|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
13-413 |
4.88e-85 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 269.29 E-value: 4.88e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 13 LVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCA 92
Cdd:PRK10504 14 IVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 93 ASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPL 172
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 173 GIAALWLAWRLIPQEASQKGvPFDALGFVLTGIACFGLMFGLDLINHPQLS-WLVPALCILGSLALGtLAVRHAKRTEHP 251
Cdd:PRK10504 174 GIIGAIATLMLMPNYTMQTR-RFDLSGFLLLAVGMATLTLALDGSKGLGLSpLAIAGLVAVGVVALL-LYLLHARNNNRA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 252 LINLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLV 331
Cdd:PRK10504 252 LFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLV 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 332 VNGLLNAATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGAL 411
Cdd:PRK10504 332 ATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGL 411
|
..
gi 1608427181 412 AL 413
Cdd:PRK10504 412 LL 413
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
17-453 |
8.69e-75 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 239.79 E-value: 8.69e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 17 AFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVN 96
Cdd:cd17503 4 GAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 97 LPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAA 176
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 177 LWLAwrlipqeasqkgvpfdalgfvltgiacfglmfgldlinhpqlswlvpalcilgslalgtlavrhakrtehPLINLW 256
Cdd:cd17503 164 LLLA----------------------------------------------------------------------PLLDLR 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 257 AMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLL 336
Cdd:cd17503 174 LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 337 NAATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALAL--- 413
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLtnr 333
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1608427181 414 ------RLAEMLMPQSGERIPLVDFQWAFVVIGVIALLAVVDCFTL 453
Cdd:cd17503 334 tqfhhsRLSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFL 379
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
17-408 |
2.74e-54 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 189.13 E-value: 2.74e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 17 AFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVN 96
Cdd:TIGR00711 10 GTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 97 LPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAA 176
Cdd:TIGR00711 90 LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 177 LWLAWRLIPQEASQKGVPFDALGFVLTGIACFGLMFGLDliNHPQLSWLVP----ALCILGSLALGTLAVrHAKRTEHPL 252
Cdd:TIGR00711 170 VVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLS--EGPERGWFDSneilILSITGLVAIIAFVV-WELTDDNPL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 253 INLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVV 332
Cdd:TIGR00711 247 VDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTI 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1608427181 333 NGLLNAATIFACAL-LTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAI 408
Cdd:TIGR00711 327 GLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTAL 403
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-448 |
2.40e-40 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 148.86 E-value: 2.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 14 VAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAA 93
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 94 SVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLG 173
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 174 IAALWLawrlipqeasqkgvpfdALGFVLTGIACFGLMFGLdlinhpqlswlvpalcilgslalgtlavrhakrtehpli 253
Cdd:cd17321 161 LVALLL-----------------ARTFSGAVLAAFLLGAAL--------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 254 nlwamriksyavtiwggtlfriaiGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVN 333
Cdd:cd17321 185 ------------------------GGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 334 GLLNAATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAI-GALA 412
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALlGALL 320
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1608427181 413 LRLAEMLMPQSGERIPLVD--------FQWAFVVIGVIALLAVV 448
Cdd:cd17321 321 TAGLSANLGDSGVAALLSAaaaafaagFHLAFLVAAALALLAAL 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-404 |
3.51e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 123.16 E-value: 3.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVP 171
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 172 LGIAALWLAWRLIPqeasqkgvpfdalgfvltgiacfglmfgldlinhpqlswlvpalcilgslalgtlAVRHAKRTEHP 251
Cdd:COG2814 173 LALLALLLLLRLLP-------------------------------------------------------ESRPAARARLR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 252 LINLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLV 331
Cdd:COG2814 198 GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1608427181 332 VNGLLnaaTIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGL 404
Cdd:COG2814 278 IGLLL---LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-408 |
2.44e-29 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 117.66 E-value: 2.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 19 FMENLDATVIVTAMPQMAAAFGvRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLP 98
Cdd:cd17502 6 FLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 99 TFTAARILQGFGGALMVP-----VGRLVVLRNTAKpdlIKAIATITWpgLVAPILGPPVGGFITTYASWHWIFILNVPLG 173
Cdd:cd17502 85 MLIVGRAIQGIGGGGLMSlafiiIADLVPPRERGK---YQGYIGAVF--GIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 174 IAALWLawrlipqeasqkgvpfdalgfvltgiacfglmfgldlinhpqlswlvpalcilgslalgtlavrhakrtehpli 253
Cdd:cd17502 160 GLALAL-------------------------------------------------------------------------- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 254 nlwamrIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRF-RFRTTLVV 332
Cdd:cd17502 166 ------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgRYKPLIVI 239
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1608427181 333 NGLLNAATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAI 408
Cdd:cd17502 240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-288 |
2.46e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.58 E-value: 2.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 5 SRASALPLLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIF 84
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 85 TLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHW 164
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 165 IFILNVPLGIAALWLAWRLIPQEASQKGVPFDALGFVLTGIACFGLMFGLDLINHPQLSWLVPALCILGSLALGTLAVRH 244
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1608427181 245 AKRTEHPLINLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLF 288
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-405 |
