histone H4 [Leishmania major strain Friedlin]
histone H4( domain architecture ID 11487839)
histone H4 is one of the four histones, along with H2A, H2B and H3, that form the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation
List of domain hits
Name | Accession | Description | Interval | E-value | |||
PTZ00015 | PTZ00015 | histone H4; Provisional |
1-99 | 3.19e-46 | |||
histone H4; Provisional : Pssm-ID: 185397 Cd Length: 102 Bit Score: 143.73 E-value: 3.19e-46
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Name | Accession | Description | Interval | E-value | |||
PTZ00015 | PTZ00015 | histone H4; Provisional |
1-99 | 3.19e-46 | |||
histone H4; Provisional Pssm-ID: 185397 Cd Length: 102 Bit Score: 143.73 E-value: 3.19e-46
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HFD_H4 | cd22912 | histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component ... |
20-98 | 1.01e-30 | |||
histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Pssm-ID: 467037 [Multi-domain] Cd Length: 79 Bit Score: 103.84 E-value: 1.01e-30
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H4 | smart00417 | Histone H4; |
15-88 | 3.34e-29 | |||
Histone H4; Pssm-ID: 128694 Cd Length: 74 Bit Score: 99.92 E-value: 3.34e-29
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HHT1 | COG2036 | Archaeal histone H3/H4 [Chromatin structure and dynamics]; |
33-91 | 1.96e-04 | |||
Archaeal histone H3/H4 [Chromatin structure and dynamics]; Pssm-ID: 441639 Cd Length: 67 Bit Score: 36.35 E-value: 1.96e-04
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Name | Accession | Description | Interval | E-value | |||
PTZ00015 | PTZ00015 | histone H4; Provisional |
1-99 | 3.19e-46 | |||
histone H4; Provisional Pssm-ID: 185397 Cd Length: 102 Bit Score: 143.73 E-value: 3.19e-46
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HFD_H4 | cd22912 | histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component ... |
20-98 | 1.01e-30 | |||
histone-fold domain found in histone H4 and similar proteins; Histone H4 is a core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Pssm-ID: 467037 [Multi-domain] Cd Length: 79 Bit Score: 103.84 E-value: 1.01e-30
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H4 | smart00417 | Histone H4; |
15-88 | 3.34e-29 | |||
Histone H4; Pssm-ID: 128694 Cd Length: 74 Bit Score: 99.92 E-value: 3.34e-29
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PLN00035 | PLN00035 | histone H4; Provisional |
11-99 | 5.83e-28 | |||
histone H4; Provisional Pssm-ID: 177669 [Multi-domain] Cd Length: 103 Bit Score: 97.60 E-value: 5.83e-28
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HFD_SF | cd00076 | histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally ... |
28-90 | 9.31e-07 | |||
histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally conserved interaction motif involved in heterodimerization of the core histones and their assembly into the nucleosome octamer. Histone fold heterodimers play crucial roles in gene regulation. The minimal HFD consists of three alpha helices connected by two short, unstructured loops. The HFD is found in core histones, TATA box-binding protein-associated factors (TAFs), and many other transcription factors. HFD plays a role in the nucleosomal core particle by conserving histone interactions; these contain more than one HFD. The structure of the nucleosome core particle has two modes that have the largest interaction surfaces, and these are the H3-H4 and H2A-H2B heterodimer interactions. Several TAFs interact via histone-fold (HF) motifs. Five HF-containing TAF pairs have been described in transcription factor II D (TFIID): TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10. Pssm-ID: 467021 Cd Length: 63 Bit Score: 42.20 E-value: 9.31e-07
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PLN00163 | PLN00163 | histone H4; Provisional |
15-57 | 4.97e-05 | |||
histone H4; Provisional Pssm-ID: 165730 Cd Length: 59 Bit Score: 37.75 E-value: 4.97e-05
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HFD_archaea_histone-like | cd22909 | histone-fold domain mainly found in archaeal histone-fold proteins, histone-like transcription ... |
33-90 | 6.30e-05 | |||
histone-fold domain mainly found in archaeal histone-fold proteins, histone-like transcription regulators and similar proteins; The family includes many archaeal histone-fold proteins and histone-like transcription regulators, which may bind and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. They can increase the resistance of DNA to thermal denaturation. Pssm-ID: 467034 Cd Length: 64 Bit Score: 37.52 E-value: 6.30e-05
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HHT1 | COG2036 | Archaeal histone H3/H4 [Chromatin structure and dynamics]; |
33-91 | 1.96e-04 | |||
Archaeal histone H3/H4 [Chromatin structure and dynamics]; Pssm-ID: 441639 Cd Length: 67 Bit Score: 36.35 E-value: 1.96e-04
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HFD_TAF8 | cd22918 | histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and ... |
57-94 | 7.54e-03 | |||
histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and similar proteins; TAF8, also called TATA Binding Protein (TBP) associated factor 8, protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, or transcription initiation factor TFIID 43 kDa subunit (TAFII-43, TAFII43), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF8 mediates both basal and activator-dependent transcription. It is involved in the differentiation of preadipocyte fibroblasts to adipocytes, however, it does not seem to play a role in differentiation of myoblasts. TAF8 is required for the integration of TAF10 in the TAF complex. It may be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo. Pssm-ID: 467043 Cd Length: 84 Bit Score: 32.52 E-value: 7.54e-03
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Blast search parameters | ||||
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