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Conserved domains on  [gi|1618902859|gb|QCC05660|]
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HAMP domain-containing protein (plasmid) [Cupriavidus necator H16]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10935 super family cl35975
nitrate/nitrite two-component system sensor histidine kinase NarQ;
53-643 4.52e-64

nitrate/nitrite two-component system sensor histidine kinase NarQ;


The actual alignment was detected with superfamily member PRK10935:

Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 221.65  E-value: 4.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  53 AINDAGSLRMRANRVAIELTlsqaGKPNALDDQIAALDNTLAqlrkgnpARPL------FLPDEpaIHAQLDRVVDGWqH 126
Cdd:PRK10935   42 AINIAGSLRMQSYRLAYDLQ----SGSPQLNAHLREFEQSLH-------SPALknlnrwYVPED--VKDRYALLIARW-L 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 127 RLKPLARAGglmagqATTAYIDALPSFVTQADRLVGMIEHVSASKTDLLRVSQ-AGLAAMACVGTVaVIYLLYLWIILPV 205
Cdd:PRK10935  108 EMKSYLEQG------DSRWYQANIANYVDQIDLFVLALQHFAERKLILLAAISlLGLILILTLVFF-TVRFTRRQVVAPL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 206 LRLQDGLRRMAAREFS-LRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARVAQKTAELAHQNRDLETLYEMAAFLNQA 284
Cdd:PRK10935  181 NQLVTASQQIEKGQFDhIPLDTTLPNELGLLAKAFNQMSSELHKLYRSLEASVEEKTRKLTQANRSLEVLYQCSQALNAS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 285 T-DAEAmcngfLQRVMRQfdadggsVRAFDDVRGkLPLMTSIGLPAALSGAAQCVSvkachcgDATTQSVIAIQDLRhap 363
Cdd:PRK10935  261 QiDVHC-----FRHILQI-------VRDHEGLDY-LELEVGENEHWRISEGQPNPE-------LPWQILPLTMEDTV--- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 364 araagpvspspctrngfqalaafrIGSLRGATGvfalhfrepreLPPSDRQLLETLGRHLGTALEQLRLSDSARQLAVVE 443
Cdd:PRK10935  318 ------------------------LGYLHWQAS-----------LPCPDEPLMNNVAQMLGRGLYFNQAQKQQQQLLLME 362

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 444 ERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGrDDLPEAREIVPMLRHGVEESYQDVRELLNNFRSRLTPGELRPAVEAT 523
Cdd:PRK10935  363 ERATIARELHDSLAQVLSYLKIQLTLLKRSLD-EDNAKAQSIIAEFDQALSDAYRQLRELLTTFRLTIQEANLGSALEEM 441

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 524 VERFRRQcrTEATLIVDDGGDVLPLHPEQQLQVLFILQEALSNVRKHALAAHVTVRLSHGRDFR--LVVHDDGEGFDPAD 601
Cdd:PRK10935  442 LDQLRNQ--TDAKITLDCRLPSQALDAQQQVHLLQIIREATLNAIKHANASEIAVSCVTNPDGEhtVSIRDDGIGIGELK 519

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 1618902859 602 laqRSDAHIGLNIMRERAARLNARLQIDSQPGAGVRIALLLP 643
Cdd:PRK10935  520 ---EPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
 
Name Accession Description Interval E-value
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
53-643 4.52e-64

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 221.65  E-value: 4.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  53 AINDAGSLRMRANRVAIELTlsqaGKPNALDDQIAALDNTLAqlrkgnpARPL------FLPDEpaIHAQLDRVVDGWqH 126
Cdd:PRK10935   42 AINIAGSLRMQSYRLAYDLQ----SGSPQLNAHLREFEQSLH-------SPALknlnrwYVPED--VKDRYALLIARW-L 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 127 RLKPLARAGglmagqATTAYIDALPSFVTQADRLVGMIEHVSASKTDLLRVSQ-AGLAAMACVGTVaVIYLLYLWIILPV 205
Cdd:PRK10935  108 EMKSYLEQG------DSRWYQANIANYVDQIDLFVLALQHFAERKLILLAAISlLGLILILTLVFF-TVRFTRRQVVAPL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 206 LRLQDGLRRMAAREFS-LRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARVAQKTAELAHQNRDLETLYEMAAFLNQA 284
Cdd:PRK10935  181 NQLVTASQQIEKGQFDhIPLDTTLPNELGLLAKAFNQMSSELHKLYRSLEASVEEKTRKLTQANRSLEVLYQCSQALNAS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 285 T-DAEAmcngfLQRVMRQfdadggsVRAFDDVRGkLPLMTSIGLPAALSGAAQCVSvkachcgDATTQSVIAIQDLRhap 363
Cdd:PRK10935  261 QiDVHC-----FRHILQI-------VRDHEGLDY-LELEVGENEHWRISEGQPNPE-------LPWQILPLTMEDTV--- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 364 araagpvspspctrngfqalaafrIGSLRGATGvfalhfrepreLPPSDRQLLETLGRHLGTALEQLRLSDSARQLAVVE 443
Cdd:PRK10935  318 ------------------------LGYLHWQAS-----------LPCPDEPLMNNVAQMLGRGLYFNQAQKQQQQLLLME 362

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 444 ERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGrDDLPEAREIVPMLRHGVEESYQDVRELLNNFRSRLTPGELRPAVEAT 523
Cdd:PRK10935  363 ERATIARELHDSLAQVLSYLKIQLTLLKRSLD-EDNAKAQSIIAEFDQALSDAYRQLRELLTTFRLTIQEANLGSALEEM 441

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 524 VERFRRQcrTEATLIVDDGGDVLPLHPEQQLQVLFILQEALSNVRKHALAAHVTVRLSHGRDFR--LVVHDDGEGFDPAD 601
Cdd:PRK10935  442 LDQLRNQ--TDAKITLDCRLPSQALDAQQQVHLLQIIREATLNAIKHANASEIAVSCVTNPDGEhtVSIRDDGIGIGELK 519

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 1618902859 602 laqRSDAHIGLNIMRERAARLNARLQIDSQPGAGVRIALLLP 643
Cdd:PRK10935  520 ---EPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
428-646 8.38e-43

