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Conserved domains on  [gi|1616595189|ref|NP_001356638|]
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zinc finger Y-chromosomal protein isoform 6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zfx_Zfy_act super family cl04690
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 22-164 1.24e-69

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


The actual alignment was detected with superfamily member pfam04704:

Pssm-ID: 461400  Cd Length: 328  Bit Score: 227.05  E-value: 1.24e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189  22 DDAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPRE 101
Cdd:pfam04704 140 DDGEKLDHIGSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPRE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 102 KMVYMTVNDSQQEDEDLS----------------------------------------------NNSDGIENRNGTASAL 135
Cdd:pfam04704 220 KMVYMAVKDSQQEDEDLNvaeiadevymevivgeedaavaheqqlddsevnktfmpiawaaaygNNTDGIENKNGTASAL 299

                         170       180
                  ....*....|....*....|....*....
gi 1616595189 136 LHIDESAGLGRLAKQKPKKKRRPDSRQYQ 164
Cdd:pfam04704 300 LHIDESASLDRLLKQKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 3.89e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.89e-04
                          10        20
                  ....*....|....*....|....*
gi 1616595189 316 ELRKHMRIHTGEKPYQCQYCEYRSA 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
297-434 7.72e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 297 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 375
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 376 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 434
Cdd:COG5048   109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR super family cl19880
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 181-203 2.84e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


The actual alignment was detected with superfamily member pfam05443:

Pssm-ID: 473244  Cd Length: 122  Bit Score: 37.83  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1616595189 181 CMICGKKFKSrgfLKRHMKNH---PE 203
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-511 5.51e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.51e-03
                          10        20
                  ....*....|....*....|....*
gi 1616595189 487 ELKKHMKTHSGRKVYQCEYCEYSTT 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 22-164 1.24e-69

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 227.05  E-value: 1.24e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189  22 DDAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPRE 101
Cdd:pfam04704 140 DDGEKLDHIGSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPRE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 102 KMVYMTVNDSQQEDEDLS----------------------------------------------NNSDGIENRNGTASAL 135
Cdd:pfam04704 220 KMVYMAVKDSQQEDEDLNvaeiadevymevivgeedaavaheqqlddsevnktfmpiawaaaygNNTDGIENKNGTASAL 299

                         170       180
                  ....*....|....*....|....*....
gi 1616595189 136 LHIDESAGLGRLAKQKPKKKRRPDSRQYQ 164
Cdd:pfam04704 300 LHIDESASLDRLLKQKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 3.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.89e-04
                          10        20
                  ....*....|....*....|....*
gi 1616595189 316 ELRKHMRIHTGEKPYQCQYCEYRSA 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-434 7.72e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 297 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 375
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 376 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 434
Cdd:COG5048   109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 181-203 2.84e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 37.83  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1616595189 181 CMICGKKFKSrgfLKRHMKNH---PE 203
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-511 5.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.51e-03
                          10        20
                  ....*....|....*....|....*
gi 1616595189 487 ELKKHMKTHSGRKVYQCEYCEYSTT 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG4957 COG4957
Predicted transcriptional regulator [Transcription];
181-201 7.67e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443984  Cd Length: 141  Bit Score: 37.11  E-value: 7.67e-03
                          10        20
                  ....*....|....*....|.
gi 1616595189 181 CMICGKKFKSrgfLKRHMKNH 201
Cdd:COG4957    74 CLEDGKKFKM---LKRHLRTT 91
 
Name Accession Description Interval E-value
Zfx_Zfy_act pfam04704
Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in ...
 22-164 1.24e-69

Zfx / Zfy transcription activation region; Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger (pfam00096). This region has been shown to activate transcription when fused to a GAL4 DNA binding domain.


Pssm-ID: 461400  Cd Length: 328  Bit Score: 227.05  E-value: 1.24e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189  22 DDAGKIEHDGSTGVTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPRE 101
Cdd:pfam04704 140 DDGEKLDHIGSTPLTMSAEVEQDSSKLDGFCPEVIKVYIFKADPGEDDLGGTEDIVESEFENGHGVLLLEQGSSGRLPRE 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 102 KMVYMTVNDSQQEDEDLS----------------------------------------------NNSDGIENRNGTASAL 135
Cdd:pfam04704 220 KMVYMAVKDSQQEDEDLNvaeiadevymevivgeedaavaheqqlddsevnktfmpiawaaaygNNTDGIENKNGTASAL 299

                         170       180
                  ....*....|....*....|....*....
gi 1616595189 136 LHIDESAGLGRLAKQKPKKKRRPDSRQYQ 164
Cdd:pfam04704 300 LHIDESASLDRLLKQKPKKKRRGESRQYQ 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-340 3.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.89e-04
                          10        20
                  ....*....|....*....|....*
gi 1616595189 316 ELRKHMRIHTGEKPYQCQYCEYRSA 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-434 7.72e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 297 SKNFPHICVECGKGFRHPSELRKHMRIHTGEKPYQCQYCEYRSADSSNLKTHI-KTKHSKEMPFKCDICLLTFSDTKEVQ 375
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhLRTHHNNPSDLNSKSLPLSNSKASSS 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1616595189 376 QHTLVHQESKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKCEMC-EKGFHRPSELKKH 434
Cdd:COG5048   109 SLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH 168
ROS_MUCR pfam05443
ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR ...
 181-203 2.84e-03

ROS/MUCR transcriptional regulator protein; This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid and is necessary for succinoglycan production. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan.


Pssm-ID: 428475  Cd Length: 122  Bit Score: 37.83  E-value: 2.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1616595189 181 CMICGKKFKSrgfLKRHMKNH---PE 203
Cdd:pfam05443  67 CLEDGKPFKT---LKRHLTAHgltPE 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-511 5.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.51e-03
                          10        20
                  ....*....|....*....|....*
gi 1616595189 487 ELKKHMKTHSGRKVYQCEYCEYSTT 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG4957 COG4957
Predicted transcriptional regulator [Transcription];
181-201 7.67e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443984  Cd Length: 141  Bit Score: 37.11  E-value: 7.67e-03
                          10        20
                  ....*....|....*....|.
gi 1616595189 181 CMICGKKFKSrgfLKRHMKNH 201
Cdd:COG4957    74 CLEDGKKFKM---LKRHLRTT 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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