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Conserved domains on  [gi|159163860]
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Chain A, RuvB-like 2

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIP49 super family cl37554
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 8-90 3.23e-31

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


The actual alignment was detected with superfamily member pfam06068:

Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 112.02  E-value: 3.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163860    8 KEETEIIEGEVVEIQI---DRPATG-TGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGR 83
Cdd:pfam06068 112 KEEKEVYEGEVVELEIeeaENPLSGgKTIKGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGR 191


                  ....*..
gi 159163860   84 SFTRARS 90
Cdd:pfam06068 192 SFARATD 198
 
Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 8-90 3.23e-31

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 112.02  E-value: 3.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163860    8 KEETEIIEGEVVEIQI---DRPATG-TGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGR 83
Cdd:pfam06068 112 KEEKEVYEGEVVELEIeeaENPLSGgKTIKGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGR 191


                  ....*..
gi 159163860   84 SFTRARS 90
Cdd:pfam06068 192 SFARATD 198
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
8-84 1.77e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 44.19  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163860   8 KEETEIIEGEVVEIQIDR---PATGTgSKV---GKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKL 81
Cdd:COG1224  126 REKRKVYEGVVKEIKIRYarhPYNPY-VKVpreATITLATKDEEKTLTVGEEIAQQLVELGIRKGDVIWIDAETGRVSKL 204


                 ...
gi 159163860  82 GRS 84
Cdd:COG1224  205 GRA 207
 
Name Accession Description Interval E-value
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 8-90 3.23e-31

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 112.02  E-value: 3.23e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163860    8 KEETEIIEGEVVEIQI---DRPATG-TGSKVGKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKLGR 83
Cdd:pfam06068 112 KEEKEVYEGEVVELEIeeaENPLSGgKTIKGGKITLKTTKMEKTLKLGPKIYEQLQKEKVSAGDVIYIDKNTGRVKKLGR 191


                  ....*..
gi 159163860   84 SFTRARS 90
Cdd:pfam06068 192 SFARATD 198
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
8-84 1.77e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 44.19  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163860   8 KEETEIIEGEVVEIQIDR---PATGTgSKV---GKLTLKTTEMETIYDLGTKMIESLTKDKVQAGDVITIDKATGKISKL 81
Cdd:COG1224  126 REKRKVYEGVVKEIKIRYarhPYNPY-VKVpreATITLATKDEEKTLTVGEEIAQQLVELGIRKGDVIWIDAETGRVSKL 204


                 ...
gi 159163860  82 GRS 84
Cdd:COG1224  205 GRA 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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