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Conserved domains on  [gi|16077993|ref|NP_388809|]
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glycerol permease [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 1-235 1.39e-86

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 257.75  E-value: 1.39e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   1 MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSlsfQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWK 80
Cdd:COG0580   3 MKRLLAEFLGTFILVLLGCGVVAVLAGTKG---GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  81 EVPVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFSTGPSIP-HTFANVLSEVIGTFVLVLGILAIGANQFTEG 159
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTFVLVFVILGITDKRAAPG 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077993 160 -LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFlpipGKGSSNWKYAWVPVVGPILGGSFGGVFYNAAFK 235
Cdd:COG0580 160 gLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL----GKGGSDWGYLWVPIVAPILGAALAALLYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 1-235 1.39e-86

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 257.75  E-value: 1.39e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   1 MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSlsfQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWK 80
Cdd:COG0580   3 MKRLLAEFLGTFILVLLGCGVVAVLAGTKG---GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  81 EVPVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFSTGPSIP-HTFANVLSEVIGTFVLVLGILAIGANQFTEG 159
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTFVLVFVILGITDKRAAPG 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077993 160 -LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFlpipGKGSSNWKYAWVPVVGPILGGSFGGVFYNAAFK 235
Cdd:COG0580 160 gLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL----GKGGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 4-230 3.17e-52

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 172.23  E-value: 3.17e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    4 FWGEVIGTMLLIIFGAGVCAGVNLKKSLSfqsGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVP 83
Cdd:PTZ00016  53 YVAEFLGTFVLLFFGEGVVATTHTVGNNG---DYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   84 VYIAAQMIGAIIGAVIIYLHYLPH----------WKSTDDPAAklGVFSTGPSIPHTFAnVLSEVIGTFVLVLGILAIGA 153
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFfkdhgipelpWETMANGFA--GVFATYPREGNFYA-IFSELILTAILLLVILAITD 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16077993  154 NQFTEGLN--PLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVGPILGGSFGGVFY 230
Cdd:PTZ00016 207 PNNCPAFNylPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFTKDNYYFWVPLVAPFVGAVLGMFLY 285
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 6-230 2.30e-51

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 167.48  E-value: 2.30e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993     6 GEVIGTMLLIIFGAGVCAGVNLKKSLSF--QSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVP 83
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAvgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    84 VYIAAQMIGAIIGAVIIYLHYLP----HWKSTDDPAAKLgvfstgpsipHTFANVLSEVIGTFVLVLGILAIG--ANQFT 157
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGlfpgNLAVNGSASAGV----------SSGQAFFVEFIGTAILVLVIFATTddRNRVP 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16077993   158 EG-LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGkgssnwkyAWVPVVGPILGGSFGGVFY 230
Cdd:TIGR00861 151 RGgFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN--------HWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 3-231 7.41e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 158.96  E-value: 7.41e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   3 AFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFqsGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEV 82
Cdd:cd00333   2 KYLAEFLGTFLLVFFGCGSVLAVKLAGGASG--GLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  83 PVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFSTGPSIPH--TFANVLSEVIGTFVLVLGILAI---GANQFT 157
Cdd:cd00333  80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSPGvsNGNAFFVEFIGTFILVLVVFATtddPNGPPP 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16077993 158 EGLNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLpipgkgsSNWKYAWVPVVGPILGGSFGGVFYN 231
Cdd:cd00333 160 GGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA-------RHWHYFWVYWVGPLIGAIAGALVYD 226
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-230 5.34e-35

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 125.51  E-value: 5.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993     3 AFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEV 82
Cdd:pfam00230  10 AVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    83 PVYIAAQMIGAIIGAVIIYLHYLphwkstddPAAKLGVFSTGPSIPHTFAN-VLSEVIGTFVLVLGILA--IGANQFTEG 159
Cdd:pfam00230  90 IFYIVAQLLGAIAGAALLYGVTV--------GLQRAGLFANTLAPGVNAGQaFVVEIILTFQLVYCVFAttDDRRNGSLG 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16077993   160 -LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHaflpipgkgsSNWKYAWVPVVGPILGGSFGGVFY 230
Cdd:pfam00230 162 tVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----------WKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 1-235 1.39e-86

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 257.75  E-value: 1.39e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   1 MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSlsfQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWK 80
Cdd:COG0580   3 MKRLLAEFLGTFILVLLGCGVVAVLAGTKG---GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  81 EVPVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFSTGPSIP-HTFANVLSEVIGTFVLVLGILAIGANQFTEG 159
Cdd:COG0580  80 DVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTFVLVFVILGITDKRAAPG 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077993 160 -LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFlpipGKGSSNWKYAWVPVVGPILGGSFGGVFYNAAFK 235
Cdd:COG0580 160 gLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL----GKGGSDWGYLWVPIVAPILGAALAALLYRALFG 232
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 4-230 3.17e-52

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 172.23  E-value: 3.17e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    4 FWGEVIGTMLLIIFGAGVCAGVNLKKSLSfqsGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVP 83
Cdd:PTZ00016  53 YVAEFLGTFVLLFFGEGVVATTHTVGNNG---DYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   84 VYIAAQMIGAIIGAVIIYLHYLPH----------WKSTDDPAAklGVFSTGPSIPHTFAnVLSEVIGTFVLVLGILAIGA 153
Cdd:PTZ00016 130 GYFVAQLLGAFVGAACVYGLYYGFfkdhgipelpWETMANGFA--GVFATYPREGNFYA-IFSELILTAILLLVILAITD 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16077993  154 NQFTEGLN--PLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVGPILGGSFGGVFY 230
Cdd:PTZ00016 207 PNNCPAFNylPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFTKDNYYFWVPLVAPFVGAVLGMFLY 285
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 6-230 2.30e-51

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 167.48  E-value: 2.30e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993     6 GEVIGTMLLIIFGAGVCAGVNLKKSLSF--QSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVP 83
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYGAvgGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    84 VYIAAQMIGAIIGAVIIYLHYLP----HWKSTDDPAAKLgvfstgpsipHTFANVLSEVIGTFVLVLGILAIG--ANQFT 157
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGlfpgNLAVNGSASAGV----------SSGQAFFVEFIGTAILVLVIFATTddRNRVP 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16077993   158 EG-LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGkgssnwkyAWVPVVGPILGGSFGGVFY 230
Cdd:TIGR00861 151 RGgFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN--------HWVYWVGPIIGAILGALVY 216
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 3-231 7.41e-48

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 158.96  E-value: 7.41e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   3 AFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFqsGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEV 82
Cdd:cd00333   2 KYLAEFLGTFLLVFFGCGSVLAVKLAGGASG--GLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  83 PVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFSTGPSIPH--TFANVLSEVIGTFVLVLGILAI---GANQFT 157
Cdd:cd00333  80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSPGvsNGNAFFVEFIGTFILVLVVFATtddPNGPPP 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16077993 158 EGLNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLpipgkgsSNWKYAWVPVVGPILGGSFGGVFYN 231
Cdd:cd00333 160 GGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA-------RHWHYFWVYWVGPLIGAIAGALVYD 226
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-230 5.34e-35

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 125.51  E-value: 5.34e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993     3 AFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEV 82
Cdd:pfam00230  10 AVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    83 PVYIAAQMIGAIIGAVIIYLHYLphwkstddPAAKLGVFSTGPSIPHTFAN-VLSEVIGTFVLVLGILA--IGANQFTEG 159
Cdd:pfam00230  90 IFYIVAQLLGAIAGAALLYGVTV--------GLQRAGLFANTLAPGVNAGQaFVVEIILTFQLVYCVFAttDDRRNGSLG 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16077993   160 -LNPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHaflpipgkgsSNWKYAWVPVVGPILGGSFGGVFY 230
Cdd:pfam00230 162 tVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----------WKWDDHWVYWVGPFIGAALGALVY 223
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 7-231 1.50e-20

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 88.43  E-value: 1.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    7 EVIGTMLLIIFGAGVCAGVNL-KKSLSFQSgwivVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVY 85
Cdd:PLN00182  48 EMIGTYFIIFSGCGVVVVNVLyGGTITFPG----ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLY 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   86 IAAQMIGAIIGAVIIYLHYlphwksTDDPAAKLGVFSTGPSIphtfANVLSEVIGTFVLVLGILAIGANQFTEG-LNPLI 164
Cdd:PLN00182 124 IGAQLTGSLLASLTLRLMF------NVTPEAFFGTTPTDSSG----QALVAEIIISFLLMFVISGVATDSRAVGeLAGIA 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077993  165 VGFLIVAIGISLGGTTGYAINPARDLGPRIAhaflpipgkgSSNWKYAWVPVVGPILGGSFGGVFYN 231
Cdd:PLN00182 194 VGMTIILNVFVAGPISGASMNPARSLGPAIV----------MGRYKGIWVYIVGPFVGIIAGGFVYN 250
PLN00026 PLN00026
aquaporin NIP; Provisional
 7-232 4.88e-20

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 87.22  E-value: 4.88e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    7 EVIGTMLLIiFGAGVCAGVNLKKSLSfqSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYI 86
Cdd:PLN00026  77 EFVGTFILI-FAATAGPIVNQKYDGA--ETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYI 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   87 AAQMIGAIIGAVIIylhylphwKSTDDPAAKLGVfsTGPSIPHTFANVLsEVIGTFVLVLGILAIGANQFTEG-LNPLIV 165
Cdd:PLN00026 154 AAQVSASICASFAL--------KGVFHPFMSGGV--TVPSVSTGQAFAL-EFIITFNLLFVVTAVATDTRAVGeLAGIAV 222

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16077993  166 GFLIVAIGISLGGTTGYAINPARDLGPRIAhaflpipgkgSSNWKYAWVPVVGPILGGSFGGVFYNA 232
Cdd:PLN00026 223 GATVMLNILVAGPSTGGSMNPVRTLGPAVA----------AGNYRAIWIYLVAPTLGALAGAGTYTA 279
PLN00184 PLN00184
aquaporin NIP1; Provisional
 6-231 4.00e-19

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 84.69  E-value: 4.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    6 GEVIGTMLLIIFGAGVCAgVNLKKSLSFQSGWIVVVfgWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVY 85
Cdd:PLN00184  59 AEVLGTYFLVFTGCASVV-VNMQNDNVVTLPGIAIV--WGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAY 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   86 IAAQMIGAIIGAVIIYLHY-LPHwkstDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEG-LNPL 163
Cdd:PLN00184 136 VISQVIGSTLAAATLRLLFgLDH----DVCSGKHDVFIGSSPVGSDLQAFVMEFIVTFYLMFIISGVATDNRAIGeLAGL 211

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16077993  164 IVGFLIVAIGISLGGTTGYAINPARDLGPRIAHaflpipgkgsSNWKYAWVPVVGPILGGSFGGVFYN 231
Cdd:PLN00184 212 AIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVY----------GCYKGIWIYIVAPTLGAIAGAWVYN 269
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 7-230 6.19e-18

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 81.06  E-value: 6.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    7 EVIGTMLLIIFGAGVCAGVNLKKSlsfQSGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYI 86
Cdd:PLN00183  51 EMVGTFILMFCVCGIIASTQLSGG---EVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYI 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   87 AAQMIGAIIGAVIIYLHYlphwkstddpAAKLGVFSTGPSIPHTFAnVLSEVIGTFVLVLgiLAIGANQFTEGLNPLiVG 166
Cdd:PLN00183 128 TAQTVGSVLATYVGVSVY----------GVKADLMTTKPAQGCSSA-FWVEFIATFIVMF--LAASLTSQPQSLGHL-SG 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16077993  167 FLI-VAIGISL---GGTTGYAINPARDLGPRIAhaflpipgkgSSNWKYAWVPVVGPILGGSFGGVFY 230
Cdd:PLN00183 194 FVIgIAIGLAVlitGPVSGGSMNPARSLGPAIV----------SWDFKDIWIYITAPTIGAVAGALMF 251
PRK05420 PRK05420
aquaporin Z; Provisional
 36-230 1.13e-13

