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Conserved domains on  [gi|1608350191|gb|QBX36269|]
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sugar ABC transporter permease [Paracoccus liaowanqingii]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
2-278 2.74e-72

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 224.24  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTSSRML-PRNDFVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFV 80
Cdd:COG1175    15 RRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLgPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  81 LGTLLAIFIDQNVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNPDLG-IERTMRNLGFSDFvlDWVVNSDTVLYAVVLAT 159
Cdd:COG1175    95 LGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGlLNALLGALGLEPI--NWLGDPSLALPAVIIVT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 160 VWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYDLIIAMTNGGPGTAS 239
Cdd:COG1175   173 VWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNST 252

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1608350191 240 EVPAKFIMDNLFERANIGLATAASTTMLVTVLLIIAPVL 278
Cdd:COG1175   253 TTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQL 291
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
2-278 2.74e-72

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 224.24  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTSSRML-PRNDFVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFV 80
Cdd:COG1175    15 RRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLgPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  81 LGTLLAIFIDQNVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNPDLG-IERTMRNLGFSDFvlDWVVNSDTVLYAVVLAT 159
Cdd:COG1175    95 LGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGlLNALLGALGLEPI--NWLGDPSLALPAVIIVT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 160 VWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYDLIIAMTNGGPGTAS 239
Cdd:COG1175   173 VWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNST 252

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1608350191 240 EVPAKFIMDNLFERANIGLATAASTTMLVTVLLIIAPVL 278
Cdd:COG1175   253 TTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQL 291
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
45-286 7.48e-16

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 75.63  E-value: 7.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  45 FVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFVLGTLLAIFIDQNVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNP 124
Cdd:PRK10561   38 FVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 125 DLG-IERTMRNLGFsdfvlDW--VVNSDTVLYAVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFII 201
Cdd:PRK10561  118 GRGlITHFLAEFGY-----DWnhAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 202 LPILRPMIITSLVL-LSISIVKMYDLIIAMTNGGPGTASEVPAKFIMDNLFerANIGLATAASTTMLVTVLLIIAPVLYS 280
Cdd:PRK10561  193 LPLIAPVSFFLLVVnLVYAFFDTFPVIDAATSGGPVQATTTLIYKIYREGF--TGLDLSSSAAQSVVLMFLVIVLTVVQF 270


                  ....*.
gi 1608350191 281 QYLGKK 286
Cdd:PRK10561  271 RYVESK 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 68-271 5.49e-06

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 46.12  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  68 VFIAIFFLAICFVLGTLLAIFIDQN-VRAEGLFRTAFLYPYAMSFVVTGLMWQWILNpdlgiertmrnlgfsdFVLDWVV 146
Cdd:cd06261     5 LLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFG----------------VLLGWGI 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 147 NSDTVLYAVVLATVWHgAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYDL 226
Cdd:cd06261    69 LPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFAL 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1608350191 227 IIAMTNGGPGTASEVPakFIMDNLFERANIGLATAASTTMLVTVL 271
Cdd:cd06261   148 VSFLGGGEAPGPGTGL--LLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 154-278 1.42e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 154 AVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYdLIIAMTNG 233
Cdd:pfam00528  54 PAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGA-VLLEFLGS 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1608350191 234 GPGTASEVPAKFIMDNLFERANIGLATAASTTMLVTVLLIIAPVL 278
Cdd:pfam00528 133 WPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLL 177
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
2-278 2.74e-72

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 224.24  E-value: 2.74e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTSSRML-PRNDFVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFV 80
Cdd:COG1175    15 RRRLAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLgPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  81 LGTLLAIFIDQNVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNPDLG-IERTMRNLGFSDFvlDWVVNSDTVLYAVVLAT 159
Cdd:COG1175    95 LGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGlLNALLGALGLEPI--NWLGDPSLALPAVIIVT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 160 VWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYDLIIAMTNGGPGTAS 239
Cdd:COG1175   173 VWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNST 252

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1608350191 240 EVPAKFIMDNLFERANIGLATAASTTMLVTVLLIIAPVL 278
Cdd:COG1175   253 TTLVLYIYQTAFQQFDFGYASAIAVVLFLIILVLTLLQL 291
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 1-287 7.63e-17

