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Conserved domains on  [gi|1608037151|gb|QBX09196|]
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helicase loader [Streptococcus satellite phage Javan324]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 30-253 6.03e-22

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member PRK08116:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 268  Bit Score: 92.01  E-value: 6.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  30 VPVLGGSERKVQAFCpECVKGEIKQKEKDllqqfEDRQAYFKTYDVLMRDSTIPNELKGATFDNFFVkTTEERQMLEFVK 109
Cdd:PRK08116   29 VVELLGKNRIVPIMC-ECEREAEEAKERE-----EENREKQRRIERLKSNSLLDEKFRNSTFENFLF-DKGSEKAYKIAR 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 110 GQAQKY--LAGMTGNTLISGSTGIGKSHLSLALAKEInesfREKNEPksVLFVSLTEIIKQIKEgwAYGRNANLTEYEAV 187
Cdd:PRK08116  102 KYVKKFeeMKKENVGLLLWGSVGTGKTYLAACIANEL----IEKGVP--VIFVNFPQLLNRIKS--TYKSSGKEDENEII 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 188 KKLVDVDFLIIDDLGAKNGTvtpksDWEQDFLFDIINNR----ETTIFNTNLDSSELRTVYNARNSSRIL 253
Cdd:PRK08116  174 RSLVNADLLILDDLGAERDT-----EWAREKVYNIIDSRyrkgLPTIVTTNLSLEELKNQYGKRIYDRIL 238
 
Name Accession Description Interval E-value
PRK08116 PRK08116
hypothetical protein; Validated
 30-253 6.03e-22

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 92.01  E-value: 6.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  30 VPVLGGSERKVQAFCpECVKGEIKQKEKDllqqfEDRQAYFKTYDVLMRDSTIPNELKGATFDNFFVkTTEERQMLEFVK 109
Cdd:PRK08116   29 VVELLGKNRIVPIMC-ECEREAEEAKERE-----EENREKQRRIERLKSNSLLDEKFRNSTFENFLF-DKGSEKAYKIAR 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 110 GQAQKY--LAGMTGNTLISGSTGIGKSHLSLALAKEInesfREKNEPksVLFVSLTEIIKQIKEgwAYGRNANLTEYEAV 187
Cdd:PRK08116  102 KYVKKFeeMKKENVGLLLWGSVGTGKTYLAACIANEL----IEKGVP--VIFVNFPQLLNRIKS--TYKSSGKEDENEII 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 188 KKLVDVDFLIIDDLGAKNGTvtpksDWEQDFLFDIINNR----ETTIFNTNLDSSELRTVYNARNSSRIL 253
Cdd:PRK08116  174 RSLVNADLLILDDLGAERDT-----EWAREKVYNIIDSRyrkgLPTIVTTNLSLEELKNQYGKRIYDRIL 238
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
76-240 3.41e-19

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 84.06  E-value: 3.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  76 LMRDSTIPnelKGATFDNF---FVKTTEERQMLEFVKGQaqkYLAGMTgNTLISGSTGIGKSHLSLALAKE-INESFRek 151
Cdd:COG1484    59 RLKAARFP---AAKTLEDFdfdAQPGLDRRQILELATLD---FIERGE-NLILLGPPGTGKTHLAIALGHEaCRAGYR-- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 152 nepksVLFVSLTEIIKQIKEGWAYGRnanltEYEAVKKLVDVDFLIIDDLGAkngtvTPKSDWEQDFLFDIINNRE---T 228
Cdd:COG1484   130 -----VRFTTAPDLVNELKEARADGR-----LERLLKRLAKVDLLILDELGY-----LPLDAEGAELLFELISDRYerrS 194

                         170
                  ....*....|..
gi 1608037151 229 TIFNTNLDSSEL 240
Cdd:COG1484   195 TIITSNLPFSEW 206
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 88-239 8.75e-11

