|
Name |
Accession |
Description |
Interval |
E-value |
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1439-1785 |
1.18e-112 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 361.96 E-value: 1.18e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1439 GYVGLYNPRAICYMNSLLTQLFMNLNFRQFVLNLKVNEGF-GSQKLLFETQRLFAQMQNSFRKWTDPRDFaGCVKSLDKT 1517
Cdd:cd02659 1 GYVGLKNQGATCYMNSLLQQLYMTPEFRNAVYSIPPTEDDdDNKSVPLALQRLFLFLQLSESPVKTTELT-DKTRSFGWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1518 PIDIAVQMDADEFYNLLFDQWEAQMFKQEHKSKFRAFYGGQTMNQIKSKECEHVSERVEPFFAVQCDIAGKANLQESLQA 1597
Cdd:cd02659 80 SLNTFEQHDVQEFFRVLFDKLEEKLKGTGQEGLIKNLFGGKLVNYIICKECPHESEREEYFLDLQVAVKGKKNLEESLDA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1598 YVEGDVMEGDNKYKCESCdGKFVDAVKryvraevrycsianadRTCLKDAPDNLIFHLKRFEFDLNDFSRRKIYDHFAFP 1677
Cdd:cd02659 160 YVQGETLEGDNKYFCEKC-GKKVDAEK----------------GVCFKKLPPVLTLQLKRFEFDFETMMRIKINDRFEFP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1678 ETLDISPYKFDHLADPE-----KPREEDVFDLVGVLVHTGTCENGHYYSYIRQRPcssesaTPTWVEFNDSEVTPFDPAE 1752
Cdd:cd02659 223 LELDMEPYTEKGLAKKEgdsekKDSESYIYELHGVLVHSGDAHGGHYYSYIKDRD------DGKWYKFNDDVVTPFDPND 296
|
330 340 350
....*....|....*....|....*....|....*..
gi 160703803 1753 IAERTFGGFTEGEGYNRQIKQF----SAYMLFYQRRS 1785
Cdd:cd02659 297 AEEECFGGEETQKTYDSGPRAFkrttNAYMLFYERKS 333
|
|
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
1441-1781 |
2.10e-53 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 190.73 E-value: 2.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1441 VGLYNPRAICYMNSLLTQLFMNLNFRQFVLN----LKVNEGFGSQKLLFETQRLFAQMQ-NSFRKWTDPRDFagcVKSLD 1515
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRisplSEDSRYNKDINLLCALRDLFKALQkNSKSSSVSPKMF---KKSLG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1516 KTPIDIAV--QMDADEFYNLLFDQWEAQMFKQEHKSK----FRAFyGGQTMNQIKSKECEHVSERVEPFFAVQCDIAGKA 1589
Cdd:pfam00443 78 KLNPDFSGykQQDAQEFLLFLLDGLHEDLNGNHSTENesliTDLF-RGQLKSRLKCLSCGEVSETFEPFSDLSLPIPGDS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1590 N------LQESLQAYVEGDVMEGDNKYKCESCdGKFVDAVKRyvraevrycsianadrTCLKDAPDNLIFHLKRFEFDLn 1663
Cdd:pfam00443 157 AelktasLQICFLQFSKLEELDDEEKYYCDKC-GCKQDAIKQ----------------LKISRLPPVLIIHLKRFSYNR- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1664 dFSRRKIYDHFAFPETLDISPYkfdhLADPEKPREEDV--FDLVGVLVHTGTCENGHYYSYIRQRPCSSesatptWVEFN 1741
Cdd:pfam00443 219 -STWEKLNTEVEFPLELDLSRY----LAEELKPKTNNLqdYRLVAVVVHSGSLSSGHYIAYIKAYENNR------WYKFD 287
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 160703803 1742 DSEVTPFDPAeiaertfggftegegynRQIKQFSAYMLFY 1781
Cdd:pfam00443 288 DEKVTEVDEE-----------------TAVLSSSAYILFY 310
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
1442-1782 |
3.45e-53 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 188.08 E-value: 3.45e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLtqlfmnlnfrqfvlnlkvnegfgsqkllfetQRLFAQMQnsfrkwtdprdfagcvksldktpidi 1521
Cdd:cd02257 1 GLNNLGNTCYLNSVL-------------------------------QALFSEQQ-------------------------- 23
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1522 avqmDADEFYNLLFDQWEAQMFKQEHKSKFRAF--------YGGQTMNQIKSKECEHVSERVEPFFAVQCDIAGKA---- 1589
Cdd:cd02257 24 ----DAHEFLLFLLDKLHEELKKSSKRTSDSSSlkslihdlFGGKLESTIVCLECGHESVSTEPELFLSLPLPVKGlpqv 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1590 NLQESLQAYVEGDVMEGDNKYKCESCdgKFVDAVKRyvraevrycsianadrTCLKDAPDNLIFHLKRFEFDlNDFSRRK 1669
Cdd:cd02257 100 SLEDCLEKFFKEEILEGDNCYKCEKK--KKQEATKR----------------LKIKKLPPVLIIHLKRFSFN-EDGTKEK 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1670 IYDHFAFPETLDISPYKFDHLADPEKPREEDVFDLVGVLVHTGTCEN-GHYYSYIRQRPCSSesatptWVEFNDSEVTPF 1748
Cdd:cd02257 161 LNTKVSFPLELDLSPYLSEGEKDSDSDNGSYKYELVAVVVHSGTSADsGHYVAYVKDPSDGK------WYKFNDDKVTEV 234
|
330 340 350
....*....|....*....|....*....|....
