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Conserved domains on  [gi|1604847874|ref|XP_028442840|]
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F-box-like/WD repeat-containing protein TBL1XR1 [Perca flavescens]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10553538)

WD40 domain-containing protein similar to Homo sapiens F-box-like/WD repeat-containing protein TBL1X/TBL1Y/TBL1XR1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 165-471 5.24e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 266.89  E-value: 5.24e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSSSTQLvlrHcireggqdvpsNKDVTSLDWNSEGTLLATG 244
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---H-----------TGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 323
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 324 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSP 402
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1604847874 403 TGpgtnnpsanLMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 7-31 5.64e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.77  E-value: 5.64e-07
                          10        20
                  ....*....|....*....|....*
gi 1604847874   7 EVNFLVYRYLQESGFSHSAFTFGIE 31
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 165-471 5.24e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 266.89  E-value: 5.24e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSSSTQLvlrHcireggqdvpsNKDVTSLDWNSEGTLLATG 244
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---H-----------TGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 323
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 324 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSP 402
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1604847874 403 TGpgtnnpsanLMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
165-514 4.77e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.61  E-value: 4.77e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSensTSSSTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 244
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGH-----------TGAVRSVAFSPDGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NT 322
Cdd:COG2319   139 SADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 323 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSP 402
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 403 TGPgtnnpsanlMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQTGALVHSYR 482
Cdd:COG2319   299 DGK---------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1604847874 483 G-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 514
Cdd:COG2319   370 GhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
PTZ00420 PTZ00420
coronin; Provisional
 342-431 8.93e-11

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 64.20  E-value: 8.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 342 PIKTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSMK-QDSCVHD-------LQAHSKEIYTIKWsptgpgtnNPSA 412
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPhNDESVKEikdpqciLKGHKKKISIIDW--------NPMN 137

                          90
                  ....*....|....*....
gi 1604847874 413 NLMLASASFDSTVRLWDVE 431
Cdd:PTZ00420  138 YYIMCSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-471 1.22e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1604847874  433 GICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
433-471 8.62e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 8.62e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1604847874 433 GICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 7-31 5.64e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.77  E-value: 5.64e-07
                          10        20
                  ....*....|....*....|....*
gi 1604847874   7 EVNFLVYRYLQESGFSHSAFTFGIE 31
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 3-36 5.98e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 42.81  E-value: 5.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1604847874    3 ISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQ 36
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 165-471 5.24e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 266.89  E-value: 5.24e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSSSTQLvlrHcireggqdvpsNKDVTSLDWNSEGTLLATG 244
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---H-----------TGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF 323
Cdd:cd00200    70 SSDKTIRLWdLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 324 -ASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSP 402
Cdd:cd00200   150 vASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1604847874 403 TGpgtnnpsanLMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:cd00200   230 DG---------YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
165-514 4.77e-80

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 255.61  E-value: 4.77e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSensTSSSTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 244
Cdd:COG2319    73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGH-----------TGAVRSVAFSPDGKTLASG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSN-NT 322
Cdd:COG2319   139 SADGTVRLWdLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKL 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 323 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSP 402
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 403 TGPgtnnpsanlMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQTGALVHSYR 482
Cdd:COG2319   299 DGK---------LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1604847874 483 G-TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 514
Cdd:COG2319   370 GhTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
165-474 2.67e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 248.29  E-value: 2.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSensTSSSTQLVLRHcireggqdvpsNKDVTSLDWNSEGTLLATG 244
Cdd:COG2319   115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA---TGKLLRTLTGH-----------SGAVTSVAFSPDGKLLASG 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNN-T 322
Cdd:COG2319   181 SDDGTVRLWdLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrL 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 323 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSP 402
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1604847874 403 TGPgtnnpsanlMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQT 474
Cdd:COG2319   341 DGK---------TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 259-515 3.20e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.65  E-value: 3.20e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 259 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTF-ASCSTDMCIHVCKL 337
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYlASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 338 GQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSPTgpgtnnpsaNLMLA 417
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---------GTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 418 SASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAG 496
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDG 231

                         250
                  ....*....|....*....
gi 1604847874 497 DKVGASASDGSVCVLDLRK 515
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
165-514 6.04e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.23  E-value: 6.04e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 165 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSEnstssstqlvlrhcIREGGQDVPSNKDVTSLDWNSEGTLLATG 244
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA--------------GALLATLLGHTAAVLSVAFSPDGRLLASA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 245 SYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGeakqqfpfhsapaldvdwqsnntf 323
Cdd:COG2319    97 SADGTVRLWdLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG------------------------ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 324 ascstdmcihvcklgqdRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWSPT 403
Cdd:COG2319   153 -----------------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 404 GPgtnnpsanlMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQTGALVHSYRG 483
Cdd:COG2319   216 GK---------LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1604847874 484 -TGGIFEVCWNAAGDKVGASASDGSVCVLDLR 514
Cdd:COG2319   287 hSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
239-514 7.34e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.26  E-value: 7.34e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 239 TLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 318
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 319 SN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYT 397
Cdd:COG2319    88 PDgRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 398 IKWSPTGpgtnnpsanLMLASASFDSTVRLWDVERGICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQTGAL 477
Cdd:COG2319   168 VAFSPDG---------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1604847874 478 VHSYRG-TGGIFEVCWNAAGDKVgASAS-DGSVCVLDLR 514
Cdd:COG2319   239 LRTLTGhSGSVRSVAFSPDGRLL-ASGSaDGTVRLWDLA 276
PTZ00420 PTZ00420
coronin; Provisional
 342-431 8.93e-11

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 64.20  E-value: 8.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 342 PIKTFQGHTNEVNAIKWDPT-GNLLASCSDDMTLKIWSMK-QDSCVHD-------LQAHSKEIYTIKWsptgpgtnNPSA 412
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPhNDESVKEikdpqciLKGHKKKISIIDW--------NPMN 137

                          90
                  ....*....|....*....
gi 1604847874 413 NLMLASASFDSTVRLWDVE 431
Cdd:PTZ00420  138 YYIMCSSGFDSFVNIWDIE 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 433-471 1.22e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.55  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1604847874  433 GICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 287-480 1.27e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 63.76  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 287 VDKTTIIWD-AHTGEAKQQFpfhsapaLDVDWQSNNTFASCSTDMCihvCKLGQDRPIktFQGHTNEVNAIKWDPTGNL- 364
Cdd:PTZ00421   23 VTPSTALWDcSNTIACNDRF-------IAVPWQQLGSTAVLKHTDY---GKLASNPPI--LLGQEGPIIDVAFNPFDPQk 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 365 LASCSDDMTLKIWSMKQ--------DSCVHdLQAHSKEIYTIKWsptgpgtnNPSANLMLASASFDSTVRLWDVERGICI 436
Cdd:PTZ00421   91 LFTASEDGTIMGWGIPEegltqnisDPIVH-LQGHTKKVGIVSF--------HPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1604847874 437 HTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWNTQTGALVHS 480
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS 205
PTZ00420 PTZ00420
coronin; Provisional
 166-309 3.20e-10

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 62.66  E-value: 3.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 166 LRGHESEVFICAWNPV-SDLLASGSGDSTARIWNLSENStSSSTQLVLRHCIREGGQdvpsnKDVTSLDWNSEGT-LLAT 243
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHND-ESVKEIKDPQCILKGHK-----KKISIIDWNPMNYyIMCS 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1604847874 244 GSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHS 309
Cdd:PTZ00420  144 SGFDSFVNIWDIENEKRAFQINMPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHD 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 341-378 4.45e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 4.45e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1604847874  341 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 378
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
433-471 8.62e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 8.62e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1604847874 433 GICIHTLTKHQEPVYSVAFSPDGRHLASGSFDKCVHIWN 471
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
341-378 2.53e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 2.53e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1604847874 341 RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWS 378
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 350-514 2.17e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 350 TNEVNAIKWDPTGNLLASCSDDMTLKIWS----MKQDSCVH----DLQAHSKeIYTIKWsptgpgtnNPSANLMLASASF 421
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRSK-LSGICW--------NSYIKSQVASSNF 553

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 422 DSTVRLWDVERGICIHTLTKHQEPVYSVAF-SPDGRHLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCW-NAAGDKV 499
Cdd:PLN00181  554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633

                         170
                  ....*....|....*
gi 1604847874 500 GASASDGSVCVLDLR 514
Cdd:PLN00181  634 AFGSADHKVYYYDLR 648
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 129-513 1.02e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.71  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 129 ENTANGEENGahalaNNHADLMEVDGDVEIPQNKAMV-LRGHESEVFICAWNPVSdlLASGSGDSTARIWNLSENSTSSS 207
Cdd:PLN00181  355 ETLAAEEEND-----DNSSKLDDTLESTLLESSRLMRnLKKLESVYFATRYRQIK--AAAAAEKPLARYYSALSENGRSS 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 208 TQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLlatgSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGV 287
Cdd:PLN00181  428 EKSSMSNPAKPPDFYINDSRQGGWIDPFLEGLC----KYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGV 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 288 DKTTIIWDAHTgEAKQQFPFHSaPALDVD---------WQS--NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAI 356
Cdd:PLN00181  504 NKKIKIFECES-IIKDGRDIHY-PVVELAsrsklsgicWNSyiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSI 581

