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Conserved domains on  [gi|1610478116|gb|TGM55009|]
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tetratricopeptide repeat protein [Leptospira biflexa]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12138008)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_11 pfam13414
TPR repeat;
159-200 1.97e-10

TPR repeat;


:

Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 55.56  E-value: 1.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1610478116 159 GDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAHWKDG 200
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
 
Name Accession Description Interval E-value
TPR_11 pfam13414
TPR repeat;
159-200 1.97e-10

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 55.56  E-value: 1.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1610478116 159 GDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAHWKDG 200
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 122-201 1.38e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.72  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610478116 122 WQVRGEGYLRLIEDRPVTAARLLDT-----TKYEEAFLAKkqGDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAH 196
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKaleldPDNPEAFALL--GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82


                  ....*
gi 1610478116 197 WKDGE 201
Cdd:COG4783    83 LKAGD 87
 
Name Accession Description Interval E-value
TPR_11 pfam13414
TPR repeat;
159-200 1.97e-10

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 55.56  E-value: 1.97e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1610478116 159 GDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAHWKDG 200
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 122-201 1.38e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.72  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610478116 122 WQVRGEGYLRLIEDRPVTAARLLDT-----TKYEEAFLAKkqGDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAH 196
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKaleldPDNPEAFALL--GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82


                  ....*
gi 1610478116 197 WKDGE 201
Cdd:COG4783    83 LKAGD 87
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 120-201 1.59e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1610478116 120 FGWQVRGEGYLRliEDRPVTAARLLDT-----TKYEEAFLAKkqGDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGK 194
Cdd:COG2956     9 LGWYFKGLNYLL--NGQPDKAIDLLEEaleldPETVEAHLAL--GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQ 84


                  ....*..
gi 1610478116 195 AHWKDGE 201
Cdd:COG2956    85 DYLKAGL 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 129-201 3.74e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 37.63  E-value: 3.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1610478116 129 YLRLIEDRPVTAARLLDTTKYEEAFLAKKQGDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAHWKDGE 201
Cdd:COG5010    31 LAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGD 103
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 150-201 4.61e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 4.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1610478116 150 EEAFLAKKQGDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAHWKDGE 201
Cdd:COG4783    70 DEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGR 121
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 159-201 4.97e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 4.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1610478116 159 GDHYFAKGQMEEALRKYKHAVSLDQSSPDLHYALGKAHWKDGE 201
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGD 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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