6.53e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.41 E-value: 6.53e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 14 VAGAFFMENLDATVIVTAMPQ-MAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCA 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 93 ASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPL 172
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 173 GIAALWLAWRLIPQEASQKGVPFDALGFVLtgiacfglMFGLDLINHPQLSWLVPALCILGslalgtlavrhakrtehpl 252
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSL--------IVAWKALLRDPVLWLLLALLLFG------------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 253 inlwamriksyavtiwggtlfrIAIGAVPFLLPLlFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVV 332
Cdd:pfam07690 214 ----------------------FAFFGLLTYLPL-YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1608427181 333 NGLLNAATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLG 405
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
12-448 |
1.22e-22 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 99.19 E-value: 1.22e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMenLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:cd17504 1 LALAALAVM--LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFGGAlMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVP 171
Cdd:cd17504 79 AFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 172 LGIAALWLAwrlipqeasqkgvpfdalgfvltgiacfglmfgldlinhpqlswlvpalcilgslalgtlavrhakrtehP 251
Cdd:cd17504 158 VAVLLAALV----------------------------------------------------------------------P 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 252 LINLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQ----IGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFR 327
Cdd:cd17504 168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 328 TTLVVnGLLNAATIFACALLTPQTPtWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIA 407
Cdd:cd17504 248 RVLLI-GLVISAVGLLLLALLHSSL-WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPA 325
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1608427181 408 IGALALRLAEMLMPqSGERIPLVDFQWAFVVIGVIALLAVV 448
Cdd:cd17504 326 IAGAILTTYTVSIT-SGGVPTEGAYVLAFLIGAALALAALL 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-448 |
4.84e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.57 E-value: 4.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 14 VAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAA 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 94 SVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLG 173
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 174 IAALWLAWRLIPQEASQKgvpfdalgfvltgiacfglmfgldlinhpqlswlvpalcilgslalgtlAVRHAKRTEHPLI 253
Cdd:cd17325 161 LLALVLALLLLPEPRPPP-------------------------------------------------NKRAVSAARLRSG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 254 NLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVN 333
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 334 GLLNAATIFacaLLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLG-IAIGALA 412
Cdd:cd17325 272 LLLSAVALL---LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGpLLGGFLY 348
|
410 420 430
....*....|....*....|....*....|....*.
gi 1608427181 413 lrlaemlmpqsgeriPLVDFQWAFVVIGVIALLAVV 448
Cdd:cd17325 349 ---------------DAFGFATPFLAAAALLLLAAV 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-413 |
5.27e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 94.15 E-value: 5.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVP 171
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 172 LGIAALWLAWRLIPQEASQKGVPFDALGFVLTgiacfglmfgldLINHPQLSWLVPalcilgslalgtlavrhakrtehp 251
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLL------------LLRNPRLRLAYL------------------------ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 252 linlwamriksyAVTIWGGTLFriaiGAVPFLLPLLFQIGFGLNAFDAGLLVLaVFAGNLVMKPFTSAVLYRFRFRTTLV 331
Cdd:cd17324 206 ------------ITFLLFGGFF----ALYTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 332 VNGLLNAATIfacALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQmNGANTLFNVSQQMGSGLGIAIGAL 411
Cdd:cd17324 269 ALLLLAAALL---LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGL 344
|
..
gi 1608427181 412 AL 413
Cdd:cd17324 345 VL 346
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
23-413 |
7.42e-21 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 95.18 E-value: 7.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 23 LDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTA 102
Cdd:PRK14995 20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 103 ARILQGFGGALMVPvGRLVVLRNTAKPDLIKAIATITWP--GLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLA 180
Cdd:PRK14995 100 TRALLAIGAAMIVP-ATLAGIRATFTEEKQRNMALGVWAavGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 181 WRLIPQEASQKGVPFDALGFVLTGIACFGLMFGLDLINHPQLSWLVPALCILGSLALGTLAVRHAKRTEHPLI--NLWAM 258
Cdd:PRK14995 179 ARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIdmRLFTH 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 259 RIKSYAVTIWGGTLfrIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNA 338
Cdd:PRK14995 259 RIILSGVVMAMTAM--ITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSA 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1608427181 339 ATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALAL 413
Cdd:PRK14995 337 LSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAIFGLLL 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-352 |
1.62e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 83.77 E-value: 1.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVP 171
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 172 LGIAALWLAWRLIpqeasqkgvpfdALGFVLTGIACFGLMF----------GLDLINHPQLSWLVPALCILGSLALGTLA 241
Cdd:COG2271 173 PGLLLALLRFWLL------------ALAYFLVYFALYGFLTwlptylvevrGLSLAQAGLLLSLPFLAGIVGSLLGGWLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 242 VRHAKRTEHPLI---------NLWAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDA--GLLVLAVFAGN 310
Cdd:COG2271 241 DRLGRRRKLVLAiglllaalaLLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTasGLVNTFGFLGG 320
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1608427181 311 LVMKPFTSAVLYRFRFRTTLVVNGLLNAATIFACALLTPQTP 352
Cdd:COG2271 321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
9-213 |
2.91e-17 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 83.20 E-value: 2.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 9 ALPLLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLAS 88
Cdd:TIGR00710 5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 89 VLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFIL 168
Cdd:TIGR00710 85 LGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 169 NVPLGIAALWLAWRLIP--------QEASQKGVPFDAL-------GFVLTGIACFGLMFG 213
Cdd:TIGR00710 165 LSLAGILLSALIFFILPetlpyearIQISTYFETFLLLlkskmfwGYALIYGASFGGFFA 224
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-453 |
4.93e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 82.62 E-value: 4.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 13 LVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCA 92
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 93 ASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTyASWHWIFILnVPL 172
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFL-LAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 173 GIAALWLAWRLIPQEASQKGVPFDALGFVLTGIacfglmfgldlinhpqlswlvpalcilgslalgtlavrhakrtehpl 252
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKK----------------------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 253 inlwAMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVL-YRFRFRTTLV 331
Cdd:cd17474 194 ----ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILV 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 332 VNGLLNAATIFACALLTPQtptWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGAL 411
Cdd:cd17474 270 IGLLLYALSLLLLGFVPSL---ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL 346
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1608427181 412 ALRLAemlmpqsgeriplvDFQWAFVVIGVIALLAVVDCFTL 453
Cdd:cd17474 347 LLEIF--------------GLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
10-212 |
8.01e-17 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 81.85 E-value: 8.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 10 LPLLVAGAFFMeNLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASV 89
Cdd:cd17320 1 LLLLALLVALG-PLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 90 LCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILN 169
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1608427181 170 VPLGIAALWLAWRLIPQEASQKGVPFD----------------ALGFVLTGIACFGLMF 212
Cdd:cd17320 160 ALLGLLLLLLVLLFLPETLPEEKRKPLlssllraykrvlknrrFLGYALALGLSFAGLF 218
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-170 |
1.69e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 78.00 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 25 ATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAAR 104
Cdd:cd17323 15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1608427181 105 ILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNV 170
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-339 |
7.60e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 75.68 E-value: 7.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 10 LPLLVAGAFFMEnLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASV 89
Cdd:cd17319 5 IPLLFLAYVINY-LDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 90 LCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILN 169
Cdd:cd17319 84 LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 170 VPLGIAALWLAWRLIPQeasqkgVPFDALGFVLTGIACFGLMF----------GLDLINHPQLSWlVPALCILGSLALGT 239
Cdd:cd17319 164 GLLGLLLAVLWWFYLRQ------VWGLALGYFGINYALYGLLTwlptylkqarGFSLKQVGLLAA-IPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 240 lavRHAKRTehplinlwaMRIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQIGFglnafdaglLVLAVFAGNLVMKPFTSA 319
Cdd:cd17319 237 ---RLSDRL---------LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL---------LSLAGFGIGAASPVFWSL 295
|
330 340
....*....|....*....|
gi 1608427181 320 VLYRFRFRTTLVVNGLLNAA 339
Cdd:cd17319 296 PADLLPGEAAATAGGLINSG 315
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
50-185 |
1.51e-14 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 70.37 E-value: 1.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 50 ISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKP 129
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1608427181 130 DLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIP 185
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
31-186 |
3.11e-14 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 74.18 E-value: 3.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 31 AMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFG 110
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1608427181 111 GALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIPQ 186
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
14-178 |
3.90e-14 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 73.45 E-value: 3.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 14 VAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAA 93
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 94 SVNLPTFTAARILQGFGGALMVPVGrLVVLRNTAKPDLIKAIAtITWPGLVAP---ILGPPVGGFITTYASWHWIF---- 166
Cdd:cd17476 83 SPNFIFFIICRALQGLGPAFLLPNA-MALLGRTYPPGPRKNIV-FSLFGATAPlgfALGGVFGGLFAQLAWWPWIFwfla 160
|
170
....*....|..
gi 1608427181 167 ILNVPLGIAALW 178
Cdd:cd17476 161 ILAAIVAVAAIF 172
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
28-224 |
2.50e-13 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 71.51 E-value: 2.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 28 IVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQ 107
Cdd:PRK15402 32 IQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 108 GFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIPQE 187
Cdd:PRK15402 112 GIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPET 191
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1608427181 188 ASQKG--VPFDALGF----VLTGIACFGLMFGLDLINHPQLSW 224
Cdd:PRK15402 192 AGRVGekLSLKELGRdyklVLKNRRFVAGALALGLVSLPLLAW 234
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
17-181 |
2.03e-10 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 62.35 E-value: 2.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 17 AFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVN 96
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 97 LPTFTAARILQGFGGALMVPVGRLVVlrNTAKPDLIKAIATITWPGL--VAPILGPPVGGFITTYASWHWIFILNVPLGI 174
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIV--ASWFPASERATAVSIFNSAqgLGGIIGGPLVGWILIHFSWQWAFIIEGVLGI 159
|
....*....
gi 1608427181 175 --AALWLAW 181
Cdd:TIGR00893 160 iwGVLWLKF 168
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-448 |
3.74e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 61.46 E-value: 3.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMenldatvIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:cd17489 6 FFFFLSFYL-------LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIAtitWPGLVAPI---LGPPVGGFITTYASWHWIFIL 168
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIG---YYGLATTLamaLGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 169 NVPLGIAALWLAWRL----IPQEASQKGVPFDALGFVLTGIacfglmfgldlinhpqlsWLVPALCILGSLALGTLAVrh 244
Cdd:cd17489 156 AAVLALLALLLVFLVkdppPVAAEEAEAGTRAFRRLVEKKV------------------LPPALILFLASIAYGAIST-- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 245 akrtehpLINLWAMRIksyavtiwggtlfriaigavpfllpLLFQIGFGLNAFDAGLLVLAVFAGNLVMkpftsavlyRF 324
Cdd:cd17489 216 -------FLPLYAAER-------------------------GISNAGLFFTVYAIALLLSRPFSGKLSD---------RK 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 325 RFRTTLVVNGLLNAATIFacaLLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGL 404
Cdd:cd17489 255 GPKTVIIPGLLLLALGLL---LLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1608427181 405 GIAIGAlalrlaeMLMPQSGeriplvdFQWAFVVIGVIALLAVV 448
Cdd:cd17489 332 GGLLLG-------LVAELFG-------YRAMFLLAAVVVLLALV 361
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
65-241 |
1.10e-09 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 60.23 E-value: 1.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 65 GWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLV 144
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 145 APILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIPQEASQKGVPFDALGFVLTGIACFG---LMFG---LDLIN 218
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRnrlFLTGaatLSLSY 231
|
170 180
....*....|....*....|....*.
