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Conserved domains on  [gi|157850994|gb|ABV90281|]
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cytochrome oxidase subunit II, partial (mitochondrion) [Filchnerella micropenna]

Protein Classification

cytochrome c oxidase subunit II( domain architecture ID 999987)

cytochrome c oxidase subunit II, part of the functional core of the enzyme, transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit I

CATH:  1.10.287.90
EC:  7.1.1.9
Gene Ontology:  GO:0004129|GO:0005507
PubMed:  6307356|8083153
TCDB:  3.D.4.6.2

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COX2 super family cl33359
cytochrome c oxidase subunit II; Provisional
 1-111 1.06e-67

cytochrome c oxidase subunit II; Provisional


The actual alignment was detected with superfamily member MTH00154:

Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 202.75  E-value: 1.06e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00154   1 MATWSNLSFQDSASPLMEQLIFFHDHTMMILIMITILVGYMMISLLFNKFTNRFLLEGQEIEIIWTILPAIILIFIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00154  81 LRLLYLLDEVNNPSITLKTIGHQWYWSYEYS 111
 
Name Accession Description Interval E-value
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 1-111 1.06e-67

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 202.75  E-value: 1.06e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00154   1 MATWSNLSFQDSASPLMEQLIFFHDHTMMILIMITILVGYMMISLLFNKFTNRFLLEGQEIEIIWTILPAIILIFIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00154  81 LRLLYLLDEVNNPSITLKTIGHQWYWSYEYS 111
COX2_TM pfam02790
Cytochrome C oxidase subunit II, transmembrane domain; The N-terminal domain of cytochrome C ...
 1-83 3.14e-24

Cytochrome C oxidase subunit II, transmembrane domain; The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.


Pssm-ID: 397083 [Multi-domain]  Cd Length: 89  Bit Score: 88.16  E-value: 3.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994    1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLM------IKYSNRYVLHGHLIETIWTALPAITLI 74
Cdd:pfam02790   1 MPTPWGLGFQDAASPLMEGLLELHDYIMFILTLILILVLYILVTCLIrfnrrkNPITARYTTHGQTIEIIWTIIPAVILI 80


                  ....*....
gi 157850994   75 FIALPSLRL 83
Cdd:pfam02790  81 LIALPSFKL 89
CyoA COG1622
Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];
7-110 3.71e-18

Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];


Pssm-ID: 441229 [Multi-domain]  Cd Length: 229  Bit Score: 76.02  E-value: 3.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   7 LSLQDSASPLMEQLSFFHDHTMTVLTLITIVVgysLSYML--MIKYSNR-------YVLHGHLIETIWTALPAITLIFIA 77
Cdd:COG1622   19 LSLPDPAGPIAEEIDDLFWVSLIIMLVIFVLV---FGLLLyfAIRYRRRkgdadpaQFHHNTKLEIVWTVIPIIIVIVLA 95

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157850994  78 LPSLRLLYMLDDSIDALITIKTIGRQWYWSYAY 110
Cdd:COG1622   96 VPTLRVLHALDDAPEDPLTVEVTGYQWKWLFRY 128
CoxB TIGR02866
cytochrome c oxidase, subunit II; Cytochrome c oxidase is the terminal electron acceptor of ...
 13-111 1.05e-10

cytochrome c oxidase, subunit II; Cytochrome c oxidase is the terminal electron acceptor of mitochondria (and one of several possible acceptors in prokaryotes) in the electron transport chain of aerobic respiration. The enzyme couples the oxidation of reduced cytochrome c with the reduction of molecular oxygen to water. This process results in the pumping of four protons across the membrane which are used in the proton gradient powered synthesis of ATP. The oxidase contains two heme a cofactors and three copper atoms as well as other bound ions. [Energy metabolism, Electron transport]


Pssm-ID: 274329 [Multi-domain]  Cd Length: 199  Bit Score: 55.85  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   13 ASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMlMIKYSNR-------YVLHGHLIETIWTALPAITLIFIALPSLRLLY 85
Cdd:TIGR02866   2 GGEIAQQIAFLFLFVLAVSTLISLLVAALLAYV-VWKFRRKgdeekpsQIHGNRRLEYVWTVIPLIIVVGLFAATAKGLL 80

                          90       100
                  ....*....|....*....|....*..
gi 157850994   86 MLDDSID-ALITIKTIGRQWYWSYAYS 111
Cdd:TIGR02866  81 YLERPIPkDALKVKVTGYQWWWDFEYP 107
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 95-111 7.60e-06

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 41.79  E-value: 7.60e-06
                         10
                 ....*....|....*..
gi 157850994  95 ITIKTIGRQWYWSYAYS 111
Cdd:cd13912    3 LTIKAIGHQWYWSYEYS 19
 
Name Accession Description Interval E-value
COX2 MTH00154
cytochrome c oxidase subunit II; Provisional
 1-111 1.06e-67

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214438 [Multi-domain]  Cd Length: 227  Bit Score: 202.75  E-value: 1.06e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00154   1 MATWSNLSFQDSASPLMEQLIFFHDHTMMILIMITILVGYMMISLLFNKFTNRFLLEGQEIEIIWTILPAIILIFIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00154  81 LRLLYLLDEVNNPSITLKTIGHQWYWSYEYS 111
COX2 MTH00139
cytochrome c oxidase subunit II; Provisional
 1-111 4.77e-46

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214429 [Multi-domain]  Cd Length: 226  Bit Score: 147.94  E-value: 4.77e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00139   1 MAYWGQLGFQDSASPLMEQLIFFHDHAMVILIMILSFVGYISLSLMSNKFTSRSLLESQEVETIWTVLPAFILLFLALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00139  81 LRLLYLMDEVSDPYLTFKAVGHQWYWSYEYS 111
COX2 MTH00038
cytochrome c oxidase subunit II; Provisional
 1-110 4.42e-45

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177113 [Multi-domain]  Cd Length: 229  Bit Score: 145.23  E-value: 4.42e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00038   1 MATWLQLGLQDASSPLMEELIYFHDYALIILTLITILVFYGLASLLFSSPTNRFFLEGQELETIWTIVPAFILIFIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAY 110
Cdd:MTH00038  81 LQLLYLMDEVNNPFLTIKAIGHQWYWSYEY 110
COX2 MTH00140
cytochrome c oxidase subunit II; Provisional
 1-111 7.36e-45

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214430 [Multi-domain]  Cd Length: 228  Bit Score: 144.70  E-value: 7.36e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00140   1 MSYWGQLGFQDPASPLMEELIFFHDHAMVVLVLIFSFVMYMLVLLLFNKFSCRTILEAQKLETIWTIVPALILVFLALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00140  81 LRLLYLLDETNNPLLTVKAIGHQWYWSYEYS 111
COX2 MTH00008
cytochrome c oxidase subunit II; Validated
 1-111 1.43e-42

cytochrome c oxidase subunit II; Validated


Pssm-ID: 164584 [Multi-domain]  Cd Length: 228  Bit Score: 138.84  E-value: 1.43e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00008   1 MPHWGQLMFQDAASPVMLQLISFHDHALLILTLVLTVVGYAMTSLMFNKLSNRYILEAQQIETIWTILPALILLFLAFPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00008  81 LRLLYLMDEVSNPSITLKTIGHQWYWSYEYS 111
COX2 MTH00117
cytochrome c oxidase subunit II; Provisional
 1-111 9.58e-42

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177178 [Multi-domain]  Cd Length: 227  Bit Score: 136.97  E-value: 9.58e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00117   1 MANPSQLGFQDASSPIMEELLFFHDHALMVALLISSLVLYLLTLMLTTKLTHTNTVDAQEVELIWTILPAIVLILLALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00117  81 LRILYLMDEINNPHLTIKAIGHQWYWSYEYT 111
COX2 MTH00168
cytochrome c oxidase subunit II; Provisional
 1-111 3.84e-41

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177223 [Multi-domain]  Cd Length: 225  Bit Score: 135.11  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00168   1 MATYSQLGLQDAASPVMEELILFHDHALLILVLILTLVLYSLLVLVTSKYTNRFLLDSQMIEFVWTIIPAFILISLALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00168  81 LRLLYLMDEIDKPDLTIKAVGHQWYWSYEYT 111
COX2 MTH00051
cytochrome c oxidase subunit II; Provisional
 7-111 8.75e-37

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177126 [Multi-domain]  Cd Length: 234  Bit Score: 124.51  E-value: 8.75e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   7 LSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPSLRLLYM 86
Cdd:MTH00051   9 LGFQDAASPVMEEIIFFHDQIMFILTIIITTVLWLIIRALTTKYYHKYLFEGTLIEIIWTLIPAAILIFIAFPSLKLLYL 88

