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Conserved domains on  [gi|1606706197|gb|QBS10654|]
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methyltransferase domain-containing protein [Legionella israelensis]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10353482)

class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-115 1.67e-13

Trans-aconitate methyltransferase [Energy production and conversion];


:

Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 64.84  E-value: 1.67e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  47 VLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLP-LTTIEASATEADhylPPHSQDLVLAHF 115
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPnVRFVVADLRDLD---PPEPFDLVVSNA 71
Methyltransf_31 super family cl48233
Methyltransferase domain; This family appears to have methyltransferase activity.
 41-186 2.45e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


The actual alignment was detected with superfamily member pfam13847:

Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 54.73  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  41 LHPHYKVLDLGVGDGTFLKQLYD-VLPKAEMTGIDLSSNMLRLAR---QKLPLTTIE---ASATEADHYLPPHSQDLVLA 113
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARenaQKLGFDNVEfeqGDIEELPELLEDDKFDVVIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197 114 HFInayipINTLFNQAKILTRA------NGYYSMITttyesfPVAQQQLAEFIAED-TLTSSVVGH-YYKAIIKNTTVAA 185
Cdd:pfam13847  81 NCV-----LNHIPDPDKVLQEIlrvlkpGGRLIISD------PDSLAELPAHVKEDsTYYAGCVGGaILKKKLYELLEEA 149


                  .
gi 1606706197 186 G 186
Cdd:pfam13847 150 G 150
 
Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-115 1.67e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 64.84  E-value: 1.67e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  47 VLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLP-LTTIEASATEADhylPPHSQDLVLAHF 115
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPnVRFVVADLRDLD---PPEPFDLVVSNA 71
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-121 1.72e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.11  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  47 VLDLGVGDGTFLKQLYDvLPKAEMTGIDLSSNMLRLARQK-----LPLTTIEASATEADhyLPPHSQDLVLAHFINAYIP 121
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR-RGGARVTGVDLSPEMLERARERaaeagLNVEFVQGDAEDLP--FPDGSFDLVVSSGVLHHLP 77
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 5-111 2.16e-11

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 62.09  E-value: 2.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   5 GMYNSIAKNYETANR---FGSisesHKV----AIEQIQkylpeLHPHYKVLDLGVGDGTFLKQLY-DVLPKAEMTGIDLS 76
Cdd:PRK00216   15 EMFDSIAPKYDLMNDllsFGL----HRVwrrkTIKWLG-----VRPGDKVLDLACGTGDLAIALAkAVGKTGEVVGLDFS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1606706197  77 SNMLRLARQKL-------PLTTIEASATEadhyLP--PHSQDLV 111
Cdd:PRK00216   86 EGMLAVGREKLrdlglsgNVEFVQGDAEA----LPfpDNSFDAV 125
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 41-186 2.45e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 54.73  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  41 LHPHYKVLDLGVGDGTFLKQLYD-VLPKAEMTGIDLSSNMLRLAR---QKLPLTTIE---ASATEADHYLPPHSQDLVLA 113
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARenaQKLGFDNVEfeqGDIEELPELLEDDKFDVVIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197 114 HFInayipINTLFNQAKILTRA------NGYYSMITttyesfPVAQQQLAEFIAED-TLTSSVVGH-YYKAIIKNTTVAA 185
Cdd:pfam13847  81 NCV-----LNHIPDPDKVLQEIlrvlkpGGRLIISD------PDSLAELPAHVKEDsTYYAGCVGGaILKKKLYELLEEA 149


                  .
gi 1606706197 186 G 186
Cdd:pfam13847 150 G 150
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 46-111 3.96e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 43.81  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1606706197  46 KVLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLP--LTTIEASATEADhyLPPHSQDLV 111
Cdd:TIGR02072  37 SVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSenVQFICGDAEKLP--LEDSSFDLI 102
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 46-113 6.15e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.26  E-value: 6.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1606706197  46 KVLDLGVGDGTFLKQLYDvLPKAEMTGIDLSSNMLRLARQKL------PLTTIEASATEADHYlPPHSQDLVLA 113
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAaalladNVEVLKGDAEELPPE-ADESFDVIIS 72
PRK05785 PRK05785
hypothetical protein; Provisional
 2-83 1.07e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 39.29  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   2 TLKGMYNSIAKNYETANR---FGSISESHKVAIEQIQKYLPELhphYKVLDLGVGDGTFLKQLYDVLpKAEMTGIDLSSN 78
Cdd:PRK05785   10 ELQEAYNKIPKAYDRANRfisFNQDVRWRAELVKTILKYCGRP---KKVLDVAAGKGELSYHFKKVF-KYYVVALDYAEN 85