gi 1608427181 219 HPQLSWLVPALCIL---GSLALGTLA 241
Cdd:PRK15403 232 IPMMSWVAVSPVILidaGGMTTSQFA 257
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-448 |
1.33e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 5 SRASALPLLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIF 84
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 85 TLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHW 164
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 165 IFILNVPLGIAALWLAWRLIpqeasqKGVPFDALGFVLTGIACFGLMFGldlinhpqlSWLVPALCILgslalgtlavrh 244
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFL------RDPPAGAAAAAKASLRDQLEALR---------DPRFWLLSLL------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 245 akrtehplinlwamriksYAVTIWGGTLFRiaigavpFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRF 324
Cdd:COG2223 214 ------------------YFGTFGSFIGFS-------SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 325 RFRTTLVVNGLLNAATIFAcaLLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGL 404
Cdd:COG2223 269 GGRRVLLIVFALMALGLLL--LALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1608427181 405 GIAIGALALRLAEmlmpqsgeriplvDFQWAFVVIGVIALLAVV 448
Cdd:COG2223 347 GPLLFGALLDATG-------------SYTAAFLVFAVLALVALV 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-413 |
1.66e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.36 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 14 VAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAA 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 94 SVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTY--ASWHWIFILNVP 171
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 172 LGIAALWLAWRLIPQEASQKGVpfdalgfvltgiacfglmfglDLINHPQLSWLVPALCILGSLALGTLAVrhakrtehp 251
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARA---------------------KNEEASSKSVLKLLKRVLKNPGLWLLLL--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 252 linlwamriksyavtiwGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLV 331
Cdd:cd06174 211 -----------------AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 332 VNGLLnaATIFACALLTPQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGAL 411
Cdd:cd06174 274 LIGLL--LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351
|
..
gi 1608427181 412 AL 413
Cdd:cd06174 352 LL 353
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
30-180 |
3.71e-09 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 58.49 E-value: 3.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 30 TAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGF 109
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1608427181 110 G-GALMVPVgrLVVLRNTAKPD-LIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLA 180
Cdd:PRK10473 104 GaGCCYVVA--FAILRDTLDDRrRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLS 174
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
50-365 |
1.79e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 56.48 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 50 ISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGA--LMVPVGRLVVLRNTA 127
Cdd:cd06179 38 STAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGtqGLGAAVASELVPNKY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 128 KPdliKAIATITWPGLVAPILGPPVGGFIT--TYASWHWIFILNVPLGIAA--LWLAW-------RLIPQEASQKGVPFD 196
Cdd:cd06179 118 RG---LVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALAliLLFFFyhppprpQLHGSSTRQKLKRLD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 197 ALGFVLTGIACFGLMFGLDLI--NHPQLSWLVPALCILGSLALGTLAVRHAK-RTEHPLInlWAMRIKSYAVTIwggTLF 273
Cdd:cd06179 195 WVGLFLLIAGLVLFLLGLSWGgnPYPWSSAHVIAPLVIGGVLLIAFGLYEWKgTKDGLLP--PRLLFRGRNFAL---ILI 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 274 RIAIGAVPF-----LLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFR-FRTTLVVNGLLNAATIFACALL 347
Cdd:cd06179 270 VAFVEGMIFyslniFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKhIKWQLVAGFVLFTAFLALLALI 349
|
330
....*....|....*...
gi 1608427181 348 TPQTPTwLILALLFVSGL 365
Cdd:cd06179 350 TPDNKA-LAIAFSVLAGI 366
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-448 |
6.47e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 6.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 30 TAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNI-----FAAAVLIFTLASVLCAASVNLPTFTAAR 104
Cdd:cd06173 20 VALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 105 ILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLI 184
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 185 PQEASQKGVPFDALGFVLTGiacfglmFGLDLINHPQLSWLVPALCilgslalgtlavrhakrtehplinlwamriksya 264
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLRE-------GLRYLRRSPLLRLLLLALA---------------------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 265 vtiwggtLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAATIFAC 344
Cdd:cd06173 219 -------LFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 345 ALLtpqTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALAlrlaemlmpqsg 424
Cdd:cd06173 292 GLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL------------ 356
|
410 420
....*....|....*....|....
gi 1608427181 425 erIPLVDFQWAFVVIGVIALLAVV 448
Cdd:cd06173 357 --ADALGLSAVFLLAGALLLLAAL 378
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
26-448 |
1.36e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 53.35 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 26 TVIVTAMPQMAAAF-GVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAAR 104
Cdd:cd17473 16 AAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 105 ILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYaSWHWIFILNVpLGIAALWLAWRLI 184
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYL-LALPVLILVLLFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 185 PQEASQKGVPfdalgfvltgiacfglmfgldlinhpqlswlvpalcilgslalgtlavrHAKRTEHPLINLWAMRIKSYA 264
Cdd:cd17473 174 PEPARKSKSA-------------------------------------------------ASPGAATAAALPWKRVLPIYF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 265 VTIWGGTLFRIaigaVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAATIFAC 344
Cdd:cd17473 205 LAFLAMLLFYV----IPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 345 ALLTPQtptWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNvsqqMGSGLGIAIGALALRLAEMLmpqsg 424
Cdd:cd17473 281 ALASGL---WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT----SAFFLGQFLSPLVLGPLVNL----- 348
|
410 420
....*....|....*....|....
gi 1608427181 425 eripLVDFQWAFVVIGVIALLAVV 448
Cdd:cd17473 349 ----TGGLSGAFLILGVLALVLAI 368
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
27-186 |
2.05e-07 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 52.79 E-value: 2.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 27 VIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARIL 106
Cdd:PRK10091 21 GIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 107 QGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIPQ 186
Cdd:PRK10091 101 SGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVPD 180
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
26-186 |
3.28e-07 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 52.22 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 26 TVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARI 105
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 106 LQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIP 185
Cdd:PRK11652 105 IQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP 184
|
.
gi 1608427181 186 Q 186
Cdd:PRK11652 185 E 185
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
12-181 |
4.50e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.82 E-value: 4.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:cd17365 2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFG-GALMVPVGRLVvlRNTAKPDLIKAIATITWPGL-VAPILGPPVGGFITTYASWHWIFILN 169
Cdd:cd17365 82 AFAQSVLQLALLRFLTGLGlGAAMPNAITLV--SEYAPARRRSLAVTLMFCGYpLGAALGGFLAAALIPAFGWRSVFLLG 159
|
170
....*....|..
gi 1608427181 170 VPLGIAALWLAW 181
Cdd:cd17365 160 GVPPLILLPLLR 171
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-185 |
4.72e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.85 E-value: 4.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 13 LVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCA 92
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 93 ASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYA-SWHWIFILNVP 171
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGV 162
|
170
....*....|....
gi 1608427181 172 LGIAALWLAWRLIP 185
Cdd:cd17328 163 LGVLLAILLLLFVR 176
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
19-188 |
4.79e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.97 E-value: 4.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 19 FMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLP 98
Cdd:TIGR00895 27 LMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 99 TFTAARILQGFG-GALMvpvGRLVVLRNTAKPDLIKA-IATITWPGLVapiLGPPVGGFITTYA----SWHWIFILNVPL 172
Cdd:TIGR00895 107 QLLILRFLAGLGlGGLM---PNLNALVSEYAPKRFRGtAVGLMFCGYP---IGAAVGGFLAGWLipvfGWRSLFYVGGIA 180
|
170
....*....|....*.
gi 1608427181 173 GIAALWLAWRLIPQEA 188
Cdd:TIGR00895 181 PLLLLLLLMRFLPESI 196
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
35-184 |
1.25e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.65 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 35 MAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALM 114
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 115 VPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLI 184
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
20-113 |
2.48e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.58 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 20 MENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPT 99
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS 105
|
90
....*....|....*.
gi 1608427181 100 FTAARILQ--GFGGAL 113
Cdd:PRK11551 106 LLVARLLTgvGLGGAL 121
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
12-448 |
2.75e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.47 E-value: 2.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 AASVNLPTFTAARILQGFG-GALMVPVGRLVVLRNTAKPDLIKAIATITWPglVAPILGPPVGGFITTY---ASWHWIF- 166
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGlGLLDVAANPYVAALGPETAASRLNLLHAFFS--LGALLGPLLGGLLILLglsLSWHLPYl 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 167 ILNVPLGIAALWLAWRLIPQEASQKGVPFDALGFVLTgiacfglmfgldLINHPQLSWLVpALCILGSLALGTlavrhak 246
Cdd:COG0738 169 ILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKS------------LLKNPRLLLGG-LAIFLYVGAEGA------- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 247 rtehplINLWamriksyavtiwggtlfriaigavpflLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRF 326
Cdd:COG0738 229 ------IGDW---------------------------LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 327 RTTLVVNGLLNAATIFACALLtpqTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFnvsqqMGSGLGI 406
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-----IMGIVGG 347
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1608427181 407 AIGALAL-RLAEMlmpqsgeriplVDFQWAFVVIGVIALLAVV 448
Cdd:COG0738 348 AIGPPLIgFLADA-----------FGLRAAFLVPLVCYLLILL 379
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-185 |
3.08e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 49.09 E-value: 3.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 17 AFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISA----YILTLTVfipaSGWIANRFGARNIFAAAVLIFTLASVLC- 91
Cdd:cd17380 7 ATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSffwgYALTQVL----GGYLADRFGGKKVLLLAVALWSLATLLTp 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 92 -AASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNV 170
Cdd:cd17380 83 lLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFG 162
|
170
....*....|....*
gi 1608427181 171 PLGIAALWLAWRLIP 185
Cdd:cd17380 163 LLGLLWALVWLIYLP 177
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-184 |
5.08e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 5.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPAS--GWIANRFGARNIFAAAVLIFTLASV 89
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALlfGYLGDRIGRKKALILTLLLFGLATL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 90 LCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATI----TWPGLVAPILGPPVGGFITTYASWHWI 165
Cdd:cd17316 82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRIL 161
|
170
....*....|....*....
gi 1608427181 166 FILNVPLGIAALWLAWRLI 184
Cdd:cd17316 162 FLIGALPALLALLLRRRTL 180
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
258-448 |
1.08e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 258 MRIKSYAVTIWGGTLFRIAIGAVPFLLPLL---FQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNG 334
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLipaLKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 335 LLNAATIFACALLTPqtpTWLILALLFVSGLTRSMQFTALNTLA---FSEVPQPQMNGANTLFNVsqqmGSGLGIAIGAL 411
Cdd:COG0738 81 LLMALGLLLFALAPS---YPLLLLALFLLGLGLGLLDVAANPYVaalGPETAASRLNLLHAFFSL----GALLGPLLGGL 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 1608427181 412 ALRLAEmlmpqsgeripLVDFQWAFVVIGVIALLAVV 448
Cdd:COG0738 154 LILLGL-----------SLSWHLPYLILAVLLLLLAL 179
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-451 |
3.57e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 269 GGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAATIFACALLT 348
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 349 PqtpTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALAlrlaemlmpqsgerIP 428
Cdd:pfam07690 84 S---LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--------------AS 146
|
170 180
....*....|....*....|...
gi 1608427181 429 LVDFQWAFVVIGVIALLAVVDCF 451
Cdd:pfam07690 147 LFGWRAAFLILAILSLLAAVLLL 169
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
53-185 |
4.91e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 45.30 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 53 YILTLtvfIPaSGWIANRFGARNIFAAAVLIftlASVLC-----AASVNLPTFTAARILQGFGGALMVPvGRLVVLRNTA 127
Cdd:cd17318 69 YILTQ---IP-GGYLAEKYGAKRVLGYSILI---TALLTlltplAARGGYGALIVLRILQGLAQGVTFP-AMHALWAKWA 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1608427181 128 KPDLIKAIATITWPG-LVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIP 185
Cdd:cd17318 141 PPLERSRLTSIAYSGsQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-191 |
7.55e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 44.88 E-value: 7.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 38 AFGVRPVDMNIGISAYILTLTVFIP-------ASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFG 110
Cdd:PRK11043 28 AFKAIQADLQTSASAVSASLSLFLAgfalgqlLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 111 G-ALMVPVGRLVVLRNTAKpdliKA---IATITwpGLVA--PILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLI 184
Cdd:PRK11043 108 VcSAAVIWQALVIDRYPAQ----KAnrvFATIM--PLVAlsPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLK 181
|
....*..
gi 1608427181 185 PQEASQK 191
Cdd:PRK11043 182 PSKKARK 188
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-217 |
7.99e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 46 MNIGISAYILTLTVFI-----PASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVGRL 120
Cdd:cd17329 32 LSASIVGLVLALSAVAgivasLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 121 VVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYaSWHWIFILN-VPLGIAALWLAWRL----IPQEASQKGVPF 195
Cdd:cd17329 112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAaVLFLLAALVLLFLLpetrPKRRAAEKTEIL 190
|
170 180
....*....|....*....|..
gi 1608427181 196 DALGFVLTGIACFGLMFGLDLI 217
Cdd:cd17329 191 RGYKIVLRDRAFLLFLLASFLI 212
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
19-166 |
8.59e-05 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 44.57 E-value: 8.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 19 FMENLDATVIVTAMPQMAAAFGVrpVDMNIGISAYILTLTVFIPA-----SGWIANRFGARNIFAAAVLIFTLASVLCAA 93
Cdd:cd17360 7 FLFGYDTGVISGALLYIKDDLGE--VVLSTGWQELIVSSTVAGAAvgaaiGGWLNDRFGRRPCILLADALFTIGAIVMAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 94 SVNLPTFTAARILQGFG---GALMVPV-----------GRLVVLRNTAkpdlikaiatITWPGLVAPILGppvGGFITTY 159
Cdd:cd17360 85 APNKEVLIVGRVLVGLGvgiASMTVPLyiaeaapprirGRLVTINVLF----------ITGGQFVAYVIN---GAFSYLP 151
|
....*..
gi 1608427181 160 ASWHWIF 166
Cdd:cd17360 152 GGWRWML 158
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-178 |
1.03e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.29 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 30 TAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQG- 108
Cdd:TIGR00881 16 LAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGi 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1608427181 109 FGGALMVPVGRLVVlRNTAKPDLIKAIATITWPGLVAPILGPPVGGF-ITTYASWHWIFIlnVPLGIAALW 178
Cdd:TIGR00881 96 FQGMGWPPCGRTVT-KWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFI--VPGIIAIIV 163
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
50-185 |
1.64e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 43.72 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 50 ISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALmVPVGRLVVLRNTAKP 129
Cdd:cd17330 40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEE 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1608427181 130 DLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIP 185
Cdd:cd17330 119 ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLP 174
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-190 |
2.18e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.32 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 5 SRASALPLLVAGAFFMENLDA--TVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVL 82
Cdd:COG2807 12 RRAGRWLLLLAIVLVALNLRPaiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 83 IFTLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTA-KPDLIKAIATITWPGLVApiLGPPVGGFITTYAS 161
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPdRVGLMTGLYTAAMGLGAA--LAAGLTVPLAAALG 169
|
170 180
....*....|....*....|....*....