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 154.78  E-value: 8.38e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 428 EQLRLSDSARQLAVVEERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGRDDlPEAREIVPMLRHGVEESYQDVRELLNNF 507
Cdd:COG4585    37 ELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADP-EAAREELEEIRELAREALAELRRLVRGL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 508 RSR-LTPGELRPAVEATVERFRRQCRTEATLIVDdgGDVLPLHPEQQLQVLFILQEALSNVRKHALAAHVTVRLSHGRD- 585
Cdd:COG4585   116 RPPaLDDLGLAAALEELAERLLRAAGIRVELDVD--GDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVTLEVDDGe 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1618902859 586 FRLVVHDDGEGFDPADLAQRsdaHIGLNIMRERAARLNARLQIDSQPGAGVRIALLLPRGE 646
Cdd:COG4585   194 LTLTVRDDGVGFDPEAAPGG---GLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 556-643 1.71e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 94.54  E-value: 1.71e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 556 VLFILQEALSNVRKHALAAHVTVRLSHGRD-FRLVVHDDGEGFDPADLAQRSdaHIGLNIMRERAARLNARLQIDSQPGA 634
Cdd:cd16917     1 LYRIVQEALTNALKHAGASRVRVTLSYTADeLTLTVVDDGVGFDGPAPPGGG--GFGLLGMRERAELLGGTLTIGSRPGG 78


                  ....*....
gi 1618902859 635 GVRIALLLP 643
Cdd:cd16917    79 GTRVTARLP 87
PilJ pfam13675
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ...
 42-151 2.78e-23

Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433397 [Multi-domain]  Cd Length: 112  Bit Score: 95.24  E-value: 2.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  42 WLSWKLEGAGAAINDAGSLRMRANRVAIELTLS------QAGKPNALDDQIAALDNTLAQLRKGNPARPLFLPDEpAIHA 115
Cdd:pfam13675   1 WTLWQSEGDAAAINAAGSLRMQSQRLAKSVLLAlagnydLAEAFADLEESIDQFDRTLAALALGDLARGLFVPAG-AIRA 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1618902859 116 QLDRVVDGWQHRLKPLARAgglMAGQATTAYIDALP 151
Cdd:pfam13675  80 QLEAVQPLWERLRKPAEAV---LAQQDTLAYLAAVL 112
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 559-643 1.14e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 61.90  E-value: 1.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  559 ILQEALSNVRKHALAA-HVTVRLSH-GRDFRLVVHDDGEGFDPADLAQ------RSDAH--------IGLNIMRERAARL 622
Cdd:smart00387   9 VLSNLLDNAIKYTPEGgRITVTLERdGDHVEITVEDNGPGIPPEDLEKifepffRTDKRsrkiggtgLGLSIVKKLVELH 88

                           90       100
                   ....*....|....*....|.
gi 1618902859  623 NARLQIDSQPGAGVRIALLLP 643
Cdd:smart00387  89 GGEISVESEPGGGTTFTITLP 109
 
Name Accession Description Interval E-value
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
53-643 4.52e-64

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 221.65  E-value: 4.52e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  53 AINDAGSLRMRANRVAIELTlsqaGKPNALDDQIAALDNTLAqlrkgnpARPL------FLPDEpaIHAQLDRVVDGWqH 126
Cdd:PRK10935   42 AINIAGSLRMQSYRLAYDLQ----SGSPQLNAHLREFEQSLH-------SPALknlnrwYVPED--VKDRYALLIARW-L 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 127 RLKPLARAGglmagqATTAYIDALPSFVTQADRLVGMIEHVSASKTDLLRVSQ-AGLAAMACVGTVaVIYLLYLWIILPV 205
Cdd:PRK10935  108 EMKSYLEQG------DSRWYQANIANYVDQIDLFVLALQHFAERKLILLAAISlLGLILILTLVFF-TVRFTRRQVVAPL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 206 LRLQDGLRRMAAREFS-LRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARVAQKTAELAHQNRDLETLYEMAAFLNQA 284
Cdd:PRK10935  181 NQLVTASQQIEKGQFDhIPLDTTLPNELGLLAKAFNQMSSELHKLYRSLEASVEEKTRKLTQANRSLEVLYQCSQALNAS 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 285 T-DAEAmcngfLQRVMRQfdadggsVRAFDDVRGkLPLMTSIGLPAALSGAAQCVSvkachcgDATTQSVIAIQDLRhap 363
Cdd:PRK10935  261 QiDVHC-----FRHILQI-------VRDHEGLDY-LELEVGENEHWRISEGQPNPE-------LPWQILPLTMEDTV--- 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 364 araagpvspspctrngfqalaafrIGSLRGATGvfalhfrepreLPPSDRQLLETLGRHLGTALEQLRLSDSARQLAVVE 443
Cdd:PRK10935  318 ------------------------LGYLHWQAS-----------LPCPDEPLMNNVAQMLGRGLYFNQAQKQQQQLLLME 362

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 444 ERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGrDDLPEAREIVPMLRHGVEESYQDVRELLNNFRSRLTPGELRPAVEAT 523
Cdd:PRK10935  363 ERATIARELHDSLAQVLSYLKIQLTLLKRSLD-EDNAKAQSIIAEFDQALSDAYRQLRELLTTFRLTIQEANLGSALEEM 441

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 524 VERFRRQcrTEATLIVDDGGDVLPLHPEQQLQVLFILQEALSNVRKHALAAHVTVRLSHGRDFR--LVVHDDGEGFDPAD 601
Cdd:PRK10935  442 LDQLRNQ--TDAKITLDCRLPSQALDAQQQVHLLQIIREATLNAIKHANASEIAVSCVTNPDGEhtVSIRDDGIGIGELK 519

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|..
gi 1618902859 602 laqRSDAHIGLNIMRERAARLNARLQIDSQPGAGVRIALLLP 643
Cdd:PRK10935  520 ---EPEGHYGLNIMQERAERLGGTLTISQPPGGGTTVSLTFP 558
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
42-641 1.68e-60

