NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|159110598|ref|NP_033205|]
View 

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467707  Cd Length: 279  Bit Score: 602.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  70 CACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQC 149
Cdd:cd23979    1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 150 RRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIAS 229
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 230 ALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 309
Cdd:cd23979  161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 159110598 310 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23979  241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
 
Name Accession Description Interval E-value
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 602.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  70 CACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQC 149
Cdd:cd23979    1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 150 RRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIAS 229
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 230 ALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 309
Cdd:cd23979  161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 159110598 310 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23979  241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-341 3.21e-97

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 288.74  E-value: 3.21e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598   96 VWTRDNMNLPPDV--QRWWMMLQpqfkshNTNEVLEKLFQIVPgenpyrfRDPQQCRRCAVVGNSGNLRGSGYGQEVDSH 173
Cdd:pfam00777   1 FLTKENFPLGEWIrySEWWLPFT------VTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  174 NFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKN-----------LPANVSFVLVPFKALDLMWIASALSTGQIR----- 237
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDskygnlgfshpRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSrslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  238 -FTYAPVKSflRVDKEKVQIYNPAFFKYIHDRWTEHHG---RYPSTGMLVLFFALHVCDEVNVYGFGA--DSRGNWHHYW 311
Cdd:pfam00777 148 lYTLKEVKI--PVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYY 225

                         250       260       270
                  ....*....|....*....|....*....|
gi 159110598  312 ENNRYAGeFRKTGVHDADFEAHIIDMLAKA 341
Cdd:pfam00777 226 DNVLMKK-GGFYGVHDMPFEFKLLQKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 70-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 602.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  70 CACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPQQC 149
Cdd:cd23979    1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMMLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 150 RRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIAS 229
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 230 ALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 309
Cdd:cd23979  161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 159110598 310 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23979  241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 72-348 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 533.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  72 CSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPqFKSHNTNEVLEKLFQIVPGENPYRFRDPQQCRR 151
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQS-SKNSDLREVLEKLFQVVPGENPYRTRDPNRCRR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 152 CAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIASAL 231
Cdd:cd23966   80 CAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 232 STGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYW 311
Cdd:cd23966  160 TTGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHYW 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 159110598 312 ENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23966  240 EKNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 70-348 1.83e-139

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 396.94  E-value: 1.83e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  70 CACSRCMGDASTSEWFDSHFDGNISPVWTRDNMNLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGE-NPYRFRDPQQ 148
Cdd:cd23980    1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLRLQREKKPKNLNDTIRELFQVVPGNvDPLLEKRLVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLMWIA 228
Cdd:cd23980   81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWVI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 229 SALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH 308
Cdd:cd23980  161 SATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADSKGNWH 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 159110598 309 HYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23980  241 HYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-341 3.21e-97

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 288.74  E-value: 3.21e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598   96 VWTRDNMNLPPDV--QRWWMMLQpqfkshNTNEVLEKLFQIVPgenpyrfRDPQQCRRCAVVGNSGNLRGSGYGQEVDSH 173
Cdd:pfam00777   1 FLTKENFPLGEWIrySEWWLPFT------VTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSH 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  174 NFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKN-----------LPANVSFVLVPFKALDLMWIASALSTGQIR----- 237
Cdd:pfam00777  68 DFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDskygnlgfshpRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSrslrv 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  238 -FTYAPVKSflRVDKEKVQIYNPAFFKYIHDRWTEHHG---RYPSTGMLVLFFALHVCDEVNVYGFGA--DSRGNWHHYW 311
Cdd:pfam00777 148 lYTLKEVKI--PVDPDKVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYY 225

                         250       260       270
                  ....*....|....*....|....*....|
gi 159110598  312 ENNRYAGeFRKTGVHDADFEAHIIDMLAKA 341
Cdd:pfam00777 226 DNVLMKK-GGFYGVHDMPFEFKLLQKLHKE 254
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 76-348 1.29e-53

