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Conserved domains on  [gi|1601838039|gb|QBQ42829|]
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ATP-binding protein [Sphingobacterium psychroaquaticum]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 11465288)

SMP-30/gluconolactonase/LRE family protein similar to Staphylococcus lactonase drp35 and Zymomonas mobilis gluconolactonase, which hydrolyzes the gluconolactone formed by glucose-fructose oxidoreductase to form gluconate;

CATH:  2.120.10.30
EC:  3.1.1.-
Gene Ontology:  GO:0005515|GO:0046872|GO:0016787
PubMed:  9868369
SCOP:  4003251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 35-260 4.38e-10

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 58.75  E-value: 4.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  35 PESVLFSAKNkVLYVSLIDGGGadkdgqggIAILNMDGSvKNKNWITGMDAPKGLAIHKD-LLYVAD-INSVSIIDIITG 112
Cdd:COG3386    10 GEGPVWDPDG-RLYWVDIPGGR--------IHRYDPDGG-AVEVFAEPSGRPNGLAFDPDgRLLVADhGRGLVRFDPADG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 113 NE---VDRVAVPGSvFLNDVAVDDNGVVYVSDTRESK----IYEL-RDHKPTVFMENTTSVNGLKFI--NGYLY--ALVG 180
Cdd:COG3386    80 EVtvlADEYGKPLN-RPNDGVVDPDGRLYFTDMGEYLptgaLYRVdPDGSLRVLADGLTFPNGIAFSpdGRTLYvaDTGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 181 PELWKIDRNK-----KSTVVAKGFELDG--DGVEPVGNGDFLVTCWG-GLVYYVKANGEIQQLLDVRGTmNTADLGFH-P 251
Cdd:COG3386   159 GRIYRFDLDAdgtlgNRRVFADLPDGPGgpDGLAVDADGNLWVALWGgGGVVRFDPDGELLGRIELPER-RPTNVAFGgP 237


                  ....*....
gi 1601838039 252 ETNTVYIPT 260
Cdd:COG3386   238 DLRTLYVTT 246
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 35-260 4.38e-10

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 58.75  E-value: 4.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  35 PESVLFSAKNkVLYVSLIDGGGadkdgqggIAILNMDGSvKNKNWITGMDAPKGLAIHKD-LLYVAD-INSVSIIDIITG 112
Cdd:COG3386    10 GEGPVWDPDG-RLYWVDIPGGR--------IHRYDPDGG-AVEVFAEPSGRPNGLAFDPDgRLLVADhGRGLVRFDPADG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 113 NE---VDRVAVPGSvFLNDVAVDDNGVVYVSDTRESK----IYEL-RDHKPTVFMENTTSVNGLKFI--NGYLY--ALVG 180
Cdd:COG3386    80 EVtvlADEYGKPLN-RPNDGVVDPDGRLYFTDMGEYLptgaLYRVdPDGSLRVLADGLTFPNGIAFSpdGRTLYvaDTGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 181 PELWKIDRNK-----KSTVVAKGFELDG--DGVEPVGNGDFLVTCWG-GLVYYVKANGEIQQLLDVRGTmNTADLGFH-P 251
Cdd:COG3386   159 GRIYRFDLDAdgtlgNRRVFADLPDGPGgpDGLAVDADGNLWVALWGgGGVVRFDPDGELLGRIELPER-RPTNVAFGgP 237


                  ....*....
gi 1601838039 252 ETNTVYIPT 260
Cdd:COG3386   238 DLRTLYVTT 246
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 63-142 1.46e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 45.36  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  63 GGIAILNMDGSVKN----KNWITGMDAPKGLAIHKDLLYVADI--NSVSIIDIiTGNEVDRVAVPGS-----VFLNDVAV 131
Cdd:cd14963    77 GRIQVFDPDGKFLKyfpeKKDRVKLISPAGLAIDDGKLYVSDVkkHKVIVFDL-EGKLLLEFGKPGSepgelSYPNGIAV 155

                          90
                  ....*....|.
gi 1601838039 132 DDNGVVYVSDT 142
Cdd:cd14963   156 DEDGNIYVADS 166
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 86-220 3.77e-05

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 44.19  E-value: 3.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  86 PKGLAIHKDLLYVADINSVSIIDIITGNEVDRVAV-PGSVFLN------------------------DVAVDDNGVVYVS 140
Cdd:NF033206  140 PYGLAIGGGTLYVADAGANALLRVDADGKVSTVAVlPPRPVTIpagpppglplpdcpvgypaqavptGVAVGPDGALYVS 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 141 -------DTRESKIYELR-DHKPTVFMENTTSVNGLKF-INGYLYAL--------VGPE---LWKIDRNKKSTVVAKGFE 200
Cdd:NF033206  220 eltgfpfPPGRARVYRVDpGGAPTVYATGFTGLTDLAFdPDGNLYVLelagggllKGDPtgsLIRIAPDGTRTTLLDGLE 299

                         170       180
                  ....*....|....*....|
gi 1601838039 201 LDGdGVEPVGNGDFLVTCWG 220
Cdd:NF033206  300 LPT-GLAVGPDGTLYVTNNG 318
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 35-260 4.38e-10