gi 160703803 1749 DPAEIAERTFggftegegynrqiKQFSAYMLFYQ 1782
Cdd:cd02257 235 SEEEVLEFGS-------------LSSSAYILFYE 255
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
1438-1789 |
3.48e-45 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 180.07 E-value: 3.48e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1438 TGYVGLYNPRAICYMNSLLTQLFMNLNFRQFVLNLKVNEGFGSQKLLFETQRLFAQMQNSfrkwTDPRDFAGCVKSLDKT 1517
Cdd:COG5077 191 TGYVGLRNQGATCYMNSLLQSLFFIAKFRKDVYGIPTDHPRGRDSVALALQRLFYNLQTG----EEPVDTTELTRSFGWD 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1518 PIDIAVQMDADEFYNLLFDQWEAQMFKQEHKSKFRAFYGGQTMNQIKSKECEHVSERVEPFFAVQCDIAGKANLQESLQA 1597
Cdd:COG5077 267 SDDSFMQHDIQEFNRVLQDNLEKSMRGTVVENALNGIFVGKMKSYIKCVNVNYESARVEDFWDIQLNVKGMKNLQESFRR 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1598 YVEGDVMEGDNKYKCEscDGKFVDAVKryvraEVRYCSIanadrtclkdaPDNLIFHLKRFEFDLNDFSRRKIYDHFAFP 1677
Cdd:COG5077 347 YIQVETLDGDNRYNAE--KHGLQDAKK-----GVIFESL-----------PPVLHLQLKRFEYDFERDMMVKINDRYEFP 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1678 ETLDISPYkfdhlADPEKPREED---VFDLVGVLVHTGTCENGHYYSYIRQRPCSSesatptWVEFNDSEVTPFDPAEIA 1754
Cdd:COG5077 409 LEIDLLPF-----LDRDADKSENsdaVYVLYGVLVHSGDLHEGHYYALLKPEKDGR------WYKFDDTRVTRATEKEVL 477
|
330 340 350
....*....|....*....|....*....|....*....
gi 160703803 1755 ERTFGG----FTEGEGYNRQIKQFSAYMLFYQRRSAVEE 1789
Cdd:COG5077 478 EENFGGdhpyKDKIRDHSGIKRFMSAYMLVYLRKSMLDD 516
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1781 |
3.65e-44 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 164.52 E-value: 3.65e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLTQLFMNLNFRQFVL-----------NLKVNEGFGSQKLLFETQRLFAQMQNSFRKWTDPRDFagc 1510
Cdd:cd02668 1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYecnstedaelkNMPPDKPHEPQTIIDQLQLIFAQLQFGNRSVVDPSGF--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1511 VKSLDktpIDIAVQMDADEFYNLLFDQWEAQMFKQEH---KSKFRAFYGGQTMNQIKSKECEHVSERVEPFFAVQCDIAG 1587
Cdd:cd02668 78 VKALG---LDTGQQQDAQEFSKLFLSLLEAKLSKSKNpdlKNIVQDLFRGEYSYVTQCSKCGRESSLPSKFYELELQLKG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1588 KANLQESLQAYVEGDVMEGDNKYKCESCDGKfVDAVKryvraevrycsianadRTCLKDAPDNLIFHLKRFEFDLNDFSR 1667
Cdd:cd02668 155 HKTLEECIDEFLKEEQLTGDNQYFCESCNSK-TDATR----------------RIRLTTLPPTLNFQLLRFVFDRKTGAK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1668 RKIYDHFAFPETLDISPYKfdhladPEKPREEDVFDLVGVLVHTGTCEN-GHYYSYIRqrpcssESATPTWVEFNDSEVT 1746
Cdd:cd02668 218 KKLNASISFPEILDMGEYL------AESDEGSYVYELSGVLIHQGVSAYsGHYIAHIK------DEQTGEWYKFNDEDVE 285
|
330 340 350
....*....|....*....|....*....|....*...
gi 160703803 1747 PFDP---AEIAERTFGGFTEGEGYNRQIKQFSAYMLFY 1781
Cdd:cd02668 286 EMPGkplKLGNSEDPAKPRKSEIKKGTHSSRTAYMLVY 323
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1781 |
5.21e-39 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 148.58 E-value: 5.21e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLL-----TQLFMNLNFRQFVLNLKVNEGFgsqKLLFETQRLFAQMQNSFRKWTDPRDFAGCVKSLDK 1516
Cdd:cd02661 3 GLQNLGNTCFLNSVLqclthTPPLANYLLSREHSKDCCNEGF---CMMCALEAHVERALASSGPGSAPRIFSSNLKQISK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1517 TpIDIAVQMDADEFYNLLFDQWEA---QMFKQEHKSKFRAF--------YGGQTMNQIKSKECEHVSERVEPFFAVQCDI 1585
Cdd:cd02661 80 H-FRIGRQEDAHEFLRYLLDAMQKaclDRFKKLKAVDPSSQettlvqqiFGGYLRSQVKCLNCKHVSNTYDPFLDLSLDI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1586 AGKANLQESLQAYVEGDVMEGDNKYKCESCdgkfvdavKRYVRAEVRYcSIanaDRtclkdAPDNLIFHLKRFEFdlndF 1665
Cdd:cd02661 159 KGADSLEDALEQFTKPEQLDGENKYKCERC--------KKKVKASKQL-TI---HR-----APNVLTIHLKRFSN----F 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1666 SRRKIYDHFAFPETLDISPYkfdhLADPekPREEDVFDLVGVLVHTGT-CENGHYYSYIRqrpcsseSATPTWVEFNDSE 1744
Cdd:cd02661 218 RGGKINKQISFPETLDLSPY----MSQP--NDGPLKYKLYAVLVHSGFsPHSGHYYCYVK-------SSNGKWYNMDDSK 284
|
330 340 350
....*....|....*....|....*....|....*..
gi 160703803 1745 VTPFDPAEIaertfggftegegYNRQikqfsAYMLFY 1781
Cdd:cd02661 285 VSPVSIETV-------------LSQK-----AYILFY 303
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1782 |
1.84e-31 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 127.61 E-value: 1.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLTQLFMNLNFRQFVLNLKVNEGFGSQKLLFETQRLFAQMQNSFRKWTDPRDfagcvKSLDKT---P 1518
Cdd:cd02664 1 GLINLGNTCYMNSVLQALFMAKDFRRQVLSLNLPRLGDSQSVMKKLQLLQAHLMHTQRRAEAPPD-----YFLEASrppW 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1519 IDIAVQMDADEFYNLLFDQWEA---QMFkqehkskfrafyGGQTMNQIKSKECEHVSERVEPFFAVQCDIagkANLQESL 1595
Cdd:cd02664 76 FTPGSQQDCSEYLRYLLDRLHTlieKMF------------GGKLSTTIRCLNCNSTSARTERFRDLDLSF---PSVQDLL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1596 QAYVEGDVMEGDNKYKCESCdgkfvdavkryvraevryCSIANADRTC-LKDAPDNLIFHLKRFEFDLNDFSRRKIYDHF 1674
Cdd:cd02664 141 NYFLSPEKLTGDNQYYCEKC------------------ASLQDAEKEMkVTGAPEYLILTLLRFSYDQKTHVREKIMDNV 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1675 AFPETL-----DISPYKFDHLADPEKPREED--------VFDLVGVLVHTGTC-ENGHYYSYIRQ----RPCSSESATP- 1735
Cdd:cd02664 203 SINEVLslpvrVESKSSESPLEKKEEESGDDgelvtrqvHYRLYAVVVHSGYSsESGHYFTYARDqtdaDSTGQECPEPk 282
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 160703803 1736 ---------TWVEFNDSEVTPFDPAEIAERTFGGFTEgegynrqikqfSAYMLFYQ 1782
Cdd:cd02664 283 daeendeskNWYLFNDSRVTFSSFESVQNVTSRFPKD-----------TPYILFYE 327
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1781 |
3.30e-30 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 123.64 E-value: 3.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLTQLFMNLNFRQFVLNLKVNEGFGSQK----LLFETQRLFAQMQNSFRK------------WTDPR 1505
Cdd:cd02660 2 GLINLGATCFMNVILQALLHNPLLRNYFLSDRHSCTCLSCSpnscLSCAMDEIFQEFYYSGDRspygpinllylsWKHSR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1506 DFAGcvksldktpidiAVQMDADEFYNLLFDQweaqmFKQEHKSKF--------------RAFYGgQTMNQIKSKECEHV 1571
Cdd:cd02660 82 NLAG------------YSQQDAHEFFQFLLDQ-----LHTHYGGDKneandeshcnciihQTFSG-SLQSSVTCQRCGGV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1572 SERVEPFFAVQCDI---------------AGKANLQESLQAYVEGDVMeGDNKYKCESCDGKfVDAVKRYVraevrycsi 1636
Cdd:cd02660 144 STTVDPFLDLSLDIpnkstpswalgesgvSGTPTLSDCLDRFTRPEKL-GDFAYKCSGCGST-QEATKQLS--------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1637 anadrtcLKDAPDNLIFHLKRFEFDLNDfSRRKIYDHFAFPETLDISPYKF--DHLADPEKPREEDV-FDLVGVLVHTGT 1713
Cdd:cd02660 213 -------IKKLPPVLCFQLKRFEHSLNK-TSRKIDTYVQFPLELNMTPYTSssIGDTQDSNSLDPDYtYDLFAVVVHKGT 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160703803 1714 CENGHYYSYIRQRpcssesaTPTWVEFNDSEVTPFDPAEI-AERtfggftegegynrqikqfsAYMLFY 1781
Cdd:cd02660 285 LDTGHYTAYCRQG-------DGQWFKFDDAMITRVSEEEVlKSQ-------------------AYLLFY 327
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1782 |
2.92e-29 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 120.11 E-value: 2.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLTQLFMNlnfrqfvlnlkvnegfgsqKLLFETQRLFAQMQNSFRKW--TDPRDFagcVKSLDK-TP 1518
Cdd:cd02663 1 GLENFGNTCYCNSVLQALYFE-------------------NLLTCLKDLFESISEQKKRTgvISPKKF---ITRLKReNE 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1519 I-DIAVQMDADEFYNLLF-----------------DQWEAQMFKQEHKSKFRAFYGGQTMNQIKSKECEHVSERVEPFFA 1580
Cdd:cd02663 59 LfDNYMHQDAHEFLNFLLneiaeildaerkaekanRKLNNNNNAEPQPTWVHEIFQGILTNETRCLTCETVSSRDETFLD 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1581 VQCDIAGKANLQESLQAYVEGDVMEGDNKYKCESCDGKfVDAVKRyVRaevrycsianadrtcLKDAPDNLIFHLKRFEF 1660
Cdd:cd02663 139 LSIDVEQNTSITSCLRQFSATETLCGRNKFYCDECCSL-QEAEKR-MK---------------IKKLPKILALHLKRFKY 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1661 DLNDFSRRKIYDHFAFPETLDIspykFDHLADPEKPreEDVFDLVGVLVHTGTCEN-GHYYSYIRqrpcssesATPTWVE 1739
Cdd:cd02663 202 DEQLNRYIKLFYRVVFPLELRL----FNTTDDAENP--DRLYELVAVVVHIGGGPNhGHYVSIVK--------SHGGWLL 267
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 160703803 1740 FNDSEVTPFDPAEIAErtFGGFTEGegynrqikQFSAYMLFYQ 1782
Cdd:cd02663 268 FDDETVEKIDENAVEE--FFGDSPN--------QATAYVLFYQ 300
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1524-1782 |
1.07e-28 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 116.62 E-value: 1.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1524 QMDADEFYNLLFDqweaqmfkqEHKSKFRAFYGGQTMNQIKSKECEHVSERVEPFFAVQCDI------AGKANLQESLQA 1597
Cdd:cd02674 22 QQDAQEFLLFLLD---------GLHSIIVDLFQGQLKSRLTCLTCGKTSTTFEPFTYLSLPIpsgsgdAPKVTLEDCLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1598 YVEGDVMEGDNKYKCESCdgkfvdavKRYVRAEvRYCSIAnadrtclkDAPDNLIFHLKRFEFDLNdfSRRKIYDHFAFP 1677
Cdd:cd02674 93 FTKEETLDGDNAWKCPKC--------KKKRKAT-KKLTIS--------RLPKVLIIHLKRFSFSRG--STRKLTTPVTFP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1678 -ETLDISPYkfdhlADPEKPREEDVFDLVGVLVHTGTCENGHYYSYIRqrpcssESATPTWVEFNDSEVTPFDPAEIAER 1756
Cdd:cd02674 154 lNDLDLTPY-----VDTRSFTGPFKYDLYAVVNHYGSLNGGHYTAYCK------NNETNDWYKFDDSRVTKVSESSVVSS 222
|
250 260
....*....|....*....|....*.
gi 160703803 1757 tfggftegegynrqikqfSAYMLFYQ 1782
Cdd:cd02674 223 ------------------SAYILFYE 230
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1503-1747 |
9.16e-22 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 97.84 E-value: 9.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1503 DPRDFAGCVKSLDKTPIDiAVQMDADEFYNLLFDqweaqmfkqehksKFRAF----YGGQTMNQIKSKECEHVSERVEPF 1578
Cdd:cd02667 31 TPKELFSQVCRKAPQFKG-YQQQDSHELLRYLLD-------------GLRTFidsiFGGELTSTIMCESCGTVSLVYEPF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1579 FAVQC----DIAGKANLQESLQAYVEGDVMEGDNKYKCESCDgkfvDAVKRYVraevrycsianadrtcLKDAPDNLIFH 1654
Cdd:cd02667 97 LDLSLprsdEIKSECSIESCLKQFTEVEILEGNNKFACENCT----KAKKQYL----------------ISKLPPVLVIH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1655 LKRFeFDLNDFSRRKIYDHFAFPETLDISPY---KFDHLADPEKPReedvFDLVGVLVHTGTCENGHYYSYIRQRPCSSE 1731
Cdd:cd02667 157 LKRF-QQPRSANLRKVSRHVSFPEILDLAPFcdpKCNSSEDKSSVL----YRLYGVVEHSGTMRSGHYVAYVKVRPPQQR 231
|
250
....*....|....*.
gi 160703803 1732 SATPTWVEFNDSEVTP 1747
Cdd:cd02667 232 LSDLTKSKPAADEAGP 247
|
|
| COG5533 |
COG5533 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
1442-1783 |
6.34e-18 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 444284 [Multi-domain] Cd Length: 284 Bit Score: 86.39 E-value: 6.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLTQLFMNLNfrqfvlnlKVNEGFGsqKLLFETQRLFAQMQNSFRKWTDPR--DFAGCVKSLDKTPI 1519
Cdd:COG5533 1 GLPNLGNTCFMNSVLQILALYLP--------KLDELLD--DLSKELKVLKNVIRKPEPDLNQEEalKLFTALWSSKEHKV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1520 ----DIAVQMDADEFYNLLFDQWEAQMFKQEHKSKFRAF--YGGQTMNQIKSKECEHVSERvepffavqcdiagKANLQE 1593
Cdd:COG5533 71 gwipPMGSQEDAHELLGKLLDELKLDLVNSFTIRIFKTTkdKKKTSTGDWFDIIIELPDQT-------------WVNNLK 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1594 SLQAYVEGDVMEGDNKykcesCDGKFVDAVKRYVRAEVRYCSIAnadrtclKDAPDNLIFHLKRFEfdlNDFSRRKIYDh 1673
Cdd:COG5533 138 TLQEFIDNMEELVDDE-----TGVKAKENEELEVQAKQEYEVSF-------VKLPKILTIQLKRFA---NLGGNQKIDT- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1674 fAFPETLDIsPYKFDhlaDPEKPREEDVFDLVGVLVHTGTCENGHYYSYIRQRpcssesatPTWVEFNDSEVTPfdpaei 1753
Cdd:COG5533 202 -EVDEKFEL-PVKHD---QILNIVKETYYDLVGFVLHQGSLEGGHYIAYVKKG--------GKWEKANDSDVTP------ 262
|
330 340 350
....*....|....*....|....*....|
gi 160703803 1754 aertfggFTEGEGYNRQIKQfsAYMLFYQR 1783
Cdd:COG5533 263 -------VSEEEAINEKAKN--AYLYFYER 283
|
|
| DUF3517 |
pfam12030 |
Domain of unknown function (DUF3517); This presumed domain is functionally uncharacterized. ... |
1913-2294 |
7.59e-16 |
|
Domain of unknown function (DUF3517); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 340 amino acids in length. This domain is found associated with pfam00443.
Pssm-ID: 463438 Cd Length: 407 Bit Score: 82.35 E-value: 7.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1913 SAMTNILIKCTHPTLRSQMRALLVDSLKSLREQ-EPSAYESDSSDSDMEVDSSTP--VEGVLVALTRrLRitaDESYEST 1989
Cdd:pfam12030 2 EALRELLLRNPDAEVRSAFGKLIVFALHKLKELyGLPDGPCDPDDLEEEWRSLSDsvLEAVVALLDH-LW---KEFHTHL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1990 RGWEDFYLLLTQIAEMGLLETAVLLNHSFLQFCLKLFCMHTH--KPSREDCPELARVMDKRRSI-FNRLICFVWKLLSQM 2066
Cdd:pfam12030 78 RSWDEYFGLLLSYANLGPREVAQLLDLGFLLKCLEIIAADEGdgPPLKYQYARMLRLVEKRRPPsYEKLIQLLSVLLRCC 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 2067 DLNLDVLNDNDT-HDRLSTFDRERMkfPLSIRETAAVMYWSDDIKaiaiidkilEVFDDSKTDHFYPGD----IIKWILE 2141
Cdd:pfam12030 158 DLSLPPQSINEGaEPLPNSLPDGPF--PLTSEEADLLRPLGRTNG---------SIFVKKLLEIDQNPEatrkILRFLLW 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 2142 SrSAKLQSDMGRTIIEGIQMEP--PFCDAYIQAALPLCEASAisekittTINTVVKMVassKRAAEDRLpsgdavlglff 2219
Cdd:pfam12030 227 E-NPELSDSILKTLLWGIRGAPahLLRDPFLRAAIVFCEDSW-------QAHRIHNLI---DHVAKQAD----------- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 2220 GLLTAENQAFF-YHK------------HPHAFYHCLMQRSSVYGIALLCHDEDRVRKSTNIFFQKLYGTKEaMALETIAI 2286
Cdd:pfam12030 285 SLNNTEGRAFLhFFKrayqcincrlgfDKEWFASQVLENIPDWAPPLLSYPDSNVRSETEDFLQEELFSHE-MGPDPQFR 363
|
....*...
gi 160703803 2287 KYKSAREL 2294
Cdd:pfam12030 364 LREAARRL 371
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1782 |
1.01e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 76.25 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLtqlfmnlnfrQFVLNLKvnegfgsqkllfetqrlfaqmqnSFRKWtdprdfagcvksLDKtpidI 1521
Cdd:cd02662 1 GLVNLGNTCFMNSVL----------QALASLP-----------------------SLIEY------------LEE----F 31
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1522 AVQMDADEFYNLLFDQWEAQMfkqehKSKFRafygGQTMNQIKSKECEHVSE-RVEPFF-----AVQCDIAGKANLQESL 1595
Cdd:cd02662 32 LEQQDAHELFQVLLETLEQLL-----KFPFD----GLLASRIVCLQCGESSKvRYESFTmlslpVPNQSSGSGTTLEHCL 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1596 QAYVEGDVMEGdnkYKCESCdgkfvdavkryvraevrycsianadRTCLKDAPDNLIFHLKRFEFDLNDFSRRKiYDHFA 1675
Cdd:cd02662 103 DDFLSTEIIDD---YKCDRC-------------------------QTVIVRLPQILCIHLSRSVFDGRGTSTKN-SCKVS 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1676 FPETLDISPYKfdhladpekpreedvfdLVGVLVHTGTCENGHYYSYIRQRPCSSESATP--------------TWVEFN 1741
Cdd:cd02662 154 FPERLPKVLYR-----------------LRAVVVHYGSHSSGHYVCYRRKPLFSKDKEPGsfvrmregpsstshPWWRIS 216
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 160703803 1742 DSEVTPFDPAEIAErtfggftegegynrqikQFSAYMLFYQ 1782
Cdd:cd02662 217 DTTVKEVSESEVLE-----------------QKSAYMLFYE 240
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1524-1781 |
1.26e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 75.67 E-value: 1.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1524 QMDADEFYNLLFDQWEAQMFKQEH------KSK---FRAFYGGQTMNQIK-SKECEHVservEPFFAVQCDIAGKANLQE 1593
Cdd:cd02665 22 QQDVSEFTHLLLDWLEDAFQAAAEaispgeKSKnpmVQLFYGTFLTEGVLeGKPFCNC----ETFGQYPLQVNGYGNLHE 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1594 SLQ-AYVEGDVmegdnkykcescDGKFVDAVKRYVRaevrycsianadRTCLKDAPDNLIFHLKRFEFdlNDFSRRKIYD 1672
Cdd:cd02665 98 CLEaAMFEGEV------------ELLPSDHSVKSGQ------------ERWFTELPPVLTFELSRFEF--NQGRPEKIHD 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1673 HFAFPETLDISPYKfdhladpekpreedvfdLVGVLVHTGTCENGHYYSYIRQRPCSSesatptWVEFNDSEVTPFDPAE 1752
Cdd:cd02665 152 KLEFPQIIQQVPYE-----------------LHAVLVHEGQANAGHYWAYIYKQSRQE------WEKYNDISVTESSWEE 208
|
250 260
....*....|....*....|....*....