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 357 KW---DPTgnLLASCSDDMTLKIWSMKQD------------SCV---------------------HDLQ----------A 390
Cdd:PLN00181  582 DYssaDPT--LLASGSDDGSVKLWSINQGvsigtiktkaniCCVqfpsesgrslafgsadhkvyyYDLRnpklplctmiG 659

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 391 HSKEIYTIKWSPTGpgtnnpsanlMLASASFDSTVRLWDVERGIC------IHTLTKHQEPVYSVAFSPDGRHLASGSFD 464
Cdd:PLN00181  660 HSKTVSYVRFVDSS----------TLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIATGSET 729

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1604847874 465 KCVHIWNTQTGALVHSYR--------------GTGGIFEVCWNAAGDKVGASASDGSVCVLDL 513
Cdd:PLN00181  730 NEVFVYHKAFPMPVLSYKfktidpvsglevddASQFISSVCWRGQSSTLVAANSTGNIKILEM 792
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 273-481 4.56e-07

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 50.35  E-value: 4.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 273 LKWNKKGNFIL---SAGVDKTTIIWdahTGEakqqfpfhsapaldvdwqsNNTFASCSTDMCIHVCKLGQDRPIKtfqgh 349
Cdd:pfam08662  11 LKWNKNGTYLLvltDTDVDKTGKSY---YGE-------------------TNLYLIGETGGPDCVVELDKEGPIH----- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 350 tnevnAIKWDPTGNLLASCSDDMTLKI--WSMKQDScVHDLQAHSKEiyTIKWSPTGPgtnnpsanlMLASASFDST--- 424
Cdd:pfam08662  64 -----DVAWSPNGKEFAVIYGYMPAKVsfFDLKGNV-IHSFGEQPRN--TIFWSPFGR---------LVLLAGFGNLagd 126

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1604847874 425 VRLWDVERGICIHTlTKHQEPVYsVAFSPDGRHLASGS------FDKCVHIWnTQTGALVHSY 481
Cdd:pfam08662 127 IEFWDVVNKKKIAT-AEASNATL-CEWSPDGRYFLTATtaprlrVDNGFKIW-HYNGALVYKY 186
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 7-31 5.64e-07

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 45.77  E-value: 5.64e-07
                          10        20
                  ....*....|....*....|....*
gi 1604847874   7 EVNFLVYRYLQESGFSHSAFTFGIE 31
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 164-198 2.13e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.13e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1604847874  164 MVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 198
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 383-429 3.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.41e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1604847874  383 SCVHDLQAHSKEIYTIKWSPTGPgtnnpsanlMLASASFDSTVRLWD 429
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK---------YLASGSDDGTIKLWD 40
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 3-36 5.98e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 42.81  E-value: 5.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1604847874    3 ISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQ 36
Cdd:smart00667   1 ISRSELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 pfam00400
WD domain, G-beta repeat;
383-429 1.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.37e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1604847874 383 SCVHDLQAHSKEIYTIKWSPTGPgtnnpsanlMLASASFDSTVRLWD 429
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK---------LLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 166-323 1.51e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.58  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 166 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENStssstqlvlrhcireGGQDVPSNKD-VTSLDWNSEGTLLAT 243
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDVERGK---------------AVEVIKCHSDqITSLEWNLDGSLLCT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 244 GSYDGFARIWT-KDGNLASTLGQHKGPIFA-LKWNKKGNFILSAGVDKT----TIIWDAHTGEAkqqfPFHSapaLDVDw 317
Cdd:PTZ00421  186 TSKDKKLNIIDpRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKSqqrqIMLWDTRKMAS----PYST---VDLD- 257


