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Chain A, Similar to S.pombe -rad4+/cut5+product (A40727)
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
BRCT_TopBP1_rpt3 | cd17718 | third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
35-116 | 1.30e-50 | |||
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain. : Pssm-ID: 349350 Cd Length: 83 Bit Score: 155.45 E-value: 1.30e-50
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Name | Accession | Description | Interval | E-value | |||
BRCT_TopBP1_rpt3 | cd17718 | third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
35-116 | 1.30e-50 | |||
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain. Pssm-ID: 349350 Cd Length: 83 Bit Score: 155.45 E-value: 1.30e-50
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BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
37-113 | 3.31e-14 | |||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 62.70 E-value: 3.31e-14
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BRCT | smart00292 | breast cancer carboxy-terminal domain; |
38-113 | 1.54e-13 | |||
breast cancer carboxy-terminal domain; Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 61.24 E-value: 1.54e-13
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Name | Accession | Description | Interval | E-value | |||
BRCT_TopBP1_rpt3 | cd17718 | third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
35-116 | 1.30e-50 | |||
third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the third BRCT domain. Pssm-ID: 349350 Cd Length: 83 Bit Score: 155.45 E-value: 1.30e-50
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BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
37-113 | 3.31e-14 | |||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 62.70 E-value: 3.31e-14
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BRCT | cd00027 | C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
44-112 | 1.23e-13 | |||
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage. Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 61.22 E-value: 1.23e-13
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BRCT | smart00292 | breast cancer carboxy-terminal domain; |
38-113 | 1.54e-13 | |||
breast cancer carboxy-terminal domain; Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 61.24 E-value: 1.54e-13
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BRCT_2 | pfam16589 | BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ... |
37-124 | 6.59e-12 | |||
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown. Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 56.99 E-value: 6.59e-12
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BRCT_Rev1 | cd17719 | BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ... |
40-124 | 4.62e-11 | |||
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light. Pssm-ID: 349351 [Multi-domain] Cd Length: 87 Bit Score: 54.88 E-value: 4.62e-11
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BRCT_XRCC1_rpt2 | cd17707 | Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ... |
39-125 | 7.78e-09 | |||
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain. Pssm-ID: 349340 Cd Length: 94 Bit Score: 49.57 E-value: 7.78e-09
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BRCT_PAXIP1_rpt3 | cd17711 | third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ... |
43-120 | 4.32e-07 | |||
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain. Pssm-ID: 349343 Cd Length: 81 Bit Score: 44.56 E-value: 4.32e-07
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BRCT_PAXIP1_rpt1 | cd17714 | first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ... |
42-120 | 1.43e-06 | |||
first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain. Pssm-ID: 349346 Cd Length: 76 Bit Score: 43.08 E-value: 1.43e-06
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BRCT_microcephalin_rpt1 | cd17716 | first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ... |
74-119 | 9.91e-06 | |||
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat. Pssm-ID: 349348 [Multi-domain] Cd Length: 78 Bit Score: 41.03 E-value: 9.91e-06
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BRCT_Bard1_rpt2 | cd17720 | second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar ... |
40-116 | 2.98e-05 | |||
