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Conserved domains on  [gi|1578049012|emb|VFH74173|]
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phage-like protein [Streptococcus pneumoniae]

Protein Classification

type II toxin-antitoxin system HicB family antitoxin( domain architecture ID 10003996)

type II toxin-antitoxin system HicB family antitoxin is the antitoxin component of a type II toxin-antitoxin (TA) system and functions as an mRNA interferase antitoxin preventing effects of the cognate HicA family toxin

Gene Ontology:  GO:0110001
PubMed:  17329807|16895922|28279904|30337369
SCOP:  4001747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
4-69 8.16e-11

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


:

Pssm-ID: 441206  Cd Length: 65  Bit Score: 54.50  E-value: 8.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578049012   4 TYPALFYYDDTDGteatYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDI 69
Cdd:COG1598     1 KYPAIIEKDEDGG----YVAEVPDLPGCVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSI 62
 
Name Accession Description Interval E-value
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
4-69 8.16e-11

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 54.50  E-value: 8.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578049012   4 TYPALFYYDDTDGteatYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDI 69
Cdd:COG1598     1 KYPAIIEKDEDGG----YVAEVPDLPGCVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSI 62
HicB_lk_antitox pfam15919
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 5-118 4.36e-08

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


Pssm-ID: 435020 [Multi-domain]  Cd Length: 123  Bit Score: 48.80  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578049012   5 YPALFYYDDTDGteatYFVHFPDFE--YSAtqGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSlidNDPfkD 82
Cdd:pfam15919   1 YPIAIEKDEDSA----YGVVVPDLPgcFSA--GDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQ---ANP--E 69

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1578049012  83 DEDFVstydldksfISMVSVDVSEYLGSQEPIKKTL 118
Cdd:pfam15919  70 YAGWI---------WALVDIDLSPLDGKSERINITL 96
 
Name Accession Description Interval E-value
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
4-69 8.16e-11

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 54.50  E-value: 8.16e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1578049012   4 TYPALFYYDDTDGteatYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDI 69
Cdd:COG1598     1 KYPAIIEKDEDGG----YVAEVPDLPGCVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSI 62
HicB_lk_antitox pfam15919
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 5-118 4.36e-08

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


Pssm-ID: 435020 [Multi-domain]  Cd Length: 123  Bit Score: 48.80  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1578049012   5 YPALFYYDDTDGteatYFVHFPDFE--YSAtqGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSlidNDPfkD 82
Cdd:pfam15919   1 YPIAIEKDEDSA----YGVVVPDLPgcFSA--GDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQ---ANP--E 69

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1578049012  83 DEDFVstydldksfISMVSVDVSEYLGSQEPIKKTL 118
Cdd:pfam15919  70 YAGWI---------WALVDIDLSPLDGKSERINITL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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