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 212.22  E-value: 1.68e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  42 WLSWKLEGAGAAINDAGSLRMRANRVAIELTLSQAGKP--NALDDQIAALDNTLAQLRKGnparplflpdepaIHAQLDR 119
Cdd:PRK10600    6 WLVQGVQGSAHAINKAGSLRMQSYRLLAAVPLSEKDKPllKEMEQTAFSPELQRAAERDG-------------QLAQLQA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 120 VVDGWQHRLKPlaragGLMAGQATTAYIDALPSFVTQADRLVGMIEHVSASKTDLLRVSQAGLAAMACVGTVAVIYLLYL 199
Cdd:PRK10600   73 LQDYWRNELKP-----ALQQAQNPEDVAADVAQFVAGLDALVSAFDHTTEMRIETVVLVHRVFAVFMALLLVFTIIWLRR 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 200 WIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARVAQKTAELAHQNRDLETLYEMAa 279
Cdd:PRK10600  148 RLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELAESYAVLEQRVQEKTAGLEQKNQILSFLWQAN- 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 280 flNQATDAEAMCNGfLQRVMRQFDAdggsvrafddvrgkLPLMTSIGLpaalsgaaqcvSVKACHCGDA----TTQSVIA 355
Cdd:PRK10600  227 --RRLHSRAPLCER-LSPVLNGLQN--------------LTLLRDIEL-----------RVYETDDEENhqefTCQSDMT 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 356 IQDlrhaPARAAGPVSPSPCTRNGfQALAaFRIGSLRGATGVFALHFREPRELPPSDRQLLETLGRHLGTALEQLRLSDS 435
Cdd:PRK10600  279 CDD----KGCQLCPRGVLPVGDRG-TTLK-WRLSDKHGQYGILLATLPQGRHLSHDQQQLVDTLVEQLTATLALERQQER 352

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 436 ARQLAVVEERNLVAQGLHDSIAQGLNFLNLQVQLLadAVGRDDLPEA-REIVPMLRHGVEESYQDVRELLNNFRSRLTPG 514
Cdd:PRK10600  353 QQQLIVMEERATIARELHDSIAQSLSCMKMQVSCL--QMQGDALPESsRELLSQIRNELNASWRQLRELLTTFRLQLTEP 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 515 ELRPAVEATVERFRRQCRTEATLIVDDGGDVLPLHpeQQLQVLFILQEALSNVRKHALAAHVTVRLS-HGRDFRLVVHDD 593
Cdd:PRK10600  431 GLRPALEASCEEFSARFGFPVKLDYQLPPRLVPSH--QAIHLLQIAREALSNALKHAQASEVVVTVAqNQNQVKLSVQDN 508

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 1618902859 594 GEGFDPAdlAQRSDaHIGLNIMRERAARLNARLQIDSQPGAGVRIALL 641
Cdd:PRK10600  509 GCGVPEN--AERSN-HYGLIIMRDRAQSLRGDCRVRRRESGGTEVVVT 553
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
428-646 8.38e-43

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 154.78  E-value: 8.38e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 428 EQLRLSDSARQLAVVEERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGRDDlPEAREIVPMLRHGVEESYQDVRELLNNF 507
Cdd:COG4585    37 ELERELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADP-EAAREELEEIRELAREALAELRRLVRGL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 508 RSR-LTPGELRPAVEATVERFRRQCRTEATLIVDdgGDVLPLHPEQQLQVLFILQEALSNVRKHALAAHVTVRLSHGRD- 585
Cdd:COG4585   116 RPPaLDDLGLAAALEELAERLLRAAGIRVELDVD--GDPDRLPPEVELALYRIVQEALTNALKHAGATRVTVTLEVDDGe 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1618902859 586 FRLVVHDDGEGFDPADLAQRsdaHIGLNIMRERAARLNARLQIDSQPGAGVRIALLLPRGE 646
Cdd:COG4585   194 LTLTVRDDGVGFDPEAAPGG---GLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 556-643 1.71e-23

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 94.54  E-value: 1.71e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 556 VLFILQEALSNVRKHALAAHVTVRLSHGRD-FRLVVHDDGEGFDPADLAQRSdaHIGLNIMRERAARLNARLQIDSQPGA 634
Cdd:cd16917     1 LYRIVQEALTNALKHAGASRVRVTLSYTADeLTLTVVDDGVGFDGPAPPGGG--GFGLLGMRERAELLGGTLTIGSRPGG 78


                  ....*....
gi 1618902859 635 GVRIALLLP 643
Cdd:cd16917    79 GTRVTARLP 87
PilJ pfam13675
Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type ...
 42-151 2.78e-23

Type IV pili methyl-accepting chemotaxis transducer N-term; This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP signature towards the C-terminus. It is a monomodular four-helix bundle and recognizes nitrate and nitrite (Matilla et al. FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433397 [Multi-domain]  Cd Length: 112  Bit Score: 95.24  E-value: 2.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  42 WLSWKLEGAGAAINDAGSLRMRANRVAIELTLS------QAGKPNALDDQIAALDNTLAQLRKGNPARPLFLPDEpAIHA 115
Cdd:pfam13675   1 WTLWQSEGDAAAINAAGSLRMQSQRLAKSVLLAlagnydLAEAFADLEESIDQFDRTLAALALGDLARGLFVPAG-AIRA 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1618902859 116 QLDRVVDGWQHRLKPLARAgglMAGQATTAYIDALP 151
Cdd:pfam13675  80 QLEAVQPLWERLRKPAEAV---LAQQDTLAYLAAVL 112
NarX_NarQ_sensor cd19408
ligand binding sensor domain of NarX and NarQ, and related chemoreceptors; The periplasmic ...
 45-174 2.45e-20

ligand binding sensor domain of NarX and NarQ, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarX and NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair, along with NarQ-NarP, control Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, whereas NarQ exhibits a relatively slight kinetic preference for NarL. There is asymmetry in the Nar cross-regulation network with NarQ shown to interact similarly with both response regulators, while NarX interacts preferentially with NarL.


Pssm-ID: 438626 [Multi-domain]  Cd Length: 126  Bit Score: 87.30  E-value: 2.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  45 WKLEGAGAAINDAGSLRMRANRVAIELTLSQAGKPNALDDQIAALDNTLAQLRKGNPARPLflpDEPAIHAQLDRVVDGW 124
Cdd:cd19408     1 ESTEGDAAAINLAGSLRMQSYRLASLLLQAALEPAEQLAQLIDEFEQRLNSPALTRALPRD---SDHPLRQAYQAVLQHW 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1618902859 125 QHRLKPLARAgGLMAGQATTAYIDALPSFVTQADRLVGMIEHVSASKTDL 174
Cdd:cd19408    78 QQELRPALEA-AASGAADREAYLAEVDEFVAQIDQLVKLLQQDTEAKIRL 126
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 421-651 4.81e-17

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 84.29  E-value: 4.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 421 RHLGTALEQL--RLSDSARQLAVVEE--RNLVAQGLHDSIAQGLNFLNLQVQLLADavgRDDLPEAREIVPMLRHGVEES 496
Cdd:COG3851   265 RQLNQQLEQElrENRALARQLVSAEEseRREIARELHDEIGQNITAIRTQASILKR---LAPQPEIEQSAQSIESLALRI 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 497 YQDVRELLNnfrsRLTPGELRP-----AVEATVERFRRQCR-TEATLIVDdgGDVLPLHPEQQLQVLFILQEALSNVRKH 570
Cdd:COG3851   342 YDTTRRLLD----RLRPAVLDElgleeALRELPRELAFEEPgISCQLDLR--GDPSLLDDTLQLTLYRLVQEALTNILKH 415

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 571 ALAAHVTVRLS-HGRDFRLVVHDDGEGFDPADLAQrsdaHIGLNIMRERAARLNARLQIDSQPGaGVRIALLLPRGEQQP 649
Cdd:COG3851   416 AEASQIRISLSqDKRLLSLEIRDDGIGLPPELRAK----GFGLRGMRERVRALGGDFRLSSAPK-GTRLSVLLPTPAASN 490


                  ..
gi 1618902859 650 DA 651
Cdd:COG3851   491 EA 492
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 180-649 1.42e-15

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 79.24  E-value: 1.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 180 AGLAAMACVGTVAVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARvaq 259
Cdd:COG5000    12 LLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEER--- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 260 ktaelahqNRDLETLyemaafLNQATDAEAMcngflqrvmrqFDADgGSVRAFDDVRGKL---PLMTSIGLPAAlsgaaq 336
Cdd:COG5000    89 --------RRYLETI------LENLPAGVIV-----------LDAD-GRITLANPAAERLlgiPLEELIGKPLE------ 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 337 cvsvkachcgdattqSVIAIQDLRHAPARAagpvspspctrngfqalaafrigslrgatgvFALHFREPRELPPSDRQLL 416
Cdd:COG5000   137 ---------------ELLPELDLAELLREA-------------------------------LERGWQEEIELTRDGRRTL 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 417 ETLGRHLGTALEQLRLSD-----SARQLAVVEErnlVAQGL-HDsIAQGLNFLNLQVQLLADAVgRDDLPEAREIVPMLR 490
Cdd:COG5000   171 LVRASPLRDDGYVIVFDDitellRAERLAAWGE---LARRIaHE-IKNPLTPIQLSAERLRRKL-ADKLEEDREDLERAL 245

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 491 HGVEESYQDVRELLNNFRS-------RLTPGELRPAVEATVERFRRQC-RTEATLIVDDGGDVLPLH--PEQqlqvlfiL 560
Cdd:COG5000   246 DTIIRQVDRLKRIVDEFLDfarlpepQLEPVDLNELLREVLALYEPALkEKDIRLELDLDPDLPEVLadRDQ-------L 318

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 561 QEALSNVRKHALAA-----HVTVRLSHGRDF-RLVVHDDGEGFDPADLAQ--------RSDAH-IGLNIMRERAARLNAR 625
Cdd:COG5000   319 EQVLINLLKNAIEAieeggEIEVSTRREDGRvRIEVSDNGPGIPEEVLERifepffttKPKGTgLGLAIVKKIVEEHGGT 398

                         490       500
                  ....*....|....*....|....
gi 1618902859 626 LQIDSQPGAGVRIALLLPRGEQQP 649
Cdd:COG5000   399 IELESRPGGGTTFTIRLPLAEEAE 422
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 559-643 4.54e-14

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 68.55  E-value: 4.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 559 ILQEALSNVRKHALAA-HVTVRLSHGRDFRLVVHDDGEGFDPADLAQRSDAH------------IGLNIMRERAARLNAR 625
Cdd:pfam02518   9 VLSNLLDNALKHAAKAgEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFstadkrggggtgLGLSIVRKLVELLGGT 88

                          90
                  ....*....|....*...
gi 1618902859 626 LQIDSQPGAGVRIALLLP 643
Cdd:pfam02518  89 ITVESEPGGGTTVTLTLP 106
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
421-644 2.45e-13

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 72.70  E-value: 2.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 421 RHLGTALeQLRLSDS---ARQLAVVEE--RNLVAQGLHDSIAQGLNFLNLQ---VQLLADAVGRddLPEAREIVPMLRHG 492
Cdd:PRK11644  274 RELNQSL-QKELARNrhlAERLLETEEsvRRDVARELHDEIGQTITAIRTQagiIKRLAADNAS--VKQSAQLIEQLSLG 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 493 VeesYQDVRELLnnfrsrltpGELRPAV------EATVERFRRQCRTEATLIV---DDGGDVLPLHPEQQLQVLFILQEA 563
Cdd:PRK11644  351 V---YDTVRRLL---------GRLRPRQlddltlEQAIRSLMREMELEDRGIVshlDWRIDESALSETQRVTLFRVCQEG 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 564 LSNVRKHALAAHVTVRLSHGRD-FRLVVHDDGEGFDPADLAQrsdaHIGLNIMRERAARLNARLQIDSQPGAgvRIALLL 642
Cdd:PRK11644  419 LNNIVKHADASAVTLQGWQQDErLMLVIEDDGSGLPPGSGQQ----GFGLRGMRERVTALGGTLTISCTHGT--RLSVSL 492


                  ..
gi 1618902859 643 PR 644
Cdd:PRK11644  493 PQ 494
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 559-643 1.14e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 61.90  E-value: 1.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  559 ILQEALSNVRKHALAA-HVTVRLSH-GRDFRLVVHDDGEGFDPADLAQ------RSDAH--------IGLNIMRERAARL 622
Cdd:smart00387   9 VLSNLLDNAIKYTPEGgRITVTLERdGDHVEITVEDNGPGIPPEDLEKifepffRTDKRsrkiggtgLGLSIVKKLVELH 88

                           90       100
                   ....*....|....*....|.
gi 1618902859  623 NARLQIDSQPGAGVRIALLLP 643
Cdd:smart00387  89 GGEISVESEPGGGTTFTITLP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
460-645 2.05e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 65.70  E-value: 2.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 460 LNFLNLQVQLLADAVGrddlPEAREIVPMLRHGVEESYQDVRELL-------NNFRSRLTPGELRPAVEATVERFRRQC- 531
Cdd:COG0642   125 LTAIRGYLELLLEELD----EEQREYLETILRSADRLLRLINDLLdlsrleaGKLELEPEPVDLAELLEEVVELFRPLAe 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 532 RTEATLIVDDGGDVLPLH-PEQQL-QVLFILqeaLSNVRKHALA-AHVTVRLS-HGRDFRLVVHDDGEGFDPADLAQ--- 604
Cdd:COG0642   201 EKGIELELDLPDDLPTVRgDPDRLrQVLLNL---LSNAIKYTPEgGTVTVSVRrEGDRVRISVEDTGPGIPPEDLERife 277

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1618902859 605 ---RSDAH-------IGLNIMRERAARLNARLQIDSQPGAGVRIALLLPRG 645
Cdd:COG0642   278 pffRTDPSrrgggtgLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 444-508 5.51e-11

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 58.40  E-value: 5.51e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1618902859 444 ERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGRDDlPEAREIVPMLRHGVEESYQDVRELLNNFR 508
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDP-EEAREQLDAIRELAREALQELRRLLGDLR 64
PtsP COG3605
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
269-445 5.90e-11

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];


Pssm-ID: 442824 [Multi-domain]  Cd Length: 188  Bit Score: 61.84  E-value: 5.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 269 RDLETLYEMAAFLNQATDAEAMCNGFLQRVMRQFDADGGSVRAFDDVRGKLPLMTSIGLPAAlsgAAQCVSVKACH--CG 346
Cdd:COG3605     1 EMLKALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLLDPDGGRLELRATEGLNPE---AVGKVRLPLGEglVG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 347 D-ATTQSVIAIQDLRHAPAraagpVSPSPCTR-NGFQALAAFRIGSLRGATGVFALHFREPRELPPSDRQLLETLGRHLG 424
Cdd:COG3605    78 LvAERGEPLNLADAASHPR-----FKYFPETGeEGFRSFLGVPIIRRGRVLGVLVVQSREPREFTEEEVEFLVTLAAQLA 152

                         170       180
                  ....*....|....*....|.
gi 1618902859 425 TALEQLRLSDSARQLAVVEER 445
Cdd:COG3605   153 EAIANAELLGELRAALAELSL 173
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
460-647 2.02e-10

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 61.46  E-value: 2.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 460 LNFLNLQVQLLADAVGRDDlPEAREIVPMLRHGVEESYQDVRELL-------NNFRSRLTPGELRPAVEATVERFRRQCR 532
Cdd:COG2205    31 LTSILGAAELLLDEEDLSP-EERRELLEIIRESAERLLRLIEDLLdlsrlesGKLSLELEPVDLAELLEEAVEELRPLAE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 533 T-EATLIVDDGGDVLPLHPEQQL--QVLFILqeaLSNVRKHALAA-HVTVRLSH-GRDFRLVVHDDGEGFDPADLAQ--- 604
Cdd:COG2205   110 EkGIRLELDLPPELPLVYADPELleQVLANL---LDNAIKYSPPGgTITISARReGDGVRISVSDNGPGIPEEELERife 186

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1618902859 605 ---RSDAH-------IGLNIMRERAARLNARLQIDSQPGAGVRIALLLPRGEQ 647
Cdd:COG2205   187 rfyRGDNSrgeggtgLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
GAF COG2203
GAF domain [Signal transduction mechanisms];
81-651 2.56e-10

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 63.67  E-value: 2.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  81 ALDDQIAALDNTLAQLRKGNPARPLFLPDEPAIHAQLDRVVDGWQHRLKPLARAGGLMAGQATTAYIDALPSFVTQADRL 160
Cdd:COG2203     2 LSVLALALAREVAAAELLEELATLLLALLLLALQALERVLETTELALALELLLERLTELRAAARLAAEAAEAALLLILLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 161 VGMIEHVSASKTDLLRVSQAGLAAMACVGTVAVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFN 240
Cdd:COG2203    82 DALVLLSLVATAGLVLELADLLLLLRLLALLVLLLVALALAEALAARLLDLLLLGLGGRLRGVVLRGLRSAALLLSRVDT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 241 RMASELQDLYRDLEARVAQKTAELAHQNRDLETLYEMAAFLNQATDAEAMCNGFLQRVMRQFDADGGSVRAFDDVRGKLP 320
Cdd:COG2203   162 DLVGQLAALAGLILDIARLLTQRARLELERLALLNEISQALRSALDLEELLQRILELAGELLGADRGAILLVDEDGGELE 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 321 LMTSIGLPAalsGAAQCVSVKACHCGDA-TTQSVIAIQDLRHAPARAAGPvsPSPCTRNGFQALAAFRIGSLRGATGVFA 399
Cdd:COG2203   242 LVAAPGLPE---EELGRLPLGEGLAGRAlRTGEPVVVNDASTDPRFAPSL--RELLLALGIRSLLCVPLLVDGRLIGVLA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 400 LHFREPRELPPSDRQLLETLGRHLGTALEQLRLSDSARQLAVVEERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGRDDL 479
Cdd:COG2203   317 LYSKEPRAFTEEDLELLEALADQAAIAIERARLYEALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLS 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 480 PEAREIVPMLRHGVEESYQDVRELLNNFRSRLTPGELRPAVEATVERFRRQCRTEATLIVDDGGDVLPLHPEQQLQVLFI 559
Cdd:COG2203   397 LLGAELLLLLLDAADLSGLLALEGLLLLDLLLLLLLLRRILLLRVLRRLLLGDEEGLVLLLALAELELLEILELLVLLAV 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 560 LQEALSNVRKHALAAHVTVRLSHGRDFRLVVHDDGEGFDPADLAQRSDAHIGLNIMRERAARLNARLQIDSQPGAGVRIA 639
Cdd:COG2203   477 ILLALALLAALLLLLLLLLALLALSALAVLASLLLALLLLLLLLLLLLLLGLLAALAADLLLLAAALLEDLLILLLVLLL 556

                         570
                  ....*....|..
gi 1618902859 640 LLLPRGEQQPDA 651
Cdd:COG2203   557 ERELLTLVGVLL 568
NarQ_sensor cd22899
ligand binding sensor domain of NarQ, and related chemoreceptors; The periplasmic ligand ...
 53-171 3.24e-10

ligand binding sensor domain of NarQ, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarQ is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarQ-NarP sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarQ has been shown to interact equally with NarP and NarL response regulators; NarL is the sensor response partner of NarX.