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 178.22  E-value: 1.29e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  76 MGDASTSEWFDSHFDGNISPVWTRDNMNlppdvQRWWMMLQ----PQ-FKSHNtNEVLEKLFQIVPG-ENPYRF---RDP 146
Cdd:cd23964    6 RKKLQKSPWFRERFIPDIKVLLDSEDFN-----PEEYNRLShyklPFgWGGLN-REVVERLLRNLNLtSSRYMFvlrGGR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 147 QQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKN-----LPA--NVSFVLVPF 219
Cdd:cd23964   80 PRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNsllkhVPQdkDTKYLFIPF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 220 KALDLMWIASALS-----TGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHH-GRYPSTGMLVLFFALHVCDE 293
Cdd:cd23964  160 KIRDYDYLDAVLSgkpvpDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSStSYRPTTGALMLLTALHTCDQ 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 159110598 294 VNVYGFGADSRGNWHHYweNNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23964  240 VSVYGFGYDPRFSLHYY--DKTFVKFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 152-338 4.33e-51

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 168.31  E-value: 4.33e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 152 CAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKalDLMWIASAL 231
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLP--LEEEVVLIL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 232 STGQIRFTYAPVKSFLRVDKEKVQIYNPA--FFKYIHDRWTEHH------GRYPSTGMLVLFFALHVCDEVNVYGFGADS 303
Cdd:cd19952   79 SRAAAADFKRLKRRKKRHDNAVLLLTDPApdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGVDS 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 159110598 304 ---RGNWHHYWENNRYAgefRKTGVHDADFEAHIIDML 338
Cdd:cd19952  159 ghaPKVPYHYYDLVEAE---EGTAVHSFDLEAELLRAL 193
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 149-335 1.58e-49

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 164.77  E-value: 1.58e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPA----NVSFVLVPFKALDL 224
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEeydsDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 225 MWIASALS----TGQIRFTYAPVKSFlRVDKEKVQIYNPaffkYIHDRWTEHHGRY----------PSTGMLVLFFALHV 290
Cdd:cd23967   82 LWLQAVIKgkkpNGKGGFWKKIATSV-PKPPKKIRILNP----YILQEAAFDLIGLpmngkqgknvPTTGIIAIVMALHY 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 159110598 291 CDEVNVYGFGAD-SRGN-WHHYWENNRYAGEFRKTGvHDADFEAHII 335
Cdd:cd23967  157 CDEVDIAGFGYDpSDPNaPLHYYDSLTMKAIKRSWT-HNVTKEKKYL 202
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 149-313 7.65e-47

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 157.90  E-value: 7.65e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLP-----ANVSFVLVPFKALD 223
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgiendPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 224 LMWIASALSTGQI--RFTYAPVKSFLRVDKEKVQIYNPAF-----FKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNV 296
Cdd:cd23982   82 FYWLYEILSNEKRvrKGFWKQPPRIWDANPKQIRILNPYYtyvaaTKLLQVPGQRKKKQKPTTGLLAITLALHLCDEVHI 161

                        170       180
                 ....*....|....*....|
gi 159110598 297 YGFGADSRGN---WHHYWEN 313
Cdd:cd23982  162 AGFGYPDNGNsnqPIHYYNQ 181
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 129-327 1.17e-34

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 128.15  E-value: 1.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 129 EKLFQIVPGENPyrFRDPQQcRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNL 208
Cdd:cd23963   46 KSLYELLPKTSP--FSHKRY-KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 209 ---PANVSFVLVPFKALD-----LMWIASALSTGQIRFTYApVKSFLRVDKEKVQI--YNPAFFKYIHDRWTEHHG-RYP 277
Cdd:cd23963  123 ynsLKKNRDRDKFLNRLKeyngsILWYPKFSFKSSTNLLLK-AARALKKNGLNLTVvySNPEHFLAVQKFWKRRGLeKRP 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 159110598 278 STGMLVLFFALHVCDEVNVYGF---GADSRGNW--HHYWENNRYAGefrKTGVHD 327
Cdd:cd23963  202 STGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPvpYHYYDDLSPST---KNKVHN 253
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 149-331 2.78e-33