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 60.56  E-value: 8.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  88 GATFDNF---FVKTTEERQM-----LEFVKGQAqkylagmtgNTLISGSTGIGKSHLSLALAKEinesFREKNepKSVLF 159
Cdd:NF038214   59 AKTLEDFdftAAPGLDKAQIrelatLDFIERAE---------NVLLLGPPGTGKTHLAIALGYA----ACRQG--YRVRF 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 160 VSLTEIIKQIKEGwaygrNANLTEYEAVKKLVDVDFLIIDDLGakngtVTPKSDWEQDFLFDIINNR-ET--TIFNTNLD 236
Cdd:NF038214  124 TTAADLVEQLAQA-----RADGRLGRLLRRLARYDLLIIDELG-----YLPFSREGANLLFELIADRyERgsTIITSNLP 193


                  ...
gi 1608037151 237 SSE 239
Cdd:NF038214  194 FSE 196
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 76-235 2.17e-05

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 44.74  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  76 LMRDSTIPNELKGATFDNFFVKTTEERQM-----LEFVKGQAqkylagmtgNTLISGSTGIGKSHLSLALAKeinESFRE 150
Cdd:pfam01695  52 LLRMAKLPPHKTLEDFDFTFAPGLDQRIVaelasLSFIDRAQ---------NVVLLGPPGVGKTHLAIALGV---EACRA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 151 KnepKSVLFVSLTEIIKQIKEGWAYGRnanlteyeAVKKL---VDVDFLIIDDLGakngtVTPKSDWEQDFLFDIINNR- 226
Cdd:pfam01695 120 G---YSVRFTSAADLVNQLKRAHGDGK--------LTRKLqqlLKPDVLILDEWG-----YLPLDQAEANLLFQVISKRy 183

                         170
                  ....*....|.
gi 1608037151 227 --ETTIFNTNL 235
Cdd:pfam01695 184 ehRSIILTSNL 194
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 90-224 1.10e-04

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 43.29  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFVktTEERQM-----LEFVKGQAQKYlagmtgNTL-ISGSTGIGKSHLSLALAKEINESFREKNepksVLFVS-- 161
Cdd:TIGR00362 109 TFDNFVV--GKSNRLahaaaLAVAENPGKAY------NPLfIYGGVGLGKTHLLHAIGNEILENNPNAK----VLYVSse 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1608037151 162 --LTEIIKQIkegwaygRNANLTEYEavKKLVDVDFLIIDD---LGAKNGTvtpksdweQDFLFDIIN 224
Cdd:TIGR00362 177 kfTNDFVNAL-------RNNKMEEFK--EKYRSVDLLLIDDiqfLAGKERT--------QEEFFHTFN 227
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 121-240 1.44e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 41.36  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 121 GNTLISGSTGIGKSHLSLALAKEINESFreknepKSVLFVSLTEIIKQIKEGWAYGRNANLTEYEAVKKlVDVDFLIIDD 200
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELFRPG------APFLYLNASDLLEGLVVAELFGHFLVRLLFELAEK-AKPGVLFIDE 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1608037151 201 LGAkngtVTPKSDWEQDFLFDIINNRET------TIFNTNLDSSEL 240
Cdd:cd00009    93 IDS----LSRGAQNALLRVLETLNDLRIdrenvrVIGATNRPLLGD 134
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 121-203 3.92e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 3.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  121 GNTLISGSTGIGKSHLSLALAKEINESFreknepKSVLFVSLTEI----IKQIKEGWAYGRNANLTEYEAVKKLV----- 191
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPG------GGVIYIDGEDIleevLDQLLLIIVGGKKASGSGELRLRLALalark 76

                           90
                   ....*....|...
gi 1608037151  192 -DVDFLIIDDLGA 203
Cdd:smart00382  77 lKPDVLILDEITS 89
 
Name Accession Description Interval E-value
PRK08116 PRK08116
hypothetical protein; Validated
 30-253 6.03e-22