                  ....*.
gi 1604847874 318 QSNNTF 323
Cdd:PTZ00421  258 QSSALF 263
WD40 pfam00400
WD domain, G-beta repeat;
164-198 1.98e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1604847874 164 MVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 198
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 256-295 2.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1604847874  256 DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 295
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 232-320 5.81e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 5.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 232 LDWNSEGTLLATGSYDG--------FARIWTKDGnlastlGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQ 303
Cdd:pfam12894   1 MSWCPTMDLIALATEDGelllhrlnWQRVWTLSP------DKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*..
gi 1604847874 304 QFPFHSAPALDVDWQSN 320
Cdd:pfam12894  75 HFSAGSDLITCLGWGEN 91
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 356-452 7.95e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 7.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 356 IKWDPTGNLLASCSDDMTL--------KIWSMKQDscvhdlqAHSKEIYTIKWSPTGPgtnnpsanlMLASASFDSTVRL 427
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTLSPD-------KEDLEVTSLAWRPDGK---------LLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....*
gi 1604847874 428 WDVERGICIHTLTKHQEPVYSVAFS 452
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
257-295 1.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.26e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1604847874 257 GNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWD 295
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-253 2.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.80e-04
                           10        20
                   ....*....|....*....|....*...
gi 1604847874  226 NKDVTSLDWNSEGTLLATGSYDGFARIW 253
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-198 4.19e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 4.19e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1604847874 164 MVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN 198
Cdd:cd00200   255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
226-253 4.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.75e-04
                          10        20
                  ....*....|....*....|....*...
gi 1604847874 226 NKDVTSLDWNSEGTLLATGSYDGFARIW 253
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 157-295 7.26e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 7.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 157 EIPQNKAMV---------LRGHESEVFICAWNPVSDLLASGSG-DSTARIWNLsENStSSSTQLVLrhcireggqdvpsN 226
Cdd:PTZ00420  103 EIPHNDESVkeikdpqciLKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI-ENE-KRAFQINM-------------P 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 227 KDVTSLDWNSEGTLLaTGSYDG--FARIWTKDGNLASTLGQHKGP-----IFALKWNKKGNFILSAGVDKTTI----IWD 295
Cdd:PTZ00420  168 KKLSSLKWNIKGNLL-SGTCVGkhMHIIDPRKQEIASSFHIHDGGkntknIWIDGLGGDDNYILSTGFSKNNMremkLWD 246
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
409-513 8.00e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 8.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 409 NPSANLMLASASFDSTVRLWDVERGICIHTLTKHQEPvYSVAFSPDGRHL-----ASGSFDKCVHIWNTQTGALVHSYRG 483
Cdd:COG3391   118 DPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPDGKRLyvansGSNTVSVIVSVIDTATGKVVATIPV 196

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1604847874 484 TGGIFEVCWNAAGDKV--------GASASDGSVCVLDL 513
Cdd:COG3391   197 GGGPVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDL 234
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 327-401 1.49e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 327 STDMCIHVCKL-GQdrpiKTFQG----HTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAHSKEIYTIKWS 401
Cdd:pfam12894  14 TEDGELLLHRLnWQ----RVWTLspdkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 352-459 2.54e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.79  E-value: 2.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874  352 EVNAIKWDPTGNLLASCSDDMTLKiwsmkqdscVHDL----------QAHSKEIYTIKWSPTG-------PGTNNPSAnl 414
Cdd:COG4946    390 RVFNPVWSPDGKKIAFTDNRGRLW---------VVDLasgkvrkvdtDGYGDGISDLAWSPDSkwlayskPGPNQLSQ-- 458

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1604847874  415 mlasasfdstVRLWDVERGIcIHTLTKHQEPVYSVAFSPDGRHLA 459
Cdd:COG4946    459 ----------IFLYDVETGK-TVQLTDGRYDDGSPAFSPDGKYLY 492
PTZ00421 PTZ00421
coronin; Provisional
 257-391 3.33e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.88  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 257 GNLAST----LGQhKGPIFALKWNKKGNFIL-SAGVDKTTIIWDAHTGEAKQQFpfhSAPALDVDWQS------------ 319
Cdd:PTZ00421   62 GKLASNppilLGQ-EGPIIDVAFNPFDPQKLfTASEDGTIMGWGIPEEGLTQNI---SDPIVHLQGHTkkvgivsfhpsa 137

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1604847874 320 NNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDSCVHDLQAH 391
Cdd:PTZ00421  138 MNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
400-511 5.68e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.52  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1604847874 400 WSPTGPGTNNPSANLMLASASFDSTVRLWDVERGICIHTLTKHQEPvYSVAFSPDGRHL-ASGSFDKCVHIWNTQTGALV 478
Cdd:COG3391    67 VADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVV 145

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1604847874 479 HSYRGTGGIFEVCWNAAGDKV-GASASDGSVCVL 511
Cdd:COG3391   146 ATIPVGAGPHGIAVDPDGKRLyVANSGSNTVSVI 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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