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 58.75  E-value: 4.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  35 PESVLFSAKNkVLYVSLIDGGGadkdgqggIAILNMDGSvKNKNWITGMDAPKGLAIHKD-LLYVAD-INSVSIIDIITG 112
Cdd:COG3386    10 GEGPVWDPDG-RLYWVDIPGGR--------IHRYDPDGG-AVEVFAEPSGRPNGLAFDPDgRLLVADhGRGLVRFDPADG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 113 NE---VDRVAVPGSvFLNDVAVDDNGVVYVSDTRESK----IYEL-RDHKPTVFMENTTSVNGLKFI--NGYLY--ALVG 180
Cdd:COG3386    80 EVtvlADEYGKPLN-RPNDGVVDPDGRLYFTDMGEYLptgaLYRVdPDGSLRVLADGLTFPNGIAFSpdGRTLYvaDTGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 181 PELWKIDRNK-----KSTVVAKGFELDG--DGVEPVGNGDFLVTCWG-GLVYYVKANGEIQQLLDVRGTmNTADLGFH-P 251
Cdd:COG3386   159 GRIYRFDLDAdgtlgNRRVFADLPDGPGgpDGLAVDADGNLWVALWGgGGVVRFDPDGELLGRIELPER-RPTNVAFGgP 237


                  ....*....
gi 1601838039 252 ETNTVYIPT 260
Cdd:COG3386   238 DLRTLYVTT 246
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 117-258 2.94e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 53.36  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 117 RVAVPGSVFLNDVAVDDNGVVYVSDTRESKIYELR--DHKPTVFMENTTSVNGLKFI-NGYLYALV-GPELWKIDR-NKK 191
Cdd:COG3386     1 KLADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDpdGGAVEVFAEPSGRPNGLAFDpDGRLLVADhGRGLVRFDPaDGE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1601838039 192 STVVAKGFELDG----DGVepVG-NGDFLVTC-----WGGLVYYVKANGEIQQLLDVRGTMNTadLGFHPETNTVYI 258
Cdd:COG3386    81 VTVLADEYGKPLnrpnDGV--VDpDGRLYFTDmgeylPTGALYRVDPDGSLRVLADGLTFPNG--IAFSPDGRTLYV 153
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 63-142 1.46e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 45.36  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  63 GGIAILNMDGSVKN----KNWITGMDAPKGLAIHKDLLYVADI--NSVSIIDIiTGNEVDRVAVPGS-----VFLNDVAV 131
Cdd:cd14963    77 GRIQVFDPDGKFLKyfpeKKDRVKLISPAGLAIDDGKLYVSDVkkHKVIVFDL-EGKLLLEFGKPGSepgelSYPNGIAV 155

                          90
                  ....*....|.
gi 1601838039 132 DDNGVVYVSDT 142
Cdd:cd14963   156 DEDGNIYVADS 166
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
44-150 2.05e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 44.69  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  44 NKVLYVSLIDGGGadkdgqggIAILNMDGSVKNKNWITGMDaPKGLAIHKD--LLYVADI--NSVSIIDIITGNEVDRVA 119
Cdd:COG3391    79 GRRLYVANSGSGR--------VSVIDLATGKVVATIPVGGG-PRGLAVDPDggRLYVADSgnGRVSVIDTATGKVVATIP 149

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1601838039 120 VPGSVflNDVAVD-DNGVVYVSDTRESKIYEL 150
Cdd:COG3391   150 VGAGP--HGIAVDpDGKRLYVANSGSNTVSVI 179
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 86-220 3.77e-05

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 44.19  E-value: 3.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  86 PKGLAIHKDLLYVADINSVSIIDIITGNEVDRVAV-PGSVFLN------------------------DVAVDDNGVVYVS 140
Cdd:NF033206  140 PYGLAIGGGTLYVADAGANALLRVDADGKVSTVAVlPPRPVTIpagpppglplpdcpvgypaqavptGVAVGPDGALYVS 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039 141 -------DTRESKIYELR-DHKPTVFMENTTSVNGLKF-INGYLYAL--------VGPE---LWKIDRNKKSTVVAKGFE 200
Cdd:NF033206  220 eltgfpfPPGRARVYRVDpGGAPTVYATGFTGLTDLAFdPDGNLYVLelagggllKGDPtgsLIRIAPDGTRTTLLDGLE 299

                         170       180
                  ....*....|....*....|
gi 1601838039 201 LDGdGVEPVGNGDFLVTCWG 220
Cdd:NF033206  300 LPT-GLAVGPDGTLYVTNNG 318
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
35-146 6.81e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 6.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  35 PESVLFSAKNKVLYVSLIDGGGadkdgqggIAILNMDGSVKNKNWITGmDAPKGLAIHKD--LLYVADINS------VSI 106
Cdd:COG3391   112 PRGLAVDPDGGRLYVADSGNGR--------VSVIDTATGKVVATIPVG-AGPHGIAVDPDgkRLYVANSGSntvsviVSV 182

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1601838039 107 IDIITGNEVDRVAVPGSVflNDVAVDDNG-VVYVSDTRESK 146
Cdd:COG3391   183 IDTATGKVVATIPVGGGP--VGVAVSPDGrRLYVANRGSNT 221
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 65-147 2.71e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 41.54  E-value: 2.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  65 IAILNMDGSVKNKNWITG-----MDAPKGLAIHKD-LLYVADI--NSVSIIDIiTGNEVDRVAVPGSV-----FLNDVAV 131
Cdd:cd05819    78 IQKFDPDGNFLASFGGSGdgdgeFNGPRGIAVDSSgNIYVADTgnHRIQKFDP-DGEFLTTFGSGGSGpgqfnGPTGVAV 156

                          90
                  ....*....|....*.
gi 1601838039 132 DDNGVVYVSDTRESKI 147
Cdd:cd05819   157 DSDGNIYVADTGNHRI 172
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
27-142 3.79e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  27 WETKDLPT----PESVLFSAKNKVLYVSLidgggadkdGQGGIAILNMD-GSVKNKNWITGMDAPKGLAIHKD-LLYVAD 100
Cdd:COG4257   135 VTEFPLPTggagPYGIAVDPDGNLWVTDF---------GANAIGRIDPDtGTLTEYALPTPGAGPRGLAVDPDgNLWVAD 205

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1601838039 101 I--NSVSIIDIITGnEVDRVAVPGSVFL-NDVAVDDNGVVYVSDT 142
Cdd:COG4257   206 TgsGRIGRFDPKTG-TVTEYPLPGGGARpYGVAVDGDGRVWFAES 249
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
61-150 5.07e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.77  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  61 GQGGIAILNM-DGSVKnKNWITGMDAPKGLAIHKD-LLYVADINSVSI--IDIITGnEVDRVAVPGSV-FLNDVAVDDNG 135
Cdd:COG4257    36 GGGRIGRLDPaTGEFT-EYPLGGGSGPHGIAVDPDgNLWFTDNGNNRIgrIDPKTG-EITTFALPGGGsNPHGIAFDPDG 113

                          90
                  ....*....|....*
gi 1601838039 136 VVYVSDTRESKIYEL 150
Cdd:COG4257   114 NLWFTDQGGNRIGRL 128
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 86-147 5.77e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 40.38  E-value: 5.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  86 PKGLAIHKD-LLYVADI--NSVSIIDIiTGNEVDRVAVPGSVFLN-----DVAVDDNGVVYVSDTRESKI 147
Cdd:cd05819    57 PAGVAVDSDgNLYVADTgnHRIQKFDP-DGNFLASFGGSGDGDGEfngprGIAVDSSGNIYVADTGNHRI 125
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 61-148 3.38e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 38.04  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  61 GQGGIAILNMDGsvKNKNWITGMD-------APKGLAIHKD-LLYVAD--INSVSIIDIiTGNEVDRVAVPGS-----VF 125
Cdd:cd14963   167 GNGRIQVFDKNG--KFIKELNGSPdgksgfvNPRGIAVDPDgNLYVVDnlSHRVYVFDE-QGKELFTFGGRGKddgqfNL 243

                          90       100
                  ....*....|....*....|...
gi 1601838039 126 LNDVAVDDNGVVYVSDTRESKIY 148
Cdd:cd14963   244 PNGLFIDDDGRLYVTDRENNRVA 266
COG5276 COG5276
Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...
 37-142 4.64e-03

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];


Pssm-ID: 444087 [Multi-domain]  Cd Length: 320  Bit Score: 38.00  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  37 SVLFSAKNKVLYVslidggGADKDGQGGIAILNmdgsVKNKNWIT--------GMDAPKGLAIHKDLLYVADINS-VSII 107
Cdd:COG5276   200 TAVPVEDGNYAYV------GDELGGPNGLRILD----VSDPANPVligtyptpGADGAHNLYVSGNYLYVADYNAgLRVL 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1601838039 108 DI---ITGNEVDRVAVPGSVF--LNDVAVDDNGVVYVSDT 142
Cdd:COG5276   270 DIsdpSNPVEIGYFDTYDAGFggAWDVYVDPGGYIYVSDI 309
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 86-148 5.17e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.57  E-value: 5.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1601838039  86 PKGLAIH-KDLLYVAD--INSVSIIDIITGnEVDRVAVPGSVFLN---DVAVDDNGVVYVSDTRESKIY 148
Cdd:cd14962    14 PYGVAADgRGRIYVADtgRGAVFVFDLPNG-KVFVIGNAGPNRFVspiGVAIDANGNLYVSDAELGKVF 81
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 86-147 7.19e-03

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 37.30  E-value: 7.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601838039  86 PKGLAIHKD-LLYVADI--NSVSIIDIiTGNEVDRVAVPGSVFL-----NDVAVDDNGVVYVSDTRESKI 147
Cdd:cd05819   151 PTGVAVDSDgNIYVADTgnHRIQVFDP-DGNFLTTFGSTGTGPGqfnypTGIAVDSDGNIYVADSGNNRV 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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