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Conserved domains on  [gi|158428112|ref|NP_001028715|]
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interleukin-20 receptor subunit beta precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 10-119 5.36e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 99.00  E-value: 5.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112   10 PFMWFFYSMTSG-FLTDAVSVLPAPQNLSVQSTNMKHLLMWNPVTQPGETVLYCVEYQgeyesLYMSHIWIPSSQCSPTK 88
Cdd:pfam01108   1 LLTLLLGLLLLAlASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNIT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 158428112   89 SLECDVTDDIT-ATVPYNFRVKAMLGSQTSAW 119
Cdd:pfam01108  76 RTECDLTDETSdLTETYYARVRAVSGGGTSSW 107
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 131-220 8.26e-07

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 46.57  E-value: 8.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112  131 TVLTPPRMEVTEHG--LHLVIE-----------LEDLGPQFEFLVVYWR-REPGAAEHVKMVRSGDIpvhLETMEPGAMY 196
Cdd:pfam09294   1 TIIGPPEVELEVEGgsLNVTVKdpetregknlsLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSFVV---LSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 158428112  197 CVKAQALVKAIGRHSAFSQPTCVE 220
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 10-119 5.36e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 99.00  E-value: 5.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112   10 PFMWFFYSMTSG-FLTDAVSVLPAPQNLSVQSTNMKHLLMWNPVTQPGETVLYCVEYQgeyesLYMSHIWIPSSQCSPTK 88
Cdd:pfam01108   1 LLTLLLGLLLLAlASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNIT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 158428112   89 SLECDVTDDIT-ATVPYNFRVKAMLGSQTSAW 119
Cdd:pfam01108  76 RTECDLTDETSdLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 131-220 8.26e-07

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 46.57  E-value: 8.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112  131 TVLTPPRMEVTEHG--LHLVIE-----------LEDLGPQFEFLVVYWR-REPGAAEHVKMVRSGDIpvhLETMEPGAMY 196
Cdd:pfam09294   1 TIIGPPEVELEVEGgsLNVTVKdpetregknlsLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSFVV---LSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 158428112  197 CVKAQALVKAIGRHSAFSQPTCVE 220
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-124 1.08e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112  31 PAPQNLSVQSTNMKHL-LMWNPVTQPGETVL-YCVEYQGEYESlymshiwiPSSQCSPTKSLECDVT-DDITATVPYNFR 107
Cdd:cd00063    2 SPPTNLRVTDVTSTSVtLSWTPPEDDGGPITgYVVEYREKGSG--------DWKEVEVTPGSETSYTlTGLKPGTEYEFR 73

                         90
                 ....*....|....*..
gi 158428112 108 VKAMLGSQTSAWSNLEH 124
Cdd:cd00063   74 VRAVNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 10-119 5.36e-26

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 99.00  E-value: 5.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112   10 PFMWFFYSMTSG-FLTDAVSVLPAPQNLSVQSTNMKHLLMWNPVTQPGETVLYCVEYQgeyesLYMSHIWIPSSQCSPTK 88
Cdd:pfam01108   1 LLTLLLGLLLLAlASAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYK-----IYGSGDWKNVPNCTNIT 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 158428112   89 SLECDVTDDIT-ATVPYNFRVKAMLGSQTSAW 119
Cdd:pfam01108  76 RTECDLTDETSdLTETYYARVRAVSGGGTSSW 107
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 131-220 8.26e-07

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 46.57  E-value: 8.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112  131 TVLTPPRMEVTEHG--LHLVIE-----------LEDLGPQFEFLVVYWR-REPGAAEHVKMVRSGDIpvhLETMEPGAMY 196
Cdd:pfam09294   1 TIIGPPEVELEVEGgsLNVTVKdpetregknlsLRDLYGSLQYRVSYWKnSSNGEKKNTTSTNSFVV---LSDLEPGTTY 77

                          90       100
                  ....*....|....*....|....
gi 158428112  197 CVKAQALVKAIGRHSAFSQPTCVE 220
Cdd:pfam09294  78 CVSVQAFSPLDNKSSQRSPPQCIR 101
fn3 pfam00041
Fibronectin type III domain;
31-120 2.50e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112   31 PAPQNLSV---QSTNMkhLLMWNPVTQPGETVL-YCVEYQGEYESLYMSHIWIPSSQCSptksleCDVTDdITATVPYNF 106
Cdd:pfam00041   1 SAPSNLTVtdvTSTSL--TVSWTPPPDGNGPITgYEVEYRPKNSGEPWNEITVPGTTTS------VTLTG-LKPGTEYEV 71

                          90
                  ....*....|....
gi 158428112  107 RVKAMLGSQTSAWS 120
Cdd:pfam00041  72 RVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 31-124 1.08e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158428112  31 PAPQNLSVQSTNMKHL-LMWNPVTQPGETVL-YCVEYQGEYESlymshiwiPSSQCSPTKSLECDVT-DDITATVPYNFR 107
Cdd:cd00063    2 SPPTNLRVTDVTSTSVtLSWTPPEDDGGPITgYVVEYREKGSG--------DWKEVEVTPGSETSYTlTGLKPGTEYEFR 73

                         90
                 ....*....|....*..
gi 158428112 108 VKAMLGSQTSAWSNLEH 124
Cdd:cd00063   74 VRAVNGGGESPPSESVT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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