Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121   9 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 88
Cdd:cd17140    1 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 80

                 ....*....
gi 159163121  89 EPFKKLEYT 97
Cdd:cd17140   81 EPFKKLEYT 89

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121   9 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 88
Cdd:cd17140    1 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 80

                 ....*....
gi 159163121  89 EPFKKLEYT 97
Cdd:cd17140   81 EPFKKLEYT 89

Doublecortin;

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 159163121   29 AISPDRFRSFEALLADLTRTLsdnVNLPQG-VRTIYTIDGlKKISSLDQLVEGESYVCGSIEPF 91
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKV---VKLPFGaVRKLYTLDG-KRVTSLDELEDGGVYVAAGREKF 60

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121   9 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 88
Cdd:cd17140    1 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 80

                 ....*....
gi 159163121  89 EPFKKLEYT 97
Cdd:cd17140   81 EPFKKLEYT 89

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121   9 KAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSI 88
Cdd:cd17141    1 KAKKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTRSLSDNVNLPQGVRTIYTIDGSKKITSLDELLEGESYVCASN 80

                 ....*
gi 159163121  89 EPFKK 93
Cdd:cd17141   81 EPFRK 85

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121     8 KKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRtlSDNVNLPQGVRTIYTIDGlKKISSLDQLVEGESYVCGS 87
Cdd:smart00537   3 VKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTE--VVKLDLPHGVRKLYTLDG-KKVTSLDELEDGGSYVASG 79

                   ....*....
gi 159163121    88 IEPFKKLEY 96
Cdd:smart00537  80 TEAFKKVDY 88

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 159163121  11 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNvnlPQGVRTIYTIDGlKKISSLDQLVEGESYVCGS 87
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLP---TGGVRKLYTPSG-KLVKSLSDLEDGESYVVCG 73

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121  11 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLtrtlSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEP 90
Cdd:cd17146    1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDL----SQRVPLPFGVRTITTPRGTHSISRLEQLEDGGCYLCSDKKY 76

                 ..
gi 159163121  91 FK 92
Cdd:cd17146   77 VK 78

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121  11 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSdnvNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEP 90
Cdd:cd17071    1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIK---APFGAVRSIYTPTGGHRVKDLDSLQNGGVYVAAGSER 77

                 ...
gi 159163121  91 FKK 93
Cdd:cd17071   78 FKK 80

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159163121  11 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTlsdnVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEP 90
Cdd:cd17151    1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTET----VKVPFGVRCLYTPRNGHRVKGLDDLQGGGKYVAAGRER 76

                 ...
gi 159163121  91 FKK 93
Cdd:cd17151   77 FKK 79

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 159163121  10 AKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGlKKISSLDQLVEGESYV 84
Cdd:cd16113    1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVT----EKVKLQTGaVRKLYTLDG-KRISDPDELVNGGQYV 71

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 159163121  16 YRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGLKkISSLDQLVEGESYVCGSIEPFKK 93
Cdd:cd17153    7 FRNGDLLSPPFRLLIPKHMLQDWETILSLLT----EKANLRTGaVRKLCTLDGVP-LSSGKELVSGQYYVAVGSEKFKD 80

Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 159163121  12 KVRFYRNGDRYFKGIVYAISpdrfRSFEALLADLTRTLsdnvNLPQGVRTIYTIDG 67
Cdd:cd17158    2 KILAYKNGEGRLRDGVLIIG----STFPGLLDQCTHRL----GLARAARRLYTADG 49