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 122.54  E-value: 2.78e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESA----KNLPANVSFVLVPFKALDL 224
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGApkseQEYDPTSLFVAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 225 MWIASALSTGQIR-----FTYAPVKSFLRVDKEKVQIYNPAFFKYI----------HDRWTEHHGRYPSTGMLVLFFALH 289
Cdd:cd23983   82 AWLKAMVKKEPLSfwsrlFFWKEVADSIPLKPSQFRILNPLIIKETaldilqypepQSRLWGWDKNVPTLGVTAVVLATH 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 159110598 290 VCDEVNVYGFGAD--SRGNWHHYWENNRYAGEFRKTgVHDADFE 331
Cdd:cd23983  162 LCDEVSLAGFGYDlsQPHAPLHYYDSVCMAAMNTQT-MHNVTKE 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 149-313 5.80e-33

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 121.78  E-value: 5.80e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLP----ANVSFVLVPFKALDL 224
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPshydPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 225 MWIASALSTGQIR---FTYAPVKSfLRVDKEKVQIYNPAFFKYIHDRW--------TEHHGRYPSTGMLVLFFALHVCDE 293
Cdd:cd23984   82 RWLLDLLMGKKVSakgFWKKPALN-LIYKPNQIRILNPFILRIAAYELlhfpkrfpKEKKPKHPTTGIIAITLALHICNE 160

                        170       180
                 ....*....|....*....|..
gi 159110598 294 VNVYGFGAD--SRGNWHHYWEN 313
Cdd:cd23984  161 VHIAGFKYDfsNLNSTLHYYGN 182
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 149-317 1.71e-28

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 109.63  E-value: 1.71e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVS----FVLVPFKALDL 224
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 225 MWIASALSTGQIRFTYAPVKSF-LRVDKE--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALHVCDE 293
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVaTRVPREphEIRILNPYFiqeaaFSFIglpFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180
                 ....*....|....*....|....*.
gi 159110598 294 VNVYGFGADSRGNWH--HYWENNRYA 317
Cdd:cd23981  162 VAVAGFGYDMNTPNAplHYYETIKMS 187
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 139-347 2.03e-28

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 112.15  E-value: 2.03e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 139 NPYRFRDPQ------QCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPAN- 211
Cdd:cd23974   68 NGQMFDWWDrpngrsPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAy 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 212 -------------VSFVLVPFKALDLMWIASALSTGQIR----FTYAPVKSF-LRVDKEKVQIYNPAFFKYIHDRW---- 269
Cdd:cd23974  148 agvgfngppqskeTRYIFLPDHDRDYLLVKAALTHTPIDrgrdKSKRPSKYFgKDVTAEKFKIYHPDFIRYLRNRFlwsp 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 270 ---TEHHGRY-PSTGMLVLFFALHVCDEVNVYGFGADSRGNWH-HYWENNRYAGEFRKTgvHDADFEAHIIDMLAKASKI 344
Cdd:cd23974  228 ilnTKQRDIYrPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYSdHYYDKTYHKVVFYAN--HDLRLEMQLWQKLHKAGLI 305


                 ...
gi 159110598 345 EVY 347
Cdd:cd23974  306 KLY 308
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 150-348 2.35e-28

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 110.82  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 150 RRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTT----HHFMYPESAKNLPANVSFVLVPFkaldLM 225
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrliNSQILSKPEFNFLTDPLYRNVTL----LV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 226 WIASALSTGQIRFTYAPVKSF--------LRVDKEKVQIYNPAFFKYIHD---RWTEH--HGRYPSTGMLVLFFALHVCD 292
Cdd:cd23968  122 WDPSSYNVNLEKWYKKPDFDFfpnyikyrRRHPEEPFYLIDPRFLWRLWDilqEYTPEkiKPNPPSSGFIGIVLMLHLCD 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 159110598 293 EVNVYGFGADSRGNWH-HYWENnrYAGEFRKTG-VHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23968  202 WVDVYEYVPSVRQTDRcHYYDV--EKDLACTLGaWHPLAAEKLLVRHLNVGSDDDIFR 257
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 141-348 1.52e-27

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 109.91  E-value: 1.52e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 141 YRFRDPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKN------------L 208
Cdd:cd23972   74 FPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNslisywnlgftrT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 209 P--ANVSFVLVPFKALDLMWIASALSTGQIRFTY----APVKSF-LRVDKEKVQIYNPAFFKYIHDRW-------TEHHG 274
Cdd:cd23972  154 PqgQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLdkgdRPHKYFgPEASAKKFKLLHPDFISYLTDRFlkskllnTHYGH 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 159110598 275 RY-PSTGMLVLFFALHVCDEVNVYGF-GADSRGNWHHYWENNRYAGEFRKTgvHDADFEAHIIDMLAKASKIEVYR 348
Cdd:cd23972  234 LYmPSTGALMLLTALHTCDQVSAYGFiTSNYWKFSDHYYERKKKPLVFYAN--HDMLLEAALWRRLHKAGILQLYQ 307
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 79-299 6.14e-26

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 105.60  E-value: 6.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598  79 ASTSEWFDSHFDGNISPVWTRDNMNlppdvQRWWMMLQ---PQFKSHNTN-----EVLE--------KLFQIVPGENpyr 142
Cdd:cd23973    9 AAKSDWFKKLFLPNITLFLDKDHFN-----MSEWDRLEhfnPPFGFMGLNytlvkEVVElipkpkeqQLLALSPPGG--- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 143 frdpQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTThhfMYPESA---------------KN 207
Cdd:cd23973   81 ----DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTS---FYVHTAhsitsslmilqkrgfKN 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 208 LPAN--VSFVLVPFKALDLMWIASALSTGQIR----FTYAPVKSF-LRVDKEKVQIYNPAFFKYIHDRW-------TEHH 273
Cdd:cd23973  154 IPQDkdIKYILFPEGPRDYQWLEALLKNKTIPsgayYGRRPRSYFsGDFTEDKYLVLHPDFLRYVKNRFlrsktlkGKYW 233

                        250       260
                 ....*....|....*....|....*..
gi 159110598 274 GRY-PSTGMLVLFFALHVCDEVNVYGF 299
Cdd:cd23973  234 AIYrPTTGAFLLLTALHLCDTVSAYGF 260
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 119-322 5.19e-25

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 102.11  E-value: 5.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 119 FKSHNTNEVLEKLFQIVPGENPYRFRdpqQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHH 198
Cdd:cd23969   37 IDRHKTVNITQDLYQLLPEVSPLKGK---HFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 199 FMYPesaknlpanvSFVLVPFKALD------------------LMWIASALSTG---QIRFTYAPVKsflrvdKEKVQI- 256
Cdd:cd23969  114 TMNP----------SVIPHAYGDLVnatdkekfverlrqlgdsILWIPAFVSKGgeeHVQWTNEIIL------KHKLNVk 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 159110598 257 --YNPA-FFKYIHDRW--TEHHGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRYAGEFRK 322
Cdd:cd23969  178 taYPPLrLNHAIRGYWltTKFRIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRavKYHYYDNRKYLTTARP 253
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 149-316 1.03e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 97.31  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLVPFKALDLM--W 226
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAILLLAGTRAPTVVvfW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 227 IASALSTGQIRFTYAPVKSFLRVDKEkVQIYNPAFFKYIH-DRWTEHH--------GRYPSTGMLVLFFALHVCDEVNVY 297
Cdd:cd23965   81 GPETKMNKDGAGKYNLLRSLSKKYPD-VEFYSLTPEKMDYaDELFEKEtgksriksGTWLSTGWFTMLLALDVCDEIKVY 159

                        170       180
                 ....*....|....*....|....*.
gi 159110598 298 GFGADS--RGNWH-----HYWENNRY 316
Cdd:cd23965  160 GMVPENycREHPNskvpyHYYEPGGL 185
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 127-327 7.92e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 96.17  E-value: 7.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 127 VLEKLFQIVPGENPYRfrdPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPtVGFEKDVGSRTT---------- 196
Cdd:cd23971   45 VNEKLFSMLPKESPFS---NKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNlvtanpsilr 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 197 ---HHFMYP-----ESAKNLPAnvSFVLVPfkaldlmwiasALSTGQ-----IRFTYApVKSFLRvdKEKVQIYNPAFFK 263
Cdd:cd23971  121 ekfHNLKKRrrpfvERMKVYGN--ALLLLP-----------AFSYTSntepsLRALYT-LEDFGS--PQKVLFFNPEYLR 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 159110598 264 YIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGF---GADSRGNW--HHYWENNRyagefRKTGVHD 327
Cdd:cd23971  185 NLSRYWKSKglKARRLSTGLMLVSAALELCENVHLYGFwpfSTDLDGNPisHHYYDNVL-----PKKGVHA 250
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 124-338 2.29e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 95.02  E-value: 2.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 124 TNEVLEKLFQIVPGENPYRFRdpqQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPE 203
Cdd:cd23988   42 TLNISQNLHSLLPEVSPMKNR---RFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPS 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 204 -------SAKNLPANVSFVLVPFKALD-LMWIASALSTGQIRFTyAPVKSFLRVDKEKVQIYNPAfFKYIH---DRWTEH 272
Cdd:cd23988  119 vvqrafgGFRNESDREKFVHRLSMLNDsVLWIPAFMVKGGEKHV-EWVNALILKNKLKVRTAYPS-LRLIHavrGYWLTN 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 159110598 273 --HGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRYAgEFRKTGVHDADFEAHIIDML 338
Cdd:cd23988  197 kvNIKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNpvKYHYYDDLKYR-YFSNAGPHRMPLEFKTLNVL 268
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 107-330 1.44e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 90.15  E-value: 1.44e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 107 DVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRfrdPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVG 186
Cdd:cd23970   29 DVRIGQLMHFDYSSHKYVFSISPNLRSLLPEVSPFQ---NKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 187 FEKDVGSRTTHHFMYPESAKNLPANVSFV------LVPFKALD--LMWIASALSTGQIRFTYAPVKSFLRV-DKEKVQIY 257
Cdd:cd23970  106 FEKDVGRKTNLTTFNPSILEKYYNNLLTIqdrnnfFLSLKKLDgaILWIPAFFFHTSATVTRTLVDFFVEHrGQLKVQLA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 258 NPA-FFKYIHDRWTEHHG--RYPSTGMLVLFFALHVCDEVNVYGF---GADSRGNW--HHYWEN--NRYAGEFRKTGVHD 327
Cdd:cd23970  186 WPGnIMQHVNRYWKTKHLspKRLSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPlpYHYYDKkgTKFTTKWQESHQLP 265


                 ...
gi 159110598 328 ADF 330
Cdd:cd23970  266 AEF 268
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 119-313 4.95e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 88.35  E-value: 4.95e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 119 FKSHNTNEVLEKLFqivPGENPYRFRdpqqCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAP-TVGFEKDVGSRTth 197
Cdd:cd23989   40 LHSHTVDNETYSLF---PQDTPLQLP----LKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKT-- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 198 hfmypesaKNLPANVSFVLVPFKalDLMWIASA----LSTGQIRFTYAPVKSF-------LRV--------DKEKVQIYN 258
Cdd:cd23989  111 --------QLVTANPSIIDKRFQ--NLLWSRKSfvesMKVYGRSYIYMPAFSMktgtdpsLRVyytladvgANQTVLFAN 180

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 159110598 259 PAFFKYIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGF-----GADSRGNWHHYWEN 313
Cdd:cd23989  181 PNFLRNVGKFWKSKgvHAKRLSTGLFLVSAALGLCEEVTIYGFwpfsvDLDERTISHHYYDN 242
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 149-315 2.59e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 85.30  E-value: 2.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTT----HHFMYPESAKNLP------ANVSFVLV- 217
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSlrvvSHTSVPLLLRNQGyffqqsRDTKYVIWg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 218 PFKALDLMWIASALSTGQIRFTYAPVKSFLRVDKEKVQiYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVY 297
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMA-YCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVY 159

                        170       180
                 ....*....|....*....|....*
gi 159110598 298 GFGADS--RGNWH-----HYWENNR 315
Cdd:cd23977  160 GMVSDSycRNKNHssvpyHYYEKGR 184
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 129-313 1.45e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 84.42  E-value: 1.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 129 EKLFQIVPGENPyrFRDPQQcRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVG-FEKDVGSRTTHHFMYPESAKN 207
Cdd:cd23991   47 ENIFRMFPKSQP--FRGYPY-KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 208 LPANVSFVLVPF--------KALDLMWIASALSTGQIRF-TYAPVKSFlrVDKEKVQIYNPAFFKYIHDRWTEHHGRYP- 277
Cdd:cd23991  124 KYAKLNERRKPFletvsvygDAFLLLPAFSYRSNTALSFkVYYTLEDF--KAKQKVIFFHPIYLKHLAQFWRSKGVQVYr 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 159110598 278 -STGMLVLFFALHVCDEVNVYGFGADSRGN-----WHHYWEN 313
Cdd:cd23991  202 lSTGLMITSAALELCEEVKLYGFWPFSKNTegkpiSHHYYDN 243
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 119-316 1.54e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 81.52  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 119 FKSHNTNEVLEKLFQIVPGENPYRfrdPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHH 198
Cdd:cd23987   37 FDRDSTMNISQNLYELLPRTSPLK---NKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 199 FMYP---ESAKNLPANVSFV---LVPFKALD--LMWIASALST-GQIRFTYapVKSFLRVDKEKVQIYNPA--FFKYIHD 267
Cdd:cd23987  114 TMNPsvvQRAFEDLVNETWKekfLQRLQSLNgsILWIPAFMAKgGEERVEW--VNDLILKHHINVRTAYPSlrLLHAVRG 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 159110598 268 RW-TEH-HGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWENNRY 316
Cdd:cd23987  192 YWlTNKvHIKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNpvKYHYYDSLKY 247
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 148-299 1.08e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.98  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 148 QCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMypesaknlpaNVSFVLVPfkalDLMWI 227
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI----------NSQLVTTE----KHKFL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 228 ASALSTGQIRFTYAPV-------KSFLRVDK---EKVQIY---NPAFFKYI---HDRWT----------EHHGRY-PSTG 280
Cdd:cd23985  110 KDSLYNEGILIVWDPApyhsdipEWYKNPDYnffENYKTYrrlNPNQPFYIlhpQMQWElwdiiqenspEEIQPNpPSSG 189

                        170
                 ....*....|....*....
gi 159110598 281 MLVLFFALHVCDEVNVYGF 299
Cdd:cd23985  190 MLGIILMMTLCDQVDVYEF 208
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 129-348 7.28e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 76.41  E-value: 7.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 129 EKLFQIVPGENPYrfrdPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTT------------ 196
Cdd:cd23986   33 EKYVPKIPLSKLH----LRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnp 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 197 -HHFMYPESAKNLPAnVSFVLVPFKALDLMWIASA---LSTGQIRFTyapvksfLRVDKEKVQIYNPAFFKYIHDRWTEH 272
Cdd:cd23986  109 nHHFIDSSLYKDVIL-VAWDPAPYSANLHKWYKKPdynLFTPYVQYR-------KRNPNQPFYILHPKFIWQLWDIIQEN 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 273 HGRY-----PSTGMLVLFFALHVCDEVNVYGFGADSR-GNWHHYWEnnRYAGEFRKTGV-HDADFEAHIIDMLAKASKIE 345
Cdd:cd23986  181 TQEKiqpnpPSSGFIGILIMMSMCREVHVYEYIPSVRqTDLCHYHE--RYYDAACTLGAyHPLLYEKLLIQRMNKGTEDD 258


                 ...
gi 159110598 346 VYR 348
Cdd:cd23986  259 LYR 261
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 149-316 3.29e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 73.81  E-value: 3.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTT----HHFMYPESAKNlP------ANVSFVLV- 217
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTirvvSHTSVPLLLKN-PdyffkeTNETIYVIw 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 218 -PFKALD----------LMWIASALSTGQIRFTyapvksflrvdKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFF 286
Cdd:cd23975   80 gPFRNMRkdgkgivynmLKKAVESYPQAKIYVT-----------TEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLIL 148

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 159110598 287 ALHVCDEVNVYGFGADS-------RGNWHHYWENNRY 316
Cdd:cd23975  149 AMDACYGIHVYGMINDTycktegyRKVPYHYYEPGRD 185
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 129-313 3.01e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 66.01  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 129 EKLFQIVPGENPYRfrdPQQCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAP-TVGFEKDVGSRTthhfmypesaKN 207
Cdd:cd23990   47 SEIFKMFPKDMPYS---RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKT----------DV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 208 LPANVSFVLVPFKALDlMWiasalstgqirftYAPVKSFLRVdKEKVQIYNPAFFK------------------------ 263
Cdd:cd23990  114 VTINPSIITERFHKLE-KW-------------RRPFYEVLQV-YENASVVLPAFYNtrntdvsirvkyvlddfesqqavy 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 159110598 264 YIHDRWTEHHGRY----------PSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 313
Cdd:cd23990  179 YFHPQYLLNVSRFwlrqgvrakrISSGLMLVTAALELCEEVHLYGFWAfpmNPSGIFitHHYYDN 243
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 149-298 3.44e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 65.26  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 149 CRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTT-----HHFMY-----PESAKNLPANVSFVL-- 216
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTlrvvaHSSVYrvlrrPQEFLNRTPETTLIFwg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 217 ------VPFKALDLMWIASALSTGqirftyaPVKSFLRVDKEKVQIYNPAFFKYI-HDRWTEHhgRYPSTGMLVLFFALH 289
Cdd:cd23978   81 ppnkmqKDGKSNLFRIIQRASMTF-------PNMSAFVVSPRRMRQFDDLFRGETgRDRKKSH--SWLSTGWFTMVIAVE 151


                 ....*....
gi 159110598 290 VCDEVNVYG 298
Cdd:cd23978  152 LCDNVHVYG 160
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 148-298 2.06e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 63.35  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 148 QCRRCAVVGNSGNLRGSGYGQEVDSHNFIMRMNQAPTVGFEKDVGSRTTHHFMYPESAKNLPANVSFVLvpfkaldlmwi 227
Cdd:cd23976   14 HCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNELL----------- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 159110598 228 asALSTGQIRFTYAPvKSFLRVDKeKVQIYN---------PAFFKYIHDR---------WTEHHGR-------YPSTGML 282
Cdd:cd23976   83 --NVSQGTVFIFWGP-SNYMRRDG-KGLVYNnlqlmnqilPKLKVYTITRhkmlqfdelFKRETGKdrkisntWLSTGWF 158

                        170
                 ....*....|....*.
gi 159110598 283 VLFFALHVCDEVNVYG 298
Cdd:cd23976  159 TMIIALELCDRINVYG 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH