NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|160358811|ref|NP_001103736|]
View 

vascular endothelial growth factor A, long form isoform 4 precursor [Mus musculus]

Protein Classification

PDGF and VEGF_C domain-containing protein( domain architecture ID 10210585)

PDGF and VEGF_C domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 89-137 7.30e-22

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


:

Pssm-ID: 405273  Cd Length: 49  Bit Score: 81.97  E-value: 7.30e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 160358811   89 CEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 137
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
PDGF super family cl00116
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 27-54 1.47e-05

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


The actual alignment was detected with superfamily member smart00141:

Pssm-ID: 444701  Cd Length: 83  Bit Score: 40.87  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|....*...
gi 160358811    27 QIMRIKPHQSQHIGEMSFLQHSRCECRP 54
Cdd:smart00141  56 QLLEISRPLSQHLVEVSFEEHTKCECRP 83
 
Name Accession Description Interval E-value
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 89-137 7.30e-22

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 81.97  E-value: 7.30e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 160358811   89 CEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 137
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 27-54 1.47e-05

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 40.87  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|....*...
gi 160358811    27 QIMRIKPHQSQHIGEMSFLQHSRCECRP 54
Cdd:smart00141  56 QLLEISRPLSQHLVEVSFEEHTKCECRP 83
 
Name Accession Description Interval E-value
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 89-137 7.30e-22

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 81.97  E-value: 7.30e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 160358811   89 CEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 137
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 27-54 1.47e-05

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 40.87  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|....*...
gi 160358811    27 QIMRIKPHQSQHIGEMSFLQHSRCECRP 54
Cdd:smart00141  56 QLLEISRPLSQHLVEVSFEEHTKCECRP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH