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Conserved domains on  [gi|157819985|ref|NP_001101492|]
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uncharacterized protein LOC314128 [Rattus norvegicus]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1012635)

methyltransferase domain-containing protein similar to Caenorhabditis elegans small RNA 2'-O-methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways

EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259
PubMed:  22536158

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG super family cl34436
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 132-254 1.12e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


The actual alignment was detected with superfamily member COG2227:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.85  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819985 132 KFIYHHVLPDlsGKVLvDVGSrlGTVLYGGYLYSSAVQLCGVELSGEFCQlqemIIKKYQFGDRIKVLHADICTQSSLLQ 211
Cdd:COG2227   16 ALLARLLPAG--GRVL-DVGC--GTGRLALALARRGADVTGVDISPEALE----IARERAAELNVDFVQGDLEDLPLEDG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819985 212 TADIIVMNNVFEYFlpeSQQASAWNFIIHNVKKQGSLLVTVPS 254
Cdd:COG2227   87 SFDLVICSEVLEHL---PDPAALLRELARLLKPGGLLLLSTPN 126
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 132-254 1.12e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.85  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819985 132 KFIYHHVLPDlsGKVLvDVGSrlGTVLYGGYLYSSAVQLCGVELSGEFCQlqemIIKKYQFGDRIKVLHADICTQSSLLQ 211
Cdd:COG2227   16 ALLARLLPAG--GRVL-DVGC--GTGRLALALARRGADVTGVDISPEALE----IARERAAELNVDFVQGDLEDLPLEDG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819985 212 TADIIVMNNVFEYFlpeSQQASAWNFIIHNVKKQGSLLVTVPS 254
Cdd:COG2227   87 SFDLVICSEVLEHL---PDPAALLRELARLLKPGGLLLLSTPN 126
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 132-254 1.12e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 43.85  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819985 132 KFIYHHVLPDlsGKVLvDVGSrlGTVLYGGYLYSSAVQLCGVELSGEFCQlqemIIKKYQFGDRIKVLHADICTQSSLLQ 211
Cdd:COG2227   16 ALLARLLPAG--GRVL-DVGC--GTGRLALALARRGADVTGVDISPEALE----IARERAAELNVDFVQGDLEDLPLEDG 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819985 212 TADIIVMNNVFEYFlpeSQQASAWNFIIHNVKKQGSLLVTVPS 254
Cdd:COG2227   87 SFDLVICSEVLEHL---PDPAALLRELARLLKPGGLLLLSTPN 126
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
139-259 3.42e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.45  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819985 139 LPDLSGKVLVDVGSrlGTVLYGGYLYSSAVQLCGVELSgefcqlQEMIIKKYQFGDRIKVLHADICTQSSLLQTADIIVM 218
Cdd:COG4976   42 LPPGPFGRVLDLGC--GTGLLGEALRPRGYRLTGVDLS------EEMLAKAREKGVYDRLLVADLADLAEPDGRFDLIVA 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157819985 219 NNVFEYF--LPESQQAsawnfIIHNVKKQGSLLVTVPSLQDSL 259
Cdd:COG4976  114 ADVLTYLgdLAAVFAG-----VARALKPGGLFIFSVEDADGSG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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