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Conserved domains on  [gi|15718247|emb|CAA83138|]
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Speckle-type POZ protein homolog [Caenorhabditis elegans]

Protein Classification

BTB/POZ and MATH domain-containing protein( domain architecture ID 12934314)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and MATH (meprin and TRAF-C homology) domain-containing protein, similar to Homo sapiens Speckle-type POZ protein (SPOP) and Drosophila melanogaster protein roadkill

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATH_SPOP cd03774
Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to ...
 92-230 2.92e-93

Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled pattern in the nuclei. It contains an N-terminal MATH domain and a C-terminal BTB (also called POZ) domain. Together with Cul3, SPOP constitutes an ubiquitin E3 ligase which is able to ubiquitinate the PcG protein BMI1, the variant histone macroH2A1 and the death domain-associated protein Daxx. Therefore, SPOP may be involved in the regulation of these proteins and may play a role in transcriptional regulation, apoptosis and X-chromosome inactivation. Cul3 binds to the BTB domain of SPOP whereas Daxx and the macroH2A1 nonhistone region have been shown to bind to the MATH domain. Both MATH and BTB domains are necessary for the nuclear speckled accumulation of SPOP. There are many proteins, mostly uncharacterized, containing both MATH and BTB domains from C. elegans and plants which are excluded from this family.


:

Pssm-ID: 239743  Cd Length: 139  Bit Score: 277.89  E-value: 2.92e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  92 KVVKFNYMWTINNFSFCREEMGEVLKSSTFSAGCNDKLKWCLRINPKGLDEESRDYLSLYLLLVQCNKSEVRAKFKFSIL 171
Cdd:cd03774   1 KVVKFCYMWTISNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSIL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15718247 172 NAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPGDRLSIFCEVSVVAE 230
Cdd:cd03774  81 NAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD 139
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 244-372 4.21e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18343:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 123  Bit Score: 158.24  E-value: 4.21e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 244 FKVPPCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMR 323
Cdd:cd18343   1 LKVPECRLAEDLGNLWENSRFTDCSLFVGG------QEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFK 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15718247 324 ELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18343  75 EMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BACK_SPOP_like cd14821
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar ...
 368-426 1.59e-29

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


:

Pssm-ID: 350517  Cd Length: 59  Bit Score: 109.41  E-value: 1.59e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRA 426
Cdd:cd14821   1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLVAEAFRA 59
 
Name Accession Description Interval E-value
MATH_SPOP cd03774
Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to ...
 92-230 2.92e-93

Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled pattern in the nuclei. It contains an N-terminal MATH domain and a C-terminal BTB (also called POZ) domain. Together with Cul3, SPOP constitutes an ubiquitin E3 ligase which is able to ubiquitinate the PcG protein BMI1, the variant histone macroH2A1 and the death domain-associated protein Daxx. Therefore, SPOP may be involved in the regulation of these proteins and may play a role in transcriptional regulation, apoptosis and X-chromosome inactivation. Cul3 binds to the BTB domain of SPOP whereas Daxx and the macroH2A1 nonhistone region have been shown to bind to the MATH domain. Both MATH and BTB domains are necessary for the nuclear speckled accumulation of SPOP. There are many proteins, mostly uncharacterized, containing both MATH and BTB domains from C. elegans and plants which are excluded from this family.


Pssm-ID: 239743  Cd Length: 139  Bit Score: 277.89  E-value: 2.92e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  92 KVVKFNYMWTINNFSFCREEMGEVLKSSTFSAGCNDKLKWCLRINPKGLDEESRDYLSLYLLLVQCNKSEVRAKFKFSIL 171
Cdd:cd03774   1 KVVKFCYMWTISNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSIL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15718247 172 NAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPGDRLSIFCEVSVVAE 230
Cdd:cd03774  81 NAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD 139
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 244-372 4.21e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 158.24  E-value: 4.21e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 244 FKVPPCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMR 323
Cdd:cd18343   1 LKVPECRLAEDLGNLWENSRFTDCSLFVGG------QEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFK 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15718247 324 ELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18343  75 EMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 255-368 1.62e-32

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 119.28  E-value: 1.62e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247   255 MYGLFDNKQFSDFTLVCKsdlgspTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:pfam00651   1 LNELREQGELCDVTLVVG------DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 15718247   335 KYiEQMAQSLIAAADKYQLDRLKVMCEQALCYQL 368
Cdd:pfam00651  75 IS-EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_SPOP_like cd14821
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar ...
 368-426 1.59e-29

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


Pssm-ID: 350517  Cd Length: 59  Bit Score: 109.41  E-value: 1.59e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRA 426
Cdd:cd14821   1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLVAEAFRA 59
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 266-368 1.03e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 94.68  E-value: 1.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247    266 DFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLI 345
Cdd:smart00225   1 DVTLVVGG------KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELL 74

                           90       100
                   ....*....|....*....|...
gi 15718247    346 AAADKYQLDRLKVMCEQALCYQL 368
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97
MATH smart00061
meprin and TRAF homology;
100-201 5.99e-13

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 64.63  E-value: 5.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247    100 WTINNFSfcREEMGEVLKSSTFSAGcndKLKWCLRINPKGldeesrDYLSLYLllvQCNKSE-------VRAKFKFSILN 172
Cdd:smart00061   4 HTFKNVS--RLEEGESYFSPSEEHF---NIPWRLKIYRKN------GFLSLYL---HCEKEEcdsrkwsIEAEFTLKLVS 69

                           90       100
                   ....*....|....*....|....*....
gi 15718247    173 AkreETKAMESQRAYRFVQGKDWGFKKFI 201
Cdd:smart00061  70 Q---NGKSLSKKDKHVFEKPSGWGFSKFI 95
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 102-209 3.46e-06

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 45.71  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247   102 INNFSfcREEMGEVLKSSTFSAGcndKLKWCLRINPKGldeesrDYLSLYLllvQCNKSE-------VRAKFKFSILNAK 174
Cdd:pfam00917   1 IKNFS--KIKEGESYYSPVEERF---NIPWRLQIYRKG------GFLGLYL---HCDKEEelergwsIETEFTLKLVSSN 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15718247   175 ReetKAMESQRAYRFVQGKDWGFKKFIRRDFLLDE 209
Cdd:pfam00917  67 G---KSVTKTDTHVFEKPKGWGWGKFISWDDLEKD 98
PHA03098 PHA03098
kelch-like protein; Provisional
 284-396 8.90e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 41.68  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  284 IHKAILAARSRVFSAMFEHHMQESDTNMTtvDDIEP--EVMRellvYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKENEINLN--IDYDSfnEVIK----YIYTGKINITSNNVKDILSIANYLIIDFLINLCI 98

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 15718247  362 QALCYQLTTDNASLTLMLADMYSASQLRAHSINFI 396
Cdd:PHA03098  99 NYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYI 133
 
Name Accession Description Interval E-value
MATH_SPOP cd03774
Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to ...
 92-230 2.92e-93

Speckle-type POZ protein (SPOP) family, MATH domain; composed of proteins with similarity to human SPOP. SPOP was isolated as a novel antigen recognized by serum from a scleroderma patient, whose overexpression in COS cells results in a discrete speckled pattern in the nuclei. It contains an N-terminal MATH domain and a C-terminal BTB (also called POZ) domain. Together with Cul3, SPOP constitutes an ubiquitin E3 ligase which is able to ubiquitinate the PcG protein BMI1, the variant histone macroH2A1 and the death domain-associated protein Daxx. Therefore, SPOP may be involved in the regulation of these proteins and may play a role in transcriptional regulation, apoptosis and X-chromosome inactivation. Cul3 binds to the BTB domain of SPOP whereas Daxx and the macroH2A1 nonhistone region have been shown to bind to the MATH domain. Both MATH and BTB domains are necessary for the nuclear speckled accumulation of SPOP. There are many proteins, mostly uncharacterized, containing both MATH and BTB domains from C. elegans and plants which are excluded from this family.


Pssm-ID: 239743  Cd Length: 139  Bit Score: 277.89  E-value: 2.92e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  92 KVVKFNYMWTINNFSFCREEMGEVLKSSTFSAGCNDKLKWCLRINPKGLDEESRDYLSLYLLLVQCNKSEVRAKFKFSIL 171
Cdd:cd03774   1 KVVKFCYMWTISNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSIL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15718247 172 NAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPGDRLSIFCEVSVVAE 230
Cdd:cd03774  81 NAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD 139
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 244-372 4.21e-47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 158.24  E-value: 4.21e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 244 FKVPPCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMR 323
Cdd:cd18343   1 LKVPECRLAEDLGNLWENSRFTDCSLFVGG------QEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFK 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 15718247 324 ELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18343  75 EMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 247-373 3.43e-46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 155.78  E-value: 3.43e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 247 PPCRLADDMYGLFDNKQFSDFTLvCKSDlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELL 326
Cdd:cd18345   1 PECRLSDDLGLLFERSAFSDVTL-CVGG-----REFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREML 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15718247 327 VYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNA 373
Cdd:cd18345  75 RFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 247-372 3.31e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 150.76  E-value: 3.31e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 247 PPCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELL 326
Cdd:cd18279   1 PECRLAEDLGNLWENSRFTDCCLCVGG------QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMM 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15718247 327 VYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18279  75 RFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 243-373 1.39e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 138.70  E-value: 1.39e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 243 LFKVPPCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVM 322
Cdd:cd18342   1 MVKVPECRLADELGGLWENSRFTDCCLCVAG------QEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVF 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15718247 323 RELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNA 373
Cdd:cd18342  75 KEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 245-373 3.74e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 121.60  E-value: 3.74e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 245 KVPPCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRE 324
Cdd:cd18344   4 KDPRHMLTDDLGELWENSLFTDCCLLVAG------HEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKE 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 15718247 325 LLVYMYTGQTKYIE--QMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNA 373
Cdd:cd18344  78 MMGFIYTGKAPHLHshSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 255-368 1.62e-32

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 119.28  E-value: 1.62e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247   255 MYGLFDNKQFSDFTLVCKsdlgspTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:pfam00651   1 LNELREQGELCDVTLVVG------DKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 15718247   335 KYiEQMAQSLIAAADKYQLDRLKVMCEQALCYQL 368
Cdd:pfam00651  75 IS-EENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_SPOP_like cd14821
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar ...
 368-426 1.59e-29

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill, and similar proteins. Both SPOP and SPOPL serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


Pssm-ID: 350517  Cd Length: 59  Bit Score: 109.41  E-value: 1.59e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRA 426
Cdd:cd14821   1 LSVENAAEVLVLADLHSAEQLKTHAIDFINSHATDVMETEGWKSMVRSHPHLVAEAFRA 59
BACK_roadkill_like cd18520
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein roadkill and ...
 368-444 1.19e-28

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also termed Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor.


Pssm-ID: 350595  Cd Length: 74  Bit Score: 107.47  E-value: 1.19e-28
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRALATQQTPPvvlVQPPKKR 444
Cdd:cd18520   1 LSVETAAEVLILADLHSADQLKAQAIDFINTHATDVMETAGWKSMIRTHPHLLAEAFRALATQQIPP---IGPPRKR 74
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-362 4.58e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 101.55  E-value: 4.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLVcksdLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMT-TVDDIEPEVMRELLVYM 329
Cdd:cd18294   1 FAADMKSLINNPEFSDVKFL----VGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPlVLSDIEPEVFRAVLEFI 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 15718247 330 YTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18294  77 YTNCVTLSNHTVIEVLAAAVEYGLDELRKLCER 109
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 98-225 1.66e-25

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 100.92  E-value: 1.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  98 YMWTINNFSfcrEEMGEVLKSSTFSAGcndKLKWCLRINPKGlDEESRDYLSLYLLLVQC----NKSEVRAKFKFSILNA 173
Cdd:cd00121   3 HTWKIVNFS---ELEGESIYSPPFEVG---GYKWRIRIYPNG-DGESGDYLSLYLELDKGesdlEKWSVRAEFTLKLVNQ 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15718247 174 KREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANglLPGDRLSIFCEV 225
Cdd:cd00121  76 NGGKSLSKSFTHVFFSEKGSGWGFPKFISWDDLEDSYY--LVDDSLTIEVEV 125
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 264-351 1.59e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 96.47  E-value: 1.59e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQS 343
Cdd:cd18186   1 LCDVTLVVGG------REFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEE 74


                ....*...
gi 15718247 344 LIAAADKY 351
Cdd:cd18186  75 LLAAADKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 266-368 1.03e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 94.68  E-value: 1.03e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247    266 DFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLI 345
Cdd:smart00225   1 DVTLVVGG------KKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELL 74

                           90       100
                   ....*....|....*....|...
gi 15718247    346 AAADKYQLDRLKVMCEQALCYQL 368
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-365 1.36e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 95.09  E-value: 1.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMY 330
Cdd:cd18280   1 LGQHFGALLESEEGADVTFNVDG------EKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIY 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15718247 331 T------------GQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALC 365
Cdd:cd18280  75 KdelpddvepagsDSSSLDTTMAQHLLAAADRYALERLRLLCESRLC 121
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 259-360 2.23e-21

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 88.17  E-value: 2.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 259 FDNKQFSDFTLVCKsdlgspTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIE 338
Cdd:cd18314   1 YNDSEFSDVVLCVG------DRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSE 74

                        90       100
                ....*....|....*....|..
gi 15718247 339 QMAQSLIAAADKYQLDRLKVMC 360
Cdd:cd18314  75 ENVLDLLMLASKYQVPDLEKLC 96
BACK_SPOPL cd18519
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, ...
 368-448 1.48e-19

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also termed HIB homolog 2, or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes containing homodimeric SPOPL or the heterodimer formed by speckle-type POZ protein (SPOP) and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP.


Pssm-ID: 350594  Cd Length: 96  Bit Score: 83.10  E-value: 1.48e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFIN------------------VNANEVMDTEGWEDLVRDHPKLLEEVFRALAT 429
Cdd:cd18519   1 LSVENVADTLILADLHSAEQLKAQAIDFINrcsvlrqlgckdgknwnsNHATDIMETAGWKSMIHSHPHLVAEAFRALAS 80

                        90
                ....*....|....*....
gi 15718247 430 QQTPPvvlVQPPKKRPKHN 448
Cdd:cd18519  81 AQCPP---FGIPRKRLKQS 96
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 264-372 2.55e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 83.72  E-value: 2.55e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLVCKSDlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQS 343
Cdd:cd18252  21 FTDITLQCASG-----QIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQS 95

                        90       100
                ....*....|....*....|....*....
gi 15718247 344 LIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18252  96 LLEAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 250-365 1.05e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 75.74  E-value: 1.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 250 RLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYM 329
Cdd:cd18287   8 FLSEDIGALFLNEEYSDVTFVVEE------KRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYI 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15718247 330 YTGQ---TKYIEQMAQSLIAAADKYQLDRLkvmcEQALC 365
Cdd:cd18287  82 YTGRltlTDLKEDVLLDVLGLAHQYGFEEL----EAAIS 116
BACK_SPOP cd18518
BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP); SPOP, also ...
 368-441 1.65e-16

BACK (BTB and C-terminal Kelch) domain found in speckle-type POZ protein (SPOP); SPOP, also termed HIB homolog 1, or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.