                  ....*
gi 1606706197  79 MLRLA 83
Cdd:PRK05785   86 MLKMN 90
 
Name Accession Description Interval E-value
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-115 1.67e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 64.84  E-value: 1.67e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  47 VLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLP-LTTIEASATEADhylPPHSQDLVLAHF 115
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPnVRFVVADLRDLD---PPEPFDLVVSNA 71
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
6-138 3.09e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 63.48  E-value: 3.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   6 MYNSIAKNYETANRFGSISESHKVAIEQIQKYLPElHPHYKVLDLGVGDGTFLKQLydvLPKA-EMTGIDLSSNMLRLAR 84
Cdd:COG4976    10 LFDQYADSYDAALVEDLGYEAPALLAEELLARLPP-GPFGRVLDLGCGTGLLGEAL---RPRGyRLTGVDLSEEMLAKAR 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1606706197  85 QK-LPLTTIEASATEADHylPPHSQDLVLAHFINAYIP-INTLFNQAKILTRANGY 138
Cdd:COG4976    86 EKgVYDRLLVADLADLAE--PDGRFDLIVAADVLTYLGdLAAVFAGVARALKPGGL 139
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 7-121 5.02e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.93  E-value: 5.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   7 YNSIAKNYETANRFgsiseshkvaIEQIQkylpeLHPHYKVLDLGVGDGTFLKQLYDvlPKAEMTGIDLSSNMLRLARQK 86
Cdd:COG2226     1 FDRVAARYDGREAL----------LAALG-----LRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARER 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1606706197  87 LP-----LTTIEASATEADhyLPPHSQDLVLAHFINAYIP 121
Cdd:COG2226    64 AAeaglnVEFVVGDAEDLP--FPDGSFDLVISSFVLHHLP 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 47-121 1.72e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 59.11  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  47 VLDLGVGDGTFLKQLYDvLPKAEMTGIDLSSNMLRLARQK-----LPLTTIEASATEADhyLPPHSQDLVLAHFINAYIP 121
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR-RGGARVTGVDLSPEMLERARERaaeagLNVEFVQGDAEDLP--FPDGSFDLVVSSGVLHHLP 77
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 5-111 2.16e-11

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 62.09  E-value: 2.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   5 GMYNSIAKNYETANR---FGSisesHKV----AIEQIQkylpeLHPHYKVLDLGVGDGTFLKQLY-DVLPKAEMTGIDLS 76
Cdd:PRK00216   15 EMFDSIAPKYDLMNDllsFGL----HRVwrrkTIKWLG-----VRPGDKVLDLACGTGDLAIALAkAVGKTGEVVGLDFS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1606706197  77 SNMLRLARQKL-------PLTTIEASATEadhyLP--PHSQDLV 111
Cdd:PRK00216   86 EGMLAVGREKLrdlglsgNVEFVQGDAEA----LPfpDNSFDAV 125
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 41-186 2.45e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 54.73  E-value: 2.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  41 LHPHYKVLDLGVGDGTFLKQLYD-VLPKAEMTGIDLSSNMLRLAR---QKLPLTTIE---ASATEADHYLPPHSQDLVLA 113
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARenaQKLGFDNVEfeqGDIEELPELLEDDKFDVVIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197 114 HFInayipINTLFNQAKILTRA------NGYYSMITttyesfPVAQQQLAEFIAED-TLTSSVVGH-YYKAIIKNTTVAA 185
Cdd:pfam13847  81 NCV-----LNHIPDPDKVLQEIlrvlkpGGRLIISD------PDSLAELPAHVKEDsTYYAGCVGGaILKKKLYELLEEA 149


                  .
gi 1606706197 186 G 186
Cdd:pfam13847 150 G 150
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 46-118 4.66e-09

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 55.72  E-value: 4.66e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1606706197  46 KVLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLPLTTIEasatEAD--HYLPPHSQDLVLAhfiNA 118
Cdd:PRK01683   34 YVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRLPDCQFV----EADiaSWQPPQALDLIFA---NA 101
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 32-138 2.55e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 51.17  E-value: 2.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  32 EQIQKYLPE-LHPHYKVLDLGVGDGTFLKQL----YDVlpkaemTGIDLSSNMLRLARQKLP---LTTIEASATEADhyL 103
Cdd:COG2227    12 RRLAALLARlLPAGGRVLDVGCGTGRLALALarrgADV------TGVDISPEALEIARERAAelnVDFVQGDLEDLP--L 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1606706197 104 PPHSQDLVLAHFINAYIP-INTLFNQAKILTRANGY 138
Cdd:COG2227    84 EDGSFDLVICSEVLEHLPdPAALLRELARLLKPGGL 119
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 48-115 2.10e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 48.04  E-value: 2.10e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1606706197  48 LDLGVGDGTFLKQLYDVLPKAemTGIDLSSNMLRLARQKL---PLTTIEASATEADhyLPPHSQDLVLAHF 115
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARV--TGVDISPEMLELAREKApreGLTFVVGDAEDLP--FPDNSFDLVLSSE 67
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 48-138 9.30e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.21  E-value: 9.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  48 LDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLP------LTTIEASATEADhYLPPHSQDLVLAHFINAYIP 121
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAalgllnAVRVELFQLDLG-ELDPGSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*...
gi 1606706197 122 -INTLFNQAKILTRANGY 138
Cdd:pfam08242  80 dPRAVLRNIRRLLKPGGV 97
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 38-142 4.27e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.45  E-value: 4.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  38 LPELHPHYKVLDLGVGDGTFLKQLYDvLPKAEMTGIDLSSNMLRLARQKLP------LTTIEASATEADHyLPPHSQDLV 111
Cdd:COG0500    21 LERLPKGGRVLDLGCGTGRNLLALAA-RFGGRVIGIDLSPEAIALARARAAkaglgnVEFLVADLAELDP-LPAESFDLV 98

