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Conserved domains on  [gi|15721939|ref|NP_031385|]
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protein CASC3 [Homo sapiens]

Protein Classification

Btz domain-containing protein( domain architecture ID 10660175)

Btz domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 146-248 7.17e-43

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


:

Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 150.29  E-value: 7.17e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939    146 RQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEV-RPKGRQ-RKLW-KDEGRWEHDK 222
Cdd:smart01044   1 RGSGDGDEKSAPVANKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGnRPKGRGrRRLWqTDEGRWTHDR 80

                           90       100
                   ....*....|....*....|....*.
gi 15721939    223 FREDEQAPKSRQELIALYGYDIRSAH 248
Cdd:smart01044  81 FEEDEQAPKSRPELVSTYGYDIRSKD 106
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 555-703 4.19e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939   555 GPIYTHGDS-PAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNP 633
Cdd:PHA03247 2860 GDVRRRPPSrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15721939   634 S--YPYAPGALPPPPPPHLYPNTQAPSQVYGGVtyynPAQQQVQPKPSPPRRTPQPVTiKPPPPEVVSRGSS 703
Cdd:PHA03247 2940 QppLAPTTDPAGAGEPSGAVPQPWLGALVPGRV----AVPRFRVPQPAPSREAPASST-PPLTGHSLSRVSS 3006
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 146-248 7.17e-43

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 150.29  E-value: 7.17e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939    146 RQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEV-RPKGRQ-RKLW-KDEGRWEHDK 222
Cdd:smart01044   1 RGSGDGDEKSAPVANKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGnRPKGRGrRRLWqTDEGRWTHDR 80

                           90       100
                   ....*....|....*....|....*.
gi 15721939    223 FREDEQAPKSRQELIALYGYDIRSAH 248
Cdd:smart01044  81 FEEDEQAPKSRPELVSTYGYDIRSKD 106
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 141-249 1.78e-29

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 113.00  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939   141 TVTGERQSG--DGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQ------EEEVRPKGRQRKLW 212
Cdd:pfam09405   1 KGESESQSGrtPSAPPTEPKEDAERKRREHEKYEKERDENPAFVPTRGAFFLHDDRFAEPaangfgKSKGRPYGRRRRLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 15721939   213 KD--EGRWEHDKFRE--DEQAPKSRQELIALYGYDIRSAHN 249
Cdd:pfam09405  81 DDasEGKWTHDLFEEvaGEQAPKSKPERVPRSGYDIRNGPG 121
PHA03247 PHA03247
large tegument protein UL36; Provisional
 555-703 4.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939   555 GPIYTHGDS-PAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNP 633
Cdd:PHA03247 2860 GDVRRRPPSrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15721939   634 S--YPYAPGALPPPPPPHLYPNTQAPSQVYGGVtyynPAQQQVQPKPSPPRRTPQPVTiKPPPPEVVSRGSS 703
Cdd:PHA03247 2940 QppLAPTTDPAGAGEPSGAVPQPWLGALVPGRV----AVPRFRVPQPAPSREAPASST-PPLTGHSLSRVSS 3006
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 146-248 7.17e-43

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 150.29  E-value: 7.17e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939    146 RQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEV-RPKGRQ-RKLW-KDEGRWEHDK 222
Cdd:smart01044   1 RGSGDGDEKSAPVANKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGnRPKGRGrRRLWqTDEGRWTHDR 80

                           90       100
                   ....*....|....*....|....*.
gi 15721939    223 FREDEQAPKSRQELIALYGYDIRSAH 248
Cdd:smart01044  81 FEEDEQAPKSRPELVSTYGYDIRSKD 106
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 141-249 1.78e-29

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 113.00  E-value: 1.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939   141 TVTGERQSG--DGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQ------EEEVRPKGRQRKLW 212
Cdd:pfam09405   1 KGESESQSGrtPSAPPTEPKEDAERKRREHEKYEKERDENPAFVPTRGAFFLHDDRFAEPaangfgKSKGRPYGRRRRLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 15721939   213 KD--EGRWEHDKFRE--DEQAPKSRQELIALYGYDIRSAHN 249
Cdd:pfam09405  81 DDasEGKWTHDLFEEvaGEQAPKSKPERVPRSGYDIRNGPG 121
PHA03247 PHA03247
large tegument protein UL36; Provisional
 555-703 4.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15721939   555 GPIYTHGDS-PAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNP 633
Cdd:PHA03247 2860 GDVRRRPPSrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15721939   634 S--YPYAPGALPPPPPPHLYPNTQAPSQVYGGVtyynPAQQQVQPKPSPPRRTPQPVTiKPPPPEVVSRGSS 703
Cdd:PHA03247 2940 QppLAPTTDPAGAGEPSGAVPQPWLGALVPGRV----AVPRFRVPQPAPSREAPASST-PPLTGHSLSRVSS 3006
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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