gi 160703803 1753 IAERTFGGFtegegynrqiKQFSAYMLFY 1781
Cdd:cd02665 209 VERDSFGGG----------RNPSAYCLMY 227
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1442-1781 |
2.68e-13 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 73.13 E-value: 2.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1442 GLYNPRAICYMNSLLTQLFMNLNFRQFVLNLKVNEGFGSQ---KLLFETQRLFAQMQNS------FRKWTDPRD----FA 1508
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCLRSVPELRDALKNYNPARRGANQssdNLTNALRDLFDTMDKKqepvppIEFLQLLRMafpqFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1509 gcvkslDKTPIDIAVQMDADEFYNLLFdqweaQMFKQE------HKSKFRAFYGGQTMNQIKSKECEHVSE-RVEPFFAV 1581
Cdd:cd02657 81 ------EKQNQGGYAQQDAEECWSQLL-----SVLSQKlpgagsKGSFIDQLFGIELETKMKCTESPDEEEvSTESEYKL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1582 QCDIAGKAN---LQESLQAYVEGDVMegdnkykcescdgKFVDAVKRyvraEVRYCSIANADRTclkdaPDNLIFHLKRF 1658
Cdd:cd02657 150 QCHISITTEvnyLQDGLKKGLEEEIE-------------KHSPTLGR----DAIYTKTSRISRL-----PKYLTVQFVRF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1659 EFDLNDFSRRKIYDHFAFPETLDIspykFDHLAdpekprEEDVFDLVGVLVHTG-TCENGHYYSYIRQrpcsseSATPTW 1737
Cdd:cd02657 208 FWKRDIQKKAKILRKVKFPFELDL----YELCT------PSGYYELVAVITHQGrSADSGHYVAWVRR------KNDGKW 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 160703803 1738 VEFNDSEVTPFDPAEIaERTFGGfteGEgynrqikQFSAYMLFY 1781
Cdd:cd02657 272 IKFDDDKVSEVTEEDI-LKLSGG---GD-------WHIAYILLY 304
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
1568-1785 |
9.63e-13 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 74.15 E-value: 9.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1568 CEHVSERVEPFFAVQCDI--------AGKANLQESLQAYVEGDVMEGDNKYKCESCDGkFVDAVKRYVraevrycsiana 1639
Cdd:COG5560 646 CEWEEKRYLSLFSYDPLWtireigaaERTITLQDCLNEFSKPEQLGLSDSWYCPGCKE-FRQASKQME------------ 712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1640 drtcLKDAPDNLIFHLKRFEFDLNdfSRRKIYDHFAFPET-LDISPYkfdhLADPEKPREedVFDLVGVLVHTGTCENGH 1718
Cdd:COG5560 713 ----LWRLPMILIIHLKRFSSVRS--FRDKIDDLVEYPIDdLDLSGV----EYMVDDPRL--IYDLYAVDNHYGGLSGGH 780
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160703803 1719 YYSYIRqrpcssESATPTWVEFNDSEVTPFDPAEIAERtfggftegegynrqikqfSAYMLFYQRRS 1785
Cdd:COG5560 781 YTAYAR------NFANNGWYLFDDSRITEVDPEDSVTS------------------SAYVLFYRRKS 823
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1440-1781 |
7.91e-12 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 69.15 E-value: 7.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1440 YVGLYNPRAICYMNSLLTQLFMNLNFRQFVLNLkvNEGFGSQKLLFETQRLFAQMQNSFRKWTDPRDFAGCVKSLDKTpI 1519
Cdd:cd02671 24 FVGLNNLGNTCYLNSVLQVLYFCPGFKHGLKHL--VSLISSVEQLQSSFLLNPEKYNDELANQAPRRLLNALREVNPM-Y 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1520 DIAVQMDADEFYNLLFDQweAQMFkqehkskFRAFYGGQTMNQIKSKECEHVSERVEPF----FAVQCDIAGK------- 1588
Cdd:cd02671 101 EGYLQHDAQEVLQCILGN--IQEL-------VEKDFQGQLVLRTRCLECETFTERREDFqdisVPVQESELSKseessei 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1589 --------ANLQESLQAYVEGDVMEGDNKYKCESCDGkfvdavkrYVRAEvrycsianadRTCLKDA-PDNLIFHLKRFE 1659
Cdd:cd02671 172 spdpktemKTLKWAISQFASVERIVGEDKYFCENCHH--------YTEAE----------RSLLFDKlPEVITIHLKCFA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1660 FDLNDFSR----RKIydHFAFPETLDISPYKFDhladpEKPReEDVFDLVGVLVHTG-TCENGHYYSYIRqrpcssesat 1734
Cdd:cd02671 234 ANGSEFDCygglSKV--NTPLLTPLKLSLEEWS-----TKPK-NDVYRLFAVVMHSGaTISSGHYTAYVR---------- 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 160703803 1735 ptWVEFNDSEVTPFDPAEiaertfggFTEGEGYNRQIKQfSAYMLFY 1781
