|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
26-393 |
1.31e-60 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 200.74 E-value: 1.31e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 26 RAITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFIC 105
Cdd:PRK10054 23 RGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIPLVNNVTLVVLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 106 LVLINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDHLPFLLSALLGLAMCLCYQRWG 185
Cdd:PRK10054 103 FALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFWLAAICSAFPLVFIQIWV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 186 ERSAPARVEGSEQAGFLSVgvqLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAARYISYLVATNAVTVIA 265
Cdd:PRK10054 183 QRSEKAIATETGSVWSPSV---LLQDKALLWFTCSGFLASFVSGAFASCISQYVMVVADSDFAEKVVAVVLPVNAAMVVS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 266 LQYVIGRRISSRQLMPWLMAGMALFLIGLLGFSLA-QSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQ 344
Cdd:PRK10054 260 LQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSgNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPGMKASYFSAQ 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1576853221 345 NLSNLGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYLGARRTP 393
Cdd:PRK10054 340 SLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVAAWLLMLKGMRARP 388
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
27-387 |
8.00e-47 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 164.32 E-value: 8.00e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 27 AITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICL 106
Cdd:cd17329 16 FMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 107 VLINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDHLPFLLSALLGLAMCLCYQRWGE 186
Cdd:cd17329 96 VLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 187 RSAPARVEGSEQAGFLSVGvQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAAryISYLVATNAVTVIAL 266
Cdd:cd17329 176 ETRPKRRAAEKTEILRGYK-IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESL--LGLLLALNALLIVLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 267 QYVIGRRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNL 346
Cdd:cd17329 253 QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1576853221 347 SN-LGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYL 387
Cdd:cd17329 333 AWgLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-352 |
1.64e-19 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 88.88 E-value: 1.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 33 LVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLA 112
Cdd:COG2814 32 ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 113 LAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD-HLPFLLSALLGLAMCLCYQRWGERSAPA 191
Cdd:COG2814 112 AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwRWVFLVNAVLALLALLLLLRLLPESRPA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 192 RvegseQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAAryISYLVATNAVTVIALQYVIG 271
Cdd:COG2814 192 A-----RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA--AGLLLALFGLGGVLGALLAG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 272 RRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNLSNLGA 351
Cdd:COG2814 265 RLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
.
gi 1576853221 352 A 352
Cdd:COG2814 345 G 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-389 |
3.61e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.02 E-value: 3.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 28 ITLPYLVVYlAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLV 107
Cdd:cd17325 14 IIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 108 LINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALV-LLDDHLPFLLSALLG-LAMCLCYQRWG 185
Cdd:cd17325 93 LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALAlLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 186 ERSAPARVEGSEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAAryISYLVATNAVTVIA 265
Cdd:cd17325 173 EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ--IGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 266 LQYVIGRRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQN 345
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1576853221 346 LS-NLGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYLGA 389
Cdd:cd17325 331 TAfSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-387 |
2.42e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 82.62 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 37 LAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVL--INLALA 114
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALqgIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 115 VVDIAAKAGfcTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDHLPFLLSALLGLAMCLCYQRWGERsaPARVE 194
Cdd:cd17474 105 GPLALTLIG--DLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE--PKEKA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 195 GSEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAARYISYLVATNAVTVIALQ--YVIGR 272
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFvgRLLKK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 273 RISSRQLMpwlMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQN-LSNLGA 351
Cdd:cd17474 261 RFGARRIL---VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNfVRFLGQ 337
|
330 340 350
....*....|....*....|....*....|....*.
gi 1576853221 352 ALGPVICGFALAHLVPVATFYLLILSVLLAALFYYL 387
Cdd:cd17474 338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-355 |
2.42e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 82.47 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 25 ARAITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFI 104
Cdd:pfam07690 11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 105 CLVLINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD-HLPFLLSALLGLAMCLCYQR 183
Cdd:pfam07690 91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGwRAAFLILAILSLLAAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 184 WGERSAPARVEGSEQAG-FLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTS-SASEAARYISYLVATNAV 261
Cdd:pfam07690 171 PRPPPESKRPKPAEEARlSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGlSALLAGLLLGLGGLLGAI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 262 TVIALQYvIGRRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYY 341
Cdd:pfam07690 251 GRLLLGR-LSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329
|
330
....*....|....*
gi 1576853221 342 GAQNL-SNLGAALGP 355
Cdd:pfam07690 330 GLYNTaGSLGGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-389 |
9.75e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 75.32 E-value: 9.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 27 AITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRS-----YTVIIAATLVFTLAFVGAVVSRELS- 100
Cdd:COG2211 27 GLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrrRPWILIGAIPLALSFVLLFTAPDLSp 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 101 -----LFFICLVLINLALAVVDIAAKAGFCTLLP-LDERSEVFSIKYSLSNVAYAVGPFVGVALVLL---DDHLPFLLSA 171
Cdd:COG2211 107 tgkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggDAALGYRLTA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 172 LLG-----LAMCLCYQRWGERSAPARvegsEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSAS 246
Cdd:COG2211 187 LIFavlglLAFLLTFFGTKERPVPEE----EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLS 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 247 EAAryISYLVATNAVTVIALQYVIG---RRISSRQLMpwlMAGMALFLIGLLGFSLAQ--SLLVWCLAMLVFTLGEIIVI 321
Cdd:COG2211 263 AAL--VGLLLALYFLAALLGAPLWPrlaKRFGKKKAF---IIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAIL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 322 PAEYMFIDSIAPEHL-------RGVYYGAQNLSN-LGAALGPVICGFALAHL--------VPVATFYLLILSVLLAALFY 385
Cdd:COG2211 338 VLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIkLGQALAGALAGLLLALFgyvagaaqSPSALTGIRLLFFLLPAVLL 417
|
....
gi 1576853221 386 YLGA 389
Cdd:COG2211 418 LLAA 421
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-394 |
1.02e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 74.91 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 28 ITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLV 107
Cdd:COG2271 27 SNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 108 LINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD-HLPFLLSALLGLAMCLCyqrwge 186
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwRAAFLILGLPGLLLALL------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 187 rsaparvegseqagflsvgvqlvkdrRLICFTLGGALSAVVFGQFTAYLSQYLVVTS--SASEAARYISYLVATNAVTVI 264
Cdd:COG2271 181 --------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRglSLAQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 265 ALQYVIGRRISSRQLMpwLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQ 344
Cdd:COG2271 235 LGGWLSDRLGRRRKLV--LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1576853221 345 NL-SNLGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYLGARRTPQ 394
Cdd:COG2271 313 NTfGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
48-387 |
1.78e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.09 E-value: 1.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 48 IGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVVDIAAKAGFCTL 127
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 128 LPLDERSEVFSIKYSLSNVAYAVGPFVGVALV-LLDDHLPFLLSALLGLAMCLCYQRWGERSAPARVEGSEQAGFLSVgv 206
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYqHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRR-- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 207 qlVKDRRLICFTLGGALSAVVFGQFTAYLSQYLvvtssASEAARYISYLVATNAVTVIALQYVIGRRISSRQLMPWLMAG 286
Cdd:cd17489 191 --LVEKKVLPPALILFLASIAYGAISTFLPLYA-----AERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 287 MALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNLS-NLGAALGPVICGFALAHL 365
Cdd:cd17489 264 LLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFfDLGIGLGGLLLGLVAELF 343
|
330 340
....*....|....*....|..
gi 1576853221 366 VPVATFYLLILSVLLAALFYYL 387
Cdd:cd17489 344 GYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-387 |
1.04e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.99 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 33 LVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLA 112
Cdd:cd06174 18 LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 113 LAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD---HLPFLLSALLGLAMCLCYQRWGERSA 189
Cdd:cd06174 98 SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgwRAVFLIAAALALLAAILLLLVVPDPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 190 PARVEGSEQAGFLSVGVQL---VKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVT--SSASEAARYISYLVATNAVTVI 264
Cdd:cd06174 178 ESARAKNEEASSKSVLKLLkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLggLSVAVAGLLLSLFGLAGALGSL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 265 ALQYVIGRRISSRqlmPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQ 344
Cdd:cd06174 258 LLGLLSDRLIGRK---PLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLL 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1576853221 345 NLS-NLGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYL 387
Cdd:cd06174 335 NTFgFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-394 |
2.53e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.60 E-value: 2.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 29 TLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVL 108
Cdd:COG2223 23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 109 INLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALV-LLDDHLPFLLSALLGLAMCLCYQRWGeR 187
Cdd:COG2223 103 LGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIaAFGWRNAFLILGILLLVVAVLAWLFL-R 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 188 SAPARVEGSEQAGFLSVGvQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVT--SSASEAARYISYLVATNAVTVIA 265
Cdd:COG2223 182 DPPAGAAAAAKASLRDQL-EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfgLSAATAGLLAALFALLGALGRPL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 266 LQYvIGRRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGeiIVIPAEYMFIDSIAPEHLRGVYYGAQN 345
Cdd:COG2223 261 GGW-LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALG--GGNGAVFALVPDIFPTKNAGAVYGLVG 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1576853221 346 LS-NLGAALGPVICGFALAHL-VPVATFYLLILSVLLAALFYYLGARRTPQ 394
Cdd:COG2223 338 AAgGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
55-388 |
3.09e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 3.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 55 ALIVAsLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVVDIAAKAGFCTLLPLDERS 134
Cdd:cd17473 45 ALFIA-LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 135 EVFSIKYSLSNVAYAVGPFVGVALVLLDDHLPF---LLSALLGLAMCLCYQRWGERSAPARVEGSEQAGFLSVGVQLVkd 211
Cdd:cd17473 124 KMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFlvyLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLP-- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 212 rrlICFTlgGALSAVVFGQFTAYLSQYLVVTSSASEAARYISYLVATNAVTVIALQY-VIGRRISSRQLMPWlmaGMALF 290
Cdd:cd17473 202 ---IYFL--AFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFgRLKRRLGKRRLLAI---GFALM 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 291 LIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNLS-NLGAALGPVICGFALAHLVPVA 369
Cdd:cd17473 274 ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAfFLGQFLSPLVLGPLVNLTGGLS 353
|
330 340
....*....|....*....|.
gi 1576853221 370 TFYLL--ILSVLLAALFYYLG 388
Cdd:cd17473 354 GAFLIlgVLALVLAIVLLLLR 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-394 |
6.04e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.25 E-value: 6.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 33 LVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLA 112
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 113 LAVVDIAAKAgFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD----HLPFLLSALLGLAMCLCYQRWgeRS 188
Cdd:COG0738 110 LGLLDVAANP-YVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslswHLPYLILAVLLLLLALLFLRS--KL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 189 APARVEGSEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYL--VVTSSASEAARYISYLVATNAVTVIAL 266
Cdd:COG0738 187 PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLkdVLGLSEATAALGLSLFWGGMTIGRFLG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 267 QYVIgRRISSRQLmpwLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNL 346
Cdd:COG0738 267 GFLL-KRFGPVRL---LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1576853221 347 SNLGAALGPVICGFaLAHLVPVATFYLLILSVLLAALFYYLGARRTPQ 394
Cdd:COG0738 343 GIVGGAIGPPLIGF-LADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-387 |
9.70e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 9.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 41 FALDISGIGLMIGGALIVASL----LSLYGGYLIDTLRSYTVIIAAT-----LVFTLAFVGAVVSRELSLFFICLVLINL 111
Cdd:cd06173 25 LVLQLTGSALLVGLVLAAFFLpfllFSPFAGVLADRFDRRRLLILADllralLAAVLALLALLGSLSLWLLLVLAFLLGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 112 ALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALV-LLDDHLPFLLSALLGLAMCLCYQRW--GERS 188
Cdd:cd06173 105 ASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVaLLGPGGAFAINALSFLLSALLLLFIrrPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 189 APARVEGSEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAAryISYLVATNAVTVIALQY 268
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG--YGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 269 VIGRRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNLSN 348
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1576853221 349 LGA-ALGPVICGFALAHLVPVATFYLLILSVLLAALFYYL 387
Cdd:cd06173 343 SGAmPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
30-392 |
2.24e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.73 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 30 LPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLI 109
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 110 NLALAVVDIAAkAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALV-LLDDHLPFLLSALLGLAMCLCYQRWGERS 188
Cdd:COG2807 117 GAGIAVGNVLL-PGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 189 APARVEGSEQAGFLSvgvqLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTS-SASEAARYISYLVATNAVTVIALQ 267
Cdd:COG2807 196 PAAAAAAPAAASLRS----LWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGlSAATAGLLLSLFQLAGIPGSLLVP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 268 YVIGRRISSRqlmPWLMAGMALFLIGLLGFSLAQSLLVWcLAMLVFTLGEIIVIPAEYMFIDSIA--PEHLRGVYYGAQN 345
Cdd:COG2807 272 LLADRLGDRR---PLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQS 347
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1576853221 346 LSNLGAALGPVICGFALAHL-VPVATFYLLILSVLLAALFYYLGARRT 392
Cdd:COG2807 348 VGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-176 |
1.35e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.05 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 25 ARAITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFI 104
Cdd:cd17325 214 AFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLL 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1576853221 105 CLVLINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALV-LLDDHLPFLLSALLGLA 176
Cdd:cd17325 294 LLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYdAFGFATPFLAAAALLLL 366
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
37-384 |
1.15e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 37 LAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVV 116
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 117 DIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVAL-VLLDDHLPFLLSALLGLAMCLCYQRWGERSAPARVEG 195
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 196 SeqaGFLSVGVQLVKDRRLICFTLGGALsaVVFGQFTAYLSQYLVVTSSASEAARYISYLVATNAVTVIALQYVIGRRIS 275
Cdd:cd17324 185 L---GLLSSLLLLLRNPRLRLAYLITFL--LFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 276 SRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHlRGVYYGAQNLS-NLGAALG 354
Cdd:cd17324 260 RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAyNLGGALG 338
|
330 340 350
....*....|....*....|....*....|
gi 1576853221 355 PVICGFALAHLVPVATFYLLILSVLLAALF 384
Cdd:cd17324 339 AALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
252-393 |
1.11e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 252 ISYLVATNAVTVIALQYVIGR---RISSRQLMpwlMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFI 328
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRlsdRFGRKRLL---LLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1576853221 329 DSIAPEHLRGVYYGAQNLSN-LGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYLGARRTP 393
Cdd:cd17325 110 ADIAPPEERGRAMGIFSSAIgLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR 175
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-315 |
2.44e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 49.11 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 37 LAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVV 116
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 117 DIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD-HLPFLLSALLGLAMCLCYQRWGERSAPARVEG 195
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGwRAIFVFLALLGLLLLLLVLLFLPETLPEEKRK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 196 SEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSASEAarYISYLVATNAVTVIALQYVIGR--- 272
Cdd:cd17320 185 PLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPA--QFGLLFALNAIALILGSLLNGRlvr 262
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1576853221 273 RISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTL 315
Cdd:cd17320 263 RFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLI 305
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
30-384 |
5.22e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 5.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 30 LPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTlRSYTVIIAATLVFTLAFVGAV-VSRELSLFFICLVL 108
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADR-KPRRYLLPLGPLLTGLGLSLLgFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 109 INLALAVVDIAAkAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDHLP-FLLSALLGLAMCLCYQRWGER 187
Cdd:cd17478 94 AGIGSAAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGlLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 188 SAPARVEGSEQAGFLSVGVqlVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVvtssaseaARYISYLVATNAVTVIALQ 267
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLK--GVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV--------QRGYSLVFAGLLLSLFLFA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 268 YVIG--------RRISSRQLMPWLMAGMALFLIGLLGFSLAQS--LLVWCLAMLVFTLGEIIVIPAEYMfidsiaPEHLR 337
Cdd:cd17478 243 GAIGtliggplsDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSyiLLVLAGFLLFASFPVTVVLAQELL------PGNVG 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1576853221 338 ---GVYYGaqnLSNLGAALGPVICGFALAHLVPVATFYLLILSVLLAALF 384
Cdd:cd17478 317 lasGLMMG---LSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
28-387 |
1.11e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.80 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 28 ITLPYLVVYLAQnfALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSY----TVIIAATLVFTLAFVGAVVSRELSLFF 103
Cdd:cd17330 14 IVFPVLPFYVRE--FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRygrkPVLLLSLAGSAVSYVLLGLSRNLWLLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 104 ICLVLINLALAVVdIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDH-LPFLLSALLGLAMCLcyq 182
Cdd:cd17330 92 LARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYaLPFLVAAALALLNLV--- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 183 rwgersaparvegseqagflsVGVQLVKDRRLICFTlgGALSAVVFGQFTAYLSQYLVVTS--SASEAARYISYLVATNA 260
Cdd:cd17330 168 ---------------------LVLFFLPPLRRLLLV--YFLIALAFAGLESVFSLFLKDRFgfSPSQIGLLLALVGIAGI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 261 VTVIALQYVIGRRISSRQLMpwlMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVY 340
Cdd:cd17330 225 LAQLLLIPRLAKRLGERKLL---RLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1576853221 341 YG-AQNLSNLGAALGPVICGFALAHLVPVATFYLLILSVLLAALFYYL 387
Cdd:cd17330 302 QGiIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
33-384 |
1.66e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 47.23 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 33 LVVYLAQNFALDISGIGLMIGGALIVAS--LLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFficlvliN 110
Cdd:PRK08633 32 IQNTLIKAYDGSEQVILTAIVNALFLLPflLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWF-------W 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 111 LALAVVDIA---------AKAGFC-TLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALV----------LLDDHLPFLLs 170
Cdd:PRK08633 105 LAFAVTFLLgaqsaiyspAKYGIIpELVGKENLSRANGLLEAFTIVAILAGTALFSFLFesvngntpseILGRIAPAGL- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 171 ALLGLAMCLCYQRWG-ERSAPARVEGSEQAGFLSVG-----VQLVKDRRLICFTLGG-----ALSAVVFGQFTAYLSQYL 239
Cdd:PRK08633 184 VLLAVAVLGLIFAYRlPKVPAAAPEVFDKKKYLFPKllwrnLKLLRSDRVLWLAIIGlsyfwFISQLAQANFPAYAKEVL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 240 VVTSsaseaARYISYLVATNAVTVIALQYVIGrRISSRQ----LMPWLMAGMALFligLLGFSLAQSLLVWCLAMLVF-T 314
Cdd:PRK08633 264 GLDN-----TFQVQYLLAASAIGIGIGSLLAG-RLSGRHielgLVPLGALGLALS---LFLLPTAPSLASVLVLFFLFgF 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1576853221 315 LGEIIVIPAEyMFIDSIAPEHLRGVYYGAQN-LSNLGAALGPVICG-FALAHLVPVATFYLLILSVLLAALF 384
Cdd:PRK08633 335 SAGLFIVPLN-ALIQFRAPEKELGKVLAANNfLQNVGMLLFLALTTlFSGLGLSPAGLFYLIALVTLIGTLY 405
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
222-393 |
1.80e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 222 ALSAVVFGQFTAYLSQYLVVTSSASEAARY------ISYLVATNAVTVIALQYVIGRRISSRQLMPWLMAGMALFLIGLL 295
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLgaspaqAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 296 GFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNLS-NLGAALGPVICGFALAHLVPVATFYLL 374
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170
....*....|....*....
gi 1576853221 375 ILSVLLAALFYYLGARRTP 393
Cdd:COG2814 171 AVLALLALLLLLRLLPESR 189
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-184 |
2.60e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 29 TLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDT-LRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLV 107
Cdd:cd17474 217 FLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIV 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1576853221 108 LINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFV-GVALVLLDDHLPFLLSALLGLAMCLCYQRW 184
Cdd:cd17474 297 LFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLfGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
48-384 |
6.28e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 6.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 48 IGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVVDIAAKAGFCTL 127
Cdd:cd17477 33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 128 LPLDERSEVFSIKYSLSNVAYAVGPFVgVALVLLDDHLPFLLSALLgLAMCLCYQRWGERSAPARVEGSEqagflsvgvq 207
Cdd:cd17477 113 ATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVL-LLLALVPLLLTRRAAPEIEEAES---------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 208 lVKDRRLICFTLGGALSAVVFGQF-TAYLSQYLVVTSSASEAARYISYLVATNAVTVIALQYVIGR---RISSRQLMPW- 282
Cdd:cd17477 181 -ISLRRLLRIAPLALLGAFVAGFLeGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWladRFDRRRVLLGc 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 283 --LMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEymfiDSIAPEHLRGVYYGAQNLSNLGAALGPVICGF 360
Cdd:cd17477 260 alLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAG----DRLPGDELVAANAALLLLYGLGSVIGPLLAGA 335
|
330 340
....*....|....*....|....
gi 1576853221 361 ALAHLVPVATFYLLILSVLLAALF 384
Cdd:cd17477 336 LMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-384 |
3.08e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 25 ARAITLPYLVVYLAQNFAldisgIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAV-VSRELSLFF 103
Cdd:cd17370 18 ARSILPLFLVVLGASAAA-----VGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLaLAGSWQLVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 104 ICLVLINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDH---LPFLLSALLGLAMCLC 180
Cdd:cd17370 93 LLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFLLAAIPALLALLI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 181 YqrwgeRSAPARVEGSEQAGFLSVGVQLVK-DRRLICFTLGGALSAvvFGQFTAYLSQYLVVTSSASEAARYISYLVAtN 259
Cdd:cd17370 173 L-----LFVVKEYPRPPKLRKKSKKTSLKKlPKAFWLYLLAVALFA--LGNFSFAFLILRAQELGLSAALIPLLYALF-N 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 260 AVTVIAlQYVIGRRISSRQLMPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGV 339
Cdd:cd17370 245 LVYALA-AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGT 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1576853221 340 YYGAQNLSN-LGAALGPVICGFALAHLVPVATFYLLILSVLLAALF 384
Cdd:cd17370 324 AYGLFNTVVgIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
28-387 |
1.10e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.63 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 28 ITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLV 107
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 108 LINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDD-HLPFLLSALLGLAMclcyqrwge 186
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGwRWAFIIEGLLGLLL--------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 187 rsaparvegseqagflsVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVT--SSASEAARYISYLVATNAVTVI 264
Cdd:cd17319 171 -----------------AVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQArgFSLKQVGLLAAIPFLAGAIGMI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 265 ALQYVIGRRISSRQLMPwLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQ 344
Cdd:cd17319 234 LGGRLSDRLLRGARRLV-IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1576853221 345 N-LSNLGAALGPVICGFALAHLV-PVATFYLLILSVLLAALFYYL 387
Cdd:cd17319 313 NsGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
32-179 |
1.19e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.91 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 32 YLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINL 111
Cdd:COG2270 260 FAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGL 339
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1576853221 112 ALAVVDIAAKAGFCTLLPLDERSEVFSIkYSLSNVAYAV-GPF-VGVALVLLDDH----LPFLLSALLGLAMCL 179
Cdd:COG2270 340 VMGGIQALSRSLLARLIPPGREAEFFGL-YALSGKAASFlGPLlFGLVTQLTGSQrlgiLSLIVFFVIGLVLLL 412
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
49-354 |
1.22e-03 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 40.81 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 49 GLMIGGAL----IVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVVDIAAKAGF 124
Cdd:PRK11646 45 AVMVGIALglrqFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALV 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 125 CTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDHLPFLLSALLgLAMCLCYQRWgerSAPARVEGSEQAGFLSV 204
Cdd:PRK11646 125 IKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLVCATGAVL-FVLAAAFNAW---LLPAYKLSTVRTPVREG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 205 GVQLVKDRRLI--CFTLGG--ALSAVVFGQFTaylsqyLVVTSSASEAArYISYLVATNAVTVIALQYVIGRRISSR-QL 279
Cdd:PRK11646 201 MTRVLRDKRFVtyVLTLTGyyMLAVQVMLMLP------IMVNDIAGSPS-AVKWMYAIEACLSLTLLYPIARWSEKRfRL 273
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1576853221 280 MPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGaqnLSNLGAALG 354
Cdd:PRK11646 274 EHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMG---FSRLGLALG 345
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
38-384 |
2.24e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 38 AQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLALAVVD 117
Cdd:cd17316 28 EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 118 IAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVGPFVGVALVLLDDH-----LPFLLSALLGLAmclcyqrwgerSAPAR 192
Cdd:cd17316 108 PGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrILFLIGALPALL-----------ALLLR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 193 vegseqagflsvgvqlvkdRRLICFTLGGALSAVVFGQFTAYLSQYLVVTS--SASEAARYISYLVATNAVTVIALQYV- 269
Cdd:cd17316 177 -------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLglSPATSSLYLLLISLGALVGALIAGLLs 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 270 --IGRRissrqlmPWLMAGMALFLIGLLGFSLAQSLLVWCLAMLVFTLGEIIVIP--AEYMFIDSIAPEHLRGVYYG-AQ 344
Cdd:cd17316 238 drIGRK-------KTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVwgALYAYLAELFPTEVRATGVGlSY 310
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1576853221 345 NLSNLGAALGPVICGFALAHLVPVATFYLLILSVLLAALF 384
Cdd:cd17316 311 NLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
217-393 |
5.66e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 5.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 217 FTLGGALSAVVFGQFTAYLSQYLVVTSSASEAAryISYLVATNAVTVIALQYVIGRRISSRQLMPWLMAGMALFLIGLLG 296
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTE--IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 297 FSLAQSLLVWCLAMLVFTLGEIIVIPAEYMFIDSIAPEHLRGVYYGAQNLS-NLGAALGPVICGFALAHLVPVATFYLLI 375
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGfGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*...
gi 1576853221 376 LSVLLAALFYYLGARRTP 393
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPE 176
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-150 |
6.55e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 6.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 11 QVRLLLLTTFILTLARAITLPYLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAF 90
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 91 VGAVVSRELSLFFICLVLINLALAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAV 150
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
32-363 |
7.45e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.35 E-value: 7.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 32 YLVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRS-------YTVIIA--ATLVFTLAFVGAVVSRELSL- 101
Cdd:cd17332 21 YLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSrwgrfrpWLLWGAipLALLFVLLFTTPDGSGTGKLi 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 102 -FFICLVLINLALAVVDIAakagFCTLLP-----LDERSEVFSIKYSLSNVAYAVGPFVGVALVLL----DDHLPFLLSA 171
Cdd:cd17332 101 yALITYILLDLLYTLVNIP----YTALIPeltddPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYfgggNASRGYFLTA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 172 LL-----GLAMCLCYQRWGERSAPARvEGSEQAGFLSVGVQLVKDRRLICFTLGGALSAVVFGQFTAYLSQYLVVTSSAS 246
Cdd:cd17332 177 LIigiigIILLLICFFGTRERVVPPE-EEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 247 EAARYISYLVATNAVTVIALQYVIGRRISSRQLMpwlMAGMALFLIGLLGFSLAQSLLVW----CLAMLVFTLGEIIVIP 322
Cdd:cd17332 256 AELVLLLLLILSGALLALLPWPPLKKRFGKKKAF---FIGLLLAILGLLLLFFLPPGNLVlilvLAVLAGIGYGGANLLP 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1576853221 323 AeYMFIDSIAPEHLR------GVYYGAQNLSN-LGAALGPVICGFALA 363
Cdd:cd17332 333 W-AMLADVIDYGELKtgkrreGIFYSVMTFFRkLGLALAGALVGLILS 379
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
33-179 |
9.08e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 37.98 E-value: 9.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1576853221 33 LVVYLAQNFALDISGIGLMIGGALIVASLLSLYGGYLIDTLRSYTVIIAATLVFTLAFVGAVVSRELSLFFICLVLINLA 112
Cdd:cd06173 231 LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLA 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1576853221 113 LAVVDIAAKAGFCTLLPLDERSEVFSIKYSLSNVAYAVG-PFVGVALVLLDDHLPFLLSALLGLAMCL 179
Cdd:cd06173 311 GGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGaLLAGLLADALGLSAVFLLAGALLLLAAL 378
|
|
| |