gi 1608427181 162 WHWIFILNVPLGIAALWLAWRLIPQEASQ 190
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAA 198
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
64-183 |
2.32e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.41 E-value: 2.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 64 SGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTF---TAARILQGFG---GALMVPV-----------GRLVVLRNT 126
Cdd:pfam00083 66 AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqlIVGRVLVGIGvggASVLAPMyiseiapkklrGALGSLYQL 145
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1608427181 127 AkpdlikaiatITWPGLVAPILGPpvgGFITTYASWHWIFILNVPLGIAALWLAWRL 183
Cdd:pfam00083 146 A----------ITFGILLAYIFGL---GLNKTSNSDGWRIPLGLQLVPALLLIIGLL 189
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
48-186 |
2.33e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 48 IGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGfGGALMVPVGRLVVlRNTA 127
Cdd:cd17472 36 LALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLA-DLTR 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1608427181 128 KPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIPQ 186
Cdd:cd17472 114 EENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD 172
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
24-110 |
2.53e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 43.32 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 24 DATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAA 103
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
....*..
gi 1608427181 104 RILQGFG 110
Cdd:cd17359 96 RIIGGLA 102
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-182 |
3.18e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 3.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 10 LPLLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAY-ILTLTVFIPASGWIANRFGARNIFAAAVLIFTLAS 88
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 89 VLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFIL 168
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
|
170
....*....|....
gi 1608427181 169 NVPLGIAALWLAWR 182
Cdd:cd17330 336 AAGLLLIALFLLSL 349
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
50-448 |
4.44e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 4.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 50 ISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFT-LASVLCAASVNLPTFTAARILQGFGGALMVPvgrLVVLRNT-- 126
Cdd:cd17490 37 LGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGIAAATWVS---FTVLYASyf 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 127 AKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRLIPQEASQKGVPFDALGFvltgia 206
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKEL------ 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 207 cfglmfgLDLINHPQLsWLVPALCILGSlalgtlavrhakrtehplinlwamriksyavtiwgGTLFRIAIGAVPfllpl 286
Cdd:cd17490 188 -------LSVLKDKKL-LFFSLLAILQQ-----------------------------------MITFSTTFGFTP----- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 287 LFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLY-RFRFRTTLVVNGLLNAAtifaCALLTPQTPT-WLILALLFVSG 364
Cdd:cd17490 220 LIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGA----YCFLIPFAPNlTLLYLLQALNG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 365 LTRSMQFTALNTLAFSEVPQPQMNGANTLFNvsqqmgsglgiAIGALALRLAEMLMPQSGERIPLvdfQWAFVVIGVIAL 444
Cdd:cd17490 296 FGTGILFPLLMSLSIEGVPAEQRSTAMGFFQ-----------AIYALGMFLGPVLVGIISEAFGL---QTGFFVIGVIAL 361
|
....
gi 1608427181 445 LAVV 448
Cdd:cd17490 362 LAAI 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
48-183 |
6.08e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 48 IGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTA 127
Cdd:COG0738 250 LGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG 329
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1608427181 128 KpDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRL 183
Cdd:COG0738 330 K-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
259-448 |
7.20e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 7.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 259 RIKSYAVTIWGGTLFRIAIGAVPFLLPLLFQiGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNA 338
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 339 ATIFACALLTPqtpTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALAlrlaem 418
Cdd:COG2814 87 LGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL------ 157
|
170 180 190
....*....|....*....|....*....|
gi 1608427181 419 lmpqsgerIPLVDFQWAFVVIGVIALLAVV 448
Cdd:COG2814 158 --------ADLFGWRWVFLVNAVLALLALL 179
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
269-448 |
8.67e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 8.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 269 GGTLFRIAIGAVPFLLPLLFQIgFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAAtifACALLT 348
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFAL---GALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 349 PQTPTWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALALRLAemlmpqsgerip 428
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL------------ 147
|
170 180
....*....|....*....|
gi 1608427181 429 LVDFQWAFVVIGVIALLAVV 448
Cdd:cd06174 148 GFGWRAVFLIAAALALLAAI 167
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
63-110 |
9.22e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.41 E-value: 9.22e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1608427181 63 ASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFG 110
Cdd:cd17315 53 FGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLG 100
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
3-183 |
1.00e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 3 FFSRASALPLLVAGAFFMENLdaTVIVTAMPQMAAA-FGVRPVDMNIGISAYILTLTVFIPASG-WIANRFGARNIFAAA 80
Cdd:cd17474 194 ALRGRGLLTFLVSAFLYFFLY--FAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 81 VLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVgrLVVLRNTAKPDLIKAIATITWPGL--VAPILGPPVGGFITT 158
Cdd:cd17474 272 LLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPL--LTTLVTELAPEEERGTASSLYNFVrfLGQAVGPLLFGLLLE 349
|
170 180
....*....|....*....|....*
gi 1608427181 159 YASWHWIFILNVPLGIAALWLAWRL 183
Cdd:cd17474 350 IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
195-446 |
1.32e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 195 FDALGFVLTGIACFGLM--FGLDLINHPQLSWLVPALCILGSLALGTLAVRHAKRTEHPLINLWAM-----RIKSYAVTI 267
Cdd:COG2211 155 FAGLGGLLASVLPPPLVaaFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESlkallKNRPFLLLL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 268 WGGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAATIFACALL 347
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 348 TPQTPtWLILALLFVSGLTRSMQFTALNT-LAFSEVPQPQMNGANT------LFNVSQQMGSGLGIAIGALALRLAEMLM 420
Cdd:COG2211 315 GPGNL-WLLLVLAALAGIGLGAILVLPWAmLADVVDYDEWKTGRRReglyfgIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
250 260
....*....|....*....|....*.
gi 1608427181 421 PQSGERIPLVDFQWAFVVIGVIALLA 446
Cdd:COG2211 394 GAAQSPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
12-114 |
1.98e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.32 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 12 LLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLC 91
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100
....*....|....*....|...
gi 1608427181 92 AASVNLPTFTAARILQGFGGALM 114
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGAL 104
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-183 |
2.23e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 8 SALPLLVAGAFFMENLDATVIVTAMPQMAAAFGVRPVDMNIGISAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLA 87
Cdd:COG2807 214 SPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 88 SVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLRNTAKP-DLIKAIATITWPGLVAPILGPPVGGFI-TTYASWHWI 165
Cdd:COG2807 294 GLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPaEAAALSGMAQSVGYLLAALGPLLVGALhDATGSWTAA 373
|
170
....*....|....*...
gi 1608427181 166 FILNVPLGIAALWLAWRL 183
Cdd:COG2807 374 LLLLAALAVLMLVAGLLA 391
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
11-242 |
2.56e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.42 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 11 PLLVAG-AFFMENLDATVIV-----TAMPQMAAAFGVRPvdmNIGISAYILTL--TVFIPASGWIANRFGARNIFAAAVL 82
Cdd:pfam06609 40 PRIIASfAAFSLNVCATYFVlqasaSALPNILQDIGQSE---NQGLFSTLWTMgqAVSILMMGRLTDRFGRRPFVIATHI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 83 IFTLASVLCAASVNLPTFTAARILQGFG----GALMVPVGRLvvLRNTAKpdlIKAIATITWPGLVAPILGPPVGGFITT 158
Cdd:pfam06609 117 IGLVGAIVGCTANKFNTLLAAMTLLGVAagpaGASPLFIGEL--MSNKTK---FLGLLIVSAPTIAMNGAGPYFGQRLAI 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 159 YASWHWIFILNVPLGIAALWL--AWRLIPQEASQKG---------VPFDALGFVLTGIACFGLMFGLDLINHPQLSWLVP 227
Cdd:pfam06609 192 QGNWRWIFYIYIIMSAIAVLLiiIWYHPPSFAQLHGkkarkrdelAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNPWNSA 271
|
250
....*....|....*
gi 1608427181 228 ALCILGSLALGTLAV 242
Cdd:pfam06609 272 KIIGLISSGAGSLVI 286
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
64-118 |
4.26e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.61 E-value: 4.26e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1608427181 64 SGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVG 118
Cdd:TIGR00898 147 FGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQA 201
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
47-183 |
4.39e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 47 NIGI--SAYILTLTVFIPASGWIANRFGARNIFAAAVLIFTLASVLCAASVNLPTFTAARILQGFGGALMVPVGRLVVLR 124
Cdd:cd17489 228 NAGLffTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVD 307
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1608427181 125 NTAKPDLIKAIATITWPGLVAPILGPPVGGFITTYASWHWIFILNVPLGIAALWLAWRL 183
Cdd:cd17489 308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
269-448 |
5.71e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 269 GGTLFRIAIGAVPFLLPLLFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAATIFACALLt 348
Cdd:cd17329 7 GSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 349 pQTPtWLILALLFVSGLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALALRLaemlmpqsgerip 428
Cdd:cd17329 86 -HSP-WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY------------- 150
|
170 180
....*....|....*....|
gi 1608427181 429 lvDFQWAFVVIGVIALLAVV 448
Cdd:cd17329 151 --SFRLLFLAAAVLFLLAAL 168
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
204-413 |
5.73e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 5.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 204 GIACFGLMFGLDLINHPQLSWLVPALCILGSLALGTLAVRHAKRTEHPLINLWAMRIKSyAVTIWGGTLFRIAIGAVPFL 283
Cdd:cd17477 132 GFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIA-PLALLGAFVAGFLEGAFYSL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 284 LPLlFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLnaATIFACALLTPQTPTWLILALLFVS 363
Cdd:cd17477 211 LPL-YGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALL--GALAALLLPLVPGLPLALLVLLFLW 287
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1608427181 364 GLTRSMQFTALNTLAFSEVPQPQMNGANTLFNVSQQMGSGLGIAIGALAL 413
Cdd:cd17477 288 GGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM 337
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
287-453 |
6.74e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 287 LFQIGFGLNAFDAGLLVLAVFAGNLVMKPFTSAVLYRFRFRTTLVVNGLLNAAtifACALLTPQTPTWLILALLFVSGLT 366
Cdd:cd17489 21 LYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFAL---ATLLYLLATSVALLLVLRLIHGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608427181 367 RSMQFTALNTLAFSEVPQPQMNGANTLFnvsqQMGSGLGIAIG-ALALRLAemlmpqsgeriPLVDFQWAFVVIGVIALL 445
Cdd:cd17489 98 WGAFTTAAATLVADIIPPSRRGEGIGYY----GLATTLAMALGpALGLFLY-----------QHLGFAVLFIVAAVLALL 162
|
....*...
gi 1608427181 446 AVVDCFTL 453
Cdd:cd17489 163 ALLLVFLV 170
|
|
| |