second (C-terminal) BRCT domain of BRCA1-associated RING domain protein 1 (Bard1) and similar proteins; Bard1, also termed BARD-1, or RING-type E3 ubiquitin transferase BARD1, is a critical factor in BRCA1-mediated tumor suppression and may also serve as a target for tumorigenic lesions in some human cancers. It associates with BRCA1 (breast cancer-1) to form a heterodimeric BRCA1/BARD1 complex that is responsible for maintaining genomic stability through nuclear functions involving DNA damage signaling and repair, transcriptional regulation, and cell cycle control. The BRCA1/BARD1 complex catalyzes autoubiquitination of BRCA1 and trans ubiquitination of other protein substrates. Its E3 ligase activity is dramatically reduced in the presence of UBX domain protein 1 (UBXN1). BARD-1 contains an N-terminal C3HC4-type RING-HC finger that binds BRCA1, and a C-terminal region with three ankyrin repeats and tandem BRCT domains that bind CstF-50 (cleavage stimulation factor) to modulate mRNA processing and RNAP II stability in response to DNA damage. The family corresponds to the second BRCT domain. Pssm-ID: 349352 Cd Length: 101 Bit Score: 40.04 E-value: 2.98e-05
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BRCT_BRC1_like_rpt1 | cd18435 | first (N-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) ... |
55-124 | 3.91e-05 | |||
first (N-terminal) BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat. Pssm-ID: 349388 Cd Length: 107 Bit Score: 40.00 E-value: 3.91e-05
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BRCT_DNA_ligase_III | cd18431 | BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ... |
39-116 | 9.09e-05 | |||
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Pssm-ID: 349384 [Multi-domain] Cd Length: 78 Bit Score: 38.45 E-value: 9.09e-05
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BRCT_DNA_ligase_IV_rpt2 | cd17717 | second BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed ... |
53-111 | 1.55e-04 | |||
second BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the second one. Pssm-ID: 349349 Cd Length: 88 Bit Score: 38.19 E-value: 1.55e-04
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BRCT_TopBP1_rpt2_like | cd17731 | second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
41-116 | 1.71e-04 | |||
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain. Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 37.52 E-value: 1.71e-04
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BRCT_BRCA1_rpt1 | cd17735 | first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins; ... |
72-124 | 2.71e-04 | |||
first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins; BRCA1, also termed RING finger protein 53 (RNF53), is a RING finger protein encoded by BRCA1, a tumor suppressor gene that regulates all DNA double-strand break (DSB) repair pathways. BRCA1 is frequently mutated in patients with hereditary breast and ovarian cancer (HBOC). Its mutation is also associated with an increased risk of pancreatic, stomach, laryngeal, fallopian tube, and prostate cancer. It plays an important role in the DNA damage response signaling, and has been implicated in various cellular processes such as cell cycle regulation, transcriptional regulation, chromatin remodeling, DNA DSBs, and apoptosis. BRCA1 contains an N-terminal C3HC4-type RING-HC finger, and two BRCT (BRCA1 C-terminus domain) repeats at the C-terminus. The family corresponds to the first BRCT domain. Pssm-ID: 349367 Cd Length: 97 Bit Score: 37.71 E-value: 2.71e-04
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BRCT_polymerase_lambda | cd17715 | BRCT domain of DNA polymerase lambda and similar proteins; DNA polymerase lambda, also termed ... |
57-119 | 4.73e-04 | |||
BRCT domain of DNA polymerase lambda and similar proteins; DNA polymerase lambda, also termed Pol Lambda, or DNA polymerase beta-2 (Pol beta2), or DNA polymerase kappa, is involved in base excision repair (BER) and is responsible for repair of lesions that give rise to abasic (AP) sites in DNA. It also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. DNA polymerase lambda has both template-dependent and template-independent (terminal transferase) DNA polymerase activities, as well as a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. DNA polymerase lambda contains one BRCT domain. Pssm-ID: 349347 Cd Length: 80 Bit Score: 36.70 E-value: 4.73e-04
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PTCB-BRCT | pfam12738 | twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ... |
44-85 | 1.00e-03 | |||
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair. Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 35.26 E-value: 1.00e-03
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BRCT_CTDP1 | cd17729 | BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ... |
41-121 | 4.39e-03 | |||
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. Pssm-ID: 349361 [Multi-domain] Cd Length: 97 Bit Score: 34.43 E-value: 4.39e-03
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BRCT_TopBP1_rpt6 | cd17727 | sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
41-112 | 4.47e-03 | |||
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain. Pssm-ID: 349359 [Multi-domain] Cd Length: 75 Bit Score: 33.72 E-value: 4.47e-03
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