                         90       100
                 ....*....|....*....|....*
gi 157850994  87 LDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00051  89 MDEVIDPALTIKAIGHQWYWSYEYS 113
COX2 MTH00023
cytochrome c oxidase subunit II; Validated
 7-111 2.58e-36

cytochrome c oxidase subunit II; Validated


Pssm-ID: 214402 [Multi-domain]  Cd Length: 240  Bit Score: 123.32  E-value: 2.58e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   7 LSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPSLRLLYM 86
Cdd:MTH00023  16 LGFQDAADPVMEEIIFFHDQIMFLLIIIITVVLWLIVEALNGKFYDRFLVDGTFLEIVWTIIPAVILVFIALPSLKLLYL 95

                         90       100
                 ....*....|....*....|....*
gi 157850994  87 LDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00023  96 MDEVVSPALTIKAIGHQWYWSYEYS 120
COX2 MTH00129
cytochrome c oxidase subunit II; Provisional
 1-111 2.88e-36

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177187 [Multi-domain]  Cd Length: 230  Bit Score: 122.90  E-value: 2.88e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00129   1 MAHPSQLGFQDAASPVMEELLHFHDHALMIVFLISTLVLYIIVAMVSTKLTNKYILDSQEIEIIWTVLPAVILILIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00129  81 LRILYLMDEINDPHLTIKAMGHQWYWSYEYT 111
COX2 MTH00098
cytochrome c oxidase subunit II; Validated
 1-111 5.37e-36

cytochrome c oxidase subunit II; Validated


Pssm-ID: 177160 [Multi-domain]  Cd Length: 227  Bit Score: 122.13  E-value: 5.37e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00098   1 MAYPFQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00098  81 LRILYMMDEINNPSLTVKTMGHQWYWSYEYT 111
COX2 MTH00185
cytochrome c oxidase subunit II; Provisional
 1-111 5.38e-36

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164736 [Multi-domain]  Cd Length: 230  Bit Score: 122.30  E-value: 5.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00185   1 MAHPSQLGLQDAASPVMEELIHFHDHTLMIVFLISTLVLYIIVAMVTTKLTNKYILDSQEIEIVWTILPAIILIMIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00185  81 LRILYLMDEINDPHLTIKAMGHQWYWSYEYT 111
COX2 MTH00076
cytochrome c oxidase subunit II; Provisional
 1-111 8.50e-34

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 164646 [Multi-domain]  Cd Length: 228  Bit Score: 116.42  E-value: 8.50e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00076   1 MAHPSQLGFQDAASPIMEELLHFHDHALMAVFLISTLVLYIITIMMTTKLTNTNTMDAQEIEMVWTIMPAIILIVIALPS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSIDALITIKTIGRQWYWSYAYS 111
Cdd:MTH00076  81 LRILYLMDEINDPHLTVKAIGHQWYWSYEYT 111
COX2_TM pfam02790
Cytochrome C oxidase subunit II, transmembrane domain; The N-terminal domain of cytochrome C ...
 1-83 3.14e-24

Cytochrome C oxidase subunit II, transmembrane domain; The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.


Pssm-ID: 397083 [Multi-domain]  Cd Length: 89  Bit Score: 88.16  E-value: 3.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994    1 MATWSILSLQDSASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMLM------IKYSNRYVLHGHLIETIWTALPAITLI 74
Cdd:pfam02790   1 MPTPWGLGFQDAASPLMEGLLELHDYIMFILTLILILVLYILVTCLIrfnrrkNPITARYTTHGQTIEIIWTIIPAVILI 80


                  ....*....
gi 157850994   75 FIALPSLRL 83
Cdd:pfam02790  81 LIALPSFKL 89
COX2 MTH00027
cytochrome c oxidase subunit II; Provisional
 7-110 2.02e-22

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214405 [Multi-domain]  Cd Length: 262  Bit Score: 87.77  E-value: 2.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   7 LSLQDSASPLMEQLSFFHDHtmtVLTLITIVVGYSLSYMLMIKYSNRYV------LHGHLIETIWTALPAITLIFIALPS 80
Cdd:MTH00027  35 LGFQDAGSPVMEEIIMLHDQ---ILFILTIIVGVVLWLIIRILLGNNYYsyywnkLDGSLIEVIWTLIPAFILILIAFPS 111

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157850994  81 LRLLYMLDDSI-DALITIKTIGRQWYWSYAY 110
Cdd:MTH00027 112 LRLLYIMDECGfSANITIKVTGHQWYWSYSY 142
CyoA COG1622
Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];
7-110 3.71e-18

Heme/copper-type cytochrome/quinol oxidase, subunit 2 [Energy production and conversion];


Pssm-ID: 441229 [Multi-domain]  Cd Length: 229  Bit Score: 76.02  E-value: 3.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   7 LSLQDSASPLMEQLSFFHDHTMTVLTLITIVVgysLSYML--MIKYSNR-------YVLHGHLIETIWTALPAITLIFIA 77
Cdd:COG1622   19 LSLPDPAGPIAEEIDDLFWVSLIIMLVIFVLV---FGLLLyfAIRYRRRkgdadpaQFHHNTKLEIVWTVIPIIIVIVLA 95

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157850994  78 LPSLRLLYMLDDSIDALITIKTIGRQWYWSYAY 110
Cdd:COG1622   96 VPTLRVLHALDDAPEDPLTVEVTGYQWKWLFRY 128
COX2 MTH00080
cytochrome c oxidase subunit II; Provisional
 23-111 2.52e-11

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 177149 [Multi-domain]  Cd Length: 231  Bit Score: 57.71  E-value: 2.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994  23 FHDHTMTVLTLITIVVGYSLSYMLMIKYSNRYVLHGHLIETIWTALPAITLIFIALPSLRLLYMLD-DSIDALITIKTIG 101
Cdd:MTH00080  25 FNCSLLFGEFVLAFVVFLFLYLISNNFYFKSKKIEYQFGELLCSVFPVLILLMQMVPSLSLLYYYGlMNLDSNLTVKVTG 104

                         90
                 ....*....|
gi 157850994 102 RQWYWSYAYS 111
Cdd:MTH00080 105 HQWYWSYEFS 114
CoxB TIGR02866
cytochrome c oxidase, subunit II; Cytochrome c oxidase is the terminal electron acceptor of ...
 13-111 1.05e-10

cytochrome c oxidase, subunit II; Cytochrome c oxidase is the terminal electron acceptor of mitochondria (and one of several possible acceptors in prokaryotes) in the electron transport chain of aerobic respiration. The enzyme couples the oxidation of reduced cytochrome c with the reduction of molecular oxygen to water. This process results in the pumping of four protons across the membrane which are used in the proton gradient powered synthesis of ATP. The oxidase contains two heme a cofactors and three copper atoms as well as other bound ions. [Energy metabolism, Electron transport]


Pssm-ID: 274329 [Multi-domain]  Cd Length: 199  Bit Score: 55.85  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157850994   13 ASPLMEQLSFFHDHTMTVLTLITIVVGYSLSYMlMIKYSNR-------YVLHGHLIETIWTALPAITLIFIALPSLRLLY 85
Cdd:TIGR02866   2 GGEIAQQIAFLFLFVLAVSTLISLLVAALLAYV-VWKFRRKgdeekpsQIHGNRRLEYVWTVIPLIIVVGLFAATAKGLL 80

                          90       100
                  ....*....|....*....|....*..
gi 157850994   86 MLDDSID-ALITIKTIGRQWYWSYAYS 111
Cdd:TIGR02866  81 YLERPIPkDALKVKVTGYQWWWDFEYP 107
COX2 MTH00047
cytochrome c oxidase subunit II; Provisional
 60-111 3.25e-07

cytochrome c oxidase subunit II; Provisional


Pssm-ID: 214412 [Multi-domain]  Cd Length: 194  Bit Score: 46.10  E-value: 3.25e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157850994  60 LIETIWTALPaiTLIFIALPSLRLLYMLDDSID-ALITIKTIGRQWYWSYAYS 111
Cdd:MTH00047  48 VLELLWTVVP--TLLVLVLCFLNLNFITSDLDCfSSETIKVIGHQWYWSYEYS 98
CcO_II_C cd13912
C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal ...
 95-111 7.60e-06

C-terminal domain of Cytochrome c Oxidase subunit II; Cytochrome c Oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit II contains a copper-copper binuclear site called CuA, which is believed to be involved in electron transfer from cytochrome c to the binuclear center (active site) in subunit I.


Pssm-ID: 259979 [Multi-domain]  Cd Length: 130  Bit Score: 41.79  E-value: 7.60e-06
                         10
                 ....*....|....*..
gi 157850994  95 ITIKTIGRQWYWSYAYS 111
Cdd:cd13912    3 LTIKAIGHQWYWSYEYS 19
COX2 pfam00116
Cytochrome C oxidase subunit II, periplasmic domain;
95-111 1.33e-04

Cytochrome C oxidase subunit II, periplasmic domain;


Pssm-ID: 395066 [Multi-domain]  Cd Length: 120  Bit Score: 38.16  E-value: 1.33e-04
                          10
                  ....*....|....*..
gi 157850994   95 ITIKTIGRQWYWSYAYS 111
Cdd:pfam00116   1 LTIKAIGHQWYWSYEYT 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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