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Conserved domains on  [gi|1610534192|gb|TGN10498|]
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tetratricopeptide repeat protein [Leptospira ilyithenensis]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12138008)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TPR_11 pfam13414
TPR repeat;
165-206 1.63e-11

TPR repeat;


:

Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 58.64  E-value: 1.63e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDG 206
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 126-338 2.53e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 126 FGWQVRGDGYLRliEDRPVTAARLLDA-----TKYEEAVMAKkqGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGK 200
Cdd:COG2956     9 LGWYFKGLNYLL--NGQPDKAIDLLEEaleldPETVEAHLAL--GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 201 VHWNDGEgYVSAAYEFSQAWKNKERFSNGQEQLL-FYLEYMRF--LIYQFKTEGKENTKNLELLPQIAKEARSLNpkNYE 277
Cdd:COG2956    85 DYLKAGL-LDRAEELLEKLLELDPDDAEALRLLAeIYEQEGDWekAIEVLERLLKLGPENAHAYCELAELYLEQG--DYD 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610534192 278 AWLYSFESA---YLQFVRANVLASGVESRKNKEewsEKAEEALLKAANLRKSDFYLHKLACEFY 338
Cdd:COG2956   162 EAIEALEKAlklDPDCARALLLLAELYLEQGDY---EEAIAALERALEQDPDYLPALPRLAELY 222
 
Name Accession Description Interval E-value
TPR_11 pfam13414
TPR repeat;
165-206 1.63e-11

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 58.64  E-value: 1.63e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDG 206
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 126-338 2.53e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 126 FGWQVRGDGYLRliEDRPVTAARLLDA-----TKYEEAVMAKkqGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGK 200
Cdd:COG2956     9 LGWYFKGLNYLL--NGQPDKAIDLLEEaleldPETVEAHLAL--GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 201 VHWNDGEgYVSAAYEFSQAWKNKERFSNGQEQLL-FYLEYMRF--LIYQFKTEGKENTKNLELLPQIAKEARSLNpkNYE 277
Cdd:COG2956    85 DYLKAGL-LDRAEELLEKLLELDPDDAEALRLLAeIYEQEGDWekAIEVLERLLKLGPENAHAYCELAELYLEQG--DYD 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610534192 278 AWLYSFESA---YLQFVRANVLASGVESRKNKEewsEKAEEALLKAANLRKSDFYLHKLACEFY 338
Cdd:COG2956   162 EAIEALEKAlklDPDCARALLLLAELYLEQGDY---EEAIAALERALEQDPDYLPALPRLAELY 222
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
170-233 2.78e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 2.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610534192 170 AKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgyVSAAYEFSQAWKNKERFSNGQEQL 233
Cdd:COG3063     4 KLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR--YDEAIALEKALKLDPNNAEALLNL 65
 
Name Accession Description Interval E-value
TPR_11 pfam13414
TPR repeat;
165-206 1.63e-11

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 58.64  E-value: 1.63e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDG 206
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 126-338 2.53e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 126 FGWQVRGDGYLRliEDRPVTAARLLDA-----TKYEEAVMAKkqGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGK 200
Cdd:COG2956     9 LGWYFKGLNYLL--NGQPDKAIDLLEEaleldPETVEAHLAL--GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 201 VHWNDGEgYVSAAYEFSQAWKNKERFSNGQEQLL-FYLEYMRF--LIYQFKTEGKENTKNLELLPQIAKEARSLNpkNYE 277
Cdd:COG2956    85 DYLKAGL-LDRAEELLEKLLELDPDDAEALRLLAeIYEQEGDWekAIEVLERLLKLGPENAHAYCELAELYLEQG--DYD 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610534192 278 AWLYSFESA---YLQFVRANVLASGVESRKNKEewsEKAEEALLKAANLRKSDFYLHKLACEFY 338
Cdd:COG2956   162 EAIEALEKAlklDPDCARALLLLAELYLEQGDY---EEAIAALERALEQDPDYLPALPRLAELY 222
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
131-219 1.88e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.29  E-value: 1.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 131 RGDGYLRLIEDRPVTAARLLDATKYEEAVMAKKQGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYV 210
Cdd:COG4785    46 LALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGD-YD 124


                  ....*....
gi 1610534192 211 SAAYEFSQA 219
Cdd:COG4785   125 AALEDFDRA 133
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
170-233 2.78e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 2.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1610534192 170 AKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgyVSAAYEFSQAWKNKERFSNGQEQL 233
Cdd:COG3063     4 KLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR--YDEAIALEKALKLDPNNAEALLNL 65
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 165-219 4.05e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 4.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:COG4783    79 GLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGR-PDEAIAALEKA 132
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 135-240 5.07e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.41  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 135 YLRLIEDRPVTAARLLDATKYEEAVMAKKQGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAY 214
Cdd:COG5010    31 LAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGD-KDEAKE 109

                          90       100
                  ....*....|....*....|....*.
gi 1610534192 215 EFSQAWKNKERFSNGQEQLLFYLEYM 240
Cdd:COG5010   110 YYEKALALSPDNPNAYSNLAALLLSL 135
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 146-331 5.63e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.37  E-value: 5.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 146 AARLLDATKYEEAVMAKKQGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHwNDGEGYVSAAYEFSQAWKNKER 225
Cdd:COG3914    66 EAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLL-LALGRLEEALAALRRALALNPD 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 226 FsngqeqLLFYLEYMRFLiyqfktegkENTKNLELLPQIAKEARSLNPKNYEAWLYsfesaylqfvRANVLasgvESRKN 305
Cdd:COG3914   145 F------AEAYLNLGEAL---------RRLGRLEEAIAALRRALELDPDNAEALNN----------LGNAL----QDLGR 195

                         170       180
                  ....*....|....*....|....*.
gi 1610534192 306 KEEwsekAEEALLKAANLRKSDFYLH 331
Cdd:COG3914   196 LEE----AIAAYRRALELDPDNADAH 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
165-219 8.18e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 8.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR-YEEALEDYDKA 102
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
165-219 9.69e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 43.37  E-value: 9.69e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:COG4785   114 GLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGR-YELAIADLEKA 167
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
165-219 1.72e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 1.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR-YEEALADYEQA 68
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
165-219 2.22e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.77  E-value: 2.22e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1610534192 165 GDHFVAKGKWDEAIRlYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:COG3063    33 GLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGD-YDEALAYLERA 85
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 127-207 2.28e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 127 GWQVRGDGYLRLieDRPVTAARLLD-ATKY--EEAVMAKKQGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHW 203
Cdd:COG4235    19 GWLLLGRAYLRL--GRYDEALAAYEkALRLdpDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAF 96


                  ....
gi 1610534192 204 NDGE 207
Cdd:COG4235    97 QQGD 100
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 134-207 2.60e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.95  E-value: 2.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1610534192 134 GYLRLIEDRPVTAARLLD---ATKYEEAVMAKKQGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGE 207
Cdd:COG4783    11 AQALLLAGDYDEAEALLEkalELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD 87
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
165-219 2.81e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 2.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR-YDEAIEAYERA 136
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 163-219 2.00e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.55  E-value: 2.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610534192 163 KQGDHFVAKGKWDEAIRLYKRAISLDPNYPDT---HFALGKVHWNDGEgYVSAAYEFSQA 219
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFPESPDAaaaLLLLGLAALRQGR-LAEAAAAYRAA 60
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 163-207 2.15e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1610534192 163 KQGDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGE 207
Cdd:COG4783     9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGD 53
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 165-207 3.01e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 3.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1610534192 165 GDHFVAKGKWDEAIRLYKRAISLDPNYPDTHFALGKVHWNDGE 207
Cdd:COG5010    95 ALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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