Pssm-ID: 350593  Cd Length: 71  Bit Score: 74.02  E-value: 1.65e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRALATQQTPpvvLVQPP 441
Cdd:cd18518   1 LSVENAAEILILADLHSADQLKTQAVDFINYHASDVMETSGWKSMVVSHPHLVAEAYRSLASAQCP---FLGPP 71
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 255-372 2.24e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 72.52  E-value: 2.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 255 MYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:cd18237  12 MNNMRKQKTLCDVILIVEG------REIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARI 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15718247 335 KYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18237  86 SVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-373 3.25e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 72.05  E-value: 3.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18256  30 ELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEI 109

                        90
                ....*....|....
gi 15718247 360 CEQALCYQLTTDNA 373
Cdd:cd18256 110 CCEFLKGQLHPSNC 123
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 248-364 3.37e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 71.52  E-value: 3.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 248 PCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLV 327
Cdd:cd18286   1 CSRLGKDLLQLFLNGEDSDITIKVDG------KTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLL 74

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15718247 328 YMYTGQTKYIE-QMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18286  75 FIYGGVLDLPDdVNLGELLSLADMYGLDGLKDVVAYTL 112
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 3.42e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 71.54  E-value: 3.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18297   6 YVNNPEMSDVTFLVEG------RPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESL 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15718247 338 EQM---AQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18297  80 DVAqddALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 260-372 8.14e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 70.58  E-value: 8.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 260 DNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQ 339
Cdd:cd18352   9 NNATLSDVTFLVEG------RRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITND 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 15718247 340 MAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18352  83 IAKDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BACK_Tdpoz cd18521
BACK (BTB and C-terminal Kelch) domain found in TD and POZ domain-containing proteins, ...
 368-431 8.99e-15

BACK (BTB and C-terminal Kelch) domain found in TD and POZ domain-containing proteins, Tdpoz1-4; TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", and are not inlcuded in this subfamily.


Pssm-ID: 350596  Cd Length: 67  Bit Score: 68.94  E-value: 8.99e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRALATQQ 431
Cdd:cd18521   1 LSVKNAAHTLILADLHSTEKLKTQALDFIAVHASEVSETSEWKSMVESHPHLVAEAFHSLASAQ 64
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 281-362 1.08e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 69.96  E-value: 1.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 281 TFHI-------HKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQM-AQSLIAAADKYQ 352
Cdd:cd18300  13 TFIVedgtipaHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLIVLANRLC 92

                        90
                ....*....|
gi 15718247 353 LDRLKVMCEQ 362
Cdd:cd18300  93 LPRLVALCEQ 102
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 255-362 1.20e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 70.01  E-value: 1.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 255 MYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:cd18238   6 LHQFYENGELCDVTLKVGE------KSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKL 79

                        90       100
                ....*....|....*....|....*...
gi 15718247 335 KYIEQMAQSLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18238  80 TLTVDNVQSLLYAASLLQVEEVAKACCE 107
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-372 1.46e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 70.62  E-value: 1.46e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTL--VCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVY 328
Cdd:cd18273  13 LLAQLKSFYDARLLTDVTIevNGPGSGPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDY 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15718247 329 MYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18273  93 CYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSN 136
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 260-360 3.89e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 68.52  E-value: 3.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 260 DNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVD--DIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18245  10 EEPHLCDATLVVGG------EEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIEleGISVEVMEEILDYIYTGQIKLS 83

                        90       100
                ....*....|....*....|...
gi 15718247 338 EQMAQSLIAAADKYQLDRLKVMC 360
Cdd:cd18245  84 EDNIQDIVQAADLLLMTDLKDLC 106
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 255-368 3.65e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 65.86  E-value: 3.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 255 MYGLFDNKQFSDFTLVCKSdlGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:cd18248  12 MNELRLSQQLCDVTLKVKY--QDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASI 89

                        90       100       110
                ....*....|....*....|....*....|....
gi 15718247 335 KYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQL 368
Cdd:cd18248  90 SVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 282-360 4.85e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 65.39  E-value: 4.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESDTN-----MTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRL 356
Cdd:cd18296  29 FPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLYVADMYLLPGL 108


                ....
gi 15718247 357 KVMC 360
Cdd:cd18296 109 KRLC 112
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-372 5.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 65.43  E-value: 5.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18240  27 VEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQFNIMGIVKA 106

                        90
                ....*....|...
gi 15718247 360 CEQALCYQLTTDN 372
Cdd:cd18240 107 CCDFLEDQLCPEN 119
MATH smart00061
meprin and TRAF homology;
100-201 5.99e-13

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 64.63  E-value: 5.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247    100 WTINNFSfcREEMGEVLKSSTFSAGcndKLKWCLRINPKGldeesrDYLSLYLllvQCNKSE-------VRAKFKFSILN 172
Cdd:smart00061   4 HTFKNVS--RLEEGESYFSPSEEHF---NIPWRLKIYRKN------GFLSLYL---HCEKEEcdsrkwsIEAEFTLKLVS 69

                           90       100
                   ....*....|....*....|....*....
gi 15718247    173 AkreETKAMESQRAYRFVQGKDWGFKKFI 201
Cdd:smart00061  70 Q---NGKSLSKKDKHVFEKPSGWGFSKFI 95
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 255-373 9.84e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 64.79  E-value: 9.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 255 MYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:cd18250  12 LSELRAERKFFDVTLCAGG------REFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRV 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15718247 335 KYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNA 373
Cdd:cd18250  86 TVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-372 1.68e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 64.47  E-value: 1.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMY 330
Cdd:cd18340  14 LQDGLKDLLDHNKFVDCVLKIKE------KEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIY 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15718247 331 TGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18340  88 TSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSN 129
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 249-373 1.86e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 64.24  E-value: 1.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 249 CRLADDMYGLFDNKQFSDftLVCKSDLGsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVY 328
Cdd:cd18274   7 CSILQQLKAMYDEGQLTD--IVVEVDHG---KTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15718247 329 MYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNA 373
Cdd:cd18274  82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNS 126
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-360 1.95e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 63.84  E-value: 1.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18247  29 QKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFLQLQSVKDA 108


                .
gi 15718247 360 C 360
Cdd:cd18247 109 C 109
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 261-372 5.81e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 63.06  E-value: 5.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 261 NKQFSDfTLVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQM 340
Cdd:cd18261  20 NQQRND-GILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGV 98

                        90       100       110
                ....*....|....*....|....*....|..
gi 15718247 341 AQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18261  99 IQDVLAAGSHLQLLELLSLCSHYLIQELNSFN 130
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 6.40e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 62.34  E-value: 6.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLvcKSDlgspTQTFHIHKAILAARSRVFSAMfehhmQESDTNMTTVDDIEPEVMRELLVYMYTGQ---- 333
Cdd:cd18303  12 LFDKELYSDITI--KLA----DKSIPAHKFVLAARSEKWSNE-----NLASTNELDLSDISYEVVLALLRWLYTDEldlt 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15718247 334 ---TKYIEqmaqsLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18303  81 lddEFLLE-----LMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-372 6.83e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 62.48  E-value: 6.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18265  33 KDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLLQVSKLREA 112

                        90
                ....*....|...
gi 15718247 360 CEQALCYQLTTDN 372
Cdd:cd18265 113 CVRFLEGQLHPCN 125
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 253-361 8.86e-12

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 61.46  E-value: 8.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 253 DDMYGLFDNKQFSDFTLVCKSDlgsptQTFHIHKAILAARSRVFSAMFehhmqesdTNMTTV---DDIEPEVMRELLVYM 329
Cdd:cd18299   1 EDLRNLLHSPSCADVVFILQGG-----VRIFAHRIVLAAASSVFADLF--------LMMTVVtldSDITPEAFRRVLEFL 67

                        90       100       110
                ....*....|....*....|....*....|..
gi 15718247 330 YTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18299  68 YTGVLDENEDDLKELKDAAELLELFDLVMMCT 99
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 264-353 9.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 61.95  E-value: 9.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLvcksdlGSPTQTFHIHKAILAARSRVFSAMFEHHMQES-DTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQ 342
Cdd:cd18254  22 FTDVTL------WAGNRSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDSLHPEVLELLLDFAYSSRIIINEENAE 95

                        90
                ....*....|.
gi 15718247 343 SLIAAADKYQL 353
Cdd:cd18254  96 SLLEAGDMLQF 106
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-368 1.37e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 61.29  E-value: 1.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18235  33 IPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACC 112


                ....*..
gi 15718247 362 QALCYQL 368
Cdd:cd18235 113 DFLQSQL 119
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 275-364 1.40e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 62.31  E-value: 1.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 275 LGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDD-IEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQL 353
Cdd:cd18267  45 LHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDsIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEF 124

                        90
                ....*....|.
gi 15718247 354 DRLKVMCEQAL 364
Cdd:cd18267 125 QDIRDACAEFL 135
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 261-373 1.75e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 61.12  E-value: 1.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 261 NKQFSDFTLVCKsdlgspTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQM 340
Cdd:cd18306  15 NRQFCDVILQVG------GHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADL 88

                        90       100       110
                ....*....|....*....|....*....|...
gi 15718247 341 AQSLIAAADKYQLDRLKVMCEQALCYQLTTDNA 373
Cdd:cd18306  89 VKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-372 4.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 60.50  E-value: 4.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMY 330
Cdd:cd18269  14 LQDGLKDLLDENKFVDCVLKIGD------KEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLY 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15718247 331 TGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18269  88 TSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSN 129
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 255-372 4.52e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 60.15  E-value: 4.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 255 MYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:cd18242  12 MNSLRKSNTLCDVTLRVEG------KEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETV 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15718247 335 KYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18242  86 HVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 260-372 5.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 59.85  E-value: 5.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 260 DNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQ 339
Cdd:cd18271  20 EQNAFFDFNIIVKD------ETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD 93

                        90       100       110
                ....*....|....*....|....*....|...
gi 15718247 340 MAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18271  94 NVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTN 126
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 253-364 7.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 58.80  E-value: 7.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 253 DDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTG 332
Cdd:cd18298   1 DSLRKAFNDPRTSDLKFRVDG------KYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTD 74

                        90       100       110
                ....*....|....*....|....*....|..
gi 15718247 333 QTKYIEQMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18298  75 QVDLPPEDAIGLLDLANSYCEERLKKLCEDII 106
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 285-372 2.02e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 57.76  E-value: 2.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 285 HKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18234  16 HRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLLQLSEVVEACCGFL 95


                ....*...
gi 15718247 365 CYQLTTDN 372
Cdd:cd18234  96 MKQLHPSN 103
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 262-372 2.71e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 57.78  E-value: 2.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 262 KQFSDFTLVCKsdlGSPTQTfhiHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEP--EVMRELLVYMYTGQTKYIEQ 339
Cdd:cd18309  18 GDFCDITLLLD---GHPIPA---HKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPsrQAFDSLLRYIYYGDVTMPPE 91

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15718247 340 MAQSLIAAADKYQL--DRLKVMCEQALCYQLTTDN 372
Cdd:cd18309  92 DSLYLFSAPYFYGFtnNRLQAYCKQNLEMNVSFEN 126
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 269-368 2.85e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 58.12  E-value: 2.85e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 269 LVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAA 348
Cdd:cd18246  38 LLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAA 117

                        90       100
                ....*....|....*....|
gi 15718247 349 DKYQLDRLKVMCEQALCYQL 368
Cdd:cd18246 118 SLLQLNGVRDACCKFLLSQL 137
BACK_AtBPM-like cd14736
BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The ...
 365-426 4.54e-10

BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins. BPM protein, also termed protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350516  Cd Length: 62  Bit Score: 55.43  E-value: 4.54e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15718247 365 CYQLTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFRA 426
Cdd:cd14736   1 CEGVDVNTVATTLALAEQHHASQLKAVCLKFVARNLAAVMQTDGFEYLKESCPSLQSELLKT 62
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 260-372 4.89e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 57.15  E-value: 4.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 260 DNKQFSDfTLVCKSDlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQ 339
Cdd:cd18253  14 DSRLFTD-VIICVEG-----REFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 15718247 340 MAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18253  88 NVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 269-368 5.97e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 56.65  E-value: 5.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 269 LVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAA 348
Cdd:cd18339  20 LLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAA 99

                        90       100
                ....*....|....*....|
gi 15718247 349 DKYQLDRLKVMCEQALCYQL 368
Cdd:cd18339 100 SLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 239-372 6.52e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 57.15  E-value: 6.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 239 NVSQL-FKVP--PCRLADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVD 315
Cdd:cd18259   4 NIDDLdFCLPshPQSILDGLQTLRSNPKLSDVTLLVGG------REFPCHRSVLALCSHYFNAMFTGDFVESISARVEIK 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15718247 316 DIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18259  78 DVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 253-362 8.70e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.14  E-value: 8.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 253 DDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHmQESDTNMTTVDDIEPE----VMRELLVY 328
Cdd:cd18292   6 QDIAQLYNNEELSDIVLRVGG------KVFHAHRLILAKSSDVFRVMLSND-WWSESKQSEIELVEDPecaaVFEKFLRY 78

                        90       100       110
                ....*....|....*....|....*....|....
gi 15718247 329 MYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18292  79 LYTGQISVNLETALPLLMLADKYNVTDLKQLCVD 112
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 255-372 1.07e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 56.21  E-value: 1.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 255 MYGLFDNKQFSDFTLVCkSDLGSPTqtfhiHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQT 334
Cdd:cd18336  10 MENYLQHKQLCDVLLIA-GNLKIPA-----HRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVL 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15718247 335 KYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18336  84 ELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSN 121
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 268-368 1.73e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 55.46  E-value: 1.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 268 TLVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAA 347
Cdd:cd18338  19 NLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPA 98

                        90       100
                ....*....|....*....|.
gi 15718247 348 ADKYQLDRLKVMCEQALCYQL 368
Cdd:cd18338  99 AGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-362 2.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 54.95  E-value: 2.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMY 330
Cdd:cd18353   7 VAESLKKEFDSPETSDLKFRVDG------KYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLY 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 15718247 331 TGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18353  81 TDSVDLPPEDAIGLLDLATSYCENRLKKLCQH 112
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 264-372 4.53e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 53.91  E-value: 4.53e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLVCKsDLgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQ- 342
Cdd:cd18302   5 LYDVTIVSE-DG----KEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNv 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 15718247 343 ----SLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18302  80 eflcNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 5.09e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 53.94  E-value: 5.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18255  12 LRAKGQLLDVTLIADG------QRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLD 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15718247 338 EQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18255  86 LDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 239-373 5.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 54.47  E-value: 5.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 239 NVSQLFKVPPCRLadDMYGLfDNKQFSDFTLVCKSDLgsptqtFHIHKAIL-AARSRVFSAMFEHHMQESDTNMTT-VDD 316
Cdd:cd18350   2 SIPEIRKTLPARL--DPHFL-NNKEMSDVTFLVEGKL------FYAHKVLLvTASNRFKSLLTNKSEQESQGSKTIeISD 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15718247 317 IEPEVMRELLVYMYTGQTKYIEqMAQS----LIAAADKYQLDRLKVMCEqALCYQ-LTTDNA 373
Cdd:cd18350  73 IKYHIFQMLMQYLYYGGTESME-IPIAdvleLLSAASLFQLDALQRHCE-ILCSQtINLENA 132
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-368 7.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 53.70  E-value: 7.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18257  30 IHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVLKECC 109


                ....*..
gi 15718247 362 QALCYQL 368
Cdd:cd18257 110 DFLESQL 116
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 281-368 1.67e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 52.16  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 281 TFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQ--TKYIEQmAQSLIAAADKYQLDRLKV 358
Cdd:cd18360  21 TVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSccPASILQ-AMALLICAEMYQVSRLQH 99

                        90
                ....*....|
gi 15718247 359 MCEQALCYQL 368
Cdd:cd18360 100 ICELYIITQL 109
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-372 1.82e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 52.93  E-value: 1.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18236  34 QEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASLFQFLRMVDA 113

                        90
                ....*....|...
gi 15718247 360 CEQALCYQLTTDN 372
Cdd:cd18236 114 CASFLTEALHPEN 126
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 280-351 2.22e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 51.13  E-value: 2.22e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKY 351
Cdd:cd01165   8 EKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 2.48e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 52.37  E-value: 2.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVC----KSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTtVDDIEPEVMRELLVYMYTGQ 333
Cdd:cd18346  16 LFNNELLSDVRFVVgkgrPRGPGPGAQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIE-LPDVEPAAFLALLRFLYSDE 94

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15718247 334 TKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18346  95 VQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-360 2.99e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 51.52  E-value: 2.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVcksdLGSP--TQTFHIHKAILAARSRVFSAMFEHHMQESDTNMtTVDDIEPEVMRELLVYMYTGQtk 335
Cdd:cd18349   2 MFNNELMADVHFI----VGPPgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEI-HIPDVEPAAFLILLKYMYSDE-- 74

                        90       100
                ....*....|....*....|....*...
gi 15718247 336 yIEQMAQSLIA---AADKYQLDRLKVMC 360
Cdd:cd18349  75 -IDLEADTVLAtlyAAKKYIVPALAKAC 101
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 249-372 5.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 51.32  E-value: 5.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 249 CRLADDMYGLFDNKQFSDFTLvCKSDLGSPTqtfhiHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVY 328
Cdd:cd18268   8 SELLRQLNSLRQERILTDVIL-CTGDKEIPC-----HRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15718247 329 MYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18268  82 VYTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPEN 125
MATH_TRIM37 cd03773
Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal ...
 101-221 6.26e-08

Tripartite motif containing protein 37 (TRIM37) family, MATH domain; TRIM37 is a peroxisomal protein and is a member of the tripartite motif (TRIM) protein subfamily, also known as the RING-B-box-coiled-coil (RBCC) subfamily of zinc-finger proteins. Mutations in the human TRIM37 gene (also known as MUL) cause Mulibrey (muscle-liver-brain-eye) nanism, a rare growth disorder of prenatal onset characterized by dysmorphic features, pericardial constriction and hepatomegaly. TRIM37, similar to other TRIMs, contains a cysteine-rich, zinc-binding RING-finger domain followed by another cysteine-rich zinc-binding domain, the B-box, and a coiled-coil domain. TRIM37 is autoubiquitinated in a RING domain-dependent manner, indicating that it functions as an ubiquitin E3 ligase. In addition to the tripartite motif, TRIM37 also contains a MATH domain C-terminal to the coiled-coil domain. The MATH domain of TRIM37 has been shown to interact with the TRAF domain of six known TRAFs in vitro, however, it is unclear whether this is physiologically relevant. Eleven TRIM37 mutations have been associated with Mulibrey nanism so far. One mutation, Gly322Val, is located in the MATH domain and is the only mutation that does not affect the length of the protein. It results in the incorrect subcellular localization of TRIM37.


Pssm-ID: 239742  Cd Length: 132  Bit Score: 51.26  E-value: 6.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 101 TINNFSFCREEmGEVLKSSTFSAgcnDKLKWCLRINPKGLDEESRDYLSLYLLLVQCNKSEVRAKFKFSILNaKREETKA 180
Cdd:cd03773  10 TLENFSTLRQS-ADPVYSDPLNV---DGLCWRLKVYPDGNGEVRGNFLSVFLELCSGLGEASKYEYRVEMVH-QANPTKN 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15718247 181 MESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPGDRLSI 221
Cdd:cd03773  85 IKREFASDFEVGECWGYNRFFRLDLLINEGYLLPENDTLIL 125
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 7.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 50.90  E-value: 7.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSDLGspTQTFHIHKAILAARSRVFSAMFEHHMqeSDTNMTT-VDDIEPEVMRELLVYMYTGQTKY 336
Cdd:cd18281  16 LFNNETLSDVHFIVGKGDN--EQRIPAHKFVLSIGSAVFDAMFNGGM--ATTSAEIeLPDVEPAAFLALLRFLYSDEVQI 91

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15718247 337 IEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18281  92 GPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-372 8.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 51.00  E-value: 8.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLvcksdlGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMY 330
Cdd:cd18341  14 LQDGLKELLDENKFVDCTL------KAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLY 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15718247 331 TGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18341  88 SAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPAN 129
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-364 9.28e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 50.09  E-value: 9.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVcksdLGSP--TQTFHIHKAILAARSRVFSAMFEHHMQESDTNMtTVDDIEPEVMRELLVYMYTGQtk 335
Cdd:cd18282   1 MFNNELMADVHFI----VGPPggTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEI-EIPDVEPAAFLNLLRYLYCDE-- 73

                        90       100       110
                ....*....|....*....|....*....|..
gi 15718247 336 yIEQMAQSLIA---AADKYQLDRLKVMCEQAL 364
Cdd:cd18282  74 -IDLEPDTVLAtlyAAKKYLVPHLARACVQFL 104
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 1.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 50.46  E-value: 1.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSDLGSptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTtVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18347  16 LFNNEVLSDVHFLVGKGLGS--QRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIE-LPDVEPAAFLALLKFLYSDEVQIG 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15718247 338 EQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18347  93 PETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-372 2.15e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 49.76  E-value: 2.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18249  33 KKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEV 112

                        90
                ....*....|...
gi 15718247 360 CEQALCYQLTTDN 372
Cdd:cd18249 113 CCEFLKRQLDPSN 125
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 247-364 4.07e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 49.68  E-value: 4.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 247 PPCRLADDmYG-LFDNKQFSDFTLVcksdLGSPTQTFHIHKAILAARSR---------------VFSAMFEHHMQESDTN 310
Cdd:cd18308   6 PKCTLHDD-FGrLLESRQFCDVEFI----VGEEEERIPAHIAFVAARSKwlrnkilqarerqkqKAEQEVEDEGSEADSS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15718247 311 MTT----------VDDIEPEVMRELLVYMYTGQTKYIEQMA-----QSLIAAADKYQL------DRLKVMCEQAL 364
Cdd:cd18308  81 SASkndspmlevrLPEADPEAFELILSFIYTDKIDPTRKGQdpgsnEVVLLMMDVYRLalqfqmSRLEQLCVQYL 155
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 264-334 6.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 47.16  E-value: 6.21e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15718247 264 FSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFehhmQESDTNMTTV---DDIEPEVMRELLVYMYTGQT 334
Cdd:cd18315   1 LVDVTLACEG------GSLKAHKLVLAAASPYFAALL----KETPPDEHPViilPDVPYSELKALLDFIYTGEV 64
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-377 8.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 48.09  E-value: 8.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVcksdLGSP--TQTFHIHKAILAARSRVFSAMFEHHMQEsDTNMTTVDDIEPEVMRELLVYMYTGQTK 335
Cdd:cd18348  15 MFNNDLMADIHFV----VGPPggTQRLPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEID 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 15718247 336 YIEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNASLTL 377
Cdd:cd18348  90 LAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-364 1.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 47.27  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEH-HMQESDTNMttvddIEPEVMRELLVYMYTGQ----TKYIEQMAQSLIAAADKYQLDRL 356
Cdd:cd18334  33 FRAHKNILAASSMYFKSLVLHdNLINLDTDM-----VNPTVFRQILDFIYTGKlltsDQPGEQNFNALLTAASYLQLHDL 107