Pssm-ID: 438631 [Multi-domain]  Cd Length: 116  Bit Score: 57.91  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  53 AINDAGSLRMRANRVAIELTlsqaGKPNALDDQIAALDNTLAQLRKGNPARPlFLPDEpaIHAQLDRVVDGWQhRLKPLA 132
Cdd:cd22899     9 AINVAGSLRMQSYRLAYDLE----SESPLLEQHIAQYEQSLHSPALQSLDRW-YVPDE--VKQRYQQLLARWQ-EMKQYL 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1618902859 133 RAGGlmagqaTTAYIDALPSFVTQADRLVGMIEHVSASK 171
Cdd:cd22899    81 LQGD------PASYLQQVASYVDQIDQFVLALQHFAERK 113
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 204-246 8.97e-10

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 54.37  E-value: 8.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1618902859 204 PVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASEL 246
Cdd:cd06225     3 PLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
182-290 1.29e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 60.80  E-value: 1.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 182 LAAMACVGTVAVIYLLYLWIILPVLRLQDGLRRMAAREFsLRLPVETRDEFGTLNEGFNRMASELQDLYRDL-EARVAQK 260
Cdd:COG2972   162 IILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVyELELEKK 240

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1618902859 261 TAEL-AHQNR--------DLETLYEMAAfLNQATDAEAM 290
Cdd:COG2972   241 EAELkALQAQinphflfnTLNSIRWLAE-LEDPEEAEEM 278
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
200-251 1.08e-08

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 51.48  E-value: 1.08e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1618902859  200 WIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQDLYR 251
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
18-273 1.54e-08

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 57.72  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  18 LSTRIISLSLASLLVVLAMIAGTLWLSWKLEGAGAAINDAGSLRMRANRVAIELTLSQAGKPNALDDQIAALDNTLAQLR 97
Cdd:COG0840    25 LAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  98 KGNPARPLFLPDEPAIHAQLDRVVDGWQHRLKPLARAGGLMAGQATTAYIDALPSFVTQADRLVGMIEHVSASKTDLLRV 177
Cdd:COG0840   105 LLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 178 SQAGLAAMACVgtVAVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQDLYRDLEA-- 255
Cdd:COG0840   185 AAALLALVALA--IILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVREsa 262

                         250
                  ....*....|....*....
gi 1618902859 256 -RVAQKTAELAHQNRDLET 273
Cdd:COG0840   263 eQVASASEELAASAEELAA 281
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 380-644 5.86e-08

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 55.19  E-value: 5.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 380 FQALAAFRIGSLRGATGVFALHFREPRELPPSDRQLLETLGRHLGTALEQLRLSDSARQLAVVEERNLVAQ--------- 450
Cdd:COG4191    62 LELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQlvqseklaa 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 451 ------GL-HDsIAQGLNFLNLQVQLLADAVGRD-DLPEAREIVPMLRHGVEesyqDVRELLNNFR--SRLTPGELRP-- 518
Cdd:COG4191   142 lgelaaGIaHE-INNPLAAILGNAELLRRRLEDEpDPEELREALERILEGAE----RAAEIVRSLRafSRRDEEEREPvd 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 519 ---AVEATVERFRRQCR-TEATLIVDDGGDVLPLH-PEQQL-QVLFILqeaLSNVRkHALAA----HVTVRLSHGRDF-R 587
Cdd:COG4191   217 lneLIDEALELLRPRLKaRGIEVELDLPPDLPPVLgDPGQLeQVLLNL---LINAI-DAMEEgeggRITISTRREGDYvV 292

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1618902859 588 LVVHDDGEGFDPADLAQ--------RSDAH---IGLNIMRERAARLNARLQIDSQPGAGVRIALLLPR 644
Cdd:COG4191   293 ISVRDNGPGIPPEVLERifepffttKPVGKgtgLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
HAMP pfam00672
HAMP domain;
196-248 6.59e-08

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 49.16  E-value: 6.59e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1618902859 196 LLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQD 248
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
467-647 1.15e-07

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 54.56  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 467 VQLLADAVGRDDlPEAREIVPMLRHGVEESYQDVRELL-------NNFRSRLTPGELRPAVEATVERFRRQCRTEA-TLI 538
Cdd:COG5002   187 LELLLDGAADDP-EERREYLEIILEEAERLSRLVNDLLdlsrlesGELKLEKEPVDLAELLEEVVEELRPLAEEKGiELE 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 539 VDDGGDVLPLH--PEQQLQVLFILqeaLSNVRKHALA-AHVTVRLSHGRDF-RLVVHDDGEGFDPADLAQ------RSDA 608
Cdd:COG5002   266 LDLPEDPLLVLgdPDRLEQVLTNL---LDNAIKYTPEgGTITVSLREEDDQvRISVRDTGIGIPEEDLPRiferfyRVDK 342

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1618902859 609 H---------IGLNIMRERAARLNARLQIDSQPGAGVRIALLLPRGEQ 647
Cdd:COG5002   343 SrsretggtgLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 558-643 1.15e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 50.13  E-value: 1.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 558 FILQEALSNVRKHALAA-------HVTVRLShGRDFRLVVHDDGEGFDPADLAQ---RSDAHIGLNIMRERAARL---NA 624
Cdd:cd16956     4 LTLQPIVENAVKHGLSGlldggrvEITARLD-GQHLLLEVEDNGGGMDPDTLARiliRSSNGLGLNLVDKRLRQAfgnDY 82

                          90
                  ....*....|....*....
gi 1618902859 625 RLQIDSQPGAGVRIALLLP 643
Cdd:cd16956    83 GLDIECAPGEGTRITIRLP 101
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
8-596 2.88e-07

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 53.58  E-value: 2.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859   8 LATLPALRHRLSTRIISLSLASLLVVLAMIAGTLWLSWKLEGAGAAINDAGSLRMRANRVAIELTLSQAGKPNALDDQIA 87
Cdd:COG2770    43 LLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  88 ALDNTLAQLRKGNPARPLFLPDEPAIHAQLDRVVDGWQHRLKPLARAGGLMAGQATTAYIDALPSFVTQADRLVGMIEHV 167
Cdd:COG2770   123 LLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVV 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 168 SASKTDLLRVSQAGLAAMACVGTVAVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQ 247
Cdd:COG2770   203 LLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLR 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 248 DLYRDLEARVAQKTAELAHQNRDLETLyEMAAFLNQATDAEAMCNGFLQRVMRQFDADGGSVRAFDDVRGKLPLMTSIGL 327
Cdd:COG2770   283 ESIEEAEEEEELAEAELARLLEALLEL-LLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLL 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 328 PAALSGAAQCVSVKACHCGDATTQSVIAIQDLRHAPARAAGPVSPSPCTRNGFQALAAFRIGSLRGATGVFALHFREPRE 407
Cdd:COG2770   362 LLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELA 441

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 408 LPPSDRQLLETLGRHLGTALEQLRLSDSARQLAVVEERNLVAQGLHDSIAQGLNFLNLQVQLLADAVGRDDLPEAREIVP 487
Cdd:COG2770   442 AAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLL 521

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 488 MLRHGVEESYQDVRELLNNFRSRLTPGELRPAVEATVERFRRQCRTEATLIVDDGGDVLPLHPEQQLQVLFILQEALSNV 567
Cdd:COG2770   522 EAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALLLAAVAALLELAALLLLLLAAAEALAALEL 601

                         570       580
                  ....*....|....*....|....*....
gi 1618902859 568 RKHALAAHVTVRLSHGRDFRLVVHDDGEG 596
Cdd:COG2770   602 ELAAAAEAALAEAELLEVAAAAEAGAALL 630
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 182-314 4.64e-07

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 52.96  E-value: 4.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 182 LAAMACVGTVAVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARVAQKT 261
Cdd:COG3850   123 RLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEA 202

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1618902859 262 AELAHQNRDLETLYEMAAFLNQATDAEAMCNGFLQRVMRQFDADGGSVRAFDD 314
Cdd:COG3850   203 ELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLA 255
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 559-643 5.63e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 48.23  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 559 ILQEALSNVRKHAL-----AAHV--TVRLSHGRDFRLVVHDDGEGFDPADLAQRS-----DAHIGLNIMRERAARL-NAR 625
Cdd:cd16955     5 MIQPLVENAIVHGIqekkgKGVVkiSVKKQLKNRLHIAVEDNGIGISPKVIERVEqdempGNKIGLLNVHQRLKLGyGEG 84

                          90
                  ....*....|....*...
gi 1618902859 626 LQIDSQPGAGVRIALLLP 643
Cdd:cd16955    85 LHIRSRPDPGTLIAFYIP 102
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
546-633 1.14e-06

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 47.99  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 546 LPLHPEQQLQVLFILQEALSNVRKHALAA----HVTVRLSHGRD-FRLVVHDDGEGFDPADLAQ----RSDAHIGLNIMR 616
Cdd:COG2172    25 LGLDEDDADDLVLAVSEAVTNAVRHAYGGdpdgPVEVELELDPDgLEIEVRDEGPGFDPEDLPDpystLAEGGRGLFLIR 104

                          90
                  ....*....|....*..
gi 1618902859 617 eraaRLNARLQIDSQPG 633
Cdd:COG2172   105 ----RLMDEVEYESDPG 117
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 499-644 3.92e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 49.90  E-value: 3.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 499 DVRELLNNFRSRL----------------TPGELRPAVEATVERFRRQCRTEATLIVDDGGDVLpLHPEQQLQVLFILQE 562
Cdd:COG3920   328 EAREALEESQNRIqalalvhellyqsedwEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVE-LPADAAVPLGLILNE 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 563 ALSNVRKHALAA----HVTVRLS-HGRDFRLVVHDDGEGFdPADLAQRSDAHIGLNIMRERAARLNARLQIDSQPGAGVR 637
Cdd:COG3920   407 LVTNALKHAFLSgeggRIRVSWRrEDGRLRLTVSDNGVGL-PEDVDPPARKGLGLRLIRALVRQLGGTLELDRPEGTRVR 485


                  ....*..
gi 1618902859 638 IALLLPR 644
Cdd:COG3920   486 ITFPLAE 492
PRK15347 PRK15347
two component system sensor kinase;
190-265 8.81e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 49.26  E-value: 8.81e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1618902859 190 TVAVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASELQDLYRDLEARVAQKTAELA 265
Cdd:PRK15347  310 TSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKAYNQLLDTLNEQYDTLENKVAERTQALA 385
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
192-257 2.57e-05

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 47.32  E-value: 2.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1618902859 192 AVIYLLYLWIILPVLRLQDGLRRMAAREFSLRLPVETRDEFGTLNEGFNRMASEL---QDLYRDLEARV 257
Cdd:PRK10549  179 LATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLeknEQMRRDFMADI 247
GAF_3 pfam13492
GAF domain;
286-429 3.95e-05

GAF domain;


Pssm-ID: 433253 [Multi-domain]  Cd Length: 129  Bit Score: 43.51  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 286 DAEAMCNGFLQRVMRQFDADGGSVRAFDDVRGKLPLMTSIGLPAALSgaaqcvsvKACHCGDATTQSVIAIQDLRHAPAR 365
Cdd:pfam13492   1 SLDEILEALLKLLVRLLGAERAAVYLLDEDGNKLQVAAGYDGEPDPS--------ESLDADSPLARRALSSGEPISGLGS 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618902859 366 AAGPVSPSpctrngfQALAAFRIGSLRGATGVFALHFREPRELPPSDRQLLETLGRHLGTALEQ 429
Cdd:pfam13492  73 AGEDGLPD-------GPALVVPLVAGRRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAIEN 129
NarX_sensor cd22900
ligand binding sensor domain of NarX, and related chemoreceptors; The periplasmic ligand ...
 53-166 5.20e-05

ligand binding sensor domain of NarX, and related chemoreceptors; The periplasmic ligand binding sensor domain of NarX is a histidine kinase receptor that responds to nitrate and nitrite to effect regulation of anaerobic respiration in various bacteria and similar proteins. It forms a homodimer and binds to ligands such as nitrate via the dimerization interface, a feature that appears to be conserved in this domain superfamily. NarX-NarL sensor-response regulator pair controls Escherichia coli gene expression in response to nitrate and nitrite. NarX has been shown to exhibit a clear kinetic preference for NarL over NarP, the sensor response partner of NarQ.


