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Concise Results
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envoplakin [Parambassis ranga]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SH3_10
pfam17902 SH3 domain; This entry represents an SH3 domain.
388-452
8.51e-23
SH3 domain; This entry represents an SH3 domain.
Pssm-ID: 407754
Cd Length: 65
Bit Score: 93.48
E-value: 8.51e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1591480471 388 PLK L RR TTTS RPI T V ES LCD WETDTGSLSR GE KF TL KS NS HN E N W DITSTN G AT K TF P A VCF Q IP 452
Cdd:pfam17902 1 PLK Q RR SPVT RPI P V KA LCD YKQGEVTVEK GE EC TL LD NS DR E K W KVQTSS G VE K LV P S VCF L IP 65
Plectin
pfam00681 Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
1827-1865
2.46e-11
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.
Pssm-ID: 459901
Cd Length: 39
Bit Score: 60.03
E-value: 2.46e-11
10 20 30
....*....|....*....|....*....|....*....
gi 1591480471 1827 LLEAQAATGGIID ISNK ER YT V HK A AT RGLID DSQL Q R L 1865
Cdd:pfam00681 1 LLEAQAATGGIID PVTG ER LS V EE A VK RGLID PETA Q K L 39
SMC_N super family
cl47134 RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1132-1538
1.25e-09
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
TIGR02169 :Pssm-ID: 481474 [Multi-domain]
Cd Length: 1164
Bit Score: 63.55
E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1132 SKKIQTNLE E E R MENNS L S RE VMDL h S RY RQVQDW K PRV E VK E IVN E IYRIDP --- NT E LEIMR L RKDIQDSSKQR S DS E 1208
Cdd:TIGR02169 186 IERLDLIID E K R QQLER L R RE REKA - E RY QALLKE K REY E GY E LLK E KEALER qke AI E RQLAS L EEELEKLTEEI S EL E 264
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1209 REITQVTAD L NI L ------ RS E KPKVEL KE VLR E VVK E ER S ----- P E N ERE IQRLNDQ L TQ L HINYNS L EEQVRL L RK E 1277
Cdd:TIGR02169 265 KRLEEIEQL L EE L nkkikd LG E EEQLRV KE KIG E LEA E IA S lersi A E K ERE LEDAEER L AK L EAEIDK L LAEIEE L ER E 344
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1278 RD E WKAE R S K IETKLVTR evikyeadplq EK E ADR LR RDVRDEA K LRRNIEEMVF D LQN K YIL L E R qkpeekvvvqevvr 1357
Cdd:TIGR02169 345 IE E ERKR R D K LTEEYAEL ----------- KE E LED LR AELEEVD K EFAETRDELK D YRE K LEK L K R -------------- 399
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1358 lqkdprqev E HER L G R T LD DEVMTRRQ L ELD L QQ L RTKVEEK E RILR E SD E RQKKIQA dselr EI R lcivqletapppve 1437
Cdd:TIGR02169 400 --------- E INE L K R E LD RLQEELQR L SEE L AD L NAAIAGI E AKIN E LE E EKEDKAL ----- EI K -------------- 451
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1438 esivveevlkverdp K L E RMISG L RL D MD K ETNDILR L ERDIRNLTAK L EI LQRE KS vektvykevvrvekdq AV EA ERD 1517
Cdd:TIGR02169 452 --------------- K Q E WKLEQ L AA D LS K YEQELYD L KEEYDRVEKE L SK LQRE LA ---------------- EA EA QAR 500
410 420
....*....|....*....|.
gi 1591480471 1518 RLR E Q V SQNKFARQD L EDE I R 1538
Cdd:TIGR02169 501 ASE E R V RGGRAVEEV L KAS I Q 521
Plectin
pfam00681 Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
1903-1941
6.88e-09
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.
Pssm-ID: 459901
Cd Length: 39
Bit Score: 53.10
E-value: 6.88e-09
10 20 30
....*....|....*....|....*....|....*....
gi 1591480471 1903 YM EAQ HH TGG LV DP K TG R RLS TLD A IGAKM ID STMMRE L 1941
Cdd:pfam00681 1 LL EAQ AA TGG II DP V TG E RLS VEE A VKRGL ID PETAQK L 39
SMC_prok_B super family
cl37069 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
548-1344
8.38e-09
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
TIGR02168 :Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 60.84
E-value: 8.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 548 K R L RE Q EKA A NTL K A L EQQKLAAQGD L qpllskdpsstssg L P L K L SAANNKYDS L AALADLYKKKANA sln L ESQIKKV 627
Cdd:TIGR02168 203 K S L ER Q AEK A ERY K E L KAELRELELA L -------------- L V L R L EELREELEE L QEELKEAEEELEE --- L TAELQEL 265
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 628 DGLVSGFEKKL SE D gpi PDRPNAI Q AR ---- SED I QSQQKSVAAAQDDVKK L SQN LE TT E QLCSS L QQSYQ E YCPDIQRQ 703
Cdd:TIGR02168 266 EEKLEELRLEV SE L --- EEEIEEL Q KE lyal ANE I SRLEQQKQILRERLAN L ERQ LE EL E AQLEE L ESKLD E LAEELAEL 342
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 704 RTEVKD L QTRYTNVANQ L K E R E IV L Q E AATKNQ E FQSTCKS L N S FLDN L GTNQITSS N DLSQVN A KQSSQ E RIMDD L KRK 783
Cdd:TIGR02168 343 EEKLEE L KEELESLEAE L E E L E AE L E E LESRLE E LEEQLET L R S KVAQ L ELQIASLN N EIERLE A RLERL E DRRER L QQE 422
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 784 QDDVDRVSDLSQ -- D LQ DL L NDY E TNIDKFNST LE DSGATVAKKPHV L TLSDAVQKEEKNVVNRY - TEATAKNTQVQKQM 860
Cdd:TIGR02168 423 IEELLKKLEEAE lk E LQ AE L EEL E EELEELQEE LE RLEEALEELREE L EEAEQALDAAERELAQL q ARLDSLERLQENLE 502
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 861 G L --- A K N LL L N NE ---------- E KVQMVAQQQV A L E SQQKSTF Q IESLLKELEEER A RTTHTETN L -- R TF ------- 918
Cdd:TIGR02168 503 G F seg V K A LL K N QS glsgilgvls E LISVDEGYEA A I E AALGGRL Q AVVVENLNAAKK A IAFLKQNE L gr V TF lpldsik 582
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 919 ----- KDRMMS LK SRR G VERI eek EVLHYYR DPKL END L A ---------- DL Q N K L hee A L RRSTTQSEV evlnkk I T TL 983
Cdd:TIGR02168 583 gteiq GNDREI LK NIE G FLGV --- AKDLVKF DPKL RKA L S yllggvlvvd DL D N A L --- E L AKKLRPGYR ------ I V TL 650
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 984 EDT L KNA ---- T PKLVTREVTEF ER DPQL dvda AK L RDEVTRIKDE I RVRDGEQIQMKT E VTV L QQMKPPIKERVVKKEV 1059
Cdd:TIGR02168 651 DGD L VRP ggvi T GGSAKTNSSIL ER RREI ---- EE L EEKIEELEEK I AELEKALAELRK E LEE L EEELEQLRKELEELSR 726
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1060 VKVEQDPEML R AVR tmdt E ISGENNKSKL L TD E IFQTRSQ I NA LE RLIPNIQPKIITK E VKKI E QDPDL ites KKIQTN L 1139
Cdd:TIGR02168 727 QISALRKDLA R LEA ---- E VEQLEERIAQ L SK E LTELEAE I EE LE ERLEEAEEELAEA E AEIE E LEAQI ---- EQLKEE L 798
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1140 EEE R MENNS L SR E VMD L HSRYRQVQDWKPRV E v KE I VNEIY R ID p NT E LE I MR L RK DI QDSSKQRSDS E RE I TQVTAD L N 1219
Cdd:TIGR02168 799 KAL R EALDE L RA E LTL L NEEAANLRERLESL E - RR I AATER R LE - DL E EQ I EE L SE DI ESLAAEIEEL E EL I EELESE L E 876
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1220 I L RS E KPKV elkevlrevvkeerspen E REIQR L NDQ L TQ L HINYNS LE EQVRL LR K E RD E WKAERSKI E TK L vtr E VIK 1299
Cdd:TIGR02168 877 A L LN E RASL ------------------ E EALAL L RSE L EE L SEELRE LE SKRSE LR R E LE E LREKLAQL E LR L --- E GLE 935
810 820 830 840
....*....|....*....|....*....|....*....|....*
gi 1591480471 1300 YEA D P LQE KEADRLRRDVRDEAK L RRN IE EMVFDLQNKYIL LE RQ 1344
Cdd:TIGR02168 936 VRI D N LQE RLSEEYSLTLEEAEA L ENK IE DDEEEARRRLKR LE NK 980
PLEC
smart00250 Plectin repeat;
1863-1900
1.22e-08
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 52.48
E-value: 1.22e-08
10 20 30
....*....|....*....|....*....|....*...
gi 1591480471 1863 QRLL N AQ K A FA G VE DP V T KER LSV G EA IQK G WMPKD T A 1900
Cdd:smart00250 1 QRLL E AQ S A IG G II DP E T GQK LSV E EA LRR G LIDPE T G 38
SPEC
smart00150 Spectrin repeats;
218-319
1.54e-06
Spectrin repeats;
Pssm-ID: 197544 [Multi-domain]
Cd Length: 101
Bit Score: 48.48
E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 218 YEYVQGCNKEL A F L GDEQGKIKKQ D WSD rmv D PPD V RRQYENFKN -- NS L LS HE SE V NK L QDE G DR L V E LK HP ASST I TA 295
Cdd:smart00150 1 QQFLRDADELE A W L EEKEQLLASE D LGK --- D LES V EALLKKHEA fe AE L EA HE ER V EA L NEL G EQ L I E EG HP DAEE I EE 77
90 100
....*....|....*....|....
gi 1591480471 296 QRDAVRNE W QKFLN L CICQETH L D 319
Cdd:smart00150 78 RLEELNER W EELKE L AEERRQK L E 101
Name
Accession
Description
Interval
E-value
SH3_10
pfam17902 SH3 domain; This entry represents an SH3 domain.
388-452
8.51e-23
SH3 domain; This entry represents an SH3 domain.
Pssm-ID: 407754
Cd Length: 65
Bit Score: 93.48
E-value: 8.51e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1591480471 388 PLK L RR TTTS RPI T V ES LCD WETDTGSLSR GE KF TL KS NS HN E N W DITSTN G AT K TF P A VCF Q IP 452
Cdd:pfam17902 1 PLK Q RR SPVT RPI P V KA LCD YKQGEVTVEK GE EC TL LD NS DR E K W KVQTSS G VE K LV P S VCF L IP 65
Plectin
pfam00681 Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
1827-1865
2.46e-11
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.
Pssm-ID: 459901
Cd Length: 39
Bit Score: 60.03
E-value: 2.46e-11
10 20 30
....*....|....*....|....*....|....*....
gi 1591480471 1827 LLEAQAATGGIID ISNK ER YT V HK A AT RGLID DSQL Q R L 1865
Cdd:pfam00681 1 LLEAQAATGGIID PVTG ER LS V EE A VK RGLID PETA Q K L 39
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1132-1538
1.25e-09
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 63.55
E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1132 SKKIQTNLE E E R MENNS L S RE VMDL h S RY RQVQDW K PRV E VK E IVN E IYRIDP --- NT E LEIMR L RKDIQDSSKQR S DS E 1208
Cdd:TIGR02169 186 IERLDLIID E K R QQLER L R RE REKA - E RY QALLKE K REY E GY E LLK E KEALER qke AI E RQLAS L EEELEKLTEEI S EL E 264
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1209 REITQVTAD L NI L ------ RS E KPKVEL KE VLR E VVK E ER S ----- P E N ERE IQRLNDQ L TQ L HINYNS L EEQVRL L RK E 1277
Cdd:TIGR02169 265 KRLEEIEQL L EE L nkkikd LG E EEQLRV KE KIG E LEA E IA S lersi A E K ERE LEDAEER L AK L EAEIDK L LAEIEE L ER E 344
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1278 RD E WKAE R S K IETKLVTR evikyeadplq EK E ADR LR RDVRDEA K LRRNIEEMVF D LQN K YIL L E R qkpeekvvvqevvr 1357
Cdd:TIGR02169 345 IE E ERKR R D K LTEEYAEL ----------- KE E LED LR AELEEVD K EFAETRDELK D YRE K LEK L K R -------------- 399
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1358 lqkdprqev E HER L G R T LD DEVMTRRQ L ELD L QQ L RTKVEEK E RILR E SD E RQKKIQA dselr EI R lcivqletapppve 1437
Cdd:TIGR02169 400 --------- E INE L K R E LD RLQEELQR L SEE L AD L NAAIAGI E AKIN E LE E EKEDKAL ----- EI K -------------- 451
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1438 esivveevlkverdp K L E RMISG L RL D MD K ETNDILR L ERDIRNLTAK L EI LQRE KS vektvykevvrvekdq AV EA ERD 1517
Cdd:TIGR02169 452 --------------- K Q E WKLEQ L AA D LS K YEQELYD L KEEYDRVEKE L SK LQRE LA ---------------- EA EA QAR 500
410 420
....*....|....*....|.
gi 1591480471 1518 RLR E Q V SQNKFARQD L EDE I R 1538
Cdd:TIGR02169 501 ASE E R V RGGRAVEEV L KAS I Q 521
Plectin
pfam00681 Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
1903-1941
6.88e-09
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.
Pssm-ID: 459901
Cd Length: 39
Bit Score: 53.10
E-value: 6.88e-09
10 20 30
....*....|....*....|....*....|....*....
gi 1591480471 1903 YM EAQ HH TGG LV DP K TG R RLS TLD A IGAKM ID STMMRE L 1941
Cdd:pfam00681 1 LL EAQ AA TGG II DP V TG E RLS VEE A VKRGL ID PETAQK L 39
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
548-1344
8.38e-09
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 60.84
E-value: 8.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 548 K R L RE Q EKA A NTL K A L EQQKLAAQGD L qpllskdpsstssg L P L K L SAANNKYDS L AALADLYKKKANA sln L ESQIKKV 627
Cdd:TIGR02168 203 K S L ER Q AEK A ERY K E L KAELRELELA L -------------- L V L R L EELREELEE L QEELKEAEEELEE --- L TAELQEL 265
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 628 DGLVSGFEKKL SE D gpi PDRPNAI Q AR ---- SED I QSQQKSVAAAQDDVKK L SQN LE TT E QLCSS L QQSYQ E YCPDIQRQ 703
Cdd:TIGR02168 266 EEKLEELRLEV SE L --- EEEIEEL Q KE lyal ANE I SRLEQQKQILRERLAN L ERQ LE EL E AQLEE L ESKLD E LAEELAEL 342
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 704 RTEVKD L QTRYTNVANQ L K E R E IV L Q E AATKNQ E FQSTCKS L N S FLDN L GTNQITSS N DLSQVN A KQSSQ E RIMDD L KRK 783
Cdd:TIGR02168 343 EEKLEE L KEELESLEAE L E E L E AE L E E LESRLE E LEEQLET L R S KVAQ L ELQIASLN N EIERLE A RLERL E DRRER L QQE 422
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 784 QDDVDRVSDLSQ -- D LQ DL L NDY E TNIDKFNST LE DSGATVAKKPHV L TLSDAVQKEEKNVVNRY - TEATAKNTQVQKQM 860
Cdd:TIGR02168 423 IEELLKKLEEAE lk E LQ AE L EEL E EELEELQEE LE RLEEALEELREE L EEAEQALDAAERELAQL q ARLDSLERLQENLE 502
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 861 G L --- A K N LL L N NE ---------- E KVQMVAQQQV A L E SQQKSTF Q IESLLKELEEER A RTTHTETN L -- R TF ------- 918
Cdd:TIGR02168 503 G F seg V K A LL K N QS glsgilgvls E LISVDEGYEA A I E AALGGRL Q AVVVENLNAAKK A IAFLKQNE L gr V TF lpldsik 582
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 919 ----- KDRMMS LK SRR G VERI eek EVLHYYR DPKL END L A ---------- DL Q N K L hee A L RRSTTQSEV evlnkk I T TL 983
Cdd:TIGR02168 583 gteiq GNDREI LK NIE G FLGV --- AKDLVKF DPKL RKA L S yllggvlvvd DL D N A L --- E L AKKLRPGYR ------ I V TL 650
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 984 EDT L KNA ---- T PKLVTREVTEF ER DPQL dvda AK L RDEVTRIKDE I RVRDGEQIQMKT E VTV L QQMKPPIKERVVKKEV 1059
Cdd:TIGR02168 651 DGD L VRP ggvi T GGSAKTNSSIL ER RREI ---- EE L EEKIEELEEK I AELEKALAELRK E LEE L EEELEQLRKELEELSR 726
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1060 VKVEQDPEML R AVR tmdt E ISGENNKSKL L TD E IFQTRSQ I NA LE RLIPNIQPKIITK E VKKI E QDPDL ites KKIQTN L 1139
Cdd:TIGR02168 727 QISALRKDLA R LEA ---- E VEQLEERIAQ L SK E LTELEAE I EE LE ERLEEAEEELAEA E AEIE E LEAQI ---- EQLKEE L 798
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1140 EEE R MENNS L SR E VMD L HSRYRQVQDWKPRV E v KE I VNEIY R ID p NT E LE I MR L RK DI QDSSKQRSDS E RE I TQVTAD L N 1219
Cdd:TIGR02168 799 KAL R EALDE L RA E LTL L NEEAANLRERLESL E - RR I AATER R LE - DL E EQ I EE L SE DI ESLAAEIEEL E EL I EELESE L E 876
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1220 I L RS E KPKV elkevlrevvkeerspen E REIQR L NDQ L TQ L HINYNS LE EQVRL LR K E RD E WKAERSKI E TK L vtr E VIK 1299
Cdd:TIGR02168 877 A L LN E RASL ------------------ E EALAL L RSE L EE L SEELRE LE SKRSE LR R E LE E LREKLAQL E LR L --- E GLE 935
810 820 830 840
....*....|....*....|....*....|....*....|....*
gi 1591480471 1300 YEA D P LQE KEADRLRRDVRDEAK L RRN IE EMVFDLQNKYIL LE RQ 1344
Cdd:TIGR02168 936 VRI D N LQE RLSEEYSLTLEEAEA L ENK IE DDEEEARRRLKR LE NK 980
PLEC
smart00250 Plectin repeat;
1863-1900
1.22e-08
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 52.48
E-value: 1.22e-08
10 20 30
....*....|....*....|....*....|....*...
gi 1591480471 1863 QRLL N AQ K A FA G VE DP V T KER LSV G EA IQK G WMPKD T A 1900
Cdd:smart00250 1 QRLL E AQ S A IG G II DP E T GQK LSV E EA LRR G LIDPE T G 38
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1187-1658
7.26e-08
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 58.02
E-value: 7.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1187 E L E IMR L RKDIQDSSKQRSDS E R E ITQVT A DLNI L RS E KPKV E L kevl REVVK EER SP E N E REIQR L NDQ L TQ L HINYNS 1266
Cdd:COG1196 259 E A E LAE L EAELEELRLELEEL E L E LEEAQ A EEYE L LA E LARL E Q ---- DIARL EER RR E L E ERLEE L EEE L AE L EEELEE 334
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1267 LEE QVRL L RK E RD E WKA E RSKI E TK L VTR E VIKY EA DPLQEKEADR L RRDVRDEAKLR R NIE E MVFD L QNKYILL E RQKP 1346
Cdd:COG1196 335 LEE ELEE L EE E LE E AEE E LEEA E AE L AEA E EALL EA EAELAEAEEE L EELAEELLEAL R AAA E LAAQ L EELEEAE E ALLE 414
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1347 EEKVVVQ E VVR L QKDPRQ - E V E H E RLGRT L DDEVMTRRQ LE LDLQQ L RTKVE E KERILRESDERQKKIQADSELREI RL c 1425
Cdd:COG1196 415 RLERLEE E LEE L EEALAE l E E E E E EEEEA L EEAAEEEAE LE EEEEA L LELLA E LLEEAALLEAALAELLEELAEAAA RL - 493
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1426 IVQ LE TAPPPVEESIV V EEV L KVERDPK L ERMISG L RLDMDKETNDI ------ LRLERDIRNLTAKLEILQRE K SVEKT v 1499
Cdd:COG1196 494 LLL LE AEADYEGFLEG V KAA L LLAGLRG L AGAVAV L IGVEAAYEAAL eaalaa ALQNIVVEDDEVAAAAIEYL K AAKAG - 572
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1500 ykevv R VEKDQAVEAERDRLREQVSQ n KF A RQDLE D EIRRLNDKINLLSSTKSS T SREE T TLTLNKDSLQ R EKDN L TREF 1579
Cdd:COG1196 573 ----- R ATFLPLDKIRARAALAAALA - RG A IGAAV D LVASDLREADARYYVLGD T LLGR T LVAARLEAAL R RAVT L AGRL 646
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1591480471 1580 R TLEARRHDIGLSFQQQSRLMS E RTQMSRQKSIKM E SDVH RL ERDI L DEKDKIHLRDSTI REL LLNLQKEESA E TRTKE 1658
Cdd:COG1196 647 R EVTLEGEGGSAGGSLTGGSRR E LLAALLEAEAEL E ELAE RL AEEE L ELEEALLAEEEEE REL AEAEEERLEE E LEEEA 725
CCDC158
pfam15921 Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
910-1658
4.20e-07
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain]
Cd Length: 1112
Bit Score: 55.51
E-value: 4.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 910 H T E TN L RTFKDRMMS L K srrgv E R IE E KEV LH YYRDPK L ENDLA DLQ N KL H E EALR R STT qse VEVLNKKITTL ED t L K N 989
Cdd:pfam15921 75 H I E RV L EEYSHQVKD L Q ----- R R LN E SNE LH EKQKFY L RQSVI DLQ T KL Q E MQME R DAM --- ADIRRRESQSQ ED - L R N 145
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 990 A tpkl VTRE V T E F E RDPQ L DV D A ak L R D EV T R I k DEI R V rdgeqi Q M KTEVT VLQ QMKPPIKERVVKKEVVKV E Q D ---- 1065
Cdd:pfam15921 146 Q ---- LQNT V H E L E AAKC L KE D M -- L E D SN T Q I - EQL R K ------ M M LSHEG VLQ EIRSILVDFEEASGKKIY E H D smst 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1066 ------- PEMLRAV R TM DTEIS gennksk L L TDE IF QTRS Q IN AL ERLIP N IQPKIITKEVKK IEQ dpd LI T E SKKIQ T N 1138
Cdd:pfam15921 213 mhfrslg SAISKIL R EL DTEIS ------- Y L KGR IF PVED Q LE AL KSESQ N KIELLLQQHQDR IEQ --- LI S E HEVEI T G 282
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1139 L E E E ---- R MEN NS LSR -- E VMDLHS R YRQVQDWKPRVEVKEI V NEI yridp NT EL - E IM R LRK D - I QDSS KQ RSDSER E 1210
Cdd:pfam15921 283 L T E K assa R SQA NS IQS ql E IIQEQA R NQNSMYMRQLSDLEST V SQL ----- RS EL r E AK R MYE D k I EELE KQ LVLANS E 357
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1211 I T QVTADLNILRS E KPKV -- E L KEV L REVV K E E RSPEN E R E I - Q RL N D QL T QLH I NYNS leeqvrl LR K E R D EWKA E RSK 1287
Cdd:pfam15921 358 L T EARTERDQFSQ E SGNL dd Q L QKL L ADLH K R E KELSL E K E Q n K RL W D RD T GNS I TIDH ------- LR R E L D DRNM E VQR 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1288 I E TK L vtr EVI K Y E ADPLQ E KEA ------- DR L RRDVRDE A K L RRNI E --- EM V FD L QN K YIL LE RQK pee KV V VQEVVR 1357
Cdd:pfam15921 431 L E AL L --- KAM K S E CQGQM E RQM aaiqgkn ES L EKVSSLT A Q L ESTK E mlr KV V EE L TA K KMT LE SSE --- RT V SDLTAS 504
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1358 LQ kdprqev E H ER LGRTLDD E VMT - R RQLE L D LQ Q L RTKVE E KERILRESD E RQK - K I Q ADSELRE I RLCIV Q L E TAPPP 1435
Cdd:pfam15921 505 LQ ------- E K ER AIEATNA E ITK l R SRVD L K LQ E L QHLKN E GDHLRNVQT E CEA l K L Q MAEKDKV I EILRQ Q I E NMTQL 577
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1436 V EESIVVEEVLK VE R d PK LE RM I SGL RL DM dk ETND IL RLER D -- IR N L T A KLEI L QR EK SVEKTVYK E VV R VE KD qa VE 1513
Cdd:pfam15921 578 V GQHGRTAGAMQ VE K - AQ LE KE I NDR RL EL -- QEFK IL KDKK D ak IR E L E A RVSD L EL EK VKLVNAGS E RL R AV KD -- IK 652
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1514 A ERD R L REQ V SQNKFARQD L EDEIRR L NDKINLL S stksstsr EE TTL T L NK ----- D S L Q R E KDNLTREFRTL E - ARR H 1587
Cdd:pfam15921 653 Q ERD Q L LNE V KTSRNELNS L SEDYEV L KRNFRNK S -------- EE MET T T NK lkmql K S A Q S E LEQTRNTLKSM E g SDG H 724
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1588 DIGLSFQQ Q SRLMSE R T Q M - SR Q KS I KM ---- ESDVHRLERDILD EK D K IHLRD ST I ---- RELLLN L QKEE S A E T R T KE 1658
Cdd:pfam15921 725 AMKVAMGM Q KQITAK R G Q I d AL Q SK I QF leea MTNANKEKHFLKE EK N K LSQEL ST V atek NKMAGE L EVLR S Q E R R L KE 804
SPEC
smart00150 Spectrin repeats;
218-319
1.54e-06
Spectrin repeats;
Pssm-ID: 197544 [Multi-domain]
Cd Length: 101
Bit Score: 48.48
E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 218 YEYVQGCNKEL A F L GDEQGKIKKQ D WSD rmv D PPD V RRQYENFKN -- NS L LS HE SE V NK L QDE G DR L V E LK HP ASST I TA 295
Cdd:smart00150 1 QQFLRDADELE A W L EEKEQLLASE D LGK --- D LES V EALLKKHEA fe AE L EA HE ER V EA L NEL G EQ L I E EG HP DAEE I EE 77
90 100
....*....|....*....|....
gi 1591480471 296 QRDAVRNE W QKFLN L CICQETH L D 319
Cdd:smart00150 78 RLEELNER W EELKE L AEERRQK L E 101
SPEC
cd00176 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
218-352
7.75e-06
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Pssm-ID: 238103 [Multi-domain]
Cd Length: 213
Bit Score: 48.98
E-value: 7.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 218 YEYVQGCNKEL A F L GDEQGKIKKQ D WS D rmv D PPD V RRQYENFKN -- NS L LS HE SE V NK L QDE G DR L V E LK HP ASST I TA 295
Cdd:cd00176 3 QQFLRDADELE A W L SEKEELLSST D YG D --- D LES V EALLKKHEA le AE L AA HE ER V EA L NEL G EQ L I E EG HP DAEE I QE 79
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1591480471 296 QRDAVRNE W QKFLN L CICQETH L DNVEEFRKYQM D TEQ L SET L TKLNNS L DTKSV GK 352
Cdd:cd00176 80 RLEELNQR W EELRE L AEERRQR L EEALDLQQFFR D ADD L EQW L EEKEAA L ASEDL GK 136
PLEC
smart00250 Plectin repeat;
1825-1858
1.94e-05
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 43.24
E-value: 1.94e-05
10 20 30
....*....|....*....|....*....|....
gi 1591480471 1825 QRLLEAQ A A T GGIID ISNKERYT V HK A AT RGLID 1858
Cdd:smart00250 1 QRLLEAQ S A I GGIID PETGQKLS V EE A LR RGLID 34
CwlO1
COG3883 Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
651-865
1.14e-04
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain]
Cd Length: 379
Bit Score: 46.75
E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 651 IQA RSEDIQSQ Q KSVA AAQ DDVKK L SQN LE TTEQLCSS LQ Q syqeycp DIQRQRT E VKD LQ TRYTNVANQLK ER EIV L Q E 730
Cdd:COG3883 18 IQA KQKELSEL Q AELE AAQ AELDA L QAE LE ELNEEYNE LQ A ------- ELEALQA E IDK LQ AEIAEAEAEIE ER REE L G E 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 731 A A TKNQEFQSTC --------- K S LNS FLD N L GTNQITSSN D LSQVNAKQSSQERIMDDLKRKQDDVDRVSD L SQD L QDLL 801
Cdd:COG3883 91 R A RALYRSGGSV syldvllgs E S FSD FLD R L SALSKIADA D ADLLEELKADKAELEAKKAELEAKLAELEA L KAE L EAAK 170
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1591480471 802 NDY E TNIDKFNST L EDSG A TV A KKPHV L TLSD A VQKEEKNVVNRYTE A T A KNTQVQKQMGL A KN 865
Cdd:COG3883 171 AEL E AQQAEQEAL L AQLS A EE A AAEAQ L AELE A ELAAAEAAAAAAAA A A A AAAAAAAAAAA A AA 234
CCDC158
pfam15921 Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
469-1254
1.65e-04
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain]
Cd Length: 1112
Bit Score: 47.04
E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 469 L ADIR K R RAALA E S L K N H ksd ISRSQQSVPVSSAPLDPKVTALAQ Q LD QL DNDLV n AE E SM L SRL R AP L SRTDP A G dl A K 548
Cdd:pfam15921 129 M ADIR R R ESQSQ E D L R N Q --- LQNTVHELEAAKCLKEDMLEDSNT Q IE QL RKMML - SH E GV L QEI R SI L VDFEE A S -- G K 202
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 549 RLR E QE kaantlk ALEQQKLAAQ G DLQPLLSKDPSSTS S G L PLKLSAANNKYDS L AA ladly KKKANAS L N L ESQIKKVD 628
Cdd:pfam15921 203 KIY E HD ------- SMSTMHFRSL G SAISKILRELDTEI S Y L KGRIFPVEDQLEA L KS ----- ESQNKIE L L L QQHQDRIE 270
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 629 G L V S GF E KKLS ---- EDGPIPDRP N A IQ ARS E D IQ S Q QKSVAAAQ dd VKK LS QNLE T TE QL C S S L QQS --- Y QEYCPDIQ 701
Cdd:pfam15921 271 Q L I S EH E VEIT glte KASSARSQA N S IQ SQL E I IQ E Q ARNQNSMY -- MRQ LS DLES T VS QL R S E L REA krm Y EDKIEELE 348
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 702 R Q ----------- RTE VKDLQTRYT N VAN QL --------- K E R E IV L QEAAT K NQEFQS T CK S LN sf L D N L GTNQITSSN 761
Cdd:pfam15921 349 K Q lvlanseltea RTE RDQFSQESG N LDD QL qklladlhk R E K E LS L EKEQN K RLWDRD T GN S IT -- I D H L RRELDDRNM 426
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 762 DLSQVN A K -------- Q SSQ ER I M DDLKR K QDDVDR VS D L SQD L Q --- DL L NDYETNIDKFNS TLE D S GA TV AK kphvlt 830
Cdd:pfam15921 427 EVQRLE A L lkamksec Q GQM ER Q M AAIQG K NESLEK VS S L TAQ L E stk EM L RKVVEELTAKKM TLE S S ER TV SD ------ 500
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 831 L SDAV Q KE E KNVVNRYT E A T AKNTQ V QKQMGLAKN l L L N NEEKVQM V AQQQV AL ES Q QKSTFQIESL lkeleeerartth 910
Cdd:pfam15921 501 L TASL Q EK E RAIEATNA E I T KLRSR V DLKLQELQH - L K N EGDHLRN V QTECE AL KL Q MAEKDKVIEI ------------- 566
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 911 tetn LR TFKDR M MS L KSRR ---- G VERI E EKE vlhyyrdpk LE NDLA D LQNK L H E EALRRSTTQSEVEV L NKKITT LE -- 984
Cdd:pfam15921 567 ---- LR QQIEN M TQ L VGQH grta G AMQV E KAQ --------- LE KEIN D RRLE L Q E FKILKDKKDAKIRE L EARVSD LE le 633
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 985 - DT L K NA - TPK L VTREVTEF ERD p QL DVDAAKL R D E VTRIKDEIR V ------ RDG E QIQMK T E v TVLQ Q M K PPIK E RVVK 1056
Cdd:pfam15921 634 k VK L V NA g SER L RAVKDIKQ ERD - QL LNEVKTS R N E LNSLSEDYE V lkrnfr NKS E EMETT T N - KLKM Q L K SAQS E LEQT 711
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1057 KEVV K VEQ -- D PEMLRAVRT M DTE I SGENNKSKL L TDE I - F QTRSQI NA lerlip N IQPKIITK E VK K IE Q DPDLI - TE S 1132
Cdd:pfam15921 712 RNTL K SME gs D GHAMKVAMG M QKQ I TAKRGQIDA L QSK I q F LEEAMT NA ------ N KEKHFLKE E KN K LS Q ELSTV a TE K 785
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1133 K K IQTN LE EE R MENNS L SRE V MDLHS ------- RYRQV QD WKP R V E ------------- VKE IVNEI Y RIDPNTELEIM r 1192
Cdd:pfam15921 786 N K MAGE LE VL R SQERR L KEK V ANMEV aldkasl QFAEC QD IIQ R Q E qesvrlklqhtld VKE LQGPG Y TSNSSMKPRLL - 864
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1591480471 1193 lrkdi Q DS S KQ R SD S EREIT Q V TA DLNILR S E K PKV e LKE ---- V L REVVK E E RS PE NE REIQR L N 1254
Cdd:pfam15921 865 ----- Q PA S FT R TH S NVPSS Q S TA SFLSHH S R K TNA - LKE dptr D L KQLLQ E L RS VI NE EPTVQ L S 924
ClyA-like
cd21116 family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
644-821
1.92e-04
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).
Pssm-ID: 439149 [Multi-domain]
Cd Length: 224
Bit Score: 45.10
E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 644 I PDR PN AIQARSEDIQ S QQKSV A A A QDDVKKLSQNLET te Q L C S SLQQS ------ Y Q E Y C PD IQRQ rte VKD L QTRYTNV 717
Cdd:cd21116 18 I LNQ PN INLIPLDLLP S LNTHQ A L A RAHALEWLNEIKP -- K L L S LPNDI igynnt F Q S Y Y PD LIEL --- ADN L IKGDQGA 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 718 AN QL KEREIV LQ EAA TK N Q EF - Q S TCKS L NS F LDN L GTNQITSSN D LSQVN A KQSSQERIMDD L KRKQDDV D RVS D LSQD 796
Cdd:cd21116 93 KQ QL LQGLEA LQ SQV TK K Q TS v T S FINE L TT F KND L DDDSRNLQT D ATKAQ A QVAVLNALKNQ L NSLAEQI D AAI D ALEK 172
170 180
....*....|....*....|....*
gi 1591480471 797 L QDLLNDYETN I DKFNST LED SGAT 821
Cdd:cd21116 173 L SNDWQTLDSD I KELITD LED AESS 197
PLEC
smart00250 Plectin repeat;
1902-1934
2.09e-04
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 40.16
E-value: 2.09e-04
10 20 30
....*....|....*....|....*....|...
gi 1591480471 1902 R YM EAQ HHT GG LV DP K TG RR LS TLD A IGAKM ID 1934
Cdd:smart00250 2 R LL EAQ SAI GG II DP E TG QK LS VEE A LRRGL ID 34
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
1204-1497
2.74e-04
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 46.21
E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1204 R SD SE RE -- IT Q V tad L NILRS E KPKVE L K EV LR E VVK --------------- EE RSP E N E R E IQRLNDQLTQLHINYNS 1266
Cdd:PRK03918 142 E SD ES RE kv VR Q I --- L GLDDY E NAYKN L G EV IK E IKR rierlekfikrteni EE LIK E K E K E LEEVLREINEISSELPE 218
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1267 L E E QVRL L R KE RD E WKAERSK IE TK lvtrevikyeadplq EKE ADR L RRDV R DEAKLR R NI EE MVFD L QNKYIL LE RQ kp 1346
Cdd:PRK03918 219 L R E ELEK L E KE VK E LEELKEE IE EL --------------- EKE LES L EGSK R KLEEKI R EL EE RIEE L KKEIEE LE EK -- 281
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1347 eekvvvqe V VR L QKDPRQEV E HER L GRTLDDEVMTR R QL E LD L QQ L R ---------- TKV EEKE RI L R E SDERQ K KIQ ad 1416
Cdd:PRK03918 282 -------- V KE L KELKEKAE E YIK L SEFYEEYLDEL R EI E KR L SR L E eeingieeri KEL EEKE ER L E E LKKKL K ELE -- 351
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1417 SE L R E IRLCIVQL E T A PPPV EE SIVVEEV L KVERDP KLE RMISG L RLDMDKETND I LRLERD I RN L ta K L EI LQRE K SV E 1496
Cdd:PRK03918 352 KR L E E LEERHELY E E A KAKK EE LERLKKR L TGLTPE KLE KELEE L EKAKEEIEEE I SKITAR I GE L -- K K EI KELK K AI E 429
.
gi 1591480471 1497 K 1497
Cdd:PRK03918 430 E 430
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
915-1319
1.43e-03
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 43.90
E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 915 LRTF K DRMMS LK S R RGVERI E E - KEV L HYYRDP K L E ndlad LQNKLHEEAL R RSTTQS E VEV L N K K I TT L EDT l K NAT P k 993
Cdd:PRK03918 367 AKAK K EELER LK K R LTGLTP E K l EKE L EELEKA K E E ----- IEEEISKITA R IGELKK E IKE L K K A I EE L KKA - K GKC P - 439
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 994 LVT RE V TE FE R DPQ L dvda AKLRD E VT RI KD E IRVRDGEQIQMKT E VTV L Q qmkppikervvkkev VKVEQDP E MLRAVR 1073
Cdd:PRK03918 440 VCG RE L TE EH R KEL L ---- EEYTA E LK RI EK E LKEIEEKERKLRK E LRE L E --------------- KVLKKES E LIKLKE 500
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1074 TMDTEISG E NNKS K LLTD E IFQTRSQINA L ERLIPNIQPK I IT -- KE VK K I E qdp D L ITESKKIQTN L E E ERM E NNS L SR 1151
Cdd:PRK03918 501 LAEQLKEL E EKLK K YNLE E LEKKAEEYEK L KEKLIKLKGE I KS lk KE LE K L E --- E L KKKLAELEKK L D E LEE E LAE L LK 577
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1152 E VMD L H sr YRQ V QDWKP R V - E VKEIV NE I yridpnte LE IMRLR K DIQDSS K QRSDS E R E ITQVTAD L NILRSEK pkvel 1230
Cdd:PRK03918 578 E LEE L G -- FES V EELEE R L k E LEPFY NE Y -------- LE LKDAE K ELEREE K ELKKL E E E LDKAFEE L AETEKRL ----- 642
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1231 k E V LR EVVK E ERSPEN E R E IQR L NDQLTQ L HINYNS L EEQVRL L R K E R D E W K AERS K IETK L VT RE VI K Y E ADP L QEKEA 1310
Cdd:PRK03918 643 - E E LR KELE E LEKKYS E E E YEE L REEYLE L SRELAG L RAELEE L E K R R E E I K KTLE K LKEE L EE RE KA K K E LEK L EKALE 721
410
....*....|.
gi 1591480471 1311 D -- R LR RD V RD 1319
Cdd:PRK03918 722 R ve E LR EK V KK 732
Name
Accession
Description
Interval
E-value
SH3_10
pfam17902 SH3 domain; This entry represents an SH3 domain.
388-452
8.51e-23
SH3 domain; This entry represents an SH3 domain.
Pssm-ID: 407754
Cd Length: 65
Bit Score: 93.48
E-value: 8.51e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1591480471 388 PLK L RR TTTS RPI T V ES LCD WETDTGSLSR GE KF TL KS NS HN E N W DITSTN G AT K TF P A VCF Q IP 452
Cdd:pfam17902 1 PLK Q RR SPVT RPI P V KA LCD YKQGEVTVEK GE EC TL LD NS DR E K W KVQTSS G VE K LV P S VCF L IP 65
Plectin
pfam00681 Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
1827-1865
2.46e-11
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.
Pssm-ID: 459901
Cd Length: 39
Bit Score: 60.03
E-value: 2.46e-11
10 20 30
....*....|....*....|....*....|....*....
gi 1591480471 1827 LLEAQAATGGIID ISNK ER YT V HK A AT RGLID DSQL Q R L 1865
Cdd:pfam00681 1 LLEAQAATGGIID PVTG ER LS V EE A VK RGLID PETA Q K L 39
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1132-1538
1.25e-09
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 63.55
E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1132 SKKIQTNLE E E R MENNS L S RE VMDL h S RY RQVQDW K PRV E VK E IVN E IYRIDP --- NT E LEIMR L RKDIQDSSKQR S DS E 1208
Cdd:TIGR02169 186 IERLDLIID E K R QQLER L R RE REKA - E RY QALLKE K REY E GY E LLK E KEALER qke AI E RQLAS L EEELEKLTEEI S EL E 264
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1209 REITQVTAD L NI L ------ RS E KPKVEL KE VLR E VVK E ER S ----- P E N ERE IQRLNDQ L TQ L HINYNS L EEQVRL L RK E 1277
Cdd:TIGR02169 265 KRLEEIEQL L EE L nkkikd LG E EEQLRV KE KIG E LEA E IA S lersi A E K ERE LEDAEER L AK L EAEIDK L LAEIEE L ER E 344
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1278 RD E WKAE R S K IETKLVTR evikyeadplq EK E ADR LR RDVRDEA K LRRNIEEMVF D LQN K YIL L E R qkpeekvvvqevvr 1357
Cdd:TIGR02169 345 IE E ERKR R D K LTEEYAEL ----------- KE E LED LR AELEEVD K EFAETRDELK D YRE K LEK L K R -------------- 399
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1358 lqkdprqev E HER L G R T LD DEVMTRRQ L ELD L QQ L RTKVEEK E RILR E SD E RQKKIQA dselr EI R lcivqletapppve 1437
Cdd:TIGR02169 400 --------- E INE L K R E LD RLQEELQR L SEE L AD L NAAIAGI E AKIN E LE E EKEDKAL ----- EI K -------------- 451
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1438 esivveevlkverdp K L E RMISG L RL D MD K ETNDILR L ERDIRNLTAK L EI LQRE KS vektvykevvrvekdq AV EA ERD 1517
Cdd:TIGR02169 452 --------------- K Q E WKLEQ L AA D LS K YEQELYD L KEEYDRVEKE L SK LQRE LA ---------------- EA EA QAR 500
410 420
....*....|....*....|.
gi 1591480471 1518 RLR E Q V SQNKFARQD L EDE I R 1538
Cdd:TIGR02169 501 ASE E R V RGGRAVEEV L KAS I Q 521
Plectin
pfam00681 Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
1903-1941
6.88e-09
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.
Pssm-ID: 459901
Cd Length: 39
Bit Score: 53.10
E-value: 6.88e-09
10 20 30
....*....|....*....|....*....|....*....
gi 1591480471 1903 YM EAQ HH TGG LV DP K TG R RLS TLD A IGAKM ID STMMRE L 1941
Cdd:pfam00681 1 LL EAQ AA TGG II DP V TG E RLS VEE A VKRGL ID PETAQK L 39
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
548-1344
8.38e-09
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 60.84
E-value: 8.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 548 K R L RE Q EKA A NTL K A L EQQKLAAQGD L qpllskdpsstssg L P L K L SAANNKYDS L AALADLYKKKANA sln L ESQIKKV 627
Cdd:TIGR02168 203 K S L ER Q AEK A ERY K E L KAELRELELA L -------------- L V L R L EELREELEE L QEELKEAEEELEE --- L TAELQEL 265
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 628 DGLVSGFEKKL SE D gpi PDRPNAI Q AR ---- SED I QSQQKSVAAAQDDVKK L SQN LE TT E QLCSS L QQSYQ E YCPDIQRQ 703
Cdd:TIGR02168 266 EEKLEELRLEV SE L --- EEEIEEL Q KE lyal ANE I SRLEQQKQILRERLAN L ERQ LE EL E AQLEE L ESKLD E LAEELAEL 342
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 704 RTEVKD L QTRYTNVANQ L K E R E IV L Q E AATKNQ E FQSTCKS L N S FLDN L GTNQITSS N DLSQVN A KQSSQ E RIMDD L KRK 783
Cdd:TIGR02168 343 EEKLEE L KEELESLEAE L E E L E AE L E E LESRLE E LEEQLET L R S KVAQ L ELQIASLN N EIERLE A RLERL E DRRER L QQE 422
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 784 QDDVDRVSDLSQ -- D LQ DL L NDY E TNIDKFNST LE DSGATVAKKPHV L TLSDAVQKEEKNVVNRY - TEATAKNTQVQKQM 860
Cdd:TIGR02168 423 IEELLKKLEEAE lk E LQ AE L EEL E EELEELQEE LE RLEEALEELREE L EEAEQALDAAERELAQL q ARLDSLERLQENLE 502
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 861 G L --- A K N LL L N NE ---------- E KVQMVAQQQV A L E SQQKSTF Q IESLLKELEEER A RTTHTETN L -- R TF ------- 918
Cdd:TIGR02168 503 G F seg V K A LL K N QS glsgilgvls E LISVDEGYEA A I E AALGGRL Q AVVVENLNAAKK A IAFLKQNE L gr V TF lpldsik 582
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 919 ----- KDRMMS LK SRR G VERI eek EVLHYYR DPKL END L A ---------- DL Q N K L hee A L RRSTTQSEV evlnkk I T TL 983
Cdd:TIGR02168 583 gteiq GNDREI LK NIE G FLGV --- AKDLVKF DPKL RKA L S yllggvlvvd DL D N A L --- E L AKKLRPGYR ------ I V TL 650
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 984 EDT L KNA ---- T PKLVTREVTEF ER DPQL dvda AK L RDEVTRIKDE I RVRDGEQIQMKT E VTV L QQMKPPIKERVVKKEV 1059
Cdd:TIGR02168 651 DGD L VRP ggvi T GGSAKTNSSIL ER RREI ---- EE L EEKIEELEEK I AELEKALAELRK E LEE L EEELEQLRKELEELSR 726
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1060 VKVEQDPEML R AVR tmdt E ISGENNKSKL L TD E IFQTRSQ I NA LE RLIPNIQPKIITK E VKKI E QDPDL ites KKIQTN L 1139
Cdd:TIGR02168 727 QISALRKDLA R LEA ---- E VEQLEERIAQ L SK E LTELEAE I EE LE ERLEEAEEELAEA E AEIE E LEAQI ---- EQLKEE L 798
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1140 EEE R MENNS L SR E VMD L HSRYRQVQDWKPRV E v KE I VNEIY R ID p NT E LE I MR L RK DI QDSSKQRSDS E RE I TQVTAD L N 1219
Cdd:TIGR02168 799 KAL R EALDE L RA E LTL L NEEAANLRERLESL E - RR I AATER R LE - DL E EQ I EE L SE DI ESLAAEIEEL E EL I EELESE L E 876
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1220 I L RS E KPKV elkevlrevvkeerspen E REIQR L NDQ L TQ L HINYNS LE EQVRL LR K E RD E WKAERSKI E TK L vtr E VIK 1299
Cdd:TIGR02168 877 A L LN E RASL ------------------ E EALAL L RSE L EE L SEELRE LE SKRSE LR R E LE E LREKLAQL E LR L --- E GLE 935
810 820 830 840
....*....|....*....|....*....|....*....|....*
gi 1591480471 1300 YEA D P LQE KEADRLRRDVRDEAK L RRN IE EMVFDLQNKYIL LE RQ 1344
Cdd:TIGR02168 936 VRI D N LQE RLSEEYSLTLEEAEA L ENK IE DDEEEARRRLKR LE NK 980
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1189-1430
1.17e-08
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 60.46
E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1189 E IMR L RKDIQDSSKQRSDSER E ITQVTAD L NI LR S E KPKV E ----- L KEV L REVVK E ER sp EN E REI Q R L NDQ L TQ L HIN 1263
Cdd:TIGR02168 240 E LEE L QEELKEAEEELEELTA E LQELEEK L EE LR L E VSEL E eeiee L QKE L YALAN E IS -- RL E QQK Q I L RER L AN L ERQ 317
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1264 YNS LE E Q VRL L RKER DE WKA E RSKI E T KL vtr E VI K Y E AD p LQ E K E ADR L RRDVRDEAKLRRNI EE MVFD L QN K YIL LE R 1343
Cdd:TIGR02168 318 LEE LE A Q LEE L ESKL DE LAE E LAEL E E KL --- E EL K E E LE - SL E A E LEE L EAELEELESRLEEL EE QLET L RS K VAQ LE L 393
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1344 Q KPEEKVVVQEVVRLQK dp R Q E VEH ERL GRTLDDE vm TRRQL E LD L QQ L RTKV EE K E RI L R E SD E R ----- QKKIQADS E 1418
Cdd:TIGR02168 394 Q IASLNNEIERLEARLE -- R L E DRR ERL QQEIEEL -- LKKLE E AE L KE L QAEL EE L E EE L E E LQ E E lerle EALEELRE E 469
250
....*....|..
gi 1591480471 1419 L R E IRLCIVQL E 1430
Cdd:TIGR02168 470 L E E AEQALDAA E 481
PLEC
smart00250 Plectin repeat;
1863-1900
1.22e-08
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 52.48
E-value: 1.22e-08
10 20 30
....*....|....*....|....*....|....*...
gi 1591480471 1863 QRLL N AQ K A FA G VE DP V T KER LSV G EA IQK G WMPKD T A 1900
Cdd:smart00250 1 QRLL E AQ S A IG G II DP E T GQK LSV E EA LRR G LIDPE T G 38
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1187-1544
2.76e-08
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 59.30
E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1187 E LE I MR L RKD I QDSS K QRSDSER E ITQVTAD L NI LR S E KPKVELKEVLREVVKEER spen E R E IQR L NDQLT QL HINYNS 1266
Cdd:TIGR02168 683 E EK I EE L EEK I AELE K ALAELRK E LEELEEE L EQ LR K E LEELSRQISALRKDLARL ---- E A E VEQ L EERIA QL SKELTE 758
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1267 LE EQVRL L RKERD E WKA E RSKI E TKLVTR E -- VIKYEADPLQEK EA - D R LR RDVRDEAKLRR N IE E MVFD L QNKYILL ER 1343
Cdd:TIGR02168 759 LE AEIEE L EERLE E AEE E LAEA E AEIEEL E aq IEQLKEELKALR EA l D E LR AELTLLNEEAA N LR E RLES L ERRIAAT ER 838
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1344 QKPEEKVVVQ E VVRLQKDPRQ E V E H ----- E R L GRT L DDEVMT R RQ LE LD L QQ LR TKV EE KERI LRE SDERQKKIQA ds E 1418
Cdd:TIGR02168 839 RLEDLEEQIE E LSEDIESLAA E I E E leeli E E L ESE L EALLNE R AS LE EA L AL LR SEL EE LSEE LRE LESKRSELRR -- E 916
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1419 L R E I R LCIV QLE TA pppveesivv E E V L K V ER D PKL ER MISGLR L DMD ------- K ETN D ILRLE R DIRN L TA K LEI L QR 1491
Cdd:TIGR02168 917 L E E L R EKLA QLE LR ---------- L E G L E V RI D NLQ ER LSEEYS L TLE eaealen K IED D EEEAR R RLKR L EN K IKE L GP 986
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1591480471 1492 eks V EKTVYK E V vrvekd QAVEAER D R L RE Q VSQNKF A RQD LE DE I RRLNDKI 1544
Cdd:TIGR02168 987 --- V NLAAIE E Y ------ EELKERY D F L TA Q KEDLTE A KET LE EA I EEIDREA 1030
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1187-1658
7.26e-08
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 58.02
E-value: 7.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1187 E L E IMR L RKDIQDSSKQRSDS E R E ITQVT A DLNI L RS E KPKV E L kevl REVVK EER SP E N E REIQR L NDQ L TQ L HINYNS 1266
Cdd:COG1196 259 E A E LAE L EAELEELRLELEEL E L E LEEAQ A EEYE L LA E LARL E Q ---- DIARL EER RR E L E ERLEE L EEE L AE L EEELEE 334
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1267 LEE QVRL L RK E RD E WKA E RSKI E TK L VTR E VIKY EA DPLQEKEADR L RRDVRDEAKLR R NIE E MVFD L QNKYILL E RQKP 1346
Cdd:COG1196 335 LEE ELEE L EE E LE E AEE E LEEA E AE L AEA E EALL EA EAELAEAEEE L EELAEELLEAL R AAA E LAAQ L EELEEAE E ALLE 414
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1347 EEKVVVQ E VVR L QKDPRQ - E V E H E RLGRT L DDEVMTRRQ LE LDLQQ L RTKVE E KERILRESDERQKKIQADSELREI RL c 1425
Cdd:COG1196 415 RLERLEE E LEE L EEALAE l E E E E E EEEEA L EEAAEEEAE LE EEEEA L LELLA E LLEEAALLEAALAELLEELAEAAA RL - 493
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1426 IVQ LE TAPPPVEESIV V EEV L KVERDPK L ERMISG L RLDMDKETNDI ------ LRLERDIRNLTAKLEILQRE K SVEKT v 1499
Cdd:COG1196 494 LLL LE AEADYEGFLEG V KAA L LLAGLRG L AGAVAV L IGVEAAYEAAL eaalaa ALQNIVVEDDEVAAAAIEYL K AAKAG - 572
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1500 ykevv R VEKDQAVEAERDRLREQVSQ n KF A RQDLE D EIRRLNDKINLLSSTKSS T SREE T TLTLNKDSLQ R EKDN L TREF 1579
Cdd:COG1196 573 ----- R ATFLPLDKIRARAALAAALA - RG A IGAAV D LVASDLREADARYYVLGD T LLGR T LVAARLEAAL R RAVT L AGRL 646
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1591480471 1580 R TLEARRHDIGLSFQQQSRLMS E RTQMSRQKSIKM E SDVH RL ERDI L DEKDKIHLRDSTI REL LLNLQKEESA E TRTKE 1658
Cdd:COG1196 647 R EVTLEGEGGSAGGSLTGGSRR E LLAALLEAEAEL E ELAE RL AEEE L ELEEALLAEEEEE REL AEAEEERLEE E LEEEA 725
CCDC158
pfam15921 Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
910-1658
4.20e-07
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain]
Cd Length: 1112
Bit Score: 55.51
E-value: 4.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 910 H T E TN L RTFKDRMMS L K srrgv E R IE E KEV LH YYRDPK L ENDLA DLQ N KL H E EALR R STT qse VEVLNKKITTL ED t L K N 989
Cdd:pfam15921 75 H I E RV L EEYSHQVKD L Q ----- R R LN E SNE LH EKQKFY L RQSVI DLQ T KL Q E MQME R DAM --- ADIRRRESQSQ ED - L R N 145
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 990 A tpkl VTRE V T E F E RDPQ L DV D A ak L R D EV T R I k DEI R V rdgeqi Q M KTEVT VLQ QMKPPIKERVVKKEVVKV E Q D ---- 1065
Cdd:pfam15921 146 Q ---- LQNT V H E L E AAKC L KE D M -- L E D SN T Q I - EQL R K ------ M M LSHEG VLQ EIRSILVDFEEASGKKIY E H D smst 212
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1066 ------- PEMLRAV R TM DTEIS gennksk L L TDE IF QTRS Q IN AL ERLIP N IQPKIITKEVKK IEQ dpd LI T E SKKIQ T N 1138
Cdd:pfam15921 213 mhfrslg SAISKIL R EL DTEIS ------- Y L KGR IF PVED Q LE AL KSESQ N KIELLLQQHQDR IEQ --- LI S E HEVEI T G 282
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1139 L E E E ---- R MEN NS LSR -- E VMDLHS R YRQVQDWKPRVEVKEI V NEI yridp NT EL - E IM R LRK D - I QDSS KQ RSDSER E 1210
Cdd:pfam15921 283 L T E K assa R SQA NS IQS ql E IIQEQA R NQNSMYMRQLSDLEST V SQL ----- RS EL r E AK R MYE D k I EELE KQ LVLANS E 357
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1211 I T QVTADLNILRS E KPKV -- E L KEV L REVV K E E RSPEN E R E I - Q RL N D QL T QLH I NYNS leeqvrl LR K E R D EWKA E RSK 1287
Cdd:pfam15921 358 L T EARTERDQFSQ E SGNL dd Q L QKL L ADLH K R E KELSL E K E Q n K RL W D RD T GNS I TIDH ------- LR R E L D DRNM E VQR 430
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1288 I E TK L vtr EVI K Y E ADPLQ E KEA ------- DR L RRDVRDE A K L RRNI E --- EM V FD L QN K YIL LE RQK pee KV V VQEVVR 1357
Cdd:pfam15921 431 L E AL L --- KAM K S E CQGQM E RQM aaiqgkn ES L EKVSSLT A Q L ESTK E mlr KV V EE L TA K KMT LE SSE --- RT V SDLTAS 504
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1358 LQ kdprqev E H ER LGRTLDD E VMT - R RQLE L D LQ Q L RTKVE E KERILRESD E RQK - K I Q ADSELRE I RLCIV Q L E TAPPP 1435
Cdd:pfam15921 505 LQ ------- E K ER AIEATNA E ITK l R SRVD L K LQ E L QHLKN E GDHLRNVQT E CEA l K L Q MAEKDKV I EILRQ Q I E NMTQL 577
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1436 V EESIVVEEVLK VE R d PK LE RM I SGL RL DM dk ETND IL RLER D -- IR N L T A KLEI L QR EK SVEKTVYK E VV R VE KD qa VE 1513
Cdd:pfam15921 578 V GQHGRTAGAMQ VE K - AQ LE KE I NDR RL EL -- QEFK IL KDKK D ak IR E L E A RVSD L EL EK VKLVNAGS E RL R AV KD -- IK 652
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1514 A ERD R L REQ V SQNKFARQD L EDEIRR L NDKINLL S stksstsr EE TTL T L NK ----- D S L Q R E KDNLTREFRTL E - ARR H 1587
Cdd:pfam15921 653 Q ERD Q L LNE V KTSRNELNS L SEDYEV L KRNFRNK S -------- EE MET T T NK lkmql K S A Q S E LEQTRNTLKSM E g SDG H 724
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1588 DIGLSFQQ Q SRLMSE R T Q M - SR Q KS I KM ---- ESDVHRLERDILD EK D K IHLRD ST I ---- RELLLN L QKEE S A E T R T KE 1658
Cdd:pfam15921 725 AMKVAMGM Q KQITAK R G Q I d AL Q SK I QF leea MTNANKEKHFLKE EK N K LSQEL ST V atek NKMAGE L EVLR S Q E R R L KE 804
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1247-1587
7.06e-07
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 54.56
E-value: 7.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1247 E REIQ RL N D Q L TQ L HINYNS LE E Q VRL ------ L RK E RD E WK AE RSKIETKLVTR E VIKY EA D pl Q E KEADR L RRDVRDE 1320
Cdd:COG1196 185 E ENLE RL E D I L GE L ERQLEP LE R Q AEK aeryre L KE E LK E LE AE LLLLKLRELEA E LEEL EA E -- L E ELEAE L EELEAEL 262
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1321 A K L RRNI EE MVFD L QNKYIL LE RQKP EE KVVVQ E VV RL QK D pr QEVEH ER LGRT lddevm TR R QL EL DLQQLRTKV E EK E 1400
Cdd:COG1196 263 A E L EAEL EE LRLE L EELELE LE EAQA EE YELLA E LA RL EQ D -- IARLE ER RREL ------ EE R LE EL EEELAELEE E LE E 334
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1401 RILRESDERQKKIQ A DS EL R E IRLCIVQL E tapppveesivveevlkv E RDPKL E RMISGLRLDMDKETNDI L RLE R DIR 1480
Cdd:COG1196 335 LEEELEELEEELEE A EE EL E E AEAELAEA E ------------------ E ALLEA E AELAEAEEELEELAEEL L EAL R AAA 396
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1481 N L T A K LE I L QRE ksvektvyk E VVRV E KDQAV E A E RDR L R E QVSQNKFARQDL E DEIRRLNDKINL L SSTKSSTSREETT 1560
Cdd:COG1196 397 E L A A Q LE E L EEA --------- E EALL E RLERL E E E LEE L E E ALAELEEEEEEE E EALEEAAEEEAE L EEEEEALLELLAE 467
330 340
....*....|....*....|....*..
gi 1591480471 1561 L TLNKDS L QREKDN L TR E FRTLE AR RH 1587
Cdd:COG1196 468 L LEEAAL L EAALAE L LE E LAEAA AR LL 494
SPEC
smart00150 Spectrin repeats;
218-319
1.54e-06
Spectrin repeats;
Pssm-ID: 197544 [Multi-domain]
Cd Length: 101
Bit Score: 48.48
E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 218 YEYVQGCNKEL A F L GDEQGKIKKQ D WSD rmv D PPD V RRQYENFKN -- NS L LS HE SE V NK L QDE G DR L V E LK HP ASST I TA 295
Cdd:smart00150 1 QQFLRDADELE A W L EEKEQLLASE D LGK --- D LES V EALLKKHEA fe AE L EA HE ER V EA L NEL G EQ L I E EG HP DAEE I EE 77
90 100
....*....|....*....|....
gi 1591480471 296 QRDAVRNE W QKFLN L CICQETH L D 319
Cdd:smart00150 78 RLEELNER W EELKE L AEERRQK L E 101
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1224-1588
5.94e-06
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 51.61
E-value: 5.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1224 EK PKV EL K EV lrevvk EE RSPENERE I QRLND QL TQ L HINYNSL E EQVR LL RKE R D ewkaersk I E TKLVTR E VIKY E AD 1303
Cdd:TIGR02169 173 EK ALE EL E EV ------ EE NIERLDLI I DEKRQ QL ER L RREREKA E RYQA LL KEK R E -------- Y E GYELLK E KEAL E RQ 238
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1304 PLQ - E KEADR L RRDV rde A KL RRN I E E MVFD L QNKYI LLE rqkpeekvvvqe VVRLQKDPRQ E V E HE R LGRTL ddevmtr 1382
Cdd:TIGR02169 239 KEA i E RQLAS L EEEL --- E KL TEE I S E LEKR L EEIEQ LLE ------------ ELNKKIKDLG E E E QL R VKEKI ------- 296
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1383 RQ LE LDLQQ L RTKVE EKER I L RESD ER QK K iq ADS E LREIRLC I VQ LE TA pppveesivv E E VLKVE RD PKL E RMIS glr 1462
Cdd:TIGR02169 297 GE LE AEIAS L ERSIA EKER E L EDAE ER LA K -- LEA E IDKLLAE I EE LE RE ---------- I E EERKR RD KLT E EYAE --- 361
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1463 ldm D KE TNDI LR L --- E R D IRNLTAKL E ILQREKSV EK TV ykevvrv EKDQAVEA E R DRL R E QVSQNKFARQ DL EDE I RR 1539
Cdd:TIGR02169 362 --- L KE ELED LR A ele E V D KEFAETRD E LKDYREKL EK LK ------- REINELKR E L DRL Q E ELQRLSEELA DL NAA I AG 431
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1591480471 1540 LND KIN L L SST K SSTSR E ETTLTLN ------- KDSLQR E KDN L TR E FRTL E ARRHD 1588
Cdd:TIGR02169 432 IEA KIN E L EEE K EDKAL E IKKQEWK leqlaad LSKYEQ E LYD L KE E YDRV E KELSK 487
SPEC
cd00176 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
218-352
7.75e-06
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Pssm-ID: 238103 [Multi-domain]
Cd Length: 213
Bit Score: 48.98
E-value: 7.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 218 YEYVQGCNKEL A F L GDEQGKIKKQ D WS D rmv D PPD V RRQYENFKN -- NS L LS HE SE V NK L QDE G DR L V E LK HP ASST I TA 295
Cdd:cd00176 3 QQFLRDADELE A W L SEKEELLSST D YG D --- D LES V EALLKKHEA le AE L AA HE ER V EA L NEL G EQ L I E EG HP DAEE I QE 79
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1591480471 296 QRDAVRNE W QKFLN L CICQETH L DNVEEFRKYQM D TEQ L SET L TKLNNS L DTKSV GK 352
Cdd:cd00176 80 RLEELNQR W EELRE L AEERRQR L EEALDLQQFFR D ADD L EQW L EEKEAA L ASEDL GK 136
PLEC
smart00250 Plectin repeat;
1825-1858
1.94e-05
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 43.24
E-value: 1.94e-05
10 20 30
....*....|....*....|....*....|....
gi 1591480471 1825 QRLLEAQ A A T GGIID ISNKERYT V HK A AT RGLID 1858
Cdd:smart00250 1 QRLLEAQ S A I GGIID PETGQKLS V EE A LR RGLID 34
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1067-1329
2.20e-05
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 49.68
E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1067 E MLRAVRTMDTE I SGENNKSKL L TD E IFQTRSQINA LE RLIPNIQPK I itk E VK K I E QD p D L ITESKKIQTN L EEERMEN 1146
Cdd:TIGR02169 706 E LSQELSDASRK I GEIEKEIEQ L EQ E EEKLKERLEE LE EDLSSLEQE I --- E NV K S E LK - E L EARIEELEED L HKLEEAL 781
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1147 N S L sr E VMDL HSR YRQV Q DW ----- KPRVEVKEIVN EI YRIDPNTE LE IMR L R K D IQ DSSK QR S D SERE I TQVTADLNI L 1221
Cdd:TIGR02169 782 N D L -- E ARLS HSR IPEI Q AE lskle EEVSRIEARLR EI EQKLNRLT LE KEY L E K E IQ ELQE QR I D LKEQ I KSIEKEIEN L 859
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1222 RSE K P kv EL K E V L R E VVKEE R SP E NE ----- R E IQR L ND QL TQ L HINYNS LE E Q VRLL RK ERD E W KA ERSKI E TK L VT re 1296
Cdd:TIGR02169 860 NGK K E -- EL E E E L E E LEAAL R DL E SR lgdlk K E RDE L EA QL RE L ERKIEE LE A Q IEKK RK RLS E L KA KLEAL E EE L SE -- 935
250 260 270
....*....|....*....|....*....|...
gi 1591480471 1297 vik Y E ADPLQEK E ADRLRRDVR D EAKLRRNI EE 1329
Cdd:TIGR02169 936 --- I E DPKGEDE E IPEEELSLE D VQAELQRV EE 965
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1189-1525
2.93e-05
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 49.30
E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1189 E IM R LRKDIQDS S KQR SD SE R E I TQVTADLNI L -- RS EK P K VE L K E VLREVVKE E RSP EN ER -------- E I QR L NDQ L T 1258
Cdd:TIGR02169 696 E LR R IENRLDEL S QEL SD AS R K I GEIEKEIEQ L eq EE EK L K ER L E E LEEDLSSL E QEI EN VK selkelea R I EE L EED L H 775
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1259 Q L HINY N S LE ----- EQVRLLRK E RDEWKA E R S K IE tk LVT RE V ikyeadplq E KEAD RL RRDVRDEA K LRRNIE E MVF D 1333
Cdd:TIGR02169 776 K L EEAL N D LE arlsh SRIPEIQA E LSKLEE E V S R IE -- ARL RE I --------- E QKLN RL TLEKEYLE K EIQELQ E QRI D 844
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1334 L Q nkyill E RQ K PE EK VVVQEVVRLQKDPRQEV E H E RLG R T L DDE vmtrrqleld L QQ L RTKVE E K E RI LRE SDERQKKI 1413
Cdd:TIGR02169 845 L K ------ E QI K SI EK EIENLNGKKEELEEELE E L E AAL R D L ESR ---------- L GD L KKERD E L E AQ LRE LERKIEEL 908
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1414 Q A DS E LREI RL ci VQ L ETA pppve ESIVV EE VLKV E RDPKLERM I SGLR L DMDKETNDIL R L E RD IR N L - TAKLEIL Q RE 1492
Cdd:TIGR02169 909 E A QI E KKRK RL -- SE L KAK ----- LEALE EE LSEI E DPKGEDEE I PEEE L SLEDVQAELQ R V E EE IR A L e PVNMLAI Q EY 981
330 340 350
....*....|....*....|....*....|...
gi 1591480471 1493 KS V E K T v YK E V vr V EK DQAV E A ER DRLR E QVSQ 1525
Cdd:TIGR02169 982 EE V L K R - LD E L -- K EK RAKL E E ER KAIL E RIEE 1011
SPEC
cd00176 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
143-320
3.05e-05
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Pssm-ID: 238103 [Multi-domain]
Cd Length: 213
Bit Score: 47.06
E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 143 N EK QKQVNVEE YG PT L ADL E KQ L AA H NI L HK E IE A YNS ---------- QL CVSSAGSK E N ---- YTA L KKQYNN L LDNSK 208
Cdd:cd00176 17 S EK EELLSSTD YG DD L ESV E AL L KK H EA L EA E LA A HEE rvealnelge QL IEEGHPDA E E iqer LEE L NQRWEE L RELAE 96
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 209 W RR HY L NSVYEYV Q GCNKELAFLGDEQG K IKKQDWS D RMV D PPD V RRQYENF K -- NNS L LS HE SEVNK L QDEGDR L V E LK 286
Cdd:cd00176 97 E RR QR L EEALDLQ Q FFRDADDLEQWLEE K EAALASE D LGK D LES V EELLKKH K el EEE L EA HE PRLKS L NELAEE L L E EG 176
170 180 190
....*....|....*....|....*....|....*
gi 1591480471 287 HP ASS - T I TAQRDAVRNE W QKF L N L CICQETH L DN 320
Cdd:cd00176 177 HP DAD e E I EEKLEELNER W EEL L E L AEERQKK L EE 211
SMC_N
pfam02463 RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
671-1505
3.97e-05
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain]
Cd Length: 1161
Bit Score: 48.81
E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 671 DV KK LSQNLETT E QLCSSLQQSY q EYCPDIQRQRTEVKDLQTRYTNVANQL K EREIVLQEAATKNQ efqstc K SLNSFL D 750
Cdd:pfam02463 168 KR KK KEALKKLI E ETENLAELII - DLEELKLQELKLKEQAKKALEYYQLKE K LELEEEYLLYLDYL ------ K LNEERI D 240
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 751 N L GTNQITSSNDLSQVNAKQSSQ E RIMDDLKRKQDDVDRVSD L SQDLQD LL ndy ETNIDKFN S T L EDSGATVAKKPHV L T 830
Cdd:pfam02463 241 L L QELLRDEQEEIESSKQEIEKE E EKLAQVLKENKEEEKEKK L QEEELK LL --- AKEEEELK S E L LKLERRKVDDEEK L K 317
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 831 L S DA - VQ K E EK NVVNRYT E ATAK ntqv Q K QMGLAKNLLLNN EE KVQMVAQQ Q VA LE SQQK --- STFQI ES LLKELEEERA 906
Cdd:pfam02463 318 E S EK e KK K A EK ELKKEKE E IEEL ---- E K ELKELEIKREAE EE EEEELEKL Q EK LE QLEE ell AKKKL ES ERLSSAAKLK 393
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 907 RTTHTETN ------------ L R TFK D RMMSL K SRRGVERI EE K E VLHYYRDPKL E NDLADLQNK L HEEALRRSTTQ SE VE 974
Cdd:pfam02463 394 EEELELKS eeekeaqlllel A R QLE D LLKEE K KEELEILE EE E E SIELKQGKLT E EKEELEKQE L KLLKDELELKK SE DL 473
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 975 VLNKKITT L E -- DT L KNATP KL VT R EVT E FERDPQ L D V DA A KLR D E V TRIKDEIRV R ------- DGEQIQMKTEVTVLQQ 1045
Cdd:pfam02463 474 LKETQLVK L Q eq LE L LLSRQ KL EE R SQK E SKARSG L K V LL A LIK D G V GGRIISAHG R lgdlgva VENYKVAISTAVIVEV 553
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1046 MKPPIKERVVK K E V VKVEQD P EML R AV R TMDTEI sg ENNKSKLLTD EI FQTRSQINALERLIPNIQPKIIT K E V KK I EQ D 1125
Cdd:pfam02463 554 SATADEVEERQ K L V RALTEL P LGA R KL R LLIPKL -- KLPLKSIAVL EI DPILNLAQLDKATLEADEDDKRA K V V EG I LK D 631
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1126 PD L ITESKKIQTN l E EERMENN SL SREVMDLHSRYRQVQDWKPRVEVKEIVN E IYRIDPNT E LEIM R LRKDIQDSSKQRS 1205
Cdd:pfam02463 632 TE L TKLKESAKAK - E SGLRKGV SL EEGLAEKSEVKASLSELTKELLEIQELQ E KAESELAK E EILR R QLEIKKKEQREKE 710
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1206 DSEREITQVTAD L NILRS E KPKV -- E LKEV L REVVK EE RSP E NEREIQRLNDQLTQLHINYNSL E EQVRLLRK E RDEW -- 1281
Cdd:pfam02463 711 ELKKLKLEAEEL L ADRVQ E AQDK in E ELKL L KQKID EE EEE E EKSRLKKEEKEEEKSELSLKEK E LAEEREKT E KLKV ee 790
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1282 --- KAERSKI E TKLVTR E VI K Y EA DP L Q E KEADRLRRDVRD E AK L RRNIE E MVFDLQNKYILL E RQKPE E KVVVQ E VVRL 1358
Cdd:pfam02463 791 eke EKLKAQE E ELRALE E EL K E EA EL L E E EQLLIEQEEKIK E EE L EELAL E LKEEQKLEKLAE E ELERL E EEITK E ELLQ 870
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1359 QKDPRQ E VEH E RLGRT ----- LDD E VMTRRQ LE LDL Q Q L RTKV E EKER I - L R ESD E RQKKIQADS E LR E IR L CIVQLETA 1432
Cdd:pfam02463 871 ELLLKE E ELE E QKLKD elesk EEK E KEEKKE LE EES Q K L NLLE E KENE I e E R IKE E AEILLKYEE E PE E LL L EEADEKEK 950
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1591480471 1433 PPPVE E SIVVEEVLKVERDPK L ERMISGLRLDMDKETNDILRL E RDIRN L TAKLEI L Q R EKSV E KTVYKEVVR 1505
Cdd:pfam02463 951 EENNK E EEEERNKRLLLAKEE L GKVNLMAIEEFEEKEERYNKD E LEKER L EEEKKK L I R AIIE E TCQRLKEFL 1023
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1092-1345
7.34e-05
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 48.14
E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1092 EIFQTRS Q INA LE RLIPNIQPK I -- IT K EVKK IEQ DPDLIT --------- E SKKIQTNLE E ERM E NN SL S R EVMDLHSRY 1160
Cdd:TIGR02169 238 QKEAIER Q LAS LE EELEKLTEE I se LE K RLEE IEQ LLEELN kkikdlgee E QLRVKEKIG E LEA E IA SL E R SIAEKEREL 317
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1161 RQVQ dwkprvev KEIVNEIYR ID p NTEL EI MR L RKD I QDSS K Q R SDSER E ITQVTAD L NI LR S E --------- KPKV ELK 1231
Cdd:TIGR02169 318 EDAE -------- ERLAKLEAE ID - KLLA EI EE L ERE I EEER K R R DKLTE E YAELKEE L ED LR A E leevdkefa ETRD ELK 388
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1232 EVLREV -- V K E E RS p E NE RE IQ RL NDQ L TQ L HINYNS L EEQVRLLRKERD E WKA E RSKIETKLVTR E vik YEADP L QEKE 1309
Cdd:TIGR02169 389 DYREKL ek L K R E IN - E LK RE LD RL QEE L QR L SEELAD L NAAIAGIEAKIN E LEE E KEDKALEIKKQ E --- WKLEQ L AADL 464
250 260 270
....*....|....*....|....*....|....*.
gi 1591480471 1310 ADRLRRDVRDEAKLR R n I E EMVFD LQ NKYILL E R Q K 1345
Cdd:TIGR02169 465 SKYEQELYDLKEEYD R - V E KELSK LQ RELAEA E A Q A 499
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1007-1545
9.18e-05
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 47.62
E-value: 9.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1007 Q L DVDAAK L RD E VTRIKD E IRVRDG E QIQMKT E VTV L QQ mkppik E RVVKKEVVKVE Q DP E ML -- RAVRTMDTE I SGENN 1084
Cdd:COG1196 236 E L EAELEE L EA E LEELEA E LEELEA E LAELEA E LEE L RL ------ E LEELELELEEA Q AE E YE ll AELARLEQD I ARLEE 309
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1085 KSKL L TDEIFQTRSQINA LE RLIPNIQPKIITK E VKKI E QDPD L ITESKKIQTNL E EERMENNS L SREVMD L HSRYRQVQ 1164
Cdd:COG1196 310 RRRE L EERLEELEEELAE LE EELEELEEELEEL E EELE E AEEE L EEAEAELAEAE E ALLEAEAE L AEAEEE L EELAEELL 389
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1165 D wk PRVEVK E IVNEIYRID p NT E LEIMRLRKDIQDSSKQRSDSER E ITQVTADLNILRS E KPKV E LKEVLR E VVKE E RSP 1244
Cdd:COG1196 390 E -- ALRAAA E LAAQLEELE - EA E EALLERLERLEEELEELEEALA E LEEEEEEEEEALE E AAEE E AELEEE E EALL E LLA 466
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1245 E NER E IQR L NDQ L TQ L HINYNSLEEQVR LL RKERDE ------- W KA ERSKIETKLVTRE V I ------- K YEA DPLQEKE A 1310
Cdd:COG1196 467 E LLE E AAL L EAA L AE L LEELAEAAARLL LL LEAEAD yegfleg V KA ALLLAGLRGLAGA V A vligvea A YEA ALEAALA A 546
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1311 DRLRRD V R D EAKLRRN IE emv FDLQN K Y ----- IL L ERQKPEEKVVVQEVVRLQKDPRQE V EHE --------- R LG R TL D 1376
Cdd:COG1196 547 ALQNIV V E D DEVAAAA IE --- YLKAA K A gratf LP L DKIRARAALAAALARGAIGAAVDL V ASD lreadaryy V LG D TL L 623
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1377 DEVMTRRQ LE LD L QQLR T KVEEKERILR E SD --------- ERQKKIQADSE L REIRLCIVQL E TA ppp V EE SIVV EE V L K 1447
Cdd:COG1196 624 GRTLVAAR LE AA L RRAV T LAGRLREVTL E GE ggsaggslt GGSRRELLAAL L EAEAELEELA E RL --- A EE ELEL EE A L L 700
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1448 V E RDPKL E RMISGLRLDMDKETNDI L RLERDIRNLTAKL E I L QR E KSV E KTVYK E VVRVEKDQAV E A E RD RL REQ ----- 1522
Cdd:COG1196 701 A E EEEER E LAEAEEERLEEELEEEA L EEQLEAEREELLE E L L EE E ELL E EEALE E LPEPPDLEEL E R E LE RL ERE iealg 780
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 1591480471 1523 -------------------- VS Q nkfa R Q DLE DEIRR L NDK I N 1545
Cdd:COG1196 781 pvnllaieeyeeleerydfl SE Q ---- R E DLE EARET L EEA I E 819
CwlO1
COG3883 Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
651-865
1.14e-04
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain]
Cd Length: 379
Bit Score: 46.75
E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 651 IQA RSEDIQSQ Q KSVA AAQ DDVKK L SQN LE TTEQLCSS LQ Q syqeycp DIQRQRT E VKD LQ TRYTNVANQLK ER EIV L Q E 730
Cdd:COG3883 18 IQA KQKELSEL Q AELE AAQ AELDA L QAE LE ELNEEYNE LQ A ------- ELEALQA E IDK LQ AEIAEAEAEIE ER REE L G E 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 731 A A TKNQEFQSTC --------- K S LNS FLD N L GTNQITSSN D LSQVNAKQSSQERIMDDLKRKQDDVDRVSD L SQD L QDLL 801
Cdd:COG3883 91 R A RALYRSGGSV syldvllgs E S FSD FLD R L SALSKIADA D ADLLEELKADKAELEAKKAELEAKLAELEA L KAE L EAAK 170
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1591480471 802 NDY E TNIDKFNST L EDSG A TV A KKPHV L TLSD A VQKEEKNVVNRYTE A T A KNTQVQKQMGL A KN 865
Cdd:COG3883 171 AEL E AQQAEQEAL L AQLS A EE A AAEAQ L AELE A ELAAAEAAAAAAAA A A A AAAAAAAAAAA A AA 234
CCDC158
pfam15921 Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
469-1254
1.65e-04
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain]
Cd Length: 1112
Bit Score: 47.04
E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 469 L ADIR K R RAALA E S L K N H ksd ISRSQQSVPVSSAPLDPKVTALAQ Q LD QL DNDLV n AE E SM L SRL R AP L SRTDP A G dl A K 548
Cdd:pfam15921 129 M ADIR R R ESQSQ E D L R N Q --- LQNTVHELEAAKCLKEDMLEDSNT Q IE QL RKMML - SH E GV L QEI R SI L VDFEE A S -- G K 202
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 549 RLR E QE kaantlk ALEQQKLAAQ G DLQPLLSKDPSSTS S G L PLKLSAANNKYDS L AA ladly KKKANAS L N L ESQIKKVD 628
Cdd:pfam15921 203 KIY E HD ------- SMSTMHFRSL G SAISKILRELDTEI S Y L KGRIFPVEDQLEA L KS ----- ESQNKIE L L L QQHQDRIE 270
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 629 G L V S GF E KKLS ---- EDGPIPDRP N A IQ ARS E D IQ S Q QKSVAAAQ dd VKK LS QNLE T TE QL C S S L QQS --- Y QEYCPDIQ 701
Cdd:pfam15921 271 Q L I S EH E VEIT glte KASSARSQA N S IQ SQL E I IQ E Q ARNQNSMY -- MRQ LS DLES T VS QL R S E L REA krm Y EDKIEELE 348
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 702 R Q ----------- RTE VKDLQTRYT N VAN QL --------- K E R E IV L QEAAT K NQEFQS T CK S LN sf L D N L GTNQITSSN 761
Cdd:pfam15921 349 K Q lvlanseltea RTE RDQFSQESG N LDD QL qklladlhk R E K E LS L EKEQN K RLWDRD T GN S IT -- I D H L RRELDDRNM 426
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 762 DLSQVN A K -------- Q SSQ ER I M DDLKR K QDDVDR VS D L SQD L Q --- DL L NDYETNIDKFNS TLE D S GA TV AK kphvlt 830
Cdd:pfam15921 427 EVQRLE A L lkamksec Q GQM ER Q M AAIQG K NESLEK VS S L TAQ L E stk EM L RKVVEELTAKKM TLE S S ER TV SD ------ 500
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 831 L SDAV Q KE E KNVVNRYT E A T AKNTQ V QKQMGLAKN l L L N NEEKVQM V AQQQV AL ES Q QKSTFQIESL lkeleeerartth 910
Cdd:pfam15921 501 L TASL Q EK E RAIEATNA E I T KLRSR V DLKLQELQH - L K N EGDHLRN V QTECE AL KL Q MAEKDKVIEI ------------- 566
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 911 tetn LR TFKDR M MS L KSRR ---- G VERI E EKE vlhyyrdpk LE NDLA D LQNK L H E EALRRSTTQSEVEV L NKKITT LE -- 984
Cdd:pfam15921 567 ---- LR QQIEN M TQ L VGQH grta G AMQV E KAQ --------- LE KEIN D RRLE L Q E FKILKDKKDAKIRE L EARVSD LE le 633
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 985 - DT L K NA - TPK L VTREVTEF ERD p QL DVDAAKL R D E VTRIKDEIR V ------ RDG E QIQMK T E v TVLQ Q M K PPIK E RVVK 1056
Cdd:pfam15921 634 k VK L V NA g SER L RAVKDIKQ ERD - QL LNEVKTS R N E LNSLSEDYE V lkrnfr NKS E EMETT T N - KLKM Q L K SAQS E LEQT 711
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1057 KEVV K VEQ -- D PEMLRAVRT M DTE I SGENNKSKL L TDE I - F QTRSQI NA lerlip N IQPKIITK E VK K IE Q DPDLI - TE S 1132
Cdd:pfam15921 712 RNTL K SME gs D GHAMKVAMG M QKQ I TAKRGQIDA L QSK I q F LEEAMT NA ------ N KEKHFLKE E KN K LS Q ELSTV a TE K 785
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1133 K K IQTN LE EE R MENNS L SRE V MDLHS ------- RYRQV QD WKP R V E ------------- VKE IVNEI Y RIDPNTELEIM r 1192
Cdd:pfam15921 786 N K MAGE LE VL R SQERR L KEK V ANMEV aldkasl QFAEC QD IIQ R Q E qesvrlklqhtld VKE LQGPG Y TSNSSMKPRLL - 864
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1591480471 1193 lrkdi Q DS S KQ R SD S EREIT Q V TA DLNILR S E K PKV e LKE ---- V L REVVK E E RS PE NE REIQR L N 1254
Cdd:pfam15921 865 ----- Q PA S FT R TH S NVPSS Q S TA SFLSHH S R K TNA - LKE dptr D L KQLLQ E L RS VI NE EPTVQ L S 924
ClyA-like
cd21116 family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including ...
644-821
1.92e-04
family of the cytolysin A (ClyA) family alpha pore-forming toxins (alpha-PFT) including Bacillus cereus HblB, Aeromonas hydrophila AhlB, Bacillus thuringiensis Cry6Aa and similar proteins; This family belongs to the ClyA family of alpha-PFT bacterial toxins. PFTs form the major group of virulence factors in many pathogenic bacteria and in general are critical components of the molecular offensive and defensive machinery of cells in all kingdoms of life. Bacterial PFTs facilitate the takeover of host resources by puncturing holes in the membrane. PFTs can be classified as alpha-PFTs and beta-PFTs depending on the secondary structures of their membrane component. Alpha-PFTs use a ring of amphipathic helices while beta-PFTs use a beta-barrel to construct the pore. Members of this family include the toxins: Bacillus cereus hemolysin binding component B (HblB or HBL-B) of the diarrheal enterotoxin hemolysin BL, Aeromonas hydrophila hemolytic (Ahl) component B (AhlB) of the tripartite AhlABC toxin, Vibrio cholerae cytotoxin motility associated killing factor A (MakA) cytotoxin, Xenorhabdus nematophila alpha-xenorhabdolysin (XaxA), Bacillus thuringiensis crystal 6Aa (Cry6Aa) parasporal crystal (Cry) toxin, and Bacillus cereus non-hemolytic enterotoxin (Nhe) component A (NheA) of the non-hemolytic enterotoxin Nhe, which, despite its name, is hemolytic, among others. In solution, ClyA proteins have an elongated, almost entirely alpha-helical structure, except for a short hydrophobic beta-hairpin known as the beta-tongue. Pore formation by ClyA requires circular oligomerization of the toxin by a sequential mechanism. This, in turn, concentrates the amphipathic helices in the center of the ring-like structure, forming a helical barrel that inserts into the membrane by a wedge-like mechanism. Compared with ClyA, NheA is almost entirely alpha-helical with an enlarged "head" domain, and an enlarged beta-tongue; it has been proposed that NheA could even form beta-barrel pores. Alpha-PFTs with similar structures are increasingly being found in eukaryotes, in particular as components of the immune systems of animals. This family may be distantly related to Escherichia coli alpha-PFT hemolysin E (HlyE, also known as ClyA or SheA).
Pssm-ID: 439149 [Multi-domain]
Cd Length: 224
Bit Score: 45.10
E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 644 I PDR PN AIQARSEDIQ S QQKSV A A A QDDVKKLSQNLET te Q L C S SLQQS ------ Y Q E Y C PD IQRQ rte VKD L QTRYTNV 717
Cdd:cd21116 18 I LNQ PN INLIPLDLLP S LNTHQ A L A RAHALEWLNEIKP -- K L L S LPNDI igynnt F Q S Y Y PD LIEL --- ADN L IKGDQGA 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 718 AN QL KEREIV LQ EAA TK N Q EF - Q S TCKS L NS F LDN L GTNQITSSN D LSQVN A KQSSQERIMDD L KRKQDDV D RVS D LSQD 796
Cdd:cd21116 93 KQ QL LQGLEA LQ SQV TK K Q TS v T S FINE L TT F KND L DDDSRNLQT D ATKAQ A QVAVLNALKNQ L NSLAEQI D AAI D ALEK 172
170 180
....*....|....*....|....*
gi 1591480471 797 L QDLLNDYETN I DKFNST LED SGAT 821
Cdd:cd21116 173 L SNDWQTLDSD I KELITD LED AESS 197
PLEC
smart00250 Plectin repeat;
1902-1934
2.09e-04
Plectin repeat;
Pssm-ID: 197605
Cd Length: 38
Bit Score: 40.16
E-value: 2.09e-04
10 20 30
....*....|....*....|....*....|...
gi 1591480471 1902 R YM EAQ HHT GG LV DP K TG RR LS TLD A IGAKM ID 1934
Cdd:smart00250 2 R LL EAQ SAI GG II DP E TG QK LS VEE A LRRGL ID 34
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
1204-1497
2.74e-04
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 46.21
E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1204 R SD SE RE -- IT Q V tad L NILRS E KPKVE L K EV LR E VVK --------------- EE RSP E N E R E IQRLNDQLTQLHINYNS 1266
Cdd:PRK03918 142 E SD ES RE kv VR Q I --- L GLDDY E NAYKN L G EV IK E IKR rierlekfikrteni EE LIK E K E K E LEEVLREINEISSELPE 218
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1267 L E E QVRL L R KE RD E WKAERSK IE TK lvtrevikyeadplq EKE ADR L RRDV R DEAKLR R NI EE MVFD L QNKYIL LE RQ kp 1346
Cdd:PRK03918 219 L R E ELEK L E KE VK E LEELKEE IE EL --------------- EKE LES L EGSK R KLEEKI R EL EE RIEE L KKEIEE LE EK -- 281
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1347 eekvvvqe V VR L QKDPRQEV E HER L GRTLDDEVMTR R QL E LD L QQ L R ---------- TKV EEKE RI L R E SDERQ K KIQ ad 1416
Cdd:PRK03918 282 -------- V KE L KELKEKAE E YIK L SEFYEEYLDEL R EI E KR L SR L E eeingieeri KEL EEKE ER L E E LKKKL K ELE -- 351
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1417 SE L R E IRLCIVQL E T A PPPV EE SIVVEEV L KVERDP KLE RMISG L RLDMDKETND I LRLERD I RN L ta K L EI LQRE K SV E 1496
Cdd:PRK03918 352 KR L E E LEERHELY E E A KAKK EE LERLKKR L TGLTPE KLE KELEE L EKAKEEIEEE I SKITAR I GE L -- K K EI KELK K AI E 429
.
gi 1591480471 1497 K 1497
Cdd:PRK03918 430 E 430
SPEC
cd00176 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
656-810
4.17e-04
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here
Pssm-ID: 238103 [Multi-domain]
Cd Length: 213
Bit Score: 43.97
E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 656 E DIQSQQ K SVA A AQDDVKKLSQNL E TTEQ L CSS L QQSYQEYCPD IQ RQ rte VKD L QT R YTNVANQLK ER EIV L Q EA ATK n 735
Cdd:cd00176 33 E SVEALL K KHE A LEAELAAHEERV E ALNE L GEQ L IEEGHPDAEE IQ ER --- LEE L NQ R WEELRELAE ER RQR L E EA LDL - 108
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1591480471 736 Q E F QSTCKS L NSF L DNL g TNQIT S S --- N DL SQ V NAKQSSQERIMDD L KRKQDDVDRVSD L SQD L QDLLNDYETNIDK 810
Cdd:cd00176 109 Q Q F FRDADD L EQW L EEK - EAALA S E dlg K DL ES V EELLKKHKELEEE L EAHEPRLKSLNE L AEE L LEEGHPDADEEIE 185
EnvC
COG4942 Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1148-1330
6.08e-04
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain]
Cd Length: 377
Bit Score: 44.37
E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1148 SLSR E VMD L HSRYRQVQDW -- KPRV E V K EIVNEIYRI dpnt E LE I MR L RKD I QDSSKQRSDS E R E ITQVTADLNI LR S -- 1223
Cdd:COG4942 24 EAEA E LEQ L QQEIAELEKE la ALKK E E K ALLKQLAAL ---- E RR I AA L ARR I RALEQELAAL E A E LAELEKEIAE LR A el 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1224 E KP K V EL K E V LR EVVKEE R -------------------------- S P ENEREIQR L NDQ L TQ L HINYNS LE EQVRL L RKE 1277
Cdd:COG4942 100 E AQ K E EL A E L LR ALYRLG R qpplalllspedfldavrrlqylkyl A P ARREQAEE L RAD L AE L AALRAE LE AERAE L EAL 179
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1591480471 1278 RD E WKA ER SKI E TKLVT R EVIKYEADPLQEKE A DR L RRDVRDEAK L RRN I EEM 1330
Cdd:COG4942 180 LA E LEE ER AAL E ALKAE R QKLLARLEKELAEL A AE L AELQQEAEE L EAL I ARL 232
YhaN
COG4717 Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1089-1540
6.14e-04
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain]
Cd Length: 641
Bit Score: 44.76
E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1089 L TD E IFQTRSQINA LE RLIPNIQPKI it KEVK K IE Q DPD L IT E SKKIQTN L E E ERMENNS L SREVMD L HSRYRQVQDWKP 1168
Cdd:COG4717 93 L QE E LEELEEELEE LE AELEELREEL -- EKLE K LL Q LLP L YQ E LEALEAE L A E LPERLEE L EERLEE L RELEEELEELEA 170
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1169 RVEVK -- E IVNEIYRIDPN TE L E IMR L RKDIQDSSKQRSDS E R E ITQVTAD L NI L R sekpkvelkevlrevv K E ERSP EN 1246
Cdd:COG4717 171 ELAEL qe E LEELLEQLSLA TE E E LQD L AEELEELQQRLAEL E E E LEEAQEE L EE L E ---------------- E E LEQL EN 234
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1247 E R E IQR L NDQ L TQLHINYNSLEEQVR LL RKERDEWKAERSKIETKLVTREVIKYEADP L -- QEKEADRLRRDVRDEAK L R 1324
Cdd:COG4717 235 E L E AAA L EER L KEARLLLLIAAALLA LL GLGGSLLSLILTIAGVLFLVLGLLALLFLL L ar EKASLGKEAEELQALPA L E 314
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1325 RNI EE MVFD L QNKYI L LERQK PEE KVVVQEVVRLQKDPRQ E V E HER lgrtldd E VMTRRQ LE LDLQQ L -- RTK VE EK E RI 1402
Cdd:COG4717 315 ELE EE ELEE L LAALG L PPDLS PEE LLELLDRIEELQELLR E A E ELE ------- E ELQLEE LE QEIAA L la EAG VE DE E EL 387
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1403 LRESDERQKKIQADS EL R E IRL civ QLE TAPPPV EE S ivveev L KVERDPK LE RMISG L RLDMDKETNDILR L ERDIRN L 1482
Cdd:COG4717 388 RAALEQAEEYQELKE EL E E LEE --- QLE ELLGEL EE L ------ L EALDEEE LE EELEE L EEELEELEEELEE L REELAE L 458
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1591480471 1483 T A K LE I L QREKSVEKTVYKE vvrvekd QAVE AE RDR L R E QVSQN K F A RQD LE DEIRRL 1540
Cdd:COG4717 459 E A E LE Q L EEDGELAELLQEL ------- EELK AE LRE L A E EWAAL K L A LEL LE EAREEY 509
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
1078-1602
1.07e-03
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 44.28
E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1078 E ISGENNKSKL L TDE I FQTRSQ I NA L ERL I PNIQP K I it KE V K KIEQDPDLITESKKI qtn L EE ERM E NNSLSREVMD L H 1157
Cdd:PRK03918 246 E LESLEGSKRK L EEK I RELEER I EE L KKE I EELEE K V -- KE L K ELKEKAEEYIKLSEF --- Y EE YLD E LREIEKRLSR L E 320
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1158 SRYRQVQD - W K PRV E VK E IVN E IYRIDPNT E LEIMR L RKDIQDSSKQRSDS E r E ITQVTAD L NI L RS EK PKV EL K E V lre 1236
Cdd:PRK03918 321 EEINGIEE r I K ELE E KE E RLE E LKKKLKEL E KRLEE L EERHELYEEAKAKK E - E LERLKKR L TG L TP EK LEK EL E E L --- 396
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1237 vvk E ERSP E N E R EI QRLNDQLTQ L HINYNS L EEQVRL L R K ER ------------------- D E WK AE RSK IE TK L VTR E V 1297
Cdd:PRK03918 397 --- E KAKE E I E E EI SKITARIGE L KKEIKE L KKAIEE L K K AK gkcpvcgrelteehrkell E E YT AE LKR IE KE L KEI E E 473
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1298 IKYEA dplq E KE ADR L RRDVRD E AK L RRN i E E MVFD L QNKYIL L ERQKP EE KVVVQ E VVRLQ K DPRQEVEH E R lg RT L DD 1377
Cdd:PRK03918 474 KERKL ---- R KE LRE L EKVLKK E SE L IKL - K E LAEQ L KELEEK L KKYNL EE LEKKA E EYEKL K EKLIKLKG E I -- KS L KK 546
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1378 E VMTRRQ L ELD L QQ L RT K VE E K E RI L R E S d ERQKKIQADSELR E IRLCIVQ LE TAPPPVE E SIVV E EV L KV E rdpkl E RM 1457
Cdd:PRK03918 547 E LEKLEE L KKK L AE L EK K LD E L E EE L A E L - LKELEELGFESVE E LEERLKE LE PFYNEYL E LKDA E KE L ER E ----- E KE 620
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1458 ISG L RLDM DK ETNDILRL E RDIRN L TAK LE I L QREK S V E -- KTVYK E VVRVEKDQ A veaerd R LR EQVSQNK farq DLED 1535
Cdd:PRK03918 621 LKK L EEEL DK AFEELAET E KRLEE L RKE LE E L EKKY S E E ey EELRE E YLELSREL A ------ G LR AELEELE ---- KRRE 690
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1591480471 1536 EI RRLND K INLLSSTKSSTSR E ETT L TLNKDSLQ -- REK dnl TREFRT L EAR R hdigl SFQQQSRLM SE 1602
Cdd:PRK03918 691 EI KKTLE K LKEELEEREKAKK E LEK L EKALERVE el REK --- VKKYKA L LKE R ----- ALSKVGEIA SE 751
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
932-1580
1.42e-03
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 43.89
E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 932 E RI EE KEVLHY yrdp K LE NDLAD LQ NK L HEE A LRR S TTQSEVEV L NKKITT LE DT L KN atpkl VTREVT E F E RDPQLDV - 1010
Cdd:TIGR02168 267 E KL EE LRLEVS ---- E LE EEIEE LQ KE L YAL A NEI S RLEQQKQI L RERLAN LE RQ L EE ----- LEAQLE E L E SKLDELA e 337
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1011 DA A K L RDEVTRI K D E I rvr DGEQIQMKTEVTV L QQMKPPIK E RVVKK E VVKVEQD p EMLRAVRTMDT EI sg E NNKSK L -- 1088
Cdd:TIGR02168 338 EL A E L EEKLEEL K E E L --- ESLEAELEELEAE L EELESRLE E LEEQL E TLRSKVA - QLELQIASLNN EI -- E RLEAR L er 411
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1089 L T D EIFQTRSQ I NA L ERLIPNIQP K IITK E V -------- KKI E QDPD L ITESKKIQTN LEE ERMENNSLS RE VMD L HS R Y 1160
Cdd:TIGR02168 412 L E D RRERLQQE I EE L LKKLEEAEL K ELQA E L eeleeele ELQ E ELER L EEALEELREE LEE AEQALDAAE RE LAQ L QA R L 491
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1161 RQVQDWKPRV E ----- VK EIVN ------------- E IYRI D PNT E LE I - MR L RKDI Q ------- DSS K QRSDSEREITQV 1214
Cdd:TIGR02168 492 DSLERLQENL E gfseg VK ALLK nqsglsgilgvls E LISV D EGY E AA I e AA L GGRL Q avvvenl NAA K KAIAFLKQNELG 571
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1215 TADLNI L R S E K PK v E LKEVL RE VV K EERSP -------- ENEREIQR - L NDQ L TQLHI n YNS L EEQVR L LR K E R dewka ER 1285
Cdd:TIGR02168 572 RVTFLP L D S I K GT - E IQGND RE IL K NIEGF lgvakdlv KFDPKLRK a L SYL L GGVLV - VDD L DNALE L AK K L R ----- PG 644
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1286 SK I E T K --------- LV T REVI K YEADP L - QEK E ADR L RRDVRDEAKLRRNI E EMVFD L QNKYIL LE RQKPEEKVVVQ E V 1355
Cdd:TIGR02168 645 YR I V T L dgdlvrpgg VI T GGSA K TNSSI L e RRR E IEE L EEKIEELEEKIAEL E KALAE L RKELEE LE EELEQLRKELE E L 724
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1356 V R LQKDP R QEV ----- E H E R L GRTLDDEVMTRRQ LE LDLQQ L RTKV EE K E RI L R E SDERQKKIQ A DS E LREIR L ci VQ L E 1430
Cdd:TIGR02168 725 S R QISAL R KDL arlea E V E Q L EERIAQLSKELTE LE AEIEE L EERL EE A E EE L A E AEAEIEELE A QI E QLKEE L -- KA L R 802
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1431 T A ppp VE E SIVVEEV L KV E RDPKL ER M i SG L RLDMDKETNDILR LE RD I RN L TAKL E I L qr EKSV E KTVYKEVVRVEKDQ 1510
Cdd:TIGR02168 803 E A --- LD E LRAELTL L NE E AANLR ER L - ES L ERRIAATERRLED LE EQ I EE L SEDI E S L -- AAEI E ELEELIEELESELE 876
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1511 A VEA ER DR L R E QVSQNKFARQD L ED E I R R L ND K INL L SSTKSSTSREETT L T L NKDS L QREK DNL TREFR 1580
Cdd:TIGR02168 877 A LLN ER AS L E E ALALLRSELEE L SE E L R E L ES K RSE L RRELEELREKLAQ L E L RLEG L EVRI DNL QERLS 946
PRK03918
PRK03918 DNA double-strand break repair ATPase Rad50;
915-1319
1.43e-03
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain]
Cd Length: 880
Bit Score: 43.90
E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 915 LRTF K DRMMS LK S R RGVERI E E - KEV L HYYRDP K L E ndlad LQNKLHEEAL R RSTTQS E VEV L N K K I TT L EDT l K NAT P k 993
Cdd:PRK03918 367 AKAK K EELER LK K R LTGLTP E K l EKE L EELEKA K E E ----- IEEEISKITA R IGELKK E IKE L K K A I EE L KKA - K GKC P - 439
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 994 LVT RE V TE FE R DPQ L dvda AKLRD E VT RI KD E IRVRDGEQIQMKT E VTV L Q qmkppikervvkkev VKVEQDP E MLRAVR 1073
Cdd:PRK03918 440 VCG RE L TE EH R KEL L ---- EEYTA E LK RI EK E LKEIEEKERKLRK E LRE L E --------------- KVLKKES E LIKLKE 500
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1074 TMDTEISG E NNKS K LLTD E IFQTRSQINA L ERLIPNIQPK I IT -- KE VK K I E qdp D L ITESKKIQTN L E E ERM E NNS L SR 1151
Cdd:PRK03918 501 LAEQLKEL E EKLK K YNLE E LEKKAEEYEK L KEKLIKLKGE I KS lk KE LE K L E --- E L KKKLAELEKK L D E LEE E LAE L LK 577
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1152 E VMD L H sr YRQ V QDWKP R V - E VKEIV NE I yridpnte LE IMRLR K DIQDSS K QRSDS E R E ITQVTAD L NILRSEK pkvel 1230
Cdd:PRK03918 578 E LEE L G -- FES V EELEE R L k E LEPFY NE Y -------- LE LKDAE K ELEREE K ELKKL E E E LDKAFEE L AETEKRL ----- 642
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1231 k E V LR EVVK E ERSPEN E R E IQR L NDQLTQ L HINYNS L EEQVRL L R K E R D E W K AERS K IETK L VT RE VI K Y E ADP L QEKEA 1310
Cdd:PRK03918 643 - E E LR KELE E LEKKYS E E E YEE L REEYLE L SRELAG L RAELEE L E K R R E E I K KTLE K LKEE L EE RE KA K K E LEK L EKALE 721
410
....*....|.
gi 1591480471 1311 D -- R LR RD V RD 1319
Cdd:PRK03918 722 R ve E LR EK V KK 732
COG4913
COG4913 Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1357-1587
1.47e-03
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain]
Cd Length: 1089
Bit Score: 43.75
E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1357 R LQ KD P R QEVEHER - LG RT lddevm T R RQ L EL dlqq L RTKVE E K E RI L R E SD ER QKKIQ A DSE - L R E I R LCIVQ L E tapp 1434
Cdd:COG4913 589 R HE KD D R RRIRSRY v LG FD ------ N R AK L AA ---- L EAELA E L E EE L A E AE ER LEALE A ELD a L Q E R R EALQR L A ---- 654
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1435 pveesivveevlkverdpklermisglrl DMDKETN D ILRL ER D I RN L T A K LE I L QREKSVEKTVYKEVVRV E KD - QAV E 1513
Cdd:COG4913 655 ----------------------------- EYSWDEI D VASA ER E I AE L E A E LE R L DASSDDLAALEEQLEEL E AE l EEL E 705
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1591480471 1514 A E R D R L REQVSQNKFARQDL E D E IRR L N D KINLLSSTKSSTS R --- EE TTLTLNK D SLQ RE - KD NL TREFRT L E AR RH 1587
Cdd:COG4913 706 E E L D E L KGEIGRLEKELEQA E E E LDE L Q D RLEAAEDLARLEL R all EE RFAAALG D AVE RE l RE NL EERIDA L R AR LN 783
SCP-1
pfam05483 Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
637-1408
2.00e-03
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain]
Cd Length: 787
Bit Score: 43.17
E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 637 K L S EDGPIPDRP N AI Q ARSED I QS Q Q K SVAAA Q DDVK K L S QN LE T teqlcsslqqsyqeycp D IQ RQRTEV K D l QTRYTN 716
Cdd:pfam05483 94 K V S IEAELKQKE N KL Q ENRKI I EA Q R K AIQEL Q FENE K V S LK LE E ----------------- E IQ ENKDLI K E - NNATRH 155
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 717 VA N Q LKE REIVLQ E AAT K NQEFQSTCKSLNSF L D N LGTNQ I TSSND L SQ vnak Q SSQE R IMDDL K R K Q D D v DRVSD L SQD 796
Cdd:pfam05483 156 LC N L LKE TCARSA E KTK K YEYEREETRQVYMD L N N NIEKM I LAFEE L RV ---- Q AENA R LEMHF K L K E D H - EKIQH L EEE 230
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 797 LQDLL ND Y E TNI dkfn S T L EDSGATVAK K PHV LT L sda VQK E EKNVV N RYT E A T AKNTQVQ K QMGLA K NL L LNNE E KVQ M 876
Cdd:pfam05483 231 YKKEI ND K E KQV ---- S L L LIQITEKEN K MKD LT F --- LLE E SRDKA N QLE E K T KLQDENL K ELIEK K DH L TKEL E DIK M 303
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 877 VA Q QQVALESQQKSTF QI esllkeleeerar T T H T ETN L RTF K DRM M slksrrgv E RIEEKEVL H YYRDPKL E NDLAD L Q 956
Cdd:pfam05483 304 SL Q RSMSTQKALEEDL QI ------------- A T K T ICQ L TEE K EAQ M -------- E ELNKAKAA H SFVVTEF E ATTCS L E 362
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 957 NK L HE E AL R RSTTQSEVEVLNKKITTLEDT L KNA T p K LVTREVT E F E RDPQLDVDAA KL R DE VTRIK deirv RDG E QIQM 1036
Cdd:pfam05483 363 EL L RT E QQ R LEKNEDQLKIITMELQKKSSE L EEM T - K FKNNKEV E L E ELKKILAEDE KL L DE KKQFE ----- KIA E ELKG 436
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1037 K - T E VTV L Q Q MKPPIKERVVKKEVVKVEQDPEM L RA V RTMD TE ISG E NN K SKL LT DE ifqtrsqinalerlipni QP K II 1115
Cdd:pfam05483 437 K e Q E LIF L L Q AREKEIHDLEIQLTAIKTSEEHY L KE V EDLK TE LEK E KL K NIE LT AH ------------------ CD K LL 498
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1116 TKEVKKIEQDP D LIT E S KK I Q TNLEEERMENNSLSREVMD L HSRYRQVQ D wkprv E VKEIVN E IYRIDPNTELEIMRLRK 1195
Cdd:pfam05483 499 LENKELTQEAS D MTL E L KK H Q EDIINCKKQEERMLKQIEN L EEKEMNLR D ----- E LESVRE E FIQKGDEVKCKLDKSEE 573
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1196 DIQDSSKQRSDS E REITQVTADL N I L RSE kpk V E L K EVLR E VVKE E RSPENEREIQR l N D QL TQLH I NY N S LE EQVRLLR 1275
Cdd:pfam05483 574 NARSIEYEVLKK E KQMKILENKC N N L KKQ --- I E N K NKNI E ELHQ E NKALKKKGSAE - N K QL NAYE I KV N K LE LELASAK 649
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1276 KERD E WKAERS K - IE T K LVTR E VIKY E ADPLQE -- K EA DR L RRDV rd EAKLRRN I E EMV fdlqnky I L L E RQ K PE - E K VV 1351
Cdd:pfam05483 650 QKFE E IIDNYQ K e IE D K KISE E KLLE E VEKAKA ia D EA VK L QKEI -- DKRCQHK I A EMV ------- A L M E KH K HQ y D K II 720
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 1591480471 1352 VQEVVR L QKDPRQ E V E HERLGRT L DD E VMTRRQLE L D L Q - QL RTKV EEKE RILR E SD E 1408
Cdd:pfam05483 721 EERDSE L GLYKNK E Q E QSSAKAA L EI E LSNIKAEL L S L K k QL EIEK EEKE KLKM E AK E 778
EnvC
COG4942 Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1381-1659
2.08e-03
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain]
Cd Length: 377
Bit Score: 42.83
E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1381 TRRQL E LD L Q QL RTKVE E K E RI L RESDERQ K KIQADSE lreirlcivqletapppveesivveevlkverdp K LER M I SG 1460
Cdd:COG4942 21 AAAEA E AE L E QL QQEIA E L E KE L AALKKEE K ALLKQLA ---------------------------------- A LER R I AA 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1461 L RLDMDKETNDILR LE RDIRN L TAKLEI L QR E KSVE K TVYK E VV R V ekd QAVEAERDR L REQV S QNK F A rq D LEDEIRR L 1540
Cdd:COG4942 67 L ARRIRALEQELAA LE AELAE L EKEIAE L RA E LEAQ K EELA E LL R A --- LYRLGRQPP L ALLL S PED F L -- D AVRRLQY L 141
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1541 NDKINLLSSTKSSTSREETT L TLNKDS L QR E KDN L TREFRT LE AR R hdiglsf QQQSR L MS ER TQMSRQKSIKMESDVHR 1620
Cdd:COG4942 142 KYLAPARREQAEELRADLAE L AALRAE L EA E RAE L EALLAE LE EE R ------- AALEA L KA ER QKLLARLEKELAELAAE 214
250 260 270
....*....|....*....|....*....|....*....
gi 1591480471 1621 L ERDILDEKD kihlrdst IRE L LLN L QK E ES A ETRTKET 1659
Cdd:COG4942 215 L AELQQEAEE -------- LEA L IAR L EA E AA A AAERTPA 245
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1382-1629
3.50e-03
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 42.35
E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1382 RRQ LE LD L Q QLR TKV EE KE R ILRESDERQKKIQ A DS E LR E I R LCIVQL E TAPPPV E ESIVV E EVLKV E RDPK - L E RM I SG 1460
Cdd:TIGR02168 707 LEE LE EE L E QLR KEL EE LS R QISALRKDLARLE A EV E QL E E R IAQLSK E LTELEA E IEELE E RLEEA E EELA e A E AE I EE 786
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1461 L RLDMDKETNDILR L ERDIRN L T A K L EI L QR E KSVEKTVYKEVV R VEKDQAVEA E R ----- DR L R E QVSQNKFARQD LE D 1535
Cdd:TIGR02168 787 L EAQIEQLKEELKA L REALDE L R A E L TL L NE E AANLRERLESLE R RIAATERRL E D leeqi EE L S E DIESLAAEIEE LE E 866
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1536 E I RR L NDKINL L SSTKS S TSREETT L TLNKDS L QR E KDN L TREFRT L EARRHDIGLSF q Q Q SR L MS E RTQMSRQKSIKME 1615
Cdd:TIGR02168 867 L I EE L ESELEA L LNERA S LEEALAL L RSELEE L SE E LRE L ESKRSE L RRELEELREKL - A Q LE L RL E GLEVRIDNLQERL 945
250
....*....|....
gi 1591480471 1616 S DVHR L ERDILDEK 1629
Cdd:TIGR02168 946 S EEYS L TLEEAEAL 959
YhaN
COG4717 Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1246-1642
3.89e-03
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain]
Cd Length: 641
Bit Score: 42.06
E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1246 N ER E IQR L NDQ L TQL --- HIN Y NS L E E QVRL L RK E RD E WK AE RSKIETK L VTR E VIKYEADPL QE K EA DRLRRDVRD E -- 1320
Cdd:COG4717 69 N LK E LKE L EEE L KEA eek EEE Y AE L Q E ELEE L EE E LE E LE AE LEELREE L EKL E KLLQLLPLY QE L EA LEAELAELP E rl 148
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1321 AK L RRNI EE MV f D L QNKYIL LE RQK p E E KVVVQ E VVRL Q KDPRQ E V E HER L GRT L DDEVMTRRQ LE LD L QQLRTKV EE K E 1400
Cdd:COG4717 149 EE L EERL EE LR - E L EEELEE LE AEL - A E LQEEL E ELLE Q LSLAT E E E LQD L AEE L EELQQRLAE LE EE L EEAQEEL EE L E 226
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1401 RI L RESDERQKKIQADSE L R E --------- IR L CIVQ L ETAPPPVEES I VVEEV L KVERDPK L ERMISGLRLDMD KE TND 1471
Cdd:COG4717 227 EE L EQLENELEAAALEER L K E arlllliaa AL L ALLG L GGSLLSLILT I AGVLF L VLGLLAL L FLLLAREKASLG KE AEE 306
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1472 ILR L ERDIRNLTAK LE I L QREKSVEKTVYK E VVRVEK D QAV E AERDRLREQVSQNKFARQD LE D EI RR L NDKINLLSSTK 1551
Cdd:COG4717 307 LQA L PALEELEEEE LE E L LAALGLPPDLSP E ELLELL D RIE E LQELLREAEELEEELQLEE LE Q EI AA L LAEAGVEDEEE 386
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1552 SSTSR E E ttltlnkdsl QR E KDN L TR E FRT LE ARRHDIGLSFQQQSRLMS E RTQMSRQKSIKM E sd VHR LE RDILDEKDK 1631
Cdd:COG4717 387 LRAAL E Q ---------- AE E YQE L KE E LEE LE EQLEELLGELEELLEALD E EELEEELEELEE E -- LEE LE EELEELREE 454
410
....*....|.
gi 1591480471 1632 IHLRDSTIRE L 1642
Cdd:COG4717 455 LAELEAELEQ L 465
EnvC
COG4942 Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
442-713
4.45e-03
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain]
Cd Length: 377
Bit Score: 41.67
E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 442 KTFPAVCFQIPPPDPEAI D KVDLLGS EL ADIRKRR A A L AES L KNH K SDISRSQQSV pvss A P L DPKVT ALA QQLDQ L DND 521
Cdd:COG4942 2 RKLLLLALLLALAAAAQA D AAAEAEA EL EQLQQEI A E L EKE L AAL K KEEKALLKQL ---- A A L ERRIA ALA RRIRA L EQE 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 522 L v N A E E SM L SR L RAPLSR tdpagd L AKR L RE Q EKA - A NT L K AL eq QK L AA Q GD L QP LLS KDPSSTS sglplklsaannk Y 600
Cdd:COG4942 78 L - A A L E AE L AE L EKEIAE ------ L RAE L EA Q KEE l A EL L R AL -- YR L GR Q PP L AL LLS PEDFLDA ------------- V 135
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 601 DS L AA L AD L YKKKANASLN L ESQIKKVDG L VSGF E KKLS E dgpipd RPNAIQARS E DIQSQQKSV A AA Q DDVKK L SQN L E 680
Cdd:COG4942 136 RR L QY L KY L APARREQAEE L RADLAELAA L RAEL E AERA E ------ LEALLAELE E ERAALEALK A ER Q KLLAR L EKE L A 209
250 260 270
....*....|....*....|....*....|...
gi 1591480471 681 TTEQLCSS LQQ SYQ E YCPD I Q R QRT E VKDLQT R 713
Cdd:COG4942 210 ELAAELAE LQQ EAE E LEAL I A R LEA E AAAAAE R 242
235kDa-fam
TIGR01612 reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
754-1299
6.75e-03
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain]
Cd Length: 2757
Bit Score: 41.58
E-value: 6.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 754 TNQ I TS - SN D LSQVNA K QSSQERIMDDL K R K QDD - V D RVSDLSQ DL Q D LLND -- YETNIDKFNSTL E DSGATVA KK PHVL 829
Cdd:TIGR01612 1110 ADE I NK i KD D IKNLDQ K IDHHIKALEEI K K K SEN y I D EIKAQIN DL E D VADK ai SNDDPEEIEKKI E NIVTKID KK KNIY 1189
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 830 ---- T L SDAVQKE EK N vvn RYTEATA K NTQVQKQMG L A K NL L LNNE E KVQMVAQQQV A L E SQQKSTFQ I ESLLK E L E E E R 905
Cdd:TIGR01612 1190 deik K L LNEIAEI EK D --- KTSLEEV K GINLSYGKN L G K LF L EKID E EKKKSEHMIK A M E AYIEDLDE I KEKSP E I E N E M 1266
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 906 ARTTHTETNLR TF -------- KDRMM S L K SRRGVER I E EK E v L HYYR D PKL E N D LA D LQNK L HEEA L RRSTTQ S EVEVLN 977
Cdd:TIGR01612 1267 GIEMDIKAEME TF nishdddk DHHII S K K HDENISD I R EK S - L KIIE D FSE E S D IN D IKKE L QKNL L DAQKHN S DINLYL 1345
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 978 KK I TTLEDT LK NATP K LVTR EV T E F ----- E RDPQLDVDAA K LRDEVTR IKD E I RV rdg E QIQM K T E V T V ---------- 1042
Cdd:TIGR01612 1346 NE I ANIYNI LK LNKI K KIID EV K E Y tkeie E NNKNIKDELD K SEKLIKK IKD D I NL --- E ECKS K I E S T L ddkdidecik 1422
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1043 - LQQM K PP I KERVVKKEVVKVEQ D p E MLRA V RTMDTE I SGEN NKS KLLTD ei FQTRSQI N ALERL I PNIQPK I ------- 1114
Cdd:TIGR01612 1423 k IKEL K NH I LSEESNIDTYFKNA D - E NNEN V LLLFKN I EMAD NKS QHILK -- IKKDNAT N DHDFN I NELKEH I dkskgck 1499
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1115 -- IT K EV K K IE QDPD L ITES KK ------------- I QTNLEEERMENNSLSR E VM D L H SRY r QVQDW K PRVEV KEI VN E I 1179
Cdd:TIGR01612 1500 de AD K NA K A IE KNKE L FEQY KK dvtellnkysala I KNKFAKTKKDSEIIIK E IK D A H KKF - ILEAE K SEQKI KEI KK E K 1578
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1591480471 1180 Y RI D ----------------------- P N TE L E I MRLR K D I Q D SS K QRSDS E RE I TQV --- TA D LNILRSEKPKVE L K E V 1233
Cdd:TIGR01612 1579 F RI E ddaakndksnkaaidiqlslenf E N KF L K I SDIK K K I N D CL K ETESI E KK I SSF sid SQ D TELKENGDNLNS L Q E F 1658
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1591480471 1234 L REVVKEERSP E NER - E IQR L NDQLTQLH I NYNSLEE -- QVRLLR K ERDEWK A ERSK IE T klv TR E V I K 1299
Cdd:TIGR01612 1659 L ESLKDQKKNI E DKK k E LDE L DSEIEKIE I DVDQHKK ny EIGIIE K IKEIAI A NKEE IE S --- IK E L I E 1724
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