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 92.01  E-value: 6.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  30 VPVLGGSERKVQAFCpECVKGEIKQKEKDllqqfEDRQAYFKTYDVLMRDSTIPNELKGATFDNFFVkTTEERQMLEFVK 109
Cdd:PRK08116   29 VVELLGKNRIVPIMC-ECEREAEEAKERE-----EENREKQRRIERLKSNSLLDEKFRNSTFENFLF-DKGSEKAYKIAR 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 110 GQAQKY--LAGMTGNTLISGSTGIGKSHLSLALAKEInesfREKNEPksVLFVSLTEIIKQIKEgwAYGRNANLTEYEAV 187
Cdd:PRK08116  102 KYVKKFeeMKKENVGLLLWGSVGTGKTYLAACIANEL----IEKGVP--VIFVNFPQLLNRIKS--TYKSSGKEDENEII 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 188 KKLVDVDFLIIDDLGAKNGTvtpksDWEQDFLFDIINNR----ETTIFNTNLDSSELRTVYNARNSSRIL 253
Cdd:PRK08116  174 RSLVNADLLILDDLGAERDT-----EWAREKVYNIIDSRyrkgLPTIVTTNLSLEELKNQYGKRIYDRIL 238
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
76-240 3.41e-19

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 84.06  E-value: 3.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  76 LMRDSTIPnelKGATFDNF---FVKTTEERQMLEFVKGQaqkYLAGMTgNTLISGSTGIGKSHLSLALAKE-INESFRek 151
Cdd:COG1484    59 RLKAARFP---AAKTLEDFdfdAQPGLDRRQILELATLD---FIERGE-NLILLGPPGTGKTHLAIALGHEaCRAGYR-- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 152 nepksVLFVSLTEIIKQIKEGWAYGRnanltEYEAVKKLVDVDFLIIDDLGAkngtvTPKSDWEQDFLFDIINNRE---T 228
Cdd:COG1484   130 -----VRFTTAPDLVNELKEARADGR-----LERLLKRLAKVDLLILDELGY-----LPLDAEGAELLFELISDRYerrS 194

                         170
                  ....*....|..
gi 1608037151 229 TIFNTNLDSSEL 240
Cdd:COG1484   195 TIITSNLPFSEW 206
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 74-253 1.48e-17

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 81.10  E-value: 1.48e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  74 DVLMRDSTIPNELKGATFDNFFV----------KTTEERQMLEFVKGQAQKYLAGMTG---NTLISGSTGIGKSHLSLAL 140
Cdd:PRK06835  124 NLYYKQSNLKEILKEENFSNFNLnyysdekdddEPLSPRKNMEKILEKCKNFIENFDKnneNLLFYGNTGTGKTFLSNCI 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 141 AKEINESFreknepKSVLFVSLTEIIKQIKEgwaYGRNANLTEYEAVKKLVDVDFLIIDDLGAKNGTVTPKSDweqdfLF 220
Cdd:PRK06835  204 AKELLDRG------KSVIYRTADELIEILRE---IRFNNDKELEEVYDLLINCDLLIIDDLGTEKITEFSKSE-----LF 269

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1608037151 221 DIINNR----ETTIFNTNLDSSELRTVYNARNSSRIL 253
Cdd:PRK06835  270 NLINKRllrqKKMIISTNLSLEELLKTYSERISSRLL 306
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 88-239 8.75e-11

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 60.56  E-value: 8.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  88 GATFDNF---FVKTTEERQM-----LEFVKGQAqkylagmtgNTLISGSTGIGKSHLSLALAKEinesFREKNepKSVLF 159
Cdd:NF038214   59 AKTLEDFdftAAPGLDKAQIrelatLDFIERAE---------NVLLLGPPGTGKTHLAIALGYA----ACRQG--YRVRF 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 160 VSLTEIIKQIKEGwaygrNANLTEYEAVKKLVDVDFLIIDDLGakngtVTPKSDWEQDFLFDIINNR-ET--TIFNTNLD 236
Cdd:NF038214  124 TTAADLVEQLAQA-----RADGRLGRLLRRLARYDLLIIDELG-----YLPFSREGANLLFELIADRyERgsTIITSNLP 193


                  ...
gi 1608037151 237 SSE 239
Cdd:NF038214  194 FSE 196
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 90-255 4.93e-10

