATase | cd06445 | The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT ... |
97-175 | 1.07e-39 | ||||
The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases are specific for repair of guanines with O6-alkyl adducts, however human ATase is not limited to O6-methylguanine, repairing many other adducts at the O6-position of guanine as well. ATase is widely distributed among species. Most ATases have N- and C-terminal domains. The C-terminal domain contains the conserved active-site cysteine motif (PCHR), the O6-alkylguanine binding channel, and the helix-turn-helix (HTH) DNA-binding motif. The active site is located near the recognition helix of the HTH motif. While the C-terminal domain of ATase contains residues that are necessary for DNA binding and alkyl transfer, the function of the N-terminal domain is still unknown. Removal of the N-terminal domain abolishes the activity of the C-terminal domain, suggesting an important structural role for the N-terminal domain in orienting the C-terminal domain for proper catalysis. Some ATase C-terminal domain homologs are either single-domain proteins that lack an N-terminal domain, or have a tryptophan substituted in place of the acceptor cysteine (i.e. the motif PCHR is replaced by PWHR). ATase null mutant mice are viable, fertile, and have a normal lifespan. Pssm-ID: 119438 [Multi-domain] Cd Length: 79 Bit Score: 129.91 E-value: 1.07e-39
|
||||||||
AdaA | COG2169 | Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ... |
24-183 | 1.67e-27 | ||||
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair]; Pssm-ID: 441772 [Multi-domain] Cd Length: 358 Bit Score: 105.91 E-value: 1.67e-27
|
||||||||
PRK15435 | PRK15435 | bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada; |
94-174 | 7.47e-27 | ||||
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada; Pssm-ID: 185333 [Multi-domain] Cd Length: 353 Bit Score: 104.10 E-value: 7.47e-27
|
||||||||
Atl1 | COG3695 | Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like ... |
95-181 | 3.14e-15 | ||||
Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain [Transcription]; Pssm-ID: 442910 Cd Length: 104 Bit Score: 67.90 E-value: 3.14e-15
|
||||||||
PRK03887 | PRK03887 | methylated-DNA--protein-cysteine methyltransferase; Provisional |
95-175 | 9.63e-11 | ||||
methylated-DNA--protein-cysteine methyltransferase; Provisional Pssm-ID: 167628 [Multi-domain] Cd Length: 175 Bit Score: 57.82 E-value: 9.63e-11
|
||||||||
Blast search parameters | ||||
|