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Conserved domains on  [gi|15929593|gb|AAH15221|]
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TESC protein [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 114-142 1.02e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 36.37  E-value: 1.02e-03
                        10        20
                ....*....|....*....|....*....
gi 15929593 114 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 142
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSL 29
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-150 1.79e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 1.79e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15929593  81 DEINFEDFLTIMsyfrpidttmdEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 150
Cdd:COG5126  48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 114-142 1.02e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.37  E-value: 1.02e-03
                        10        20
                ....*....|....*....|....*....
gi 15929593 114 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 142
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSL 29
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-150 1.79e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 1.79e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15929593  81 DEINFEDFLTIMsyfrpidttmdEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 150
Cdd:COG5126  48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
EF-hand_7 pfam13499
EF-hand domain pair;
112-157 2.49e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 35.31  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15929593   112 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSI 157
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEEL 45
 
Name Accession Description Interval E-value
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 114-142 1.02e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.37  E-value: 1.02e-03
                        10        20
                ....*....|....*....|....*....
gi 15929593 114 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 142
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSL 29
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
81-150 1.79e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 37.46  E-value: 1.79e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15929593  81 DEINFEDFLTIMsyfrpidttmdEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIE 150
Cdd:COG5126  48 GRISREEFVAGM-----------ESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTALGVSEEEAD 106
EF-hand_7 pfam13499
EF-hand domain pair;
112-157 2.49e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 35.31  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15929593   112 KEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPhIEKESARSI 157
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEP-LSDEEVEEL 45
EF-hand_6 pfam13405
EF-hand domain;
114-142 4.71e-03

EF-hand domain;


Pssm-ID: 463869 [Multi-domain]  Cd Length: 30  Bit Score: 33.69  E-value: 4.71e-03
                          10        20
                  ....*....|....*....|....*....
gi 15929593   114 KLRFLFHMYDSDSDGRITLEEYRNVVEEL 142
Cdd:pfam13405   1 ELREAFKLFDKDGDGKISLEELRKALRSL 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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