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Conserved domains on  [gi|161353477|ref|NP_689949|]
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zinc finger and SCAN domain-containing protein 26 isoform c [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11986654)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-334 9.54e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 174 KPYQCNECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHSQEEPCECK--ECGKTFSQAL 245
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 246 -----LLTHHQRIHSHSKSHQC--NECGKAFSLTSDLIRHHRIHTGEKP--FKCNICQKAFRLNSHLAQHVRIHNEEKPY 316
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 161353477 317 QCSECGeAFRQRSGLFQH 334
Cdd:COG5048  448 LCSILK-SFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 148-170 9.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.04  E-value: 9.99e-03
                          10        20
                  ....*....|....*....|...
gi 161353477  148 HQCHECGKAFQRSSHLVRHQKIH 170
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-334 9.54e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 174 KPYQCNECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHSQEEPCECK--ECGKTFSQAL 245
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 246 -----LLTHHQRIHSHSKSHQC--NECGKAFSLTSDLIRHHRIHTGEKP--FKCNICQKAFRLNSHLAQHVRIHNEEKPY 316
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 161353477 317 QCSECGeAFRQRSGLFQH 334
Cdd:COG5048  448 LCSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
162-187 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 161353477  162 HLVRHQKIHLGEKPYQCNECGKVFSQ 187
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 148-170 9.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.04  E-value: 9.99e-03
                          10        20
                  ....*....|....*....|...
gi 161353477  148 HQCHECGKAFQRSSHLVRHQKIH 170
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-334 9.54e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 174 KPYQCNECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHSQEEPCECK--ECGKTFSQAL 245
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 246 -----LLTHHQRIHSHSKSHQC--NECGKAFSLTSDLIRHHRIHTGEKP--FKCNICQKAFRLNSHLAQHVRIHNEEKPY 316
Cdd:COG5048  368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 161353477 317 QCSECGeAFRQRSGLFQH 334
Cdd:COG5048  448 LCSILK-SFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-301 1.39e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477  95 IEYKCSEREQRFIQHLDLIEHASTHTGKKLCESDVC-QSSSLTGHKKVLSREKG-----HQCHECGKAFQRSSHLVRHQ- 167
Cdd:COG5048  231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPtASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLr 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 168 -KIHLGE--KPYQCNE--CGKVFSQNAGLLEHLRIHTGEKPYLCI--HCGKNFRRSSHLNRHQRIHSQEEPCECKE---- 236
Cdd:COG5048  311 sVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetl 390

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 237 ---CGKTFSQALLLTHHQRIHSHSKSHQCN--ECGKAFSLTSDLIRHHRIHTGEKPFKCNICQKAFRLNS 301
Cdd:COG5048  391 snsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-263 3.73e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 3.73e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161353477 202 KPYLCIHCGKNFRRSSHLNRHQRIHSQEEPCEC--KECGKTFSQALLLTHHQRIHSHSKSHQCN 263
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-321 1.37e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 132 SSSLTGHKKVLSREKGHQCHECGKAFQRSSHLVRHQKIHLGEKPYQCN--ECGKVFSQNAGLLEHLRIHTGEKPYLCIHC 209
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 210 GK--NFRRSSHLNRHQRIHSQE-EPCECKECGKTFSQALLLTHHQRIHSHSKS-HQCNECGKAFSLTSDLI--------- 276
Cdd:COG5048   98 LPlsNSKASSSSLSSSSSNSNDnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpansls 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 161353477 277 ----------RHHRIHTGEKPFKCNICQKAFRLNSHLAQHVRIHNEEKPYQCSEC 321
Cdd:COG5048  178 kdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232
zf-H2C2_2 pfam13465
Zinc-finger double domain;
162-187 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 161353477  162 HLVRHQKIHLGEKPYQCNECGKVFSQ 187
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-343 1.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161353477 286 KPFKCNICQKAFRLNSHLAQHVRIHNEEKPYQCSECGEAFRQRSG--LFQHQRYHHKDKL 343
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-297 4.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|....
gi 161353477  274 DLIRHHRIHTGEKPFKCNICQKAF 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-339 8.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 37.78  E-value: 8.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161353477 284 GEKPFKCNI--CQKAF---------RLNSHLAQ----------HVRIHNEEKPYQCSECGEAFRQRSGLFQHQRYHH 339
Cdd:COG5189  346 DGKPYKCPVegCNKKYknqnglkyhMLHGHQNQklhenpspekMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
302-327 8.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 8.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 161353477  302 HLAQHVRIHNEEKPYQCSECGEAFRQ 327
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 148-170 9.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.04  E-value: 9.99e-03
                          10        20
                  ....*....|....*....|...
gi 161353477  148 HQCHECGKAFQRSSHLVRHQKIH 170
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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