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 58.63  E-value: 4.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFVKTTEERQMLEfvkgQAQKYLAGMTGNT---LISGSTGIGKSHLSLALAKEInesfreKNEPKSVLFVSLTEII 166
Cdd:PRK07952   70 SFENYRVECEGQMNALS----KARQYVEEFDGNIasfIFSGKPGTGKNHLAAAICNEL------LLRGKSVLIITVADIM 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 167 KQIKEGWaygRNANLTEYEAVKKLVDVDFLIIDDLGakngtVTPKSDWEQDFLFDIINNRET----TIFNTNLDSSELRT 242
Cdd:PRK07952  140 SAMKDTF---SNSETSEEQLLNDLSNVDLLVIDEIG-----VQTESRYEKVIINQIVDRRSSskrpTGMLTNSNMEEMTK 211

                         170
                  ....*....|...
gi 1608037151 243 VYNARNSSRILKG 255
Cdd:PRK07952  212 LLGERVMDRMRLG 224
PRK12377 PRK12377
putative replication protein; Provisional
 90-252 1.98e-09

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 56.77  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFVKTTEERQMLEFVKGQAQKYLAGMTgNTLISGSTGIGKSHLSLALAKEINESFReknepkSVLFVSLTEIIKQI 169
Cdd:PRK12377   72 SFANYQVQNDGQRYALSQAKSIADELMTGCT-NFVFSGKPGTGKNHLAAAIGNRLLAKGR------SVIVVTVPDVMSRL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 170 KEGWAYGRnanlTEYEAVKKLVDVDFLIIDDLGAKNGTVTpksdwEQDFLFDIINNRETTIFN----TNLDSSELRTVYN 245
Cdd:PRK12377  145 HESYDNGQ----SGEKFLQELCKVDLLVLDEIGIQRETKN-----EQVVLNQIIDRRTASMRSvgmlTNLNHEAMSTLLG 215


                  ....*..
gi 1608037151 246 ARNSSRI 252
Cdd:PRK12377  216 ERVMDRM 222
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 44-240 9.24e-07

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 49.10  E-value: 9.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  44 CPECVKGEIKQKEKDLLQqfedrqayfktydvLMrdsTIPNELKGATFDNFFVKTTEERQMLEFVKGQAQKYLAGMTGNT 123
Cdd:PRK08939   96 TPEKIEADEEKAIKKRIQ--------------SI---YMPKDLLQASLADIDLDDRDRLDALMAALDFLEAYPPGEKVKG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 124 L-ISGSTGIGKSHLSLALAKEInesfreKNEPKSVLFVSLTEIIKQIKEgwAYGRNANLTEYEAVKKlvdVDFLIIDDLG 202
Cdd:PRK08939  159 LyLYGDFGVGKSYLLAAIANEL------AKKGVSSTLLHFPEFIRELKN--SISDGSVKEKIDAVKE---APVLMLDDIG 227

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1608037151 203 AKngTVTPksdWEQDFLFDII-----NNRETTIFNTNLDSSEL 240
Cdd:PRK08939  228 AE--QMSS---WVRDEVLGVIlqyrmQEELPTFFTSNFDFDEL 265
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
90-224 2.34e-06

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 47.88  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFV-KTTEE-RQMLEFVkgqAQKylAGMTGNTL-ISGSTGIGKSHLSLALAKEInesfREKNEPKSVLFVS----L 162
Cdd:COG0593     6 TFDNFVVgPSNRLaHAAALAV---AEW--PGKAYNPLfLYGGVGLGKTHLLHAIGNEA----LENNPGARVVYLTaeefT 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1608037151 163 TEIIKQIkegwaygRNANLTEYEavKKLVDVDFLIIDD---LGAKNGTvtpksdweQDFLFDIIN 224
Cdd:COG0593    77 NDFINAI-------RNNTIEEFK--EKYRSVDVLLIDDiqfLAGKEAT--------QEEFFHTFN 124
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 76-235 2.17e-05

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 44.74  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  76 LMRDSTIPNELKGATFDNFFVKTTEERQM-----LEFVKGQAqkylagmtgNTLISGSTGIGKSHLSLALAKeinESFRE 150
Cdd:pfam01695  52 LLRMAKLPPHKTLEDFDFTFAPGLDQRIVaelasLSFIDRAQ---------NVVLLGPPGVGKTHLAIALGV---EACRA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 151 KnepKSVLFVSLTEIIKQIKEGWAYGRnanlteyeAVKKL---VDVDFLIIDDLGakngtVTPKSDWEQDFLFDIINNR- 226
Cdd:pfam01695 120 G---YSVRFTSAADLVNQLKRAHGDGK--------LTRKLqqlLKPDVLILDEWG-----YLPLDQAEANLLFQVISKRy 183

                         170
                  ....*....|.
gi 1608037151 227 --ETTIFNTNL 235
Cdd:pfam01695 184 ehRSIILTSNL 194
PRK08181 PRK08181
transposase; Validated
 88-226 3.45e-05

transposase; Validated


Pssm-ID: 136670 [Multi-domain]  Cd Length: 269  Bit Score: 44.15  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  88 GATFDNF---FVKTTEERQMLEFVKGQAqkYLAgMTGNTLISGSTGIGKSHLSLALAKEINES-FReknepksVLFVSLT 163
Cdd:PRK08181   74 GKTLDSFdfeAVPMVSKAQVMAIAAGDS--WLA-KGANLLLFGPPGGGKSHLAAAIGLALIENgWR-------VLFTRTT 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1608037151 164 EIIKQIKegwAYGRNANLTeyEAVKKLVDVDFLIIDDLgaknGTVTpKSDWEQDFLFDIINNR 226
Cdd:PRK08181  144 DLVQKLQ---VARRELQLE--SAIAKLDKFDLLILDDL----AYVT-KDQAETSVLFELISAR 196
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 90-224 1.10e-04

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 43.29  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFVktTEERQM-----LEFVKGQAQKYlagmtgNTL-ISGSTGIGKSHLSLALAKEINESFREKNepksVLFVS-- 161
Cdd:TIGR00362 109 TFDNFVV--GKSNRLahaaaLAVAENPGKAY------NPLfIYGGVGLGKTHLLHAIGNEILENNPNAK----VLYVSse 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1608037151 162 --LTEIIKQIkegwaygRNANLTEYEavKKLVDVDFLIIDD---LGAKNGTvtpksdweQDFLFDIIN 224
Cdd:TIGR00362 177 kfTNDFVNAL-------RNNKMEEFK--EKYRSVDLLLIDDiqfLAGKERT--------QEEFFHTFN 227
dnaA PRK00149
chromosomal replication initiator protein DnaA;
90-224 1.17e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 43.20  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFVktTEERQM-----LEFVKGQAQKYlagmtgNTL-ISGSTGIGKSHLSLALAKEInesfREKNEPKSVLFVS-- 161
Cdd:PRK00149   71 TFDNFVV--GKSNRLahaaaLAVAENPGKAY------NPLfIYGGVGLGKTHLLHAIGNYI----LEKNPNAKVVYVTse 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1608037151 162 --LTEIIKQIKEGwaygrnanltEYEAVK-KLVDVDFLIIDD---LGAKNGTvtpksdweQDFLFDIIN 224
Cdd:PRK00149  139 kfTNDFVNALRNN----------TMEEFKeKYRSVDVLLIDDiqfLAGKERT--------QEEFFHTFN 189
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 121-240 1.44e-04

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 41.36  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 121 GNTLISGSTGIGKSHLSLALAKEINESFreknepKSVLFVSLTEIIKQIKEGWAYGRNANLTEYEAVKKlVDVDFLIIDD 200
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELFRPG------APFLYLNASDLLEGLVVAELFGHFLVRLLFELAEK-AKPGVLFIDE 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1608037151 201 LGAkngtVTPKSDWEQDFLFDIINNRET------TIFNTNLDSSEL 240
Cdd:cd00009    93 IDS----LSRGAQNALLRVLETLNDLRIdrenvrVIGATNRPLLGD 134
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 121-203 3.92e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 3.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  121 GNTLISGSTGIGKSHLSLALAKEINESFreknepKSVLFVSLTEI----IKQIKEGWAYGRNANLTEYEAVKKLV----- 191
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPG------GGVIYIDGEDIleevLDQLLLIIVGGKKASGSGELRLRLALalark 76

                           90
                   ....*....|...
gi 1608037151  192 -DVDFLIIDDLGA 203
Cdd:smart00382  77 lKPDVLILDEITS 89
Bac_DnaA pfam00308
Bacterial dnaA protein;
90-225 5.29e-04

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 40.39  E-value: 5.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  90 TFDNFFVKTTEErqmLEFVKGQAQKYLAGMTGNTL-ISGSTGIGKSHLSLALAKEINESFREKNepksVLFVS----LTE 164
Cdd:pfam00308   6 TFENFVIGPSNR---FAHAAALTVAKAPGKAYNPLfIYGGVGLGKTHLLHAIGNYALQNAPNLR----VVYLTaeefLND 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1608037151 165 IIKQIKEGwaygrnanltEYEAVK-KLVDVDFLIIDD---LGAKNGTvtpksdweQDFLFDIINN 225
Cdd:pfam00308  79 FVDAIRDN----------KTNQFKeKYRNVDVLLIDDiqfLAGKEGT--------QEEFFHTFNA 125
PRK06921 PRK06921
hypothetical protein; Provisional
 76-274 7.10e-04

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 40.15  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  76 LMRDSTIPNELKGATFDNFFVK------------TTEERQMLEFVKGQAQKYLAgmtgntlISGSTGIGKSHLSLALAke 143
Cdd:PRK06921   68 LLKASEITEAFRKLTFKNFKTEgkpqaikdayecAVEYVKDFEKIQESRKNSIA-------LLGQPGSGKTHLLTAAA-- 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151 144 iNESFREKNEPksVLFVSLTEIIKQIKEGWAyGRNANLteyEAVKKlvdVDFLIIDDLGAKNGTVTPKSDWEQDFLFDII 223
Cdd:PRK06921  139 -NELMRKKGVP--VLYFPFVEGFGDLKDDFD-LLEAKL---NRMKK---VEVLFIDDLFKPVNGKPRATEWQIEQMYSVL 208

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1608037151 224 N----NRETTIFNTNLDSSELRTVYNARnSSRILKGLEGNTfkaFTIKDKRYTIN 274
Cdd:PRK06921  209 NyrylNHKPILISSELTIDELLDIDEAL-GSRIVEMCKDYL---VIIKGDSFELN 259
ATPase pfam06745
KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and ...
 122-194 6.60e-03

KaiC; This family is in the P-loop NTPase superfamily and is found in archaea, bacteria and eukaryotes. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria.


Pssm-ID: 429095 [Multi-domain]  Cd Length: 231  Bit Score: 37.23  E-value: 6.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1608037151 122 NTLISGSTGIGKSHLSLALAKeinESFREKNEPksVLFVSLTEIIKQIKE-----GWaygrnaNLTEYEAVKKLVDVD 194
Cdd:pfam06745  21 VVLITGGPGTGKTIFGLQFLY---NGALKYGEP--GVFVTLEEPPEDLREnarsfGW------DLEKLEEEGKLAIID 87
RadA_SMS_N cd01121
bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a ...
 96-170 6.76e-03

bacterial RadA DNA repair protein; Sms or bacterial RadA is a DNA repair protein that plays a role in recombination and recombinational repair of DNA damaged by UV radiation, X-rays, and chemical agent and is responsible for the stabilization or processing of branched DNA molecules.


Pssm-ID: 410866 [Multi-domain]  Cd Length: 268  Bit Score: 37.13  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1608037151  96 VKTTEERQML----EF--------VKGQAqkylagmtgnTLISGSTGIGKSHLSLALAKEInesfreKNEPKSVLFVSLT 163
Cdd:cd01121    56 VEAEEEERIStgigELdrvlggglVPGSV----------VLIGGDPGIGKSTLLLQVAARL------AQRGGKVLYVSGE 119


                  ....*..
gi 1608037151 164 EIIKQIK 170
Cdd:cd01121   120 ESLSQIK 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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