Cdd:cd02671 296 --WLLFDDSEVKVTEEKD--------FLEALSPNTSSTS-TPYLLFY 331
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1524-1745 |
1.27e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 61.96 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1524 QMDADEFYNLLFDQWEaQMFKQEHKSKFRAFYGGQTMNQIKSKECEHV--SERVEPFFA--VQCDIAGKA---------- 1589
Cdd:cd02658 100 QQDALEFLLHLIDKLD-RESFKNLGLNPNDLFKFMIEDRLECLSCKKVkyTSELSEILSlpVPKDEATEKeegelvyepv 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1590 NLQESLQAYVEGDVMEgdnkYKCESCDGKfVDAVKRyvraevrycsianadrTCLKDAPDNLIFHLKRFEFDLNdFSRRK 1669
Cdd:cd02658 179 PLEDCLKAYFAPETIE----DFCSTCKEK-TTATKT----------------TGFKTFPDYLVINMKRFQLLEN-WVPKK 236
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160703803 1670 IYDHFAFPETLDISPYKfdhladpekpreedvfdLVGVLVHTGTCEN-GHYYSYIRQRpcssESATPTWVEFNDSEV 1745
Cdd:cd02658 237 LDVPIDVPEELGPGKYE-----------------LIAFISHKGTSVHsGHYVAHIKKE----IDGEGKWVLFNDEKV 292
|
|
| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1439-1746 |
2.78e-06 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 52.32 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1439 GYVGLYNPRAICYMNSLLtQLFMNLN-FRQFVLNLKVNEGFGSQK--LLFETQRLFAQMQNS--FRKWTDPRDFAGCVKS 1513
Cdd:cd02669 118 GFVGLNNIKNNDYANVII-QALSHVKpIRNFFLLYENYENIKDRKseLVKRLSELIRKIWNPrnFKGHVSPHELLQAVSK 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1514 LDKTPIDIAVQMDADEFYNLLFDQWEAQM--FKQEHKSKF-RAFYG---------GQTMNQIKSKECEHVSERVE----- 1576
Cdd:cd02669 197 VSKKKFSITEQSDPVEFLSWLLNTLHKDLggSKKPNSSIIhDCFQGkvqietqkiKPHAEEEGSKDKFFKDSRVKktsvs 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1577 PFFAVQCDIAGKANLQeslqayvegDVMEGD-----------NKYkcescDGKFVDAVKRYVRaevrycsianadRTCLK 1645
Cdd:cd02669 277 PFLLLTLDLPPPPLFK---------DGNEENiipqvplkqllKKY-----DGKTETELKDSLK------------RYLIS 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1646 DAPDNLIFHLKRfeFDLNDFSRRKIYDHFAFPETLDISPYKFDHLADPEKPREEdvFDLVGVLVHTGT-CENGHYYSYIR 1724
Cdd:cd02669 331 RLPKYLIFHIKR--FSKNNFFKEKNPTIVNFPIKNLDLSDYVHFDKPSLNLSTK--YNLVANIVHEGTpQEDGTWRVQLR 406
|
330 340
....*....|....*....|..
gi 160703803 1725 QRpcssesATPTWVEFNDSEVT 1746
Cdd:cd02669 407 HK------STNKWFEIQDLNVK 422
|
|
| Peptidase_C19N |
cd02670 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1522-1782 |
2.80e-05 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239135 [Multi-domain] Cd Length: 241 Bit Score: 47.91 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1522 AVQMDADEFYNLLFDQweaqMFKQEHKSKFRAFYGGQTmnqiKSKECEHVSERVEPFFAVQCDIAGKANLQESLQAYveg 1601
Cdd:cd02670 21 AEQQDPEEFFNFITDK----LLMPLLEPKVDIIHGGKK----DQDDDKLVNERLLQIPVPDDDDGGGITLEQCLEQY--- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1602 dvmegdnkykcescdgkFVDAVkryvraevrycsianadrtcLKDAPDNLIFHLKRFEFdlNDFSRRKIYDHFAFPETLD 1681
Cdd:cd02670 90 -----------------FNNSV--------------------FAKAPSCLIICLKRYGK--TEGKAQKMFKKILIPDEID 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160703803 1682 ISPYKFD--------------HLADPEKPREEDVFDLV--GVLVHTGT-CENGHYYSYIRQrpcSSESATPTWVEFNDSE 1744
Cdd:cd02670 131 IPDFVADdpracskcqlecrvCYDDKDFSPTCGKFKLSlcSAVCHRGTsLETGHYVAFVRY---GSYSLTETDNEAYNAQ 207
|
250 260 270
....*....|....*....|....*....|....*...
gi 160703803 1745 VTPFDPAEIAERTFGGFTEGEGYNrqikQFSAYMLFYQ 1782
Cdd:cd02670 208 WVFFDDMADRDGVSNGFNIPAARL----LEDPYMLFYQ 241
|
|
| |