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1606706197 112 LA----HFINAyIPINTLFNQAKILTRANGYYSMI 142
Cdd:COG0500    99 VAfgvlHHLPP-EEREALLRELARALKPGGVLLLS 132
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 46-111 3.96e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 43.81  E-value: 3.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1606706197  46 KVLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLP--LTTIEASATEADhyLPPHSQDLV 111
Cdd:TIGR02072  37 SVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSenVQFICGDAEKLP--LEDSSFDLI 102
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 46-113 6.15e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 41.26  E-value: 6.15e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1606706197  46 KVLDLGVGDGTFLKQLYDvLPKAEMTGIDLSSNMLRLARQKL------PLTTIEASATEADHYlPPHSQDLVLA 113
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELARKAAaalladNVEVLKGDAEELPPE-ADESFDVIIS 72
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
3-87 2.51e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 41.27  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   3 LKGMYNSIAKNYETANRFGSISEsHKVAIEQIQKYLPELHPHyKVLDL--GVGDGTFlKQLYDVLPKAEMTGIDLSSNML 80
Cdd:pfam01209   4 VGDVFSSVASKYDLMNDVISFGI-HRLWKDFTMKCMGVKRGN-KFLDVagGTGDWTF-GLSDSAGSSGKVVGLDINENML 80


                  ....*..
gi 1606706197  81 RLARQKL 87
Cdd:pfam01209  81 KEGEKKA 87
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
47-131 2.72e-04

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 42.16  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  47 VLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNML-----RLARQKLPLTTIEASATEADHYLPPHSQDLV----LAHFIN 117
Cdd:PRK06922  422 IVDVGAGGGVMLDMIEEETEDKRIYGIDISENVIdtlkkKKQNEGRSWNVIKGDAINLSSSFEKESVDTIvyssILHELF 501

                          90
                  ....*....|....*
gi 1606706197 118 AYIPINTL-FNQAKI 131
Cdd:PRK06922  502 SYIEYEGKkFNHEVI 516
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 40-87 3.83e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 39.91  E-value: 3.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1606706197  40 ELHPHYKVLDLGVGDGTFLKQL---YDVlpkaEMTGIDLSSNMLRLARQKL 87
Cdd:COG2230    48 GLKPGMRVLDIGCGWGGLALYLarrYGV----RVTGVTLSPEQLEYARERA 94
PRK05785 PRK05785
hypothetical protein; Provisional
 2-83 1.07e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 39.29  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197   2 TLKGMYNSIAKNYETANR---FGSISESHKVAIEQIQKYLPELhphYKVLDLGVGDGTFLKQLYDVLpKAEMTGIDLSSN 78
Cdd:PRK05785   10 ELQEAYNKIPKAYDRANRfisFNQDVRWRAELVKTILKYCGRP---KKVLDVAAGKGELSYHFKKVF-KYYVVALDYAEN 85


                  ....*
gi 1606706197  79 MLRLA 83
Cdd:PRK05785   86 MLKMN 90
PRK08317 PRK08317
hypothetical protein; Provisional
 46-85 1.41e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.15  E-value: 1.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1606706197  46 KVLDLGVGDGTFLKQLYD-VLPKAEMTGIDLSSNMLRLARQ 85
Cdd:PRK08317   22 RVLDVGCGPGNDARELARrVGPEGRVVGIDRSEAMLALAKE 62
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 31-121 5.37e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.44  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606706197  31 IEQIQKYLPELHPHyKVLDLGVGDG----TFLKQLydvlPKAEMTGIDLSSNMLRLARQ-------KLPLTTIEASATEA 99
Cdd:COG2890   101 VELALALLPAGAPP-RVLDLGTGSGaialALAKER----PDARVTAVDISPDALAVARRnaerlglEDRVRFLQGDLFEP 175

                          90       100
                  ....*....|....*....|....
gi 1606706197 100 dhyLPPHSQ-DLVLAhfiNA-YIP 121
Cdd:COG2890   176 ---LPGDGRfDLIVS---NPpYIP 193
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
41-90 7.87e-03

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 36.73  E-value: 7.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1606706197  41 LHPH-YKVLDLGVGDGTFLKQLYDVLPKAEMTGIDLSSNMLRLARQKLPLT 90
Cdd:COG0421    34 FHPNpKRVLIIGGGDGGLARELLKHPPVERVDVVEIDPEVVELAREYFPLL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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