Pssm-ID: 438632 [Multi-domain]  Cd Length: 116  Bit Score: 42.94  E-value: 5.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859  53 AINDAGSLRMRANRV--AIELTLsqagkpnALDDQIAALDNTLAQLRKGNPARplflpdEPAIHAQLDRVVDGWQHRLKP 130
Cdd:cd22900     9 AINKAGSLRMQSYRLlaAVPLNP-------QDQALLDELEQTLSSPELQRAAR------REGLQSQLQALQQYWQQQLKP 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1618902859 131 laragGLMAGQATTAYIDALPSFVTQADRLVGMIEH 166
Cdd:cd22900    76 -----ALLAAKNPEDARAEVAAFVAQLDQLVSQIDQ 106
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
575-647 8.49e-05

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.39  E-value: 8.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 575 HVTVRLSHGRdFRLVVHDDGEGFDPADLAQ--------RSDAHIGLNIMRERAARL---NARLQIDSQPGAGVRIALLLP 643
Cdd:COG2972   363 RISIRKEGDR-LVITVEDNGVGMPEEKLEKlleelsskGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIP 441


                  ....
gi 1618902859 644 RGEQ 647
Cdd:COG2972   442 LEEE 445
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 543-643 4.79e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 40.48  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 543 GDVLPLHPEQQLQVLFILQEALSNVRKHAL--AAH--VTVRLSHGRDFRLV-VHDDGEGFdPADLAQRSDAHIGLNIMRE 617
Cdd:cd16951    27 GDTGPVSSEVATAIGLVVNELLQNALKHAFsdREGgtITIRSVVDGDYLRItVIDDGVGL-PQDEDWPNKGSLGLQIVRS 105

                          90       100
                  ....*....|....*....|....*..
gi 1618902859 618 R-AARLNARLQIDSQpGAGVRIALLLP 643
Cdd:cd16951   106 LvEGELKAFLEVQSA-ENGTRVNIDIP 131
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
356-662 5.38e-04

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 43.13  E-value: 5.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 356 IQDLRHAPARAAGPVSPSpctRNGFQALAAFRIGSlrGATGVFALHFREPRELPP-SDRQLLETLGRHLGTALEQLRLSD 434
Cdd:PRK13837  358 VFVDRNGPVRKRSCLTRR---GPALWACLAFKSGD--RIVALLGLGRQRYGLRPPaGELQLLELALDCLAHAIERRRLET 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 435 SARQLAVVEE--RNLVAQG-LHDSIAQglNFLNLQVQLL-----ADAVGRDDlPEAREIVPMLRHGVEESYQDVRELLNN 506
Cdd:PRK13837  433 ERDALERRLEhaRRLEAVGtLASGIAH--NFNNILGAILgyaemALNKLARH-SRAARYIDEIISAGARARLIIDQILAF 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 507 FR---SRLTPGELRPAVEATVERFRRQCRTEATLIVD--DGGDVLPLHPEQQLQVLFIL-----QEALSN------VRKH 570
Cdd:PRK13837  510 GRkgeRNTKPFDLSELVTEIAPLLRVSLPPGVELDFDqdQEPAVVEGNPAELQQVLMNLcsnaaQAMDGAgrvdisLSRA 589

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 571 ALAAHVtvRLSHG----RDF-RLVVHDDGEGFDPADLAQ--------RSDAH-IGLNIMRERAARLNARLQIDSQPGAGV 636
Cdd:PRK13837  590 KLRAPK--VLSHGvlppGRYvLLRVSDTGAGIDEAVLPHifepffttRAGGTgLGLATVHGIVSAHAGYIDVQSTVGRGT 667

                         330       340
                  ....*....|....*....|....*.
gi 1618902859 637 RIALLLPRGEQQPDAMAASQLQNTFP 662
Cdd:PRK13837  668 RFDVYLPPSSKVPVAPQAFFGPGPLP 693
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 558-645 6.60e-04

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 42.52  E-value: 6.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 558 FILQEALSNVRKHALA-----AHVTVRLSHGRDF-RLVVHDDGEG---------FD-------PADlaQRSDAHIGLNIM 615
Cdd:PRK11100  367 FLLRQALGNLLDNAIDfspegGTITLSAEVDGEQvALSVEDQGPGipdyalpriFErfyslprPAN--GRKSTGLGLAFV 444

                          90       100       110
                  ....*....|....*....|....*....|
gi 1618902859 616 RERAARLNARLQIDSQPGAGVRIALLLPRG 645
Cdd:PRK11100  445 REVARLHGGEVTLRNRPEGGVLATLTLPRH 474
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 559-616 8.99e-04

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 38.79  E-value: 8.99e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1618902859 559 ILQEALSNVRKHALAAH----VTVRLSHGRD-FRLVVHDDGEGFDPADLAQRSDAHI----GLNIMR 616
Cdd:cd16936     4 AVSEAVTNAVRHAYRHDgpgpVRLELDLDPDrLRVEVTDSGPGFDPLRPADPDAGLReggrGLALIR 70
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 516-647 7.50e-03

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 39.38  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 516 LRPAVEATVERFRRQCR-TEATLIVDDG----GDvlplhpEQQLQVLFilQEALSNVRKH---ALAAHVTVR-LSHGRDF 586
Cdd:COG4251   358 LNELLEEVLEDLEPRIEeRGAEIEVGPLptvrGD------PTLLRQVF--QNLISNAIKYsrpGEPPRIEIGaEREGGEW 429

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1618902859 587 RLVVHDDGEGFDPADLA------QRSDAH-------IGLNIMRERAARLNARLQIDSQPGAGVRIALLLPRGEQ 647
Cdd:COG4251   430 VFSVRDNGIGIDPEYAEkifeifQRLHSRdeyegtgIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 576-647 9.72e-03

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 38.68  E-value: 9.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1618902859 576 VTVRLS-HGRDFRLVVHDDGEGFDPADLAQ---------RSDAH-IGLNIMRERAARLNARLQIDSQPGAGVRIALLLPR 644
Cdd:COG3290   307 VELSIRdDGDELVIEVEDSGPGIPEELLEKifergfstkLGEGRgLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386


                  ...
gi 1618902859 645 GEQ 647
Cdd:COG3290   387 EGE 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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