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Conserved domains on  [gi|157822109|ref|NP_001101291|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase beta [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-261 7.53e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 171.35  E-value: 7.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  62 IISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:COG0204   15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 142 NRQQAKTAMSLMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSfSSFYNVKTKLFTSG 221
Cdd:COG0204   95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 157822109 222 TIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISE 261
Cdd:COG0204  173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRA 212
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-261 7.53e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 171.35  E-value: 7.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  62 IISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:COG0204   15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 142 NRQQAKTAMSLMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSfSSFYNVKTKLFTSG 221
Cdd:COG0204   95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 157822109 222 TIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISE 261
Cdd:COG0204  173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRA 212
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 67-240 1.94e-51

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 166.68  E-value: 1.94e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  67 VRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQA 146
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 147 KTAMSLMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSFSSFYNVKTKLFTSGTIRVQ 226
Cdd:cd07989   81 RSAREALREAIEAL-KEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                        170
                 ....*....|....
gi 157822109 227 VLDAVPTNGLTDAD 240
Cdd:cd07989  160 IGEPIPPEGLELAE 173
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 77-205 2.80e-43

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 143.96  E-value: 2.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109   77 RFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157822109  154 ADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:pfam01553  81 EYLVELL-REGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 92-205 5.23e-35

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 122.08  E-value: 5.23e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109    92 CVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADLGDLMvKENLKVW 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELL-KEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 157822109   169 IYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 75-205 8.18e-35

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 122.07  E-value: 8.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109   75 GLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMA 154
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157822109  155 DLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:TIGR00530  81 AAIEVL-KQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 32-273 2.34e-23

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 95.47  E-value: 2.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  32 LYCVLCLSFsaaASIVCLLrhGGRTVDNMSIISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEIL 111
Cdd:PRK15018  12 IYSILVCVF---GSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 112 PKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADLGDLMVKENLKVWIYPEGTRNDNGDLLPFKKGAFYL 191
Cdd:PRK15018  87 QPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 192 AIQAQVPIIPVVYSSFSSfyNVKTKLFTSGTIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRAtflQISEIPQENSTIKE 271
Cdd:PRK15018 167 AIAAGVPIIPVCVSTTSN--KINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQ---KIAELDKEVAEREA 241


                 ..
gi 157822109 272 SG 273
Cdd:PRK15018 242 AG 243
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 62-261 7.53e-53

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 171.35  E-value: 7.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  62 IISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:COG0204   15 LVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGWLLRALGAIPV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 142 NRQQAKTAMSLMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSfSSFYNVKTKLFTSG 221
Cdd:COG0204   95 DRSKRRAALRALRQAVEAL-KAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDG-TERALPKGFLPRPG 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 157822109 222 TIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISE 261
Cdd:COG0204  173 KVTVRIGPPIDPSDLEGEDRRELAERLRAAIEALLAELRA 212
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 67-240 1.94e-51

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 166.68  E-value: 1.94e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  67 VRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQA 146
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 147 KTAMSLMADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSFSSFYNVKTKLFTSGTIRVQ 226
Cdd:cd07989   81 RSAREALREAIEAL-KEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                        170
                 ....*....|....
gi 157822109 227 VLDAVPTNGLTDAD 240
Cdd:cd07989  160 IGEPIPPEGLELAE 173
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 77-205 2.80e-43

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 143.96  E-value: 2.80e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109   77 RFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLM 153
Cdd:pfam01553   1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKrgrPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157822109  154 ADLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:pfam01553  81 EYLVELL-REGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 92-205 5.23e-35

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 122.08  E-value: 5.23e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109    92 CVIISNHQSILDMMGLMEILPK---RCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADLGDLMvKENLKVW 168
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELL-KEGEWLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 157822109   169 IYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIR 116
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 75-205 8.18e-35

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 122.07  E-value: 8.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109   75 GLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMA 154
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157822109  155 DLGDLMvKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYS 205
Cdd:TIGR00530  81 AAIEVL-KQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 32-273 2.34e-23

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 95.47  E-value: 2.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  32 LYCVLCLSFsaaASIVCLLrhGGRTVDNMSIISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEIL 111
Cdd:PRK15018  12 IYSILVCVF---GSIYCLF--SPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMVTASNIV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 112 PKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADLGDLMVKENLKVWIYPEGTRNDNGDLLPFKKGAFYL 191
Cdd:PRK15018  87 QPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109 192 AIQAQVPIIPVVYSSFSSfyNVKTKLFTSGTIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRAtflQISEIPQENSTIKE 271
Cdd:PRK15018 167 AIAAGVPIIPVCVSTTSN--KINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQ---KIAELDKEVAEREA 241


                 ..
gi 157822109 272 SG 273
Cdd:PRK15018 242 AG 243
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 79-203 5.24e-18

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 80.16  E-value: 5.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  79 EVSGQKKL-EVDGPCVIISNHQSILDMMGLMEIlpKRCVQ-IAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADL 156
Cdd:PLN02901  38 EVEGLENLpSPDEPAVYVSNHQSFLDIYTLFHL--GRPFKfISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLKRC 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157822109 157 GDLmVKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVV 203
Cdd:PLN02901 116 MEL-LKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPIT 161
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 75-203 8.20e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 70.91  E-value: 8.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  75 GLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLM----EILPKRCVQIAKRELMFTGPVgliMYLGGVYFINRQQAKTAM 150
Cdd:cd06551   11 FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFllleRGLRRDVYGLMDEELLERYPF---FTRLGAFSVDRDSPRSAA 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157822109 151 SLMADLGDLMVKENLKVWIYPEGTRNDNGD-LLPFKKGAFYLAIQAQVPIIPVV 203
Cdd:cd06551   88 KSLKYVARLLSKPGSVVWIFPEGTRTRRDKrPLQFKPGVAHLAEKAGVPIVPVA 141
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 67-212 2.51e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 61.47  E-value: 2.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  67 VRSFKYVYGL-RFEVSGQKKLEVDGPcVIISNHQSILDMMGLMEILPkrCVQIAKRELMFTGPVGLIM-YLGGVYFiNRQ 144
Cdd:cd07991    1 ARVLLFAFGFyVIKVHGKPDPPEAPR-IIVANHTSFIDPLILFSDLF--PSIVAKKELGKLPFIGTILrALGCIFV-DRS 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157822109 145 QAKTAMS---LMADLGDLMvkENLKVWIYPEGTRNDNGDLLPFKKGAFYLaiqaQVPIIPVV--YSSFSSFYN 212
Cdd:cd07991   77 EPKDRKKvveEIKERATDP--NWPPILIFPEGTTTNGKALIMFKKGAFEP----GVPVQPVAirYPNKFVDAF 143
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 70-175 3.34e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 58.02  E-value: 3.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  70 FKYVYGLRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQ-----IAKRELMFTGPVGLIMYLGGVYFINRQ 144
Cdd:cd07990    4 FEWLSGVKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLgrlkiVLKDSLKYPPLGGWGWQLGEFIFLKRK 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822109 145 QAKTAMSLMADLGDLmVKENLKVW--IYPEGTR 175
Cdd:cd07990   84 WEKDEKTIKRQLKRL-KDSPEPFWllIFPEGTR 115
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 63-202 6.92e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 57.27  E-value: 6.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  63 ISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQ-SILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:cd07992    1 VRLLSRVILRIYFRRITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157822109 142 NRQQ-AKTAMSLMADLGDLM--VKENLK----VWIYPEGTRNDNGDLLPFKKGAFYLAIQA------QVPIIPV 202
Cdd:cd07992   81 YRPKdLARGGIGKISNAAVFdaVGEALKaggaIGIFPEGGSHDRPRLLPLKAGAARMALEAleagqkDVKIVPV 154
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 62-208 1.01e-07

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 53.00  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109   62 IISWFVRSFKYvyglRFEVSGQKKLEVDGPCVIISNHQSILDMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFI 141
Cdd:PRK08633  417 FLLLLLMHTRY----RLRVEGRENIPAKGGALLLGNHVSWIDWALLQAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPI 492

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822109  142 NRQQAKTAMSLMA---DLGDLmvkenlkVWIYPEGTRNDNGDLLPFKKGaFYLAIQ-AQVPIIPvVY------SSFS 208
Cdd:PRK08633  493 SSGGSKESLEFIRkalDDGEV-------VCIFPEGAITRNGQLNEFKRG-FELIVKgTDVPIIP-FYirglwgSIFS 560
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 93-202 2.23e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 49.52  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  93 VIISNHQSILD---MMGLMEILpKRCVQIAKRELMFTGPVGLIM-YLGGVYfINRQQAktamslmADLGDLMVK-----E 163
Cdd:cd07988   24 VIGAPHTSNWDfvlGLLAAFAL-GLKISFLGKHSLFKPPLGPFMrWLGGIP-VDRSRA-------GGLVEQVVEefrrrE 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157822109 164 NLKVWIYPEGTRNDNGdllPFKKGAFYLAIQAQVPIIPV 202
Cdd:cd07988   95 EFVLAIAPEGTRSKVD---KWKTGFYHIARGAGVPILLV 130
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 70-202 5.45e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 40.35  E-value: 5.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  70 FKYVYgLRFEVSGQKKLEVDGPCVIISNHqSILDMMGLM------EILPKRCVQIAKRELMFTGPVG--LIMYLGGVyfi 141
Cdd:cd07987    1 HRKYF-RVYEVRGLENIPDEGPALLVHPH-GGLPIDGALlaaaflLLFPGRLPRALADHFLFPLPGLrdLLRRLGAV--- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822109 142 nRQQAKTAMSLMADlGDLMVkenlkvwIYPEGTR-------NDNGDLLPFKKGAFYLAIQAQVPIIPV 202
Cdd:cd07987   76 -PGSRENCVRLLRE-GELVL-------IFPGGARealkskrEEYYLLWKKRKGFARLALRAGAPIVPV 134
PLN02833 PLN02833
glycerol acyltransferase family protein
 93-219 6.30e-03

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 37.45  E-value: 6.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822109  93 VIISNHQSILDMMGLMEILPkrCVQIAKRElmfTGPVGLIM-----YLGGVYFiNRQQAKTAMSLMADLGD-LMVKENLK 166
Cdd:PLN02833 166 VFVANHTSMIDFIVLEQMTP--FAVIMQKH---PGWVGFLQntileSVGCIWF-NRTEAKDREVVAKKLRDhVQDPDRNP 239

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157822109 167 VWIYPEGTRNDNGDLLPFKKGAFYLAiqAQVPIIPVVYSSF--SSFYNVKTKLFT 219
Cdd:PLN02833 240 LLIFPEGTCVNNEYTVMFKKGAFELG--CTVCPIAIKYNKIfvDAFWNSRKQSFT 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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