Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247   21 LNFYLEQEQRYQPREKgliLMEATPENDNtlcsRLRNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSC 100
Cdd:pfam00134   3 FQYLRELELKYLPKPD---YMDQQPDINP----KMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 161621247  101 IGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHYEL 153
Cdd:pfam00134  76 VGVTCLFIAAKY--EEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126

Cyclin [Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247  41 MEATPENDNTLCSRLRNAKVEDlrslTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVP 120
Cdd:COG5024  202 LIKQSLYEWSMRSILVDWLVEV----HGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKY--EEVNCP 275

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 161621247 121 PTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFL 162
Cdd:COG5024  276 SIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFL 317

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247  56 RNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEEGDVPPTHDVIRISQCKCTA 135
Cdd:cd20523    1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDLIRISQCGCTA 80

                         90
                 ....*....|....
gi 161621247 136 SDIKRMEKIISEKL 149
Cdd:cd20523   81 ADLMRMEGIILEKL 94

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247  56 RNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEEGDVPPTHDVIRISQCKCTA 135
Cdd:cd20526    2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCSV 81

                         90
                 ....*....|....*...
gi 161621247 136 SDIKRMEKIISEKLHYEL 153
Cdd:cd20526   82 AEVLRMERIILDKLHWDL 99

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHY 151
Cdd:cd20507   56 ETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKY--EEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHY 151
Cdd:cd20567   73 ETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKY--EEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247  63 LRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEegdvPPTHDVIrISQCKCTASDIKRME 142
Cdd:cd00043    6 IRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEEL----PRTLKEI-AKVSGVSEKELRKAE 80

                 ..
gi 161621247 143 KI 144
Cdd:cd00043   81 KE 82

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHY 151
Cdd:cd20568   60 ETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161621247  74 TETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKII 145
Cdd:cd20504   53 PETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAKY--EEIYPPEVEEFVYITDDTYTKKQVLRMEHLV 122

Cyclin [Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247  41 MEATPENDNTLCSRLRNAKVEDlrslTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVP 120
Cdd:COG5024  202 LIKQSLYEWSMRSILVDWLVEV----HGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKY--EEVNCP 275

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 161621247 121 PTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALNFL 162
Cdd:COG5024  276 SIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFL 317

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161621247  56 RNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALM---KVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDvIRISQCK 132
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYdlpKDKPWMLQLLAVACLSLAAKM--EETDVPLLVD-LQVEEPK 78

                         90
                 ....*....|....*....
gi 161621247 133 --CTASDIKRMEKIISEKL 149
Cdd:cd20543   79 yvFEAKTIQRMELLVLSTL 97

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHYE 152
Cdd:cd20562   61 DTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKY--EEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEegdVPPTHDVIrisqCKCTASDIKRME 142
Cdd:cd20574   75 EVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKET---IPLTAEKL----CIYTDNSIKPQE 135

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161621247  75 ETFVLAVNILDRFLALMK-VKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHY 151
Cdd:cd20580   62 ETFYLAQDFFDRFMLTQKnINKSMLQLIGITSLFIASKL--EEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAE 114
Cdd:cd20575   75 EVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRE 114

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLAEEegdVPPTHDVIRI-SQCKCTASDIKRMEKIISEKLHYE 152
Cdd:cd20573   74 EVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKET---IPLTAEKLCIyTDNSIRPEELLQMELLVLNKLKWD 149

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161621247  75 ETFVLAVNILDRFLALMKVKPKHLSCIGVCCFLLAARLaeEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHY 151
Cdd:cd20565   55 ETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKY--EEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129