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 68.46  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   36 GWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYLhyLPHWKSTDDpA 115
Cdd:PRK05420  35 GFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVPYIIAQVVGGIAAAAVLYL--IASGKAGFD-L 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  116 AKLGVFSTG-----PSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGLNPLIVGF---LIVAIGISLGGTTgyaINPA 187
Cdd:PRK05420 112 AGSGFASNGygehsPGGYSLLAALVCEVVLTAFFLLVILGATDKRAPAGFAPIAIGLaltLIHLISIPVTNTS---VNPA 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 16077993  188 RDLGPRIAhaflpipgkgSSNWKYA--WVPVVGPILGGSFGGVFY 230
Cdd:PRK05420 189 RSTGVALF----------VGGWALEqlWLFWVAPIVGAIIGGLIY 223
PLN00166 PLN00166
aquaporin TIP2; Provisional
 1-240 7.17e-10

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 58.02  E-value: 7.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993    1 MTAFWGEVIGTMLLIIFGAG-VCAGVNLKKSLSFQSGWIVVV-----FGWGLGVAMAAyavgGISGAHLNPALTIALAFV 74
Cdd:PLN00166  18 LKAYLSEFIATLLFVFAGVGsAIAFAKLTSDAALDPAGLVAVavahaFALFVGVSIAA----NISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   75 GDFPWKEVPVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDPAAKLGVFStgpsiphtfaNVLSEVIGTFVLVLGILAIGAN 154
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLGAIE----------GVVMEIVVTFALVYTVYATAAD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  155 QFTEGLN---PLIVGFLIVAIGISLGGTTGYAINPARDLGPRIahaflpIPGKGSSNWKYaWvpvVGPILGGSFGGVFYN 231
Cdd:PLN00166 164 PKKGSLGtiaPIAIGFIVGANILAAGPFSGGSMNPARSFGPAV------VSGDFSQIWIY-W---VGPLVGGALAGLIYG 233


                 ....*....
gi 16077993  232 AAFKGHITS 240
Cdd:PLN00166 234 DVFIGSYAA 242
PLN00027 PLN00027
aquaporin TIP; Provisional
 35-239 2.57e-04

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 41.31  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   35 SGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIiyLHYLPHWKSTddp 114
Cdd:PLN00027  56 AGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRGILYWIAQLLGSVVACLL--LKFSTGGLET--- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  115 aaklGVFSTGPSIPHTFANVLsEVIGTFVLVLGILAIGANQFTEGLN---PLIVGFLIVAIGISLGGTTGYAINPARDLG 191
Cdd:PLN00027 131 ----SAFSLSSGVGVWNAFVF-EIVMTFGLVYTVYATAVDPKKGDLGiiaPIAIGFIVGANILAGGAFDGASMNPAVSFG 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 16077993  192 PRIAhaflpipgkgSSNWKYAWVPVVGPILGGSFGGVFYNAAFKGHIT 239
Cdd:PLN00027 206 PAVV----------SWTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243
PLN00167 PLN00167
aquaporin TIP5; Provisional
 35-231 4.78e-04

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 40.66  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993   35 SGWIVVVFGWGLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYLHYLPHWKSTDDP 114
Cdd:PLN00167  58 SSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQHVPTYKI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16077993  115 AAKLGVFStgpsiphtfANVLSEVIgTFVLVLGILAIGANQFTE--GLNPLIVGFLIVAIGISLGGTTGYAINPARDLGP 192
Cdd:PLN00167 138 AEEMTGFG---------ASVLEGVL-TFGLVYTVYAAGDPRRGLlgAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGS 207

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 16077993  193 RIAhaflpipgkgSSNWKYAWVPVVGPILGGSFGGVFYN 231
Cdd:PLN00167 208 AVV----------AGSFKNQAVYWVGPLLGGAVAGLLYD 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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