                ....*...
gi 15718247 357 KVMCEQAL 364
Cdd:cd18334 108 AALCRKKL 115
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 264-360 1.14e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 46.72  E-value: 1.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIE---PEVMRELLVYMYTGQTKYIEQM 340
Cdd:cd18307   1 FCDVVISVDN------HSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDylsPETVEQLLDYFYTGKIVISEKN 74

                        90       100
                ....*....|....*....|
gi 15718247 341 AQSLIAAADKYQLDRLKVMC 360
Cdd:cd18307  75 VEDLLKGAKYFNIPRLKDHC 94
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 1.29e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 47.69  E-value: 1.29e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSDlgsptqTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18270  20 FYEQQLLTDIVLIVEGT------EFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAIN 93

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15718247 338 EQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18270  94 DSTVEQLYETACFLQVEDVLQRCREYLIKKINAEN 128
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 102-209 3.46e-06

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 45.71  E-value: 3.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247   102 INNFSfcREEMGEVLKSSTFSAGcndKLKWCLRINPKGldeesrDYLSLYLllvQCNKSE-------VRAKFKFSILNAK 174
Cdd:pfam00917   1 IKNFS--KIKEGESYYSPVEERF---NIPWRLQIYRKG------GFLGLYL---HCDKEEelergwsIETEFTLKLVSSN 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15718247   175 ReetKAMESQRAYRFVQGKDWGFKKFIRRDFLLDE 209
Cdd:pfam00917  67 G---KSVTKTDTHVFEKPKGWGWGKFISWDDLEKD 98
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 271-364 3.47e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 45.96  E-value: 3.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 271 CKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADK 350
Cdd:cd18263  14 CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                        90
                ....*....|....
gi 15718247 351 YQLDRLKVMCEQAL 364
Cdd:cd18263  94 LQISGALALCLDFL 107
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 262-372 4.10e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 45.73  E-value: 4.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 262 KQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMT---TVDDIEPEVMRELLVYMYTGQTKYIE 338
Cdd:cd18258  15 KEFTDLKIIVEG------KEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKlelTMSNINADVLELLLEFVYTGSLIIDS 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 15718247 339 QMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18258  89 ANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASN 122
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 260-364 4.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 46.04  E-value: 4.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 260 DNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQ 339
Cdd:cd18272  28 EDGLFADVTISVEG------KEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVE 101

                        90       100
                ....*....|....*....|....*
gi 15718247 340 MAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18272 102 ELQETYEVADMYQLTALFEECSRFL 126
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 259-348 5.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 45.17  E-value: 5.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 259 FDNKQFSDFtlVCKSDLGSPTQTFHIHKAILAARSRVFSAMF--EHHMQESdtnMTTVDDIEPEVMRELLVYMYTGQTKY 336
Cdd:cd18212  14 FEEQRKKDF--LCDITLIVENVQFRAHKALLAASSEYFSMMFadEGEVGQS---IYMLEGMVAETFGALLEFIYTGCLQV 88

                        90
                ....*....|..
gi 15718247 337 IEQMAQSLIAAA 348
Cdd:cd18212  89 GEKSLEQILATA 100
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 259-364 9.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 44.54  E-value: 9.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 259 FDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEhhmqESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIE 338
Cdd:cd18354  15 FDNPDTADLKFLVDG------KYIYVHKVLLKIRCEHFRSLLN----ENEEEIIEMSQFSYPVYRAFLEYLYTDSISLSP 84

                        90       100
                ....*....|....*....|....*.
gi 15718247 339 QMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18354  85 EDAIGLLDLATFYRENRLKKLCQQTI 110
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 266-372 1.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 44.80  E-value: 1.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 266 DFTLVCksdlGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLI 345
Cdd:cd18239  25 DVTLVP----GDGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTL 100

                        90       100
                ....*....|....*....|....*..
gi 15718247 346 AAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18239 101 EAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 266-372 1.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 44.42  E-value: 1.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 266 DFTLVCKsdlgspTQTFHIHKAILAARSRVFSAMFEhhmQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLI 345
Cdd:cd18260  20 DLTIATK------TKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTGKLTLSLYTIGSTI 90

                        90       100
                ....*....|....*....|....*..
gi 15718247 346 AAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18260  91 SAASYLQIHALVKMCCDFLMQEMNVEN 117
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 263-372 1.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 44.46  E-value: 1.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 263 QFSDFTLVCKsdlGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDT------NMTTVDDIEPEVMRELLVYMYTGQTKY 336
Cdd:cd18241  22 LFCDITLAFG---GAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSgrvemrKWSSEPGPDPDTVEAVIQYMYTGRIRV 98

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15718247 337 IEQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18241  99 STGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-374 2.51e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 43.79  E-value: 2.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18244  24 LYEEGLLLDVTLVIED------HQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELS 97

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15718247 338 EQMAQSLIAAADKYQLDRLKVMCEQALCYQLTTDNAS 374
Cdd:cd18244  98 MLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCA 134
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 250-339 2.79e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 43.83  E-value: 2.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 250 RLADDMYGLFDNKQ--FSDFTLVCksDLGSPTqtfHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEP-------- 319
Cdd:cd18310   2 KLSSDLENLLDSPDlfYSDAEIIV--EGGRPV---PVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELipggivgy 76

                        90       100
                ....*....|....*....|
gi 15718247 320 EVMRELLVYMYTGQTKYIEQ 339
Cdd:cd18310  77 DAFMLVLSYLYSGRLRLVPK 96
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-372 3.67e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 43.25  E-value: 3.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18276  33 FPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQ 112

                        90
                ....*....|.
gi 15718247 362 QALCYQLTTDN 372
Cdd:cd18276 113 KYMMDHMDASN 123
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 264-369 4.93e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 42.64  E-value: 4.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLvcKSDLGsptqTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQM-AQ 342
Cdd:cd18358  20 FSDVTF--KLDDG----TINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADLdPL 93

                        90       100
                ....*....|....*....|....*..
gi 15718247 343 SLIAAADKYQLDRLKVMCEQALCYQLT 369
Cdd:cd18358  94 ELIALANRFCLPHLVALTEQHAVQELT 120
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-361 5.41e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 42.45  E-value: 5.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFTLVCKSDlgsptQTFHIHKAILAARSRVFSAMFEHH---MQESDTNMT---TVDDIEPEVMRE 324
Cdd:cd18288   5 LAADFSAMVNNPHLSDVQFQTDSG-----EVLYAHSFVLYARCPLLIQMVHSEgfsVEEEGGVTTrrvLLGDVSGEAARC 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15718247 325 LLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18288  80 FLQYLYTADTGLPPGLSPHVSELADRFGVSELVHLCE 116
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 369-416 6.77e-05

