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Conserved domains on  [gi|157833501]
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Chain A, N-(5'PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE

Protein Classification

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase( domain architecture ID 11484157)

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase catalyzes the fourth and fifth steps of tryptophan biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-452 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


:

Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 926.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHY 80
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  81 ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGV 160
Cdd:PRK09427  83 ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 161 LTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALM 240
Cdd:PRK09427 163 LTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 241 AHDDLHAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVV 320
Cdd:PRK09427 243 AEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 321 DKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLG 400
Cdd:PRK09427 323 DIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSLD 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157833501 401 NVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 452
Cdd:PRK09427 403 NVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-452 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 926.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHY 80
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  81 ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGV 160
Cdd:PRK09427  83 ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 161 LTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALM 240
Cdd:PRK09427 163 LTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 241 AHDDLHAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVV 320
Cdd:PRK09427 243 AEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 321 DKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLG 400
Cdd:PRK09427 323 DIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSLD 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157833501 401 NVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 452
Cdd:PRK09427 403 NVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
5-251 2.16e-135

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 389.35  E-value: 2.16e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501    5 LAKIVADKAIWVEARKQQQPLASFQNEV-QPSTRHFYDALQGA--RTAFILECKKASPSKGVIRDDFDPARIAAIYKHY- 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAArAPPTRSFYDALRESrgRPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   81 ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  161 LTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELS-HFANGFLIGSAL 239
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKeHGANAFLVGESL 240

                         250
                  ....*....|..
gi 157833501  240 MAHDDLHAAVRR 251
Cdd:pfam00218 241 MRQEDVRAAIRE 252
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 7.73e-131

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 377.83  E-value: 7.73e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   2 QTVLAKIVADKAIWVEARKQQQPLASFQNEV--QPSTRHFYDALQGA-RTAFILECKKASPSKGVIRDDFDPARIAAIYK 78
Cdd:COG0134    1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALRAAgGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  79 HY-ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLE 157
Cdd:COG0134   81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 158 MGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIG 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLaAAGADAFLVG 240

                        250
                 ....*....|....*..
gi 157833501 237 SALMAHDDLHAAVRRVL 253
Cdd:COG0134  241 EALMRAPDPGAALRELL 257
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 39-252 1.95e-106

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 314.40  E-value: 1.95e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  39 FYDALQGA-RTAFILECKKASPSKGVIRDDFDPARIAAIYKHY-ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDF 116
Cdd:cd00331    1 FKAALKRPgGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 117 IIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLN 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157833501 197 RTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIGSALMAHDDLHAAVRRV 252
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLaEAGADAVLIGESLMRAPDPGAALREL 217
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 1-452 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 926.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHY 80
Cdd:PRK09427   3 MPTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  81 ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGV 160
Cdd:PRK09427  83 ASAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 161 LTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALM 240
Cdd:PRK09427 163 LTEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLM 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 241 AHDDLHAAVRRVLLGENKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVV 320
Cdd:PRK09427 243 AEDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIV 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 321 DKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLG 400
Cdd:PRK09427 323 DIAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGDTLPARDLQHVDRYLLDNGQGGTGQTFDWSLLPGQSLD 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157833501 401 NVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 452
Cdd:PRK09427 403 NVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRAY 454
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
5-251 2.16e-135

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 389.35  E-value: 2.16e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501    5 LAKIVADKAIWVEARKQQQPLASFQNEV-QPSTRHFYDALQGA--RTAFILECKKASPSKGVIRDDFDPARIAAIYKHY- 80
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQAAArAPPTRSFYDALRESrgRPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   81 ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGV 160
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  161 LTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELS-HFANGFLIGSAL 239
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKeHGANAFLVGESL 240

                         250
                  ....*....|..
gi 157833501  240 MAHDDLHAAVRR 251
Cdd:pfam00218 241 MRQEDVRAAIRE 252
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 2-253 7.73e-131

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 377.83  E-value: 7.73e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   2 QTVLAKIVADKAIWVEARKQQQPLASFQNEV--QPSTRHFYDALQGA-RTAFILECKKASPSKGVIRDDFDPARIAAIYK 78
Cdd:COG0134    1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALRAAgGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  79 HY-ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLE 157
Cdd:COG0134   81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 158 MGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIG 236
Cdd:COG0134  161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLaAAGADAFLVG 240

                        250
                 ....*....|....*..
gi 157833501 237 SALMAHDDLHAAVRRVL 253
Cdd:COG0134  241 EALMRAPDPGAALRELL 257
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
1-256 3.63e-108

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 320.56  E-value: 3.63e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEV--QPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIY- 77
Cdd:PRK00278   1 MMDILDKIVAYKREEVAARKAQVPLAELKARAaaAPPPRDFAAALRAGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYe 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  78 KHYASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLE 157
Cdd:PRK00278  81 AGGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 158 MGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIG 236
Cdd:PRK00278 161 LDVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLaKAGADAVLVG 240

                        250       260
                 ....*....|....*....|
gi 157833501 237 SALMAHDDLHAAVRRVLLGE 256
Cdd:PRK00278 241 ESLMRADDPGAALRELLGAK 260
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 39-252 1.95e-106

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 314.40  E-value: 1.95e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  39 FYDALQGA-RTAFILECKKASPSKGVIRDDFDPARIAAIYKHY-ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDF 116
Cdd:cd00331    1 FKAALKRPgGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 117 IIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLN 196
Cdd:cd00331   81 IIDPYQIYEARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLN 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157833501 197 RTRELAPKLGHNVTVISESGINTYAQVREL-SHFANGFLIGSALMAHDDLHAAVRRV 252
Cdd:cd00331  161 TTERLAPLIPKDVILVSESGISTPEDVKRLaEAGADAVLIGESLMRAPDPGAALREL 217
PRAI pfam00697
N-(5'phosphoribosyl)anthranilate (PRA) isomerase;
257-447 1.95e-83

N-(5'phosphoribosyl)anthranilate (PRA) isomerase;


Pssm-ID: 395566  Cd Length: 193  Bit Score: 254.96  E-value: 1.95e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  257 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGN 336
Cdd:pfam00697   1 AKICGLTRLSDVKAAVKAGADYLGLIFSESSKRQVSPEQAQELRSPVPLLLVGVFVNQPIDDVLRIAQVLGLDVVQLHGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  337 EEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSL--GNVLLAGGLGADNCV 414
Cdd:pfam00697  81 EDQEYENLLPTGVPVIKAIWVPDSVDTVDIARRADHVDLPLLDSGAGGTGELFDWSLVSKWLKsgLKVILAGGLNPDNVV 160

                         170       180       190
                  ....*....|....*....|....*....|....
gi 157833501  415 EAAQT-GCAGLDFNSAVESQpGIKDARLLASVFQ 447
Cdd:pfam00697 161 EAIKTpGVIGVDVSSGVETN-GIKDLNKIRKFVQ 193
TrpF COG0135
Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; ...
 257-451 4.24e-72

Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Phosphoribosylanthranilate isomerase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439905  Cd Length: 208  Bit Score: 226.17  E-value: 4.24e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 257 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLH 334
Cdd:COG0135    4 VKICGLTRPEDARAAVEAGADALGFVFYPKSPRYVSPEQAAELAAALPpfVKKVGVFVNADPEEILEIVEAVGLDAVQLH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 335 GNEEQLYIDTLREALPahVAIWKALSVGET---LPAREFQ-HVDKYVLD----NGQGGSGQRFDWSLLNGQSLG-NVLLA 405
Cdd:COG0135   84 GDESPEYCAALRERLG--LPVIKAIRVGDGadlEEAAAYApVADALLLDakvpGLYGGTGKTFDWSLLAGLALPkPVILA 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 157833501 406 GGLGADNCVEA-AQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRA 451
Cdd:COG0135  162 GGLTPENVAEAiRLVRPYGVDVSSGVESAPGVKDPDKIRAFVEAVRA 208
PRAI cd00405
Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan ...
 257-447 4.54e-68

Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.


Pssm-ID: 238237  Cd Length: 203  Bit Score: 215.52  E-value: 4.54e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 257 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLH 334
Cdd:cd00405    1 VKICGITTLEDALAAAEAGADAIGFIFAPKSPRYVSPEQAREIVAALPpfVKRVGVFVNEDLEEILEIAEELGLDVVQLH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 335 GNEEQLYIDTLREALpaHVAIWKALSVGETLP----AREFQHVDKYVLDN----GQGGSGQRFDWSLLNGQSLG-NVLLA 405
Cdd:cd00405   81 GDESPEYCAQLRARL--GLPVIKAIRVKDEEDlekaAAYAGEVDAILLDSksggGGGGTGKTFDWSLLRGLASRkPVILA 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 157833501 406 GGLGADNCVEA-AQTGCAGLDFNSAVESQPGIKDARLLASVFQ 447
Cdd:cd00405  159 GGLTPDNVAEAiRLVRPYGVDVSSGVETSPGIKDPEKIRAFIE 201
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 2-244 1.11e-61

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 203.86  E-value: 1.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   2 QTVLAKIVADKAIWVEARKQQQPLASFQNEVQ--PSTRHFYDALQGART-----AFILECKKASPSKGVIRDDFDPARIA 74
Cdd:PLN02460  66 RNILEEIVWYKDVEVAQMKERKPLYLLKKALQnaPPARDFVGALRAAHKrtgqpGLIAEVKKASPSRGVLRENFDPVEIA 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  75 AIY-KHYASAISVLTDEKYFQGSFNFLPIVSQIAPQ-PILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAV 152
Cdd:PLN02460 146 QAYeKGGAACLSVLTDEKYFQGSFENLEAIRNAGVKcPLLCKEFIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKI 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 153 AHSLEMGVLTEVSNEEEQERAIAL-GAKVVGINNRDLRDLSIDLNRTREL-APKLGH-----NVTVISESGINT---YAQ 222
Cdd:PLN02460 226 CKSLGMAALIEVHDEREMDRVLGIeGVELIGINNRSLETFEVDISNTKKLlEGERGEqirekGIIVVGESGLFTpddVAY 305

                        250       260
                 ....*....|....*....|..
gi 157833501 223 VRELSHFAngFLIGSALMAHDD 244
Cdd:PLN02460 306 VQNAGVKA--VLVGESLVKQDD 325
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 1-248 7.62e-48

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 164.67  E-value: 7.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   1 MQTVLAKIVADKAIWVEARKQQQPLASFQNEVQpstrhfyDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHY 80
Cdd:PRK13957   1 MHRVLREIIETKQNEIEKISRWDPLPDRGLPLR-------DSLKSRSFSIIAECKRKSPSAGELRADYHPVQIAKTYETL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  81 -ASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMG 159
Cdd:PRK13957  74 gASAISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMD 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 160 VLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSAL 239
Cdd:PRK13957 154 VLVEVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFLPPNIVKVGESGIESRSDLDKFRKLVDAALIGTYF 233


                 ....*....
gi 157833501 240 MAHDDLHAA 248
Cdd:PRK13957 234 MEKKDIRKA 242
PRK01222 PRK01222
phosphoribosylanthranilate isomerase;
258-452 1.17e-47

phosphoribosylanthranilate isomerase;


Pssm-ID: 234923  Cd Length: 210  Bit Score: 162.67  E-value: 1.17e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 258 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLHG 335
Cdd:PRK01222   6 KICGITTPEDAEAAAELGADAIGFVFYPKSPRYVSPEQAAELAAALPpfVKVVGVFVNASDEEIDEIVETVPLDLLQLHG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 336 NEEQLYIDTLREALpaHVAIWKALSVGE--TLPA--REFQHVDKYVLD---NGQGGSGQRFDWSLLNGQSLGNVLLAGGL 408
Cdd:PRK01222  86 DETPEFCRQLKRRY--GLPVIKALRVRSagDLEAaaAYYGDADGLLLDayvGLPGGTGKTFDWSLLPAGLAKPWILAGGL 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 157833501 409 GADNCVEA-AQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY 452
Cdd:PRK01222 164 NPDNVAEAiRQVRPYGVDVSSGVESAPGIKDPEKIRAFIEAVKSA 208
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 3-253 1.54e-44

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 165.20  E-value: 1.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501   3 TVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFyDALQGARTA----FILECKKASPSKGVIRDDFDPARIAAIY- 77
Cdd:PRK13802   2 SVLDELVAGALEDQRTRELTVSLEEVKKAAAAAPAPI-DATRWLKRAdgipVIAEIKRASPSKGHLSDIPDPAALAREYe 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  78 KHYASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLE 157
Cdd:PRK13802  81 QGGASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAHGADLVLLIVAALDDAQLKHLLDLAHELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 158 MGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHF-ANGFLIG 236
Cdd:PRK13802 161 MTVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDDVIKVAESGVFGAVEVEDYARAgADAVLVG 240

                        250
                 ....*....|....*..
gi 157833501 237 SALMAHDDLHAAVRRVL 253
Cdd:PRK13802 241 EGVATADDHELAVERLV 257
PLN02363 PLN02363
phosphoribosylanthranilate isomerase
 258-439 3.31e-26

phosphoribosylanthranilate isomerase


Pssm-ID: 215207  Cd Length: 256  Bit Score: 106.48  E-value: 3.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 258 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP---LQYVGVFRNHDIADVVDKAKVLSLAAVQLH 334
Cdd:PLN02363  50 KMCGITSARDAAMAVEAGADFIGMILWPKSKRSISLSVAKEISQVAReggAKPVGVFVDDDANTILRAADSSDLELVQLH 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 335 GNEEqlyidtlREALPAHVAIWKALSV---------GETLPAREFQHVDKYVLDNGQGGSGQRFDWS---LLNGQSLGNV 402
Cdd:PLN02363 130 GNGS-------RAAFSRLVRERKVIYVlnanedgklLNVVPEEDCHLADWILVDSATGGSGKGFNWQnfkLPSVRSRNGW 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 157833501 403 LLAGGLGADNCVEAAqtgCA----GLDFNSAVESQPGI-KDA 439
Cdd:PLN02363 203 LLAGGLTPENVHEAV---SLlkptGVDVSSGICGPDGIrKDP 241
PRK13803 PRK13803
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
 258-450 2.44e-15

bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 237513 [Multi-domain]  Cd Length: 610  Bit Score: 78.31  E-value: 2.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 258 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVE-QAQEVMAAAP---LQYVGVFRNHDIADVVDKAKVLSLAAVQL 333
Cdd:PRK13803   6 KICGIKDSALISKAVDMLPDFIGFIFYEKSPRFVGNKfLAPNLEKAIRkagGRPVGVFVNESAKAMLKFSKKNGIDFVQL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 334 HGNEEQLYIDTLREALPAHVAIWKALSVGEtlpAREFQHVDKY-------VLDN---GQGGSGQRFDWSLLNGQSLGNV- 402
Cdd:PRK13803  86 HGAESKAEPAYCQRIYKKSIKKIGSFLIDD---AFGFEVLDEYrdhvkyfLFDNktkIYGGSGKSFDWEKFYNYNFKFPf 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157833501 403 LLAGGLGADNCVEAAQTGCA---GLDFNSAVESQPGIKDARLLASVFQTLR 450
Cdd:PRK13803 163 FLSGGLSPTNFDRIINLTHPqilGIDVSSGFEDSPGNKKLTLLKSFITNVK 213
TIM_phosphate_binding cd04722
TIM barrel proteins share a structurally conserved phosphate binding motif and in general ...
 67-237 3.52e-14

TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate comes either from the substrate, as in the case of inosine monophosphate dehydrogenase (IMPDH), or from ribulose-5-phosphate 3-epimerase (RPE) or from cofactors, like FMN.


Pssm-ID: 240073 [Multi-domain]  Cd Length: 200  Bit Score: 71.08  E-value: 3.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501  67 DFDPARIAAIYKHY-ASAISVLTDEKYFQGSFNF----LPIVSQIAPQPILCKDFIIDPYQIY-----LARYYQADACLL 136
Cdd:cd04722   11 SGDPVELAKAAAEAgADAIIVGTRSSDPEEAETDdkevLKEVAAETDLPLGVQLAINDAAAAVdiaaaAARAAGADGVEI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 137 MLSV-----LDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRT---RELAPKLGHN 208
Cdd:cd04722   91 HGAVgylarEDLELIRELREAVPDVKVVVKLSPTGELAAAAAEEAGVDEVGLGNGGGGGGGRDAVPIadlLLILAKRGSK 170

                        170       180       190
                 ....*....|....*....|....*....|
gi 157833501 209 VTVISESGINTYAQVRELSHF-ANGFLIGS 237
Cdd:cd04722  171 VPVIAGGGINDPEDAAEALALgADGVIVGS 200
PRK13958 PRK13958
N-(5'-phosphoribosyl)anthranilate isomerase; Provisional
 258-450 3.27e-13

N-(5'-phosphoribosyl)anthranilate isomerase; Provisional


Pssm-ID: 184418  Cd Length: 207  Bit Score: 68.21  E-value: 3.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 258 KVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAP--LQYVGVFRNHDIADVVDKAKVLSLAAVQLHG 335
Cdd:PRK13958   4 KFCGFTTIKDVTAASQLPIDAIGFIHYEKSKRHQTITQIKKLASAVPnhIDKVCVVVNPDLTTIEHILSNTSINTIQLHG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157833501 336 NEEQLYIDTLREALPaHVAIWKALSVGETLPAREFQ---HVDKYVLDNGQ---GGSGQRFDWSLLNGQSLGNVLLAGGLG 409
Cdd:PRK13958  84 TESIDFIQEIKKKYS-SIKIIKALPADENIIQNINKykgFVDLFIIDTPSvsyGGTGQTYDWTILKHIKDIPYLIAGGIN 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 157833501 410 ADNC--VEAAQTGCAGLDFNSAVESQpGIKDARLLASVFQTLR 450
Cdd:PRK13958 163 SENIqtVEQLKLSHQGYDIASGIETN-GRKDINKMTAIVNIVK 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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