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 78.65  E-value: 7.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   1 MRRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTSSRMLPRNDFV-GFDQYAQLFGTSRWLTSLENFVFIAIFFLAICF 79
Cdd:COG1176     5 LRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGfTLENYARLFTDPLYLKVLLRTLWIALLTTLICL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  80 VLGTLLAIFIdqnVRAEGLFRTAFLY----PYAMSFVVTGLMWQWILNPDLGIERTMRNLGFSDFVLDWVvNSDTvlyAV 155
Cdd:COG1176    85 LLGYPIAYFL---ARAPPRWRNLLLLlvilPFWTSFLVRTYAWIVLLGRNGLLNSLLLALGLIDEPLRLL-YTEF---AV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 156 VLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYdlIIAMTNGGP 235
Cdd:COG1176   158 VIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAF--VTPALLGGG 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1608350191 236 GTAseVPAKFIMDNLFERANIGLATAASTTMLVTVLLIIApvLYSQYLGKKG 287
Cdd:COG1176   236 KVL--MIGNLIYQQFLSALNWPLAAALAVVLLLIVLLVLL--LYLRLLRRRR 283
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
45-286 7.48e-16

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 75.63  E-value: 7.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  45 FVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFVLGTLLAIFIDQNVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNP 124
Cdd:PRK10561   38 FVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 125 DLG-IERTMRNLGFsdfvlDW--VVNSDTVLYAVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFII 201
Cdd:PRK10561  118 GRGlITHFLAEFGY-----DWnhAQNSGQAMFLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 202 LPILRPMIITSLVL-LSISIVKMYDLIIAMTNGGPGTASEVPAKFIMDNLFerANIGLATAASTTMLVTVLLIIAPVLYS 280
Cdd:PRK10561  193 LPLIAPVSFFLLVVnLVYAFFDTFPVIDAATSGGPVQATTTLIYKIYREGF--TGLDLSSSAAQSVVLMFLVIVLTVVQF 270


                  ....*.
gi 1608350191 281 QYLGKK 286
Cdd:PRK10561  271 RYVESK 276
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
2-215 5.20e-09

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 56.71  E-value: 5.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTssrmlprndfVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFVL 81
Cdd:COG1178     4 RPRRRPRLLLLLLALLLALLVLLPLLALLLRAFT----------DGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  82 GTLLAIFIDQ-NVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNPDLGIERTMRNLgfsdfvLDWVVNSDTVLYAVVLATV 160
Cdd:COG1178    74 GVPLAWLLARtDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGLLNTLLRAL------FGLEPPDIYGLGGIILVLV 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1608350191 161 WHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVL 215
Cdd:COG1178   148 LFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALL 202
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 2-287 2.31e-08

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 53.96  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGtMAWSVRLSFTSSRmLPRNDFVGF--DQYAQLFGTSRWLTSLENFVFIAIFFLAICF 79
Cdd:COG1177     1 SSRLGRLLLRLFLALVLLFLYLP-ILVLVLYSFNDSW-FLTFPPEGFtlRWYAELFSDPRLLDALLNSLLIALLSTLLAT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  80 VLGTLLAIFIDQ-NVRAEGLFRTAFLYPYAMSFVVTGLmwqwilnpdlGIERTMRNLGFSDfvldwvvnsdtVLYAVVLA 158
Cdd:COG1177    79 VLGTPAALALARyRFRGRRLLLALLLLPLVVPGIVLGV----------ALLLLFSALGLSG-----------GLWGLILA 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 159 TVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVL---LSISivkmyDLIIAMTNGGP 235
Cdd:COG1177   138 HVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLaftLSFD-----EFVITLFLAGP 212

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1608350191 236 GTASeVPAKfimdnLFERANIGLATAASTTMLVTVLLIIAPVLYSQYLGKKG 287
Cdd:COG1177   213 GVTT-LPVY-----IYSMIRRGISPEINALSTLLILLSLLLLLLAERLRRRG 258
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
2-275 1.19e-06

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 49.39  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTSSrmlprndfVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFVL 81
Cdd:COG1178   286 WRWLALALCLLLVLLGLLLPLLALLLWSLTKALDDN--------LTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLL 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  82 GTLLAIFID-QNVRAEGLFRTAFLYPYAMSFVVTGLMWQWILNPDLGIertmrnlgfsdfvldwvVNSDTVLyAVVLATV 160
Cdd:COG1178   358 ALLLAYLVRrRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPL-----------------LLYGTLA-ILVLAYV 419

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 161 WHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYDLIIAMTNGGPGTASe 240
Cdd:COG1178   420 VRFLPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPGFETLA- 498