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 40.34  E-value: 6.77e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 15718247 369 TTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDH 416
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVEL 48
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 285-372 6.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 42.36  E-value: 6.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 285 HKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18337  38 HRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 117


                ....*...
gi 15718247 365 CYQLTTDN 372
Cdd:cd18337 118 MKQLHPSN 125
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-372 1.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 41.89  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKsdlGSPtqtFHIHKAILAARSRVFSAMFEHHmQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18351  18 FLNNKEMSDVTFLVE---GRP---FYAHKVLLFTASPRFKALLSNK-PSAENTCIEISYVKYHIFQLVMQYLYCGGTESL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15718247 338 -----EQMaqSLIAAADKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18351  91 liknnEIM--ELLSAAKFFQLEALQRHCEIICAKSINTEN 128
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 250-361 1.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 41.40  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 250 RLADDMYGLFDNKQ----FSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMREL 325
Cdd:cd18215   1 RHASDVLLNLNRLRsrdiLTDVVLVVGR------EQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRIL 74

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 15718247 326 LVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18215  75 LDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCR 110
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-364 1.33e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 41.43  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHhmqesdTNMTTVDD--IEPEVMRELLVYMYTGQTKYIEQMAQ----SLIAAADKYQLDR 355
Cdd:cd18333  33 FRAHKNILAASSVYLKSLVVH------DNLINLDHemVSPGIFRLILDYIYTGRLSEGDPGSEqnlgAVLAAASYLQIPD 106


                ....*....
gi 15718247 356 LKVMCEQAL 364
Cdd:cd18333 107 LVALCKKKL 115
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 279-364 1.44e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 41.17  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 279 TQTFHIHKAILAARSRVFSAMFEHHMQEsdtnmTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKV 358
Cdd:cd18205  27 SQEFHAHRTVLACTSKMFEILFHRNSQH-----YTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAEILEIEYLEE 101


                ....*.
gi 15718247 359 MCEQAL 364
Cdd:cd18205 102 QCLKIL 107
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 266-333 1.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 41.13  E-value: 1.77e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15718247 266 DFTLVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHhmQESDTNMTTVDDIEPEVMRELLVYMYTGQ 333
Cdd:cd18193  17 EFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVH--QTSECVRLKPTDIQPDIFSYLLHLMYTGK 82
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 245-362 1.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 41.38  E-value: 1.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 245 KVPPCRLADDMYGLFDNKQFSDFTLvcKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQeSDTNMTTV--DDIEPEVM 322
Cdd:cd18211   6 KSAPSNLLNEMHKLRLLGHLCDVTV--QVEHQGSKEEFSAHKAVLAASSKYFKEVFLNEKI-SDGKNTNVmlNEIYTADF 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15718247 323 RELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18211  83 ASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ 122
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 285-360 3.30e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 40.41  E-value: 3.30e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15718247 285 HKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMC 360
Cdd:cd18335  34 HRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLSQVVEVC 109
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 368-425 4.47e-04

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 38.26  E-value: 4.47e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15718247 368 LTTDNASLTLMLADMYSASQLRAHSINFINVNANEVMDTEGWEDLVRDHPKLLEEVFR 425
Cdd:cd18500   1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYR 58
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 266-333 5.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 39.88  E-value: 5.90e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15718247 266 DFTLVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHhmQESDTNMTTVDDIEPEVMRELLVYMYTGQ 333
Cdd:cd18213  17 EFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIH--QSSECIKIQPTDIQPDIFSYLLHIMYTGK 82
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 258-362 7.47e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 39.11  E-value: 7.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCKSDlgsptQTFHIHKAILAARSRVFsAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYI 337
Cdd:cd18311   8 LFNKTEYCDLTLQFRDN-----EQLKVHRLVLSACTDYF-NVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEFE 81

                        90       100
                ....*....|....*....|....*
gi 15718247 338 EQMAQSLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18311  82 EKSYGKLLRTAKELNMTVLLKLLEA 106
PHA03098 PHA03098
kelch-like protein; Provisional
 284-396 8.90e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 41.68  E-value: 8.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  284 IHKAILAARSRVFSAMFEHHMQESDTNMTtvDDIEP--EVMRellvYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:PHA03098  25 VHKIILSSSSEYFKKMFKNNFKENEINLN--IDYDSfnEVIK----YIYTGKINITSNNVKDILSIANYLIIDFLINLCI 98

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 15718247  362 QALCYQLTTDNASLTLMLADMYSASQLRAHSINFI 396
Cdd:PHA03098  99 NYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYI 133
MATH_TRAF6 cd03776
Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF ...
 98-226 1.03e-03

Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF6 subfamily, TRAF domain, C-terminal MATH subdomain; composed of proteins with similarity to human TRAF6, including the Drosophila protein DTRAF2. TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses. TRAF6 is the most divergent in its TRAF domain among the mammalian TRAFs. In addition to mediating TNFR family signaling, it is also an essential signaling molecule of the interleukin-1/Toll-like receptor superfamily. Whereas other TRAF molecules display similar and overlapping TNFR-binding specificities, TRAF6 binds completely different sites on receptors such as CD40 and RANK. TRAF6 serves as a molecular bridge between innate and adaptive immunity and plays a central role in osteoimmunology. DTRAF2, as an activator of nuclear factor-kappaB, plays a pivotal role in Drosophila development and innate immunity. TRAF6 contains a RING finger domain, five zinc finger domains, and a TRAF domain. The TRAF domain can be divided into a more divergent N-terminal alpha helical region (TRAF-N), and a highly conserved C-terminal MATH subdomain (TRAF-C) with an eight-stranded beta-sandwich structure. TRAF-N mediates trimerization while TRAF-C interacts with receptors.


Pssm-ID: 239745  Cd Length: 147  Bit Score: 39.23  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247  98 YMWTINNFSFCREEMGE----VLKSSTFSAGCNDkLKWCLRINPKGLDEESRDYLSLYLLLVQcnkSE--------VRAK 165
Cdd:cd03776   3 YVWKIKNFSNLRRSMEAgspvVIHSPGFYTSPPG-YKLCARLNLSLPEARCPNYISLFVHLMQ---GEndshldwpFQGT 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15718247 166 FKFSILNAKREE---TKAMES-------QRAYRFVQGKDWGFKKFIRRDFLLDEanGLLPGDRLSIFCEVS 226
Cdd:cd03776  79 ITLTLLDQSEPRqniHETMMSkpellafQRPTTDRNPKGFGYVEFAHIEDLLQR--GFVKNDTLLIKIEVN 147
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 258-333 1.56e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 38.38  E-value: 1.56e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15718247 258 LFDNKQFSDFTLVCksdLGSPtqtFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQ 333
Cdd:cd18295  13 LLEQGSYSDVTFNV---HGES---FPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGR 82
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 258-365 1.68e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 38.03  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 258 LFDNKQFSDFTLVCksdLGsptQTFHIHKAILAaRSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELL--VY--MYTGQ 333
Cdd:cd18305   9 LFLNGENSDITICA---LG---REWKLHKIYLC-QSGYFASMFSGSWKESKETVINLEIPDDNITVEALnvVFgsLYRDE 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 15718247 334 TKYIEQMAQSLIAAADKYQLDRLKVMCEQALC 365
Cdd:cd18305  82 IEIKPSRVVSILAAATLLQLDGLIQQCSEVMK 113
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 264-362 1.78e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 38.45  E-value: 1.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 264 FSDFTLVCksDLGsptqTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQ-TKYIEQMAQ 342
Cdd:cd18359  20 FSDVTFML--DDG----TISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQfSSSPDLDDM 93

                        90       100
                ....*....|....*....|
gi 15718247 343 SLIAAADKYQLDRLKVMCEQ 362
Cdd:cd18359  94 KLIILANRLCLPHLVALTEQ 113
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-361 1.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 37.81  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEhhmqESDTNMTTVD--DIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18217  30 FKAHRNVLAAFSEYFGAQYK----DTEDNIVFLDqsQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAK 105


                ..
gi 15718247 360 CE 361
Cdd:cd18217 106 CK 107
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 269-372 1.94e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 38.24  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 269 LVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAA 348
Cdd:cd18264  27 FLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAA 106

                        90       100
                ....*....|....*....|....
gi 15718247 349 DKYQLDRLKVMCEQALCYQLTTDN 372
Cdd:cd18264 107 SYLQVTEAIGLCSQYLINNLAPEN 130
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-362 2.25e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 37.71  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESdTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18204  30 FRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCS 108


                .
gi 15718247 362 Q 362
Cdd:cd18204 109 Q 109
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-364 2.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 38.10  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARsrvfSAMFEHHMQESDTNMTTVDDIE-PEVMRELLVYMYTGqtKYIEQMAQ--SLIAAADKYQLDRL 356
Cdd:cd18222  35 QSFRAHKVVLAAS----SPYFRDHMSLNEMSTVSISVIKnPTVFEQLLSFCYTG--RICLQLADiiSYLTAASFLQMQHI 108


                ....*...
gi 15718247 357 KVMCEQAL 364
Cdd:cd18222 109 IDKCTQIL 116
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 250-331 2.60e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 37.33  E-value: 2.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 250 RLADDMYGLFDNKQFSDFTLVCKSDLgsptqtFHIHKAILAARSRVFSAMFEHHMQESDTNMTT-VDDIEPEVMRELLVY 328
Cdd:cd18285   1 HLSQDLLRLLREELHTDVTFYVGSTL------FKAHKAILLARVPEFFSHIIGKLSSLEDQEPInIENLEASEFKTFLRQ 74


                ...
gi 15718247 329 MYT 331
Cdd:cd18285  75 VYT 77
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 263-333 2.82e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 37.67  E-value: 2.82e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15718247 263 QFSDFTLVCKSdlgsptQTFHIHKAILAARSRVFSAMFEHHMQESdtnMTTVDDIEPEVMRELLVYMYTGQ 333
Cdd:cd18221  17 QFTDITLIVDG------HQFKAHKAVLAACSQFFYKFFQDFTQEP---LVEIEGVSNMAFRHLIEFTYTAK 78
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 280-364 3.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 37.53  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 280 QTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVM 359
Cdd:cd18331  34 EQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDT 113


                ....*
gi 15718247 360 CEQAL 364
Cdd:cd18331 114 CRKFI 118
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 269-364 3.76e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 37.22  E-value: 3.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 269 LVCKSDLGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAA 348
Cdd:cd18326  24 LLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAA 103

                        90
                ....*....|....*.
gi 15718247 349 DKYQLDRLKVMCEQAL 364
Cdd:cd18326 104 RLLEIPAVSHVCADLL 119
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-374 3.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 37.71  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18324  35 FRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCK 114

                        90
                ....*....|...
gi 15718247 362 QALCYQLTTDNAS 374
Cdd:cd18324 115 KKLKEKATTEADS 127
MATH_HAUSP cd03772
Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, ...
 101-230 3.90e-03

Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence playing an important role in the p53-MDM2 pathway. It contains an N-terminal TRAF-like domain and a C-terminal catalytic protease (C19 family) domain. The tumor suppressor p53 protein is a transcription factor that responds to many cellular stress signals and is regulated primarily through ubiquitylation and subsequent degradation. MDM2 is a RING-finger E3 ubiquitin ligase that promotes p53 ubiquitinylation. p53 and MDM2 bind to the same site in the N-terminal TRAF-like domain of HAUSP in a mutually exclusive manner. HAUSP also interacts with the Epstein-Barr nuclear antigen 1 (EBNA1) protein of the Epstein-Barr virus (EBV), which efficiently immortalizes infected cells predisposing the host to a variety of cancers. EBNA1 plays several important roles in EBV latent infection and cellular transformation. It binds the same pocket as p53 in the HAUSP TRAF-like domain. Through interactions with p53, MDM2 and EBNA1, HAUSP plays a role in cell proliferation, apoptosis and EBV-mediated immortalization.


Pssm-ID: 239741  Cd Length: 137  Bit Score: 37.43  E-value: 3.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 101 TINNFSfcreemgeVLKSSTFSAGCNDK-LKWCLRINPKGLDEESRDYLSLYLLLvQCNKSE------VRAKFKFSILNA 173
Cdd:cd03772   8 TVERFS--------RLSESVLSPPCFVRnLPWKIMVMPRNYPDRNPHQKSVGFFL-QCNAESdstswsCHAQAVLRIINY 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15718247 174 KREETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPGDrlSIFCEVSVVAE 230
Cdd:cd03772  79 KDDEPSFSRRISHLFFSKENDWGFSNFMTWSEVTDPEKGFIEDD--TITLEVYVQAD 133
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 251-364 4.41e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 37.08  E-value: 4.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 251 LADDMYGLFDNKQFSDFT-LVCKSDLGSPTQTFHIHKAILAARSrvfSAMFEHHMQESDTNMTTVDDIEPEVmRELLVYM 329
Cdd:cd18304   4 LSEDLGLLYDSQQGCDFNiSVLTAGGEEEELTFCAHRVILMLSP---EANFLHKTGSSNITLDVDEECLPHV-PDFLRYF 79

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15718247 330 YTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18304  80 YTRQIDITLTSVKCFHKLASIYGVRKLREYCGQLF 114
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-364 4.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 37.13  E-value: 4.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEH-HMQESDTNMTTvddiePEVMRELLVYMYTGQ---TKYIEQMAQSLIAAADKYQLDRLK 357
Cdd:cd18216  32 FRAHKNVLAASSGYFKSLVLHdNLIHLDQDMVS-----PTVFQQILDFIYTGKlldSLFEEPNLSEVLAAANYLQLPDLA 106


                ....*..
gi 15718247 358 VMCEQAL 364
Cdd:cd18216 107 ALCRSKL 113
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 250-364 5.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 36.73  E-value: 5.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 250 RLADDMYGLFDNKQFSDFTLVCKsdlgspTQTFHIHKAILAARSRVFSAMFEHhmqeSDTNMTTVDDIEPEVMRELLVYM 329
Cdd:cd18225   9 QLLQQLHTLRKEQQFCDCTIFIG------TFHFRAHKLVLAASSLLFKSLLDS----TDTISIDASVVSPEEFALLLEMV 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15718247 330 YTGQTKYIEQMAQSLIAAADKYQLDRLKVMCEQAL 364
Cdd:cd18225  79 YTGKLPPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 270-364 8.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 36.05  E-value: 8.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 270 VCKSD--LGSPTQTFHIHKAILAARSRVFSAMFEHHMQESDTNMtTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAA 347
Cdd:cd18231  14 LCDVDivLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQRVEL-SLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNA 92

                        90
                ....*....|....*..
gi 15718247 348 ADKYQLDRLKVMCEQAL 364
Cdd:cd18231  93 AAVLQMNDIAASCQELI 109
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 282-364 9.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 36.34  E-value: 9.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15718247 282 FHIHKAILAARSRVFSAMFEHHMQESDTNMTTVDDIEPEVMRELLVYMYTGQTKYIEQMAQSLIAAADKYQLDRLKVMCE 361
Cdd:cd18323  35 FLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCK 114


                ...
gi 15718247 362 QAL 364
Cdd:cd18323 115 KRL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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