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Conserved domains on  [gi|1573349498|gb|QBC65411|]
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MC021L, partial [Molluscum contagiosum virus subtype 2]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03003 super family cl31820
palmytilated EEV membrane glycoprotein; Provisional
 1-83 4.78e-31

palmytilated EEV membrane glycoprotein; Provisional


The actual alignment was detected with superfamily member PHA03003:

Pssm-ID: 177506 [Multi-domain]  Cd Length: 369  Bit Score: 111.29  E-value: 4.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573349498   1 TLPATLplALPAGSMLTYDCFDTLISQTQSELCIASYCCNLRSTPEGGHVLLRLLELARANVRVTIIVDEQSRDADATQL 80
Cdd:PHA03003   18 TLPKSL--GIATQHMSTYECFDEIISQAKKYIYIASFCCNLRSTPEGRLILDKLKEAAESGVKVTILVDEQSGDKDEEEL 95


                  ...
gi 1573349498  81 AGV 83
Cdd:PHA03003   96 QSS 98
 
Name Accession Description Interval E-value
PHA03003 PHA03003
palmytilated EEV membrane glycoprotein; Provisional
 1-83 4.78e-31

palmytilated EEV membrane glycoprotein; Provisional


Pssm-ID: 177506 [Multi-domain]  Cd Length: 369  Bit Score: 111.29  E-value: 4.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573349498   1 TLPATLplALPAGSMLTYDCFDTLISQTQSELCIASYCCNLRSTPEGGHVLLRLLELARANVRVTIIVDEQSRDADATQL 80
Cdd:PHA03003   18 TLPKSL--GIATQHMSTYECFDEIISQAKKYIYIASFCCNLRSTPEGRLILDKLKEAAESGVKVTILVDEQSGDKDEEEL 95


                  ...
gi 1573349498  81 AGV 83
Cdd:PHA03003   96 QSS 98
PLDc_vPLD3_4_5_like_1 cd09106
Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral ...
 1-87 5.60e-20

Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Putative catalytic domain, repeat 1, of vertebrate phospholipases D, PLD3, PLD4, and PLD5 (EC 3.1.4.4), viral envelope proteins (vaccinia virus proteins K4 and p37), and similar proteins. Most family members contain two copies of the HKD motifs (H-x-K-x(4)-D, where x represents any amino acid residue), and have been classified into the phospholipase D (PLD) superfamily. Proteins in this subfamily are associated with Golgi membranes, altering their lipid content by the conversion of phospholipids into phosphatidic acid, which is thought to be involved in the regulation of lipid movement. ADP ribosylation factor (ARF), a small guanosine triphosphate binding protein, might be required activity. The vaccinia virus p37 protein, encoded by the F13L gene, is also associated with Golgi membranes and is required for the envelopment and spread of the extracellular enveloped virus (EEV). The vaccinia virus protein K4, encoded by the HindIII K4L gene, remains to be characterized. Sequence analysis indicates that the vaccinia virus proteins K4 and p37 might have evolved from one or more captured eukaryotic genes involved in cellular lipid metabolism. Up to date, no catalytic activity of PLD3 has been shown. Furthermore, due to the lack of functional important histidine and lysine residues in the HKD motif, mammalian PLD5 has been characterized as an inactive PLD. The poxvirus p37 proteins may also lack PLD enzymatic activity, since they contain only one partially conserved HKD motif (N-x-K-x(4)-D).


Pssm-ID: 197205 [Multi-domain]  Cd Length: 153  Bit Score: 78.06  E-value: 5.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573349498   1 TLPATLPLALPAGSMLTYDCFDTLISQTQSELCIASYCCNLR--------STPEGGHVLLRLLELARANVRVTIIVDEQS 72
Cdd:cd09106     4 SIPEGLTFLSSSSHLSTFEAWMELISSAKKSIDIASFYWNLRgtdtnpdsSAQEGEDIFNALLEAAKRGVKIRILQDKPS 83

                          90
                  ....*....|....*...
gi 1573349498  73 R---DADATQLAGVPNLR 87
Cdd:cd09106    84 KdkpDEDDLELAALGGAE 101
 
Name Accession Description Interval E-value
PHA03003 PHA03003
palmytilated EEV membrane glycoprotein; Provisional
 1-83 4.78e-31

palmytilated EEV membrane glycoprotein; Provisional


Pssm-ID: 177506 [Multi-domain]  Cd Length: 369  Bit Score: 111.29  E-value: 4.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573349498   1 TLPATLplALPAGSMLTYDCFDTLISQTQSELCIASYCCNLRSTPEGGHVLLRLLELARANVRVTIIVDEQSRDADATQL 80
Cdd:PHA03003   18 TLPKSL--GIATQHMSTYECFDEIISQAKKYIYIASFCCNLRSTPEGRLILDKLKEAAESGVKVTILVDEQSGDKDEEEL 95


                  ...
gi 1573349498  81 AGV 83
Cdd:PHA03003   96 QSS 98
PLDc_vPLD3_4_5_like_1 cd09106
Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral ...
 1-87 5.60e-20

Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Putative catalytic domain, repeat 1, of vertebrate phospholipases D, PLD3, PLD4, and PLD5 (EC 3.1.4.4), viral envelope proteins (vaccinia virus proteins K4 and p37), and similar proteins. Most family members contain two copies of the HKD motifs (H-x-K-x(4)-D, where x represents any amino acid residue), and have been classified into the phospholipase D (PLD) superfamily. Proteins in this subfamily are associated with Golgi membranes, altering their lipid content by the conversion of phospholipids into phosphatidic acid, which is thought to be involved in the regulation of lipid movement. ADP ribosylation factor (ARF), a small guanosine triphosphate binding protein, might be required activity. The vaccinia virus p37 protein, encoded by the F13L gene, is also associated with Golgi membranes and is required for the envelopment and spread of the extracellular enveloped virus (EEV). The vaccinia virus protein K4, encoded by the HindIII K4L gene, remains to be characterized. Sequence analysis indicates that the vaccinia virus proteins K4 and p37 might have evolved from one or more captured eukaryotic genes involved in cellular lipid metabolism. Up to date, no catalytic activity of PLD3 has been shown. Furthermore, due to the lack of functional important histidine and lysine residues in the HKD motif, mammalian PLD5 has been characterized as an inactive PLD. The poxvirus p37 proteins may also lack PLD enzymatic activity, since they contain only one partially conserved HKD motif (N-x-K-x(4)-D).


Pssm-ID: 197205 [Multi-domain]  Cd Length: 153  Bit Score: 78.06  E-value: 5.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573349498   1 TLPATLPLALPAGSMLTYDCFDTLISQTQSELCIASYCCNLR--------STPEGGHVLLRLLELARANVRVTIIVDEQS 72
Cdd:cd09106     4 SIPEGLTFLSSSSHLSTFEAWMELISSAKKSIDIASFYWNLRgtdtnpdsSAQEGEDIFNALLEAAKRGVKIRILQDKPS 83

                          90
                  ....*....|....*...
gi 1573349498  73 R---DADATQLAGVPNLR 87
Cdd:cd09106    84 KdkpDEDDLELAALGGAE 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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