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1608350191 241 vpakFIMDNLFERANIGLATAASTTMLVTVLLIIA 275
Cdd:COG1178   499 ----VLIYQLASSGRYGEAAALALLLVLVSLLPVL 529
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 68-271 5.49e-06

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 46.12  E-value: 5.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  68 VFIAIFFLAICFVLGTLLAIFIDQN-VRAEGLFRTAFLYPYAMSFVVTGLMWQWILNpdlgiertmrnlgfsdFVLDWVV 146
Cdd:cd06261     5 LLLALIATLLALVLGLLLGIILARKrGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFG----------------VLLGWGI 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 147 NSDTVLYAVVLATVWHgAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYDL 226
Cdd:cd06261    69 LPGLGLPALILALLLI-APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFAL 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1608350191 227 IIAMTNGGPGTASEVPakFIMDNLFERANIGLATAASTTMLVTVL 271
Cdd:cd06261   148 VSFLGGGEAPGPGTGL--LLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 154-278 1.42e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 154 AVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVLLSISIVKMYdLIIAMTNG 233
Cdd:pfam00528  54 PAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGA-VLLEFLGS 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1608350191 234 GPGTASEVPAKFIMDNLFERANIGLATAASTTMLVTVLLIIAPVL 278
Cdd:pfam00528 133 WPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLL 177
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 2-216 2.38e-04

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 41.91  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLGTMAWSVRLSFTSSrmlprnDFVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFVL 81
Cdd:PRK15050   19 RRRLRPLLWLLLPLLVLAPLVVYPLVRVVLQSLTGE------HGLGLATYRAVLGSPDFRGALLTTLQIAFASTAGCLVL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  82 GTLLAIFIdqnvraeglfrtaFLYPYAMSFVVTGLMWQWILNPDLGIERT---------------MRNLGFSDFVLDWVv 146
Cdd:PRK15050   93 GVLLALVL-------------AFVPFPGASLVGRFIDTFVAFPSFLITLAftflygsagsvnialQRLFGLEAPPLDFL- 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1608350191 147 nsdTVLYAVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMII--TSLVLL 216
Cdd:PRK15050  159 ---YSPGGVILAEITFYTPFVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAagGSLCLL 227
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 2-215 3.77e-03

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 38.15  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191   2 RRNTAAYLALLPMAAIVVFAYLgtmaWSVRLSFTSSRMLPRNDFVG------FDQYAQLFGTSRWLTSLENFVFIAIFFL 75
Cdd:COG0395    12 LGRILLYLLLILLALLFLFPLY----WMVVTSFKPPAEIFSGPPSLlpseftLENYRAAFTDGPFGRYLLNSLIVAVVST 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  76 AICFVLGTLLAIFIdqnVRAEGLFRTAFLYpyamsFVVTGLM--WQWILNPdlgIERTMRNLGFsdfvldwvVNSdtvLY 153
Cdd:COG0395    88 VLSLLLSSLAAYAL---ARFRFRGRKLLFL-----LILATLMipGQVLLIP---LYLLFRQLGL--------LNT---YW 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1608350191 154 AVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIPLWRAYAFIILPILRPMIITSLVL 215
Cdd:COG0395   146 GLILPYLAFGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIF 207
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 37-274 3.92e-03

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 38.19  E-value: 3.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191  37 SRMLPRNDFVGFDQYAQLFGTSRWLTSLENFVFIAIFFLAICFVLGTLLAIFIdqnVRAE----GLFRTAFLYPYAMSFV 112
Cdd:COG0555    29 AALVLKAAGLGWAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAWVL---VRYRfpgkRLVDALVDLPFALPTA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 113 VTGLMWQWILNPDLGIERTMRNLGFSdfvldwVVNSdtvLYAVVLATVWHGAGLVMALLLAGLRGIDTDLWKATRIDGIP 192
Cdd:COG0555   106 VAGIALLLLFGPNGWLGQLLAPLGIK------VAFT---PLGIVLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGAS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608350191 193 LWRAYAFIILPILRPMIITSLVL---LSIS---IVkmydLIIAmtnGGPGTASEVPAKFIMDNLfERANIGLATAASTTM 266
Cdd:COG0555   177 RWQTFRRVILPLLLPALLTGFALafaRALGefgAV----IFIA---GNLPMKTEILPLLIYLKL-EEGDYAGATAIALVL 248


                  ....*...
gi 1608350191 267 LVTVLLII 274
Cdd:COG0